المؤلفون: Teresa A. Kimber, David Martin, Clifford W. Shults

المصدر: NeuroReport. 7:627-631

مصطلحات موضوعية: Apomorphine, Dopamine Agents, Nerve Tissue Proteins, Substantia nigra, Striatum, Pharmacology, Injections, Rats, Sprague-Dawley, Dopamine, Neurotrophic factors, medicine, Glial cell line-derived neurotrophic factor, Animals, Glial Cell Line-Derived Neurotrophic Factor, Nerve Growth Factors, Oxidopamine, Hydroxydopamine, biology, Pars compacta, business.industry, General Neuroscience, Dopaminergic, Immunohistochemistry, Rats, Neostriatum, Amphetamine, nervous system, Anesthesia, Dopamine Agonists, Sympatholytics, biology.protein, Female, Stereotyped Behavior, business, medicine.drug

الوصف: Our study was designed to determine whether intrastriatal administration of glial cell line-derived neurotrophic factor (GDNF) can attenuate the behavioral effects and injury to the mesostriatal dopaminergic system caused by 6-hydroxydopamine (6-OHDA). Four groups of rats received a series of four intrastriatal injections of vehicle or one of three doses of GDNF (0.1, 1 or 10 micrograms per injection) on days 1,3,5 and 8. On day 4 the animals received a single, intrastriatal injection of 25 micrograms 6-OHDA. Treatment with GDNF significantly reduced the development of amphetamine-induced rotation, and the dose of 1 microgram per injection appeared to be the most effective. The group treated with this dose had significantly greater preservation of tyrosine hydroxylase-immunoreactive (TH-IR) fibers adjacent to the injection site in the striatum and significantly greater preservation of Nissl-stained and TH-IR neurons in the substantia nigra pars compacta (SNpc).

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3d4c5f87e1e27b29e82a09dd2d55ca
https://doi.org/10.1097/00001756-199601310-00060