المؤلفون: Mahin Abad Dar, Franziska Maiwald, Diego Benítez, Laurent Meijer, Nadège Loaëc, Conrad Kunick, Lutz Preu, Hanna Erdmann, Marcelo A. Comini, Oliver Koch, Diego Charquero, Christoph Hölscher

المساهمون: Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig], Institut Pasteur de Montevideo, Réseau International des Instituts Pasteur (RIIP), Forschungszentrum Borstel - Research Center Borstel, Technische Universität Dortmund [Dortmund] (TU), ManRos Therapeutics, This project was funded by the German 'Bundesministerium für Bildung und Forschung' (KMU-innovativ 5, Förderkennzeichen 0315814, to F. M., M. A. D., O. K., C. H., and C. K.). The support of FOCEM (MERCOSUR Structural Convergence Fund, COF 03/11) and ANII (grant Innova Uruguay, agreement DCI-ALA/2007/19.040 between Uruguay and the European Commission, INI_X_2011_1_4077 and POS_NAC_2013_1_114477) is acknowledged by M. A. C., D. B. and D. C.. L. M. was supported by a grant from the ‘Agence Nationale de la Recherche’ (ANR- 11-RPIB-0016 grant, Transleish).

المصدر: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2014, 83, pp.274-283. ⟨10.1016/j.ejmech.2014.06.020⟩

مصطلحات موضوعية: MESH: Trypanocidal Agents/chemical synthesis, MESH: Benzazepines/toxicity, Nagana, Mice, Chalcones, MESH: Structure-Activity Relationship, MESH: Cell Proliferation/drug effects, Human trypanosomiasis, Drug Discovery, MESH: Animals, MESH: Benzazepines/chemistry, biology, MESH: Trypanosoma brucei brucei/physiology, Chemistry, MESH: Macrophages/drug effects, General Medicine, Trypanocidal Agents, 3. Good health, MESH: Trypanocidal Agents/pharmacology, Biochemistry, Paullones, MESH: Trypanocidal Agents/toxicity, MESH: Trypanosomiasis, African/parasitology, Trypanosoma brucei brucei, Cell Line, Structure-Activity Relationship, Heck reaction, parasitic diseases, medicine, Animals, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, MESH: Trypanosoma brucei brucei/drug effects, MESH: Drug Design, MESH: Mice, Cell Proliferation, Pharmacology, MESH: Humans, MESH: Benzazepines/chemical synthesis, MESH: Trypanocidal Agents/chemistry, Macrophages, Organic Chemistry, MESH: Benzazepines/pharmacology, Benzazepines, biology.organism_classification, medicine.disease, Antiparasitic agent, Cinnamides, MESH: Cell Line, Trypanosomiasis, African, Drug Design, Trypanosoma

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0f950885441e6cd8f086d1dfed0feca
https://doi.org/10.1016/j.ejmech.2014.06.020

المصدر: Journal of Ethnopharmacology; 3; 569 - 575; 96

مصطلحات الفهرس: New Caledonia, Vanuatu, Leishmanicidal activity, Trypanocidal activity, Animals, Drug Evaluation, Preclinical, Leishmania donovani/drug effects, Mice, Microbial Sensitivity Tests, Plant Extracts/chemistry, Plant Extracts/pharmacology, Plants, Medicinal/chemistry, Trypanocidal Agents/chemistry, Trypanocidal Agents/pharmacology, Trypanosoma cruzi/drug effects, Artículo

URL: http://dspace.conacyt.gov.py/xmlui/handle/123456789/42275
http://dspace.conacyt.gov.py/jspui/bitstream/123456789/42275/1/2004screeningofnewcaledonianandvanuatumedicinalplantsforantiprotozoalactivity.pdf
http://dspace.conacyt.gov.py/jspui/bitstream/123456789/42275/1/2004 screening of new caledonian and vanuatu medicinal plants for antiprotozoal activity.pdf

المصدر: Journal of Ethnopharmacology; 3; 569 - 575; 96

مصطلحات الفهرس: New Caledonia, Vanuatu, Leishmanicidal activity, Trypanocidal activity, Animals, Drug Evaluation, Preclinical, Leishmania donovani/drug effects, Mice, Microbial Sensitivity Tests, Plant Extracts/chemistry, Plant Extracts/pharmacology, Plants, Medicinal/chemistry, Trypanocidal Agents/chemistry, Trypanocidal Agents/pharmacology, Trypanosoma cruzi/drug effects, Artículo

