المؤلفون: Benatar M; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: mbenatar@miami.edu., Hansen T; Orphazyme, Copenhagen, Denmark., Rom D; Prosoft Clinical, Chesterbrook, PA, USA., Geist MA; Orphazyme, Copenhagen, Denmark., Blaettler T; Orphazyme, Copenhagen, Denmark., Camu W; Department of Neurology University of Montpellier, CHU Montpellier, INM INSERM, Montpellier, France., Kuzma-Kozakiewicz M; Department of Neurology, Medical University of Warsaw, Warsaw, Poland., van den Berg LH; Department of Neurology, University Medical Center Utrecht, Utrecht, Netherlands., Morales RJ; Department of Neurology, Vall d'Hebron University Hospital, Barcelona, Spain., Chio A; Rita Levi Montalcini Department of Neuroscience, University of Torino, Torino, Italy., Andersen PM; Department of Clinical Sciences, Neuroscience, Umeå University, Umeå, Sweden., Pradat PF; APHP, Department of Neurology, Hôpital Pitié-Salpêtrière, Paris, France., Lange D; Department of Neurology, Hospital for Special Surgery, New York, NY, USA., Van Damme P; Department of Neurology, University Hospital Leuven, KU Leuven, Leuven, Belgium., Mora G; Istituti Clinici Scientifici Maugeri, IRCCS Milano, Milan, Italy., Grudniak M; Research and Development Department, Polish Stem Cell Bank, Warsaw, Poland., Elliott M; University of Virginia Medical Center, Charlottesville, VA, USA., Petri S; Department of Neurology, Hannover Medical School, Hannover, Germany., Olney N; Providence Portland Medical Center, Providence Brain and Spine Institute, Portland, OR, USA., Ladha S; Department of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA., Goyal NA; Department of Neurology, University of California Irvine, Irvine, CA, USA., Meyer T; Department of Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Hanna MG; University College London, National Hospital for Neurology and Neurosurgery, London, UK., Quinn C; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Genge A; Department of Neurology, Montreal Neurological Institute, Montreal, QC, Canada., Zinman L; Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Jabari D; Department of Neurology, The University of Kansas Medical Center, Kansas City, KS, USA., Shoesmith C; Department of Clinical Neurological Sciences, London Health Sciences Centre, Western University, London, ON, Canada., Ludolph AC; Department of Neurology, University of Ulm, Ulm, Germany., Neuwirth C; Neuromuscular Disease Unit/ALS Clinic, Kantonspital St Gallen, St Gallen, Switzerland., Nations S; University of Texas Southwestern, Dallas, TX, USA., Shefner JM; Department of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA., Turner MR; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Wuu J; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA., Bennett R; Orphazyme, Copenhagen, Denmark., Dang H; Orphazyme, Copenhagen, Denmark., Sundgreen C; Orphazyme, Copenhagen, Denmark.

مؤلفون مشاركون: ORARIALS-01 trial team

المصدر: The Lancet. Neurology [Lancet Neurol] 2024 Jul; Vol. 23 (7), pp. 687-699. Date of Electronic Publication: 2024 May 20.

نوع المنشور: Journal Article; Randomized Controlled Trial; Multicenter Study; Clinical Trial, Phase III

بيانات الدورية: Publisher: Lancet Pub. Group Country of Publication: England NLM ID: 101139309 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-4465 (Electronic) Linking ISSN: 14744422 NLM ISO Abbreviation: Lancet Neurol Subsets: MEDLINE

مواضيع طبية MeSH: Amyotrophic Lateral Sclerosis*/drug therapy , Neuroprotective Agents*/therapeutic use , Neuroprotective Agents*/adverse effects, Humans ; Male ; Female ; Double-Blind Method ; Middle Aged ; Aged ; Treatment Outcome ; Adult ; Hydroxylamines/therapeutic use ; Hydroxylamines/adverse effects ; Hydroxylamines/pharmacology ; Oxadiazoles/therapeutic use ; Oxadiazoles/adverse effects

