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1
المؤلفون: Xu Feng Zhang, Timothy M. Pawlik, Guillaume Martel, Feng Xue, Sorin Alexandrescu, Bas Groot Koerkamp, Luca Aldrighetti, Shishir K. Maithel, Hugo Marques, Yi Lv, Feng Shen, Jin He, Oliver Soubrane, Carlo Pulitano, Endo Itaru, George A. Poultsides, Todd W. Bauer
المساهمون: Zhang, X. -F., Xue, F., He, J., Alexandrescu, S., Marques, H. P., Aldrighetti, L., Maithel, S. K., Pulitano, C., Bauer, T. W., Shen, F., Poultsides, G. A., Soubrane, O., Martel, G., Koerkamp, B. G., Itaru, E., Lv, Y., Pawlik, T. M., Surgery
المصدر: HPB, 23(9), 1456-1466. John Wiley & Sons Inc.
مصطلحات موضوعية: medicine.medical_specialty, Lymph node metastasis, Stage ii, TNM staging system, Cholangiocarcinoma, Cholangiocarcinoma* / surgery, SDG 3 - Good Health and Well-being, Cholangiocarcinoma* / pathology, medicine, Humans, Stage (cooking), Bile Ducts, Intrahepatic / pathology, Intrahepatic Cholangiocarcinoma, Intrahepatic cholangiocarcinoma, AJCC staging system, Neoplasm Staging, Hepatology, business.industry, Gastroenterology, External validation, Cancer, Bile Duct Neoplasms* / pathology, medicine.disease, HCC CIR, Prognosis, Bile Duct Neoplasms* / surgery, Bile Ducts, Intrahepatic, Bile Duct Neoplasms, Radiology, business
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2
المصدر: Journal of Experimental & Clinical Cancer Research. 41(1)
مصطلحات موضوعية: B7-H1 Antigen/metabolism, PROGNOSTIC IMPACT, Cholangiocarcinoma/pathology, MICROENVIRONMENT, CD8-Positive T-Lymphocytes, DENDRITIC CELLS, Tumor-infiltrating lymphocytes (TIL), Cholangiocarcinoma, Tumor Microenvironment, Humans, INTRAHEPATIC CHOLANGIOCARCINOMA, Molecular pathogenesis, Lymphocytes, Tumor-Infiltrating, Bile Duct Neoplasms/pathology, Intrahepatic/metabolism, IMMUNOSUPPRESSION, T-LYMPHOCYTE, Prognosis, CANCER, Oncological prognosis, IMMUNE CELLS, Immunotherapy/methods, Systematic review, Bile Ducts, Immunotherapy, TERTIARY LYMPHOID STRUCTURES, RESPONSES
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3Trends in use of lymphadenectomy in surgery with curative intent for intrahepatic cholangiocarcinoma
المؤلفون: Yi Lv, Fabio Bagante, Eliza W. Beal, Matthew J. Weiss, Qinyu Chen, Feng Shen, Luca Aldrighetti, Carlo Pulitano, Alfredo Guglielmi, Timothy M. Pawlik, Endo Itaru, Guillaume Martel, Shishir K. Maithel, George A. Poultsides, Hugo Marques, Todd W. Bauer, Oliver Soubrane, Jeffery Chakedis, B. Groot Koerkamp, Irinel Popescu, X-F Zhang
المساهمون: Surgery, Zhang, Xf, Chakedis, J, Bagante, F, Chen, Q, Beal, Ew, Lv, Y, Weiss, M, Popescu, I, Marques, Hp, Aldrighetti, L, Maithel, Sk, Pulitano, C, Bauer, Tw, Shen, F, Poultsides, Ga, Soubrane, O, Martel, G, Koerkamp, Bg, Guglielmi, A, Itaru, E, Pawlik, Tm
المصدر: British Journal of Surgery, 105(7), 857-866. John Wiley & Sons Ltd.