URL: http://dspace.conacyt.gov.py/xmlui/handle/123456789/42275
http://dspace.conacyt.gov.py/jspui/bitstream/123456789/42275/1/2004screeningofnewcaledonianandvanuatumedicinalplantsforantiprotozoalactivity.pdf
http://dspace.conacyt.gov.py/jspui/bitstream/123456789/42275/1/2004 screening of new caledonian and vanuatu medicinal plants for antiprotozoal activity.pdf

المصدر: P L o S Pathogens, 7 (6

مصطلحات الفهرس: Sciences exactes et naturelles, Sciences bio-médicales et agricoles, Amino Acid Sequence, Animals, Antibodies, Protozoan -- immunology -- pharmacology -- therapeutic use, Antibody Affinity, Cells, Cultured, Down-Regulation -- drug effects, Endocytosis -- drug effects, Humans, Mice, Mice, Inbred C57BL, Models, Biological, Models, Molecular, Molecular Sequence Data, Nanoparticles, Trypanocidal Agents -- pharmacology -- therapeutic use, Trypanosoma brucei brucei -- immunology -- metabolism -- physiology -- ultrastructure, Trypanosomiasis, African -- immunology -- metabolism -- therapy, Variant Surface Glycoproteins, Trypanosoma -- immunology, info:eu-repo/semantics/article, info:ulb-repo/semantics/articlePeerReview, info:ulb-repo/semantics/openurl/article

URL: https://dipot.ulb.ac.be/dspace/bitstream/2013/160716/4/doi_146170.pdf
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/160716
http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL

المصدر: The Journal of biological chemistry, 285 (3

مصطلحات الفهرس: Sciences bio-médicales et agricoles, Amino Acid Sequence, Benzamides -- chemistry, Benzamides -- metabolism, Benzamides -- pharmacology, Benzamides -- therapeutic use, Biocatalysis, Crystallography, X-Ray, Cytochrome P-450 Enzyme System -- antagonists & inhibitors, Cytochrome P-450 Enzyme System -- chemistry, Cytochrome P-450 Enzyme System -- metabolism, Drug Design, Enzyme Inhibitors -- chemistry, Enzyme Inhibitors -- metabolism, Enzyme Inhibitors -- pharmacology, Enzyme Inhibitors -- therapeutic use, Humans, Ligands, Microsomes -- enzymology, Models, Molecular, Protein Conformation, Sterols -- biosynthesis, Substrate Specificity, Trypanocidal Agents -- chemistry, Trypanocidal Agents -- metabolism, Trypanocidal Agents -- pharmacology, Trypanocidal Agents -- therapeutic use, Trypanosoma brucei brucei -- drug effects, Trypanosoma brucei brucei -- enzymology, Trypanosomiasis, African -- drug therapy, info:eu-repo/semantics/article, info:ulb-repo/semantics/articlePeerReview, info:ulb-repo/semantics/openurl/article

URL: https://dipot.ulb.ac.be/dspace/bitstream/2013/51605/5/doi_26716.pdf
https://dipot.ulb.ac.be/dspace/bitstream/2013/51605/3/doi_26716.pdf
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/51605
http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL

المصدر: The Journal of biological chemistry, 285 (3

مصطلحات الفهرس: Sciences bio-médicales et agricoles, Amino Acid Sequence, Benzamides -- chemistry, Benzamides -- metabolism, Benzamides -- pharmacology, Benzamides -- therapeutic use, Biocatalysis, Crystallography, X-Ray, Cytochrome P-450 Enzyme System -- antagonists & inhibitors, Cytochrome P-450 Enzyme System -- chemistry, Cytochrome P-450 Enzyme System -- metabolism, Drug Design, Enzyme Inhibitors -- chemistry, Enzyme Inhibitors -- metabolism, Enzyme Inhibitors -- pharmacology, Enzyme Inhibitors -- therapeutic use, Humans, Ligands, Microsomes -- enzymology, Models, Molecular, Protein Conformation, Sterols -- biosynthesis, Substrate Specificity, Trypanocidal Agents -- chemistry, Trypanocidal Agents -- metabolism, Trypanocidal Agents -- pharmacology, Trypanocidal Agents -- therapeutic use, Trypanosoma brucei brucei -- drug effects, Trypanosoma brucei brucei -- enzymology, Trypanosomiasis, African -- drug therapy, info:eu-repo/semantics/article, info:ulb-repo/semantics/articlePeerReview, info:ulb-repo/semantics/openurl/article