المؤلفون: Olney NT; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA., Ong E; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA., Goh SM; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA., Bajorek L; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA., Dever R; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA., Staffaroni AM; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA., Cobigo Y; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA., Bock M; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA., Chiang K; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA., Ljubenkov P; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA., Kornak J; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA., Heuer HW; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA., Wang P; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA., Rascovsky K; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Wolf A; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA., Appleby B; Department of Neurology, Case Western Reserve University, Cleveland, OH, USA., Bove J; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Bordelon Y; Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA., Brannelly P; Tau Consortium, Rainwater Charitable Foundation, Fort Worth, TX, USA., Brushaber D; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA., Caso C; Department of Neurology, University of Washington, Seattle, WA, USA., Coppola G; Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA., Dickerson BC; Department of Neurology, Frontotemporal Disorders Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Dickinson S; Association for Frontotemporal Degeneration, Radnor, PA, USA., Domoto-Reilly K; Department of Neurology, University of Washington, Seattle, WA, USA., Faber K; National Centralized Repository for Alzheimer's Disease and Related Disorders (NCRAD), Indiana University, Indianapolis, IN, USA., Ferrall J; Department of Neurology, University of North Carolina, Chapel Hill, NC, USA., Fields J; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Fishman A; Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Fong J; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA., Foroud T; National Centralized Repository for Alzheimer's Disease and Related Disorders (NCRAD), Indiana University, Indianapolis, IN, USA., Forsberg LK; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Gearhart DJ; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Ghazanfari B; Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada., Ghoshal N; Department of Psychiatry, Washington University, St. Louis, MO, USA.; Department of Neurology, Washington University, St. Louis, MO, USA., Goldman J; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Columbia University, New York, NY, USA., Graff-Radford J; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Graff-Radford NR; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Grant I; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Grossman M; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Haley D; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Hsiung G; Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Huey ED; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Columbia University, New York, NY, USA., Irwin DJ; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Jones DT; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Kantarci K; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Karydas AM; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA., Kaufer D; Department of Neurology, University of North Carolina, Chapel Hill, NC, USA., Kerwin D; Department of Neurology and Neurotherapeutics, Center for Alzheimer's and Neurodegenerative Diseases, The University of Texas, Southwestern Medical Center at Dallas, Dallas, TX, USA.; Department of Internal Medicine, The University of Texas, Southwestern Medical Center at Dallas, Dallas, TX, USA., Knopman DS; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Kramer JH; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA., Kraft R; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Kremers W; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA., Kukull W; National Alzheimer Coordinating Center (NACC), University of Washington, Seattle, WA, USA., Lapid MI; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Litvan I; Department of Neurosciences, Parkinson and Other Movement Disorders Center, University of California, San Diego, San Diego, CA, USA., Mackenzie IR; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada., Maldonado M; Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA., Manoochehri M; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.; Department of Neurology, Columbia University, New York, NY, USA., McGinnis SM; Department of Neurology, Frontotemporal Disorders Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., McKinley EC; Department of Neurology, Alzheimer's Disease Center, University of Alabama at Birmingham, Birmingham, AL, USA., Mendez MF; Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA., Miller BL; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA., Onyike C; Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Pantelyat A; Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Pearlman R; The Bluefield Project, San Francisco, CA, USA., Petrucelli L; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Potter M; National Centralized Repository for Alzheimer's Disease and Related Disorders (NCRAD), Indiana University, Indianapolis, IN, USA., Rademakers R; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Ramos EM; Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA., Rankin KP; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA., Roberson ED; Department of Neurology, Alzheimer's Disease Center, University of Alabama at Birmingham, Birmingham, AL, USA., Rogalski E; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Sengdy P; Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Shaw LM; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Syrjanen J; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA., Tartaglia MC; Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada., Tatton N; Association for Frontotemporal Degeneration, Radnor, PA, USA., Taylor J; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA., Toga A; Laboratory of Neuroimaging (LONI), University of Southern California, Los Angeles, CA, USA., Trojanowski JQ; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Weintraub S; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Wong B; Department of Neurology, Frontotemporal Disorders Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Wszolek Z; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Boxer AL; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA., Boeve BF; Department of Neurology, Mayo Clinic, Rochester, MN, USA., Rosen HJ; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA.

