المؤلفون: Bingbing Chang, Miao Zhong, Jintao Zhao, Qianhe Xu, Xinming Li, Zihua Wang, Jianguo Fang

المصدر: Journal of Medicinal Chemistry. 64:17979-17991

مصطلحات موضوعية: Male, Apoptosis, Diselenide, Mice, chemistry.chemical_compound, In vivo, Drug Discovery, medicine, Animals, Humans, Prodrugs, heterocyclic compounds, Selenium Compounds, Cytotoxicity, neoplasms, Cell Proliferation, Fluorescent Dyes, Mice, Inbred BALB C, Superoxide Dismutase, Superoxide, Optical Imaging, Selenol, Hep G2 Cells, Glutathione, Prodrug, Antineoplastic Agents, Phytogenic, Xenograft Model Antitumor Assays, Combinatorial chemistry, Oxidative Stress, chemistry, Molecular Medicine, Camptothecin, Drug Screening Assays, Antitumor, Topoisomerase I Inhibitors, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54dd636222b8c256b01b02fdf6cb99a6
https://doi.org/10.1021/acs.jmedchem.1c01362

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المؤلفون: Wojciech Bocian, Beata Naumczuk, Magdalena Urbanowicz, Jerzy Sitkowski, Elżbieta Bednarek, Katarzyna Wiktorska, Anna Pogorzelska, Ewelina Wielgus, Lech Kozerski

المصدر: Molecules; Volume 27; Issue 20; Pages: 6946

مصطلحات موضوعية: Topoisomerase Inhibitors, Organic Chemistry, Pharmaceutical Science, DNA, Ligands, Analytical Chemistry, DNA Topoisomerases, Type I, Pharmaceutical Preparations, Chemistry (miscellaneous), topoisomerase I inhibitor, SN38, molecular dynamics, docking analysis, NMR, MALDI-ToF MS, Drug Discovery, Molecular Medicine, Camptothecin, Physical and Theoretical Chemistry, Protons, Topoisomerase I Inhibitors

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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21e158bc309f2dd72520b3c5d86a57ab

المؤلفون: Francesco Madeddu, Jessica Di Martino, Michele Pieroni, Davide Del Buono, Paolo Bottoni, Lorenzo Botta, Tiziana Castrignanò, Raffaele Saladino

المصدر: International Journal of Molecular Sciences; Volume 23; Issue 23; Pages: 14652

مصطلحات موضوعية: Organic Chemistry, DNA, General Medicine, Molecular Dynamics Simulation, Catalysis, Computer Science Applications, Molecular Docking Simulation, Inorganic Chemistry, DNA Topoisomerases, Type I, Humans, Camptothecin, Topoisomerase I Inhibitors, Enzyme Inhibitors, Physical and Theoretical Chemistry, Molecular Biology, Spectroscopy, camptothecin, human topoisomerase I, molecular docking, molecular dynamics, ligand-receptor interaction

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22038b950e61faa9e988aa9b365ac9ad
https://doi.org/10.3390/ijms232314652

المؤلفون: Florence Gattacceca, Alexandre Evrard, Marc Ychou, Laure Deyme, Dominique Barbolosi, Nicole Tubiana-Mathieu, Litaty Mbatchi

المساهمون: Méthodes computationnelles pour la prise en charge thérapeutique en oncologie : Optimisation des stratégies par modélisation mécaniste et statistique (COMPO), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Universitaire Carémeau [Nîmes] (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), CHU Limoges, Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), GATTACCECA, Florence

المصدر: Cancer Chemotherapy and Pharmacology
Cancer Chemotherapy and Pharmacology, 2021, 88 (2), pp.247-258. ⟨10.1007/s00280-021-04255-9⟩
Cancer Chemotherapy and Pharmacology, Springer Verlag, 2021, 88 (2), pp.247-258. ⟨10.1007/s00280-021-04255-9⟩

مصطلحات موضوعية: Male, 0301 basic medicine, Oncology, Cancer Research, FOLFIRINOX, Leucovorin, Toxicology, 0302 clinical medicine, CPT-11, Antineoplastic Combined Chemotherapy Protocols, Pharmacology (medical), Population pharmacokinetics, ComputingMilieux_MISCELLANEOUS, education.field_of_study, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, [SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences, Oxaliplatin, 030220 oncology & carcinogenesis, FOLFIRI, Female, Fluorouracil, Folfirinox Regimen, Colorectal Neoplasms, medicine.drug, medicine.medical_specialty, Population, [SDV.CAN]Life Sciences [q-bio]/Cancer, Context (language use), Irinotecan, Nonlinear mixed effect modelling, 03 medical and health sciences, [SDV.CAN] Life Sciences [q-bio]/Cancer, Pharmacokinetics, Internal medicine, medicine, Humans, education, Pharmacology, business.industry, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, stomatognathic diseases, 030104 developmental biology, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, Camptothecin, Topoisomerase I Inhibitors, business

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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104f89d9adaa70ea34468906b96ef3b6
https://doi.org/10.1007/s00280-021-04255-9

المؤلفون: Guangxuan Liu, Yingjie Qi

المصدر: Drug Delivery, Vol 28, Iss 1, Pp 171-182 (2021)
Drug Delivery
article-version (VoR) Version of Record