URL: https://dipot.ulb.ac.be/dspace/bitstream/2013/51605/5/doi_26716.pdf
https://dipot.ulb.ac.be/dspace/bitstream/2013/51605/3/doi_26716.pdf
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/51605
http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL

المصدر: Current drug targets, 9 (11

مصطلحات الفهرس: Sciences bio-médicales et agricoles, Animals, DNA-Directed RNA Polymerases -- antagonists & inhibitors, DNA-Directed RNA Polymerases -- genetics, DNA-Directed RNA Polymerases -- metabolism, Gene Expression Regulation -- drug effects, Humans, Models, Biological, Protozoan Infections -- drug therapy, Protozoan Infections -- parasitology, Transcription Factors -- antagonists & inhibitors, Transcription Factors -- genetics, Transcription Factors -- metabolism, Trypanocidal Agents -- pharmacology, Trypanocidal Agents -- therapeutic use, Trypanosoma -- enzymology, Trypanosoma -- genetics, Trypanosoma -- metabolism, info:eu-repo/semantics/article, info:ulb-repo/semantics/articlePeerReview, info:ulb-repo/semantics/openurl/article

URL: https://dipot.ulb.ac.be/dspace/bitstream/2013/51914/3/Vanhammecurdrugtargets2008.pdf
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/51914
http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL

المصدر: Current drug targets, 9 (11

مصطلحات الفهرس: Sciences bio-médicales et agricoles, Animals, DNA-Directed RNA Polymerases -- antagonists & inhibitors, DNA-Directed RNA Polymerases -- genetics, DNA-Directed RNA Polymerases -- metabolism, Gene Expression Regulation -- drug effects, Humans, Models, Biological, Protozoan Infections -- drug therapy, Protozoan Infections -- parasitology, Transcription Factors -- antagonists & inhibitors, Transcription Factors -- genetics, Transcription Factors -- metabolism, Trypanocidal Agents -- pharmacology, Trypanocidal Agents -- therapeutic use, Trypanosoma -- enzymology, Trypanosoma -- genetics, Trypanosoma -- metabolism, info:eu-repo/semantics/article, info:ulb-repo/semantics/articlePeerReview, info:ulb-repo/semantics/openurl/article

URL: https://dipot.ulb.ac.be/dspace/bitstream/2013/51914/3/Vanhammecurdrugtargets2008.pdf
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/51914
http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 104 (10

مصطلحات الفهرس: Sciences bio-médicales et agricoles, Animals, Antigens, Neoplasm -- blood, Antigens, Neoplasm -- physiology, Apolipoproteins -- blood, Apolipoproteins -- physiology, Blood Proteins -- physiology, Blotting, Western, Chromatography, Affinity, Haptoglobins -- physiology, Humans, Immune System, Kinetics, Lipoproteins, HDL -- blood, Lipoproteins, HDL -- physiology, Mice, Recombinant Proteins -- chemistry, Trypanocidal Agents -- pharmacology, Trypanosoma brucei brucei -- metabolism, Trypanosomiasis, African -- drug therapy, Haptoglobin receptor, Innate immunity, Sleeping sickness, Trypanolytic factor, Trypanosoma brucei, info:eu-repo/semantics/article, info:ulb-repo/semantics/articlePeerReview, info:ulb-repo/semantics/openurl/article

URL: https://dipot.ulb.ac.be/dspace/bitstream/2013/51584/4/PMC1820718.pdf
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/51584
http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL

مصطلحات الفهرس: Animals, Carbon-Nitrogen Ligases/*biosynthesis/*chemistry, Cytidine/chemistry, Cytosine/chemistry, Dose-Response Relationship; Drug, Enzyme Inhibitors/pharmacology, Humans, Kinetics, Male, Mice, Mice; Inbred C57BL, Trypanocidal Agents/pharmacology, Trypanosoma brucei brucei/*enzymology, Trypanosoma brucei gambiense/*enzymology, Trypanosomiasis; African/*therapy, Article in journal, info:eu-repo/semantics/article, text

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-6341
Journal of biological chemistry, 0021-9258, 2007, 282:16, s. 11858-11865