مؤلفون مشاركون: ARTFL and LEFFTDS consortia

المصدر: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2020 Jan; Vol. 16 (1), pp. 49-59. Date of Electronic Publication: 2020 Jan 06.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE

مواضيع طبية MeSH: Frontotemporal Lobar Degeneration*/genetics , Frontotemporal Lobar Degeneration*/pathology , Genetic Predisposition to Disease*, Atrophy/*pathology , Image Processing, Computer-Assisted/*statistics & numerical data , Neuropsychological Tests/*statistics & numerical data, C9orf72 Protein/genetics ; Female ; Humans ; Longitudinal Studies ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Progranulins/genetics ; Temporal Lobe/pathology ; tau Proteins/genetics

المؤلفون: Meeter LHH; Alzheimer Center and Department of Neurology, Erasmus MC, Rotterdam, The Netherlands., Steketee RME; Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, Zuid-Holland, The Netherlands., Salkovic D; Alzheimer Center and Department of Neurology, Erasmus MC, Rotterdam, The Netherlands., Vos ME; Alzheimer Center and Department of Neurology, Erasmus MC, Rotterdam, The Netherlands., Grossman M; Penn FTD Center, Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., McMillan CT; Penn FTD Center, Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Irwin DJ; Penn FTD Center, Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Boxer AL; Neurology, Memory and Aging Center University of California San Francisco, San Francisco, California, USA., Rojas JC; Neurology, Memory and Aging Center University of California San Francisco, San Francisco, California, USA., Olney NT; Neurology, University of California San Francisco Memory and Aging Center, San Francisco, California, USA., Karydas A; Neurology, University of California San Francisco Memory and Aging Center, San Francisco, California, USA., Miller BL; Neurology, Memory and Aging Center University of California San Francisco, San Francisco, California, USA., Pijnenburg YAL; Alzheimer Center and Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands., Barkhof F; Department of Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.; Neurology and Healthcare Engineering, University College London Medical School, London, UK., Sánchez-Valle R; Department of Neurology, Hospital Clinic de Barcelona, Barcelona, Catalunya, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain., Lladó A; Department of Neurology, Hospital Clinic de Barcelona, Barcelona, Catalunya, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain., Borrego-Ecija S; Department of Neurology, Hospital Clinic de Barcelona, Barcelona, Catalunya, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain., Diehl-Schmid J; Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technical University of Munich, School of Medicine, Munich, Germany., Grimmer T; Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technical University of Munich, School of Medicine, Munich, Germany., Goldhardt O; Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technical University of Munich, School of Medicine, Munich, Germany., Santillo AF; Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund, Sweden., Hansson O; Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund, Sweden., Vestberg S; Psychology, Lund University, Lund, Sweden., Borroni B; Centre for Ageing Brain and Neurodegenerative Disorders, Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Padovani A; Centre for Ageing Brain and Neurodegenerative Disorders, Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Galimberti D; Neurodegenerative Diseases Unit, Fondazione IRCCS Ca' Granda, Ospedale Policlinico, Milan, Italy.; Biomedical, Surgical and Dental Sciences, University of Milan, Centro Dino Ferrari, Milan, Italy., Scarpini E; Neurodegenerative Diseases Unit, Fondazione IRCCS Ca' Granda, Ospedale Policlinico, Milan, Italy.; Pathophysiology and Transplantation, University of Milan, Centro Dino Ferrari, Milan, Italy., Rohrer JD; Dementia Research Centre, Department of Neurodegenerative Diseases, UCL Institute of Neurology, London, UK., Woollacott IOC; Dementia Research Centre, Department of Neurodegenerative Diseases, UCL Institute of Neurology, London, UK., Synofzik M; Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, Tübingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Wilke C; Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, Tübingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., de Mendonca A; Institute of Molecular Medicine and Faculty of Medicine, University of Lisbon, Lisbon, Portugal., Vandenberghe R; Department of Neurology, University Hospital Leuven, Leuven, Belgium.; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Vlaanderen, Belgium., Benussi L; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Ghidoni R; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Binetti G; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.; MAC Memory Clinic, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Niessen WJ; Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, Zuid-Holland, The Netherlands.; Imaging Physics, Applied Sciences, Delft University of Technology, Delft, The Netherlands., Papma JM; Alzheimer Center and Department of Neurology, Erasmus MC, Rotterdam, The Netherlands., Seelaar H; Alzheimer Center and Department of Neurology, Erasmus MC, Rotterdam, The Netherlands., Jiskoot LC; Alzheimer Center and Department of Neurology, Erasmus MC, Rotterdam, The Netherlands., de Jong FJ; Alzheimer Center and Department of Neurology, Erasmus MC, Rotterdam, The Netherlands., Donker Kaat L; Alzheimer Center and Department of Neurology, Erasmus MC, Rotterdam, The Netherlands.; Department of Clinical Genetics, Leids Universitair Medisch Centrum, Leiden, Zuid-Holland, The Netherlands., Del Campo M; Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands., Teunissen CE; Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands., Bron EE; Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, Zuid-Holland, The Netherlands., Van den Berg E; Alzheimer Center and Department of Neurology, Erasmus MC, Rotterdam, The Netherlands., Van Swieten JC; Alzheimer Center and Department of Neurology, Erasmus MC, Rotterdam, The Netherlands j.c.vanswieten@erasmusmc.nl.