مصطلحات موضوعية: Carcinoma, Hepatocellular, Berberine, Mice, Nude, Pharmaceutical Science, RM1-950, 02 engineering and technology, Topoisomerase-I Inhibitor, 030226 pharmacology & pharmacy, Microsphere, liver cancer, Mice, 03 medical and health sciences, chemistry.chemical_compound, Drug Delivery Systems, 0302 clinical medicine, Cell Line, Tumor, medicine, Animals, Humans, lipid microsphere, biology, Chemistry, Topoisomerase, Liver Neoplasms, synergistic treatment, General Medicine, Hypoxia-Inducible Factor 1, alpha Subunit, bbr, 021001 nanoscience & nanotechnology, medicine.disease, Antineoplastic Agents, Phytogenic, Xenograft Model Antitumor Assays, Microspheres, Rats, Drug Liberation, 10-hcpt, Cancer research, biology.protein, Camptothecin, Therapeutics. Pharmacology, Topoisomerase I Inhibitors, 0210 nano-technology, Liver cancer, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6578bde835e7c08adeb912a6ca724035
https://doi.org/10.1080/10717544.2020.1870020

المؤلفون: Katsuzumi Okumura, Rino Suzuki, Takuya Hayakawa, Shin-ichiro Takebayashi, Kazuhiro Kagotani

المصدر: Cytogenetic and Genome Research. 161:437-444

مصطلحات موضوعية: DNA Replication, Replication timing, Retinal pigment epithelium, DNA Replication Timing, Cell, DNA replication, Retinal Pigment Epithelium, Biology, Topoisomerase-I Inhibitor, Cell biology, medicine.anatomical_structure, Replication Initiation, Replication (statistics), Genetics, medicine, Humans, Camptothecin, Topoisomerase I Inhibitors, Molecular Biology, Genetics (clinical), medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4180cd15b583a3122cbb55e709cc6a7
https://doi.org/10.1159/000518263

المؤلفون: Xuan Wang, Mara Lennard Richard, Hongkuan Fan, Brittany Henry, Weiru Zhang, Gary S. Gilkeson, Steven Schutt, Xian K. Zhang, Pengfei Li, Xue-Zhong Yu

المصدر: J Immunol

مصطلحات موضوعية: Sp1 Transcription Factor, T-Lymphocytes, Immunology, Regulator, Article, CCL5, Jurkat Cells, Mice, Transcription (biology), Animals, Humans, Immunology and Allergy, Endothelium, Molecular Targeted Therapy, RNA, Small Interfering, Promoter Regions, Genetic, Transcription factor, Sp1 transcription factor, Proto-Oncogene Protein c-fli-1, Chemistry, ETS transcription factor family, fungi, Granulocyte-Macrophage Colony-Stimulating Factor, DNA-binding domain, Cell biology, Gene Expression Regulation, NIH 3T3 Cells, Camptothecin, Topoisomerase I Inhibitors, Chromatin immunoprecipitation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf664dba5b3e2e44db001e981b06e54
https://doi.org/10.4049/jimmunol.2000664

المؤلفون: Linda Sciuto, Yves Pommier, Cody J. Peer, William D. Figg, Thomas P. C. Dorlo, Lisa M. Cordes, Anish Thomas, Susan Wroblewski, Alwin D. R. Huitema, Keith T. Schmidt, Ravi A. Madan

المصدر: Cancer Chemotherapy and Pharmacology

مصطلحات موضوعية: Male, Cancer Research, Population, Phases of clinical research, Pharmacology, Toxicology, Models, Biological, Piperazines, Nanoparticle, Pharmacokinetics, NLMEM, Neoplasms, Antineoplastic Combined Chemotherapy Protocols, Nitriles, Phenylthiohydantoin, medicine, Distribution (pharmacology), Humans, Pharmacology (medical), Population pharmacokinetics, education, Aged, Neoplasm Staging, education.field_of_study, Cyclodextrins, Chemistry, Drug release, Middle Aged, Pharmacokinetic analysis, Topoisomerase I, Drug Liberation, Oncology, Benzamides, Phthalazines, Original Article, Camptothecin, Female, Topoisomerase I Inhibitors, medicine.drug, Clearance, Conjugate, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa45f81de46ecd74a5d93ae1ea7af06b
http://europepmc.org/articles/PMC7515962

المؤلفون: Ho Sub Lee, Jin Woo Choi, Mi Ran Byun, Cheol Hyun Kim, Sang Kwan Lee

المصدر: Phytochemistry. 164:223-227

مصطلحات موضوعية: 0106 biological sciences, Cell Survival, Panax, Plant Science, Synthetic lethality, Horticulture, Topoisomerase-I Inhibitor, Pharmacology, complex mixtures, 01 natural sciences, Biochemistry, Ginseng, Gene expression, Tumor Cells, Cultured, medicine, Humans, Molecular Biology, Molecular Structure, biology, Plant Extracts, 010405 organic chemistry, Gene Expression Profiling, Topoisomerase, Drug Repositioning, food and beverages, General Medicine, HCT116 Cells, 0104 chemical sciences, DNA Topoisomerases, Type I, Drug development, biology.protein, DNA supercoil, Topoisomerase I Inhibitors, Camptothecin, 010606 plant biology & botany, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::494ca9e175e893159e81c06f60961c59
https://doi.org/10.1016/j.phytochem.2019.04.002