المصدر: Journal of neurology, neurosurgery, and psychiatry [J Neurol Neurosurg Psychiatry] 2019 Sep; Vol. 90 (9), pp. 997-1004. Date of Electronic Publication: 2019 May 23.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: BMJ Publishing Group Country of Publication: England NLM ID: 2985191R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-330X (Electronic) Linking ISSN: 00223050 NLM ISO Abbreviation: J Neurol Neurosurg Psychiatry Subsets: MEDLINE

مواضيع طبية MeSH: Frontotemporal Dementia/*cerebrospinal fluid , Neurofilament Proteins/*cerebrospinal fluid, Aged ; Case-Control Studies ; Cross-Sectional Studies ; Female ; Frontotemporal Dementia/diagnosis ; Frontotemporal Dementia/diagnostic imaging ; Frontotemporal Dementia/mortality ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neuroimaging ; Neuropsychological Tests ; Proportional Hazards Models ; Retrospective Studies

المؤلفون: Olney NT; Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, California, United States of America.; Department of Neurology, University of California San Francisco Amyotrophic Lateral Sclerosis Center, University of California San Francisco, San Francisco, California, United States of America., Bischof A; Department of Neurology, University of California San Francisco, San Francisco, California, United States of America.; Department of Neurology and Immunology Clinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, Basel, Switzerland., Rosen H; Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, California, United States of America., Caverzasi E; Department of Neurology, University of California San Francisco, San Francisco, California, United States of America., Stern WA; Department of Neurology, University of California San Francisco, San Francisco, California, United States of America., Lomen-Hoerth C; Department of Neurology, University of California San Francisco Amyotrophic Lateral Sclerosis Center, University of California San Francisco, San Francisco, California, United States of America., Miller BL; Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, California, United States of America., Henry RG; Department of Neurology, University of California San Francisco, San Francisco, California, United States of America., Papinutto N; Department of Neurology, University of California San Francisco, San Francisco, California, United States of America.

المصدر: PloS one [PLoS One] 2018 Nov 29; Vol. 13 (11), pp. e0208255. Date of Electronic Publication: 2018 Nov 29 (Print Publication: 2018).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Motor Neuron Disease/*pathology , Spinal Cord/*pathology, Adult ; Aged ; Amyotrophic Lateral Sclerosis/diagnostic imaging ; Amyotrophic Lateral Sclerosis/pathology ; Atrophy/diagnostic imaging ; Atrophy/pathology ; Female ; Frontotemporal Dementia/diagnostic imaging ; Frontotemporal Dementia/pathology ; Gray Matter/diagnostic imaging ; Gray Matter/pathology ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Motor Neuron Disease/diagnostic imaging ; Spinal Cord/diagnostic imaging ; White Matter/diagnostic imaging ; White Matter/pathology

SCR Disease Name: Frontotemporal Dementia With Motor Neuron Disease

المؤلفون: Li Y; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 94143, USA. yi.li@ucsf.edu., Barkovich MJ; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 94143, USA., Karch CM; Department of Psychiatry, Washington University, St. Louis, MO, 63110, USA., Nillo RM; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 94143, USA., Fan CC; Department of Cognitive Sciences, University of California, San Diego, La Jolla, CA, 92093, USA., Broce IJ; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 94143, USA., Tan CH; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 94143, USA., Cuneo D; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 94143, USA., Hess CP; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 94143, USA., Dillon WP; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 94143, USA., Glenn OA; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 94143, USA., Glastonbury CM; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 94143, USA., Olney N; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, 94158, USA., Yokoyama JS; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, 94158, USA., Bonham LW; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, 94158, USA., Miller B; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, 94158, USA., Kao A; Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, 94158, USA., Schmansky N; Athinoula A. Martinos Center, Harvard Medical School, Charlestown, MA, 02129, USA., Fischl B; Athinoula A. Martinos Center, Harvard Medical School, Charlestown, MA, 02129, USA.; Health Science and Technology Program and Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Boston, MA, 02139, USA., Andreassen OA; NORMENT Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Jernigan T; Department of Cognitive Sciences, University of California, San Diego, La Jolla, CA, 92093, USA., Dale A; Department of Cognitive Sciences, University of California, San Diego, La Jolla, CA, 92093, USA.; Departments of Radiology and Neurosciences, University of California, San Diego, La Jolla, California, United States of America., Barkovich AJ; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 94143, USA.; Departments of Neurology and Pediatrics, University of California, San Francisco, San Francisco, CA, 94143, USA., Desikan RS; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 94143, USA.; Departments of Neurology and Pediatrics, University of California, San Francisco, San Francisco, CA, 94143, USA., Sugrue LP; Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 94143, USA. leo.sugrue@ucsf.edu.

المصدر: Scientific reports [Sci Rep] 2018 Sep 06; Vol. 8 (1), pp. 13373. Date of Electronic Publication: 2018 Sep 06.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation, Neoplastic*, Cerebellum/*metabolism , Neurodevelopmental Disorders/*metabolism , Tuberous Sclerosis/*metabolism , Tuberous Sclerosis Complex 1 Protein/*biosynthesis , Tuberous Sclerosis Complex 2 Protein/*biosynthesis, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cerebellum/pathology ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Neurodevelopmental Disorders/pathology ; Tuberous Sclerosis/pathology

المؤلفون: Olney NT; Department of Neurology, Memory and Aging Center, University of California, Box 1207, San Francisco, CA, 94158, USA., Alquezar C; Department of Neurology, Memory and Aging Center, University of California, Box 1207, San Francisco, CA, 94158, USA., Ramos EM; Department of Neurology and Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, 90095, USA., Nana AL; Department of Neurology, Memory and Aging Center, University of California, Box 1207, San Francisco, CA, 94158, USA., Fong JC; Department of Neurology, Memory and Aging Center, University of California, Box 1207, San Francisco, CA, 94158, USA., Karydas AM; Department of Neurology, Memory and Aging Center, University of California, Box 1207, San Francisco, CA, 94158, USA., Taylor JB; Department of Neurology, Memory and Aging Center, University of California, Box 1207, San Francisco, CA, 94158, USA., Stephens ML; Department of Neurology, Memory and Aging Center, University of California, Box 1207, San Francisco, CA, 94158, USA., Argouarch AR; Department of Neurology, Memory and Aging Center, University of California, Box 1207, San Francisco, CA, 94158, USA., Van Berlo VA; Department of Neurology and Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, 90095, USA., Dokuru DR; Department of Neurology and Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, 90095, USA., Sherr EH; Department of Neurology and Pediatrics, University of California, San Francisco, CA, 94158, USA., Jicha GA; Department of Neurology, Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, 40536, USA., Dillon WP; Department of Radiology, University of California, San Francisco, CA, 94158, USA., Desikan RS; Department of Radiology, University of California, San Francisco, CA, 94158, USA., De May M; Department of Neurology, Memory and Aging Center, University of California, Box 1207, San Francisco, CA, 94158, USA., Seeley WW; Department of Neurology, Memory and Aging Center, University of California, Box 1207, San Francisco, CA, 94158, USA., Coppola G; Department of Neurology and Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, 90095, USA., Miller BL; Department of Neurology, Memory and Aging Center, University of California, Box 1207, San Francisco, CA, 94158, USA., Kao AW; Department of Neurology, Memory and Aging Center, University of California, Box 1207, San Francisco, CA, 94158, USA. aimee.kao@ucsf.edu.

المصدر: Acta neuropathologica [Acta Neuropathol] 2017 Nov; Vol. 134 (5), pp. 813-816. Date of Electronic Publication: 2017 Aug 21.

نوع المنشور: Case Reports; Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE

مواضيع طبية MeSH: Mutation*, Frontotemporal Dementia/*genetics , Signal Transduction/*physiology , TOR Serine-Threonine Kinases/*metabolism , Tuberous Sclerosis/*genetics , Tumor Suppressor Proteins/*genetics, Frontotemporal Dementia/metabolism ; Frontotemporal Dementia/pathology ; Humans ; Male ; Middle Aged ; Tuberous Sclerosis/metabolism ; Tuberous Sclerosis/pathology ; Tuberous Sclerosis Complex 1 Protein ; Tumor Suppressor Proteins/metabolism

المؤلفون: Olney NT; Department of Neurology, UCSF Memory and Aging Center, San Francisco, CA, USA. Electronic address: Nicholas.Olney@ucsf.edu., Spina S; Department of Neurology, UCSF Memory and Aging Center, San Francisco, CA, USA., Miller BL; Department of Neurology, UCSF Memory and Aging Center, San Francisco, CA, USA; UCSF School of Medicine, San Francisco, CA, USA.

المصدر: Neurologic clinics [Neurol Clin] 2017 May; Vol. 35 (2), pp. 339-374.

نوع المنشور: Historical Article; Journal Article; Review

بيانات الدورية: Publisher: Saunders Country of Publication: United States NLM ID: 8219232 Publication Model: Print Cited Medium: Internet ISSN: 1557-9875 (Electronic) Linking ISSN: 07338619 NLM ISO Abbreviation: Neurol Clin Subsets: MEDLINE

مواضيع طبية MeSH: Brain/*pathology , Frontotemporal Dementia/*pathology , Frontotemporal Dementia/*physiopathology, Brain/metabolism ; Frontotemporal Dementia/epidemiology ; Frontotemporal Dementia/history ; History, 20th Century ; Humans ; Supranuclear Palsy, Progressive/pathology ; Supranuclear Palsy, Progressive/physiopathology

المؤلفون: Olney NT; UCSF School of Medicine, San Francisco, CA 94143-1207, USA., Goodkind MS, Lomen-Hoerth C, Whalen PK, Williamson CA, Holley DE, Verstaen A, Brown LM, Miller BL, Kornak J, Levenson RW, Rosen HJ

المصدر: Brain : a journal of neurology [Brain] 2011 Dec; Vol. 134 (Pt 12), pp. 3458-69. Date of Electronic Publication: 2011 Dec 06.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0372537 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2156 (Electronic) Linking ISSN: 00068950 NLM ISO Abbreviation: Brain Subsets: MEDLINE

مواضيع طبية MeSH: Affective Symptoms/*physiopathology , Amyotrophic Lateral Sclerosis/*physiopathology , Brain/*physiopathology , Crying/*physiology , Laughter/*physiology, Adult ; Affective Symptoms/etiology ; Aged ; Amyotrophic Lateral Sclerosis/complications ; Emotions/physiology ; Female ; Humans ; Male ; Middle Aged ; Reflex, Startle/physiology

المؤلفون: Petrus M; Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA. mpetrus@gnf.org, Peier AM, Bandell M, Hwang SW, Huynh T, Olney N, Jegla T, Patapoutian A

المصدر: Molecular pain [Mol Pain] 2007 Dec 17; Vol. 3, pp. 40. Date of Electronic Publication: 2007 Dec 17.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Sage Publications Inc Country of Publication: United States NLM ID: 101242662 Publication Model: Electronic Cited Medium: Internet ISSN: 1744-8069 (Electronic) Linking ISSN: 17448069 NLM ISO Abbreviation: Mol Pain Subsets: MEDLINE

مواضيع طبية MeSH: Hyperalgesia/*metabolism , Transient Receptor Potential Channels/*physiology, Animals ; Behavior, Animal/drug effects ; Bradykinin/adverse effects ; CHO Cells ; Calcium Signaling/drug effects ; Cricetinae ; Cricetulus ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Interactions ; Humans ; Hyperalgesia/genetics ; Hyperalgesia/physiopathology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Oocytes ; Pain Measurement/methods ; Rats ; Rats, Sprague-Dawley ; TRPA1 Cation Channel ; Transfection/methods ; Transient Receptor Potential Channels/antagonists & inhibitors ; Transient Receptor Potential Channels/deficiency ; Transient Receptor Potential Channels/genetics ; Xenopus