مصطلحات موضوعية: Male, medicine.medical_specialty, Databases, Factual, medicine.medical_treatment, 030230 surgery, Cholangiocarcinoma, 03 medical and health sciences, 0302 clinical medicine, intrahepatic cholangiocarcinoma, Bile Duct Neoplasms / surgery, Humans, Hepatectomy, Medicine, Bile Duct Neoplasms / classification, Lymph node, Intrahepatic Cholangiocarcinoma, Aged, Neoplasm Staging, business.industry, Incidence (epidemiology), Middle Aged, HCC CIR, Lymph Node Excision / statistics & numerical data, Cholangiocarcinoma / classification, Bile Duct Neoplasms / pathology, Surgery, Dissection, medicine.anatomical_structure, Bile Duct Neoplasms, Cholangiocarcinoma / pathology, lymphadenectomy, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Concomitant, Lymph Node Excision, Female, Lymphadenectomy, Cholangiocarcinoma / surgery, Lymph, business
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4
المؤلفون: Kota Sahara, Fabio Bagante, Olivier Soubrane, Matthew J. Weiss, Alfredo Guglielmi, Carlo Pulitano, Hugo Marques, Katiuscha Merath, Timothy M. Pawlik, B. Groot Koerkamp, Itaru Endo, Shishir K. Maithel, Ryusei Matsuyama, Luca Aldrighetti, Sorin Alexandrescu, George A. Poultsides, Todd W. Bauer, Guillaume Martel, Diamantis I. Tsilimigras, Feng Shen
المساهمون: Surgery, Sahara, K., Tsilimigras, D. I., Merath, K., Bagante, F., Guglielmi, A., Aldrighetti, L., Weiss, M., Bauer, T. W., Alexandrescu, S., Poultsides, G. A., Maithel, S. K., Marques, H. P., Martel, G., Pulitano, C., Shen, F., Soubrane, O., Koerkamp, B. G., Matsuyama, R., Endo, I., Pawlik, T. M.
المصدر: Annals of Surgical Oncology, 26(9), 2959-2968. Springer New York
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAPمصطلحات موضوعية: Male, medicine.medical_treatment, Midlle Aged, 030230 surgery, Gastroenterology, Intrahepatic cholangiocarcinoma, lymph node metastasis, Hepatectomy / mortality, Cholangiocarcinoma, 0302 clinical medicine, Carcinoembryonic antigen, Surgical oncology, Interquartile range, Bile Duct Neoplasms / surgery, Intrahepatic Cholangiocarcinoma, Intrahepatic cholangiocarcinoma, Lymph Nodes / pathology, biology, lymph node metastasis, Middle Aged, Prognosis, Survival Rate, medicine.anatomical_structure, Therapeutic Index, Oncology, Cholangiocarcinoma / pathology, 030220 oncology & carcinogenesis, Lymphatic Metastasis, Cohort, Female, medicine.medical_specialty, Bile Duct Neoplasms / secondary, 03 medical and health sciences, Internal medicine, medicine, Hepatectomy, Humans, Survival rate, Aged, Neoplasm Staging, business.industry, Hepatoduodenal ligament, HCC CIR, Lymph Node Excision / mortality, Bile Duct Neoplasms, biology.protein, Lymph Node Excision, Surgery, Lymphadenectomy, Cholangiocarcinoma / surgery, Lymph Nodes, business, Follow-Up Studies
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5
المؤلفون: Rishabh Chawla, Lisa Hoenicke, Nir Rozenblum, Jule Harbig, Johannes Zuber, Marco Seehawer, Gregory J. Dore, Hien Dang, Pierre-François Roux, Florian Heinzmann, Mihael Vucur, Thomas Longerich, Tom Luedde, Bence Sipos, Oliver Bischof, Tae-Won Kang, Xin Wei Wang, Lucas Robinson, Mathias Heikenwalder, Sabrina Klotz, Mareike Roth, Thorsten Buch, Luana D’Artista, Lars Zender
المساهمون: Universitätsklinikum Tübingen - University Hospital of Tübingen, Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, Organisation Nucléaire et Oncogenèse / Nuclear Organization and Oncogenesis, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Equipe labellisée Ligue contre le Cancer, National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), Universität Zürich [Zürich] = University of Zurich (UZH), Universitätsklinikum RWTH Aachen - University Hospital Aachen [Aachen, Germany] (UKA), RWTH Aachen University, Vienna Biocenter - VBC [Austria], University of Tübingen, Heidelberg University Hospital [Heidelberg], German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), German Cancer Consortium [Heidelberg] (DKTK), This work was supported by the ERC Consolidator Grant ‘CholangioConcept’ (to L.Z.), the German Research Foundation (DFG): grants FOR2314, SFB685, SFB/TR209 and the Gottfried Wilhelm Leibniz Program (to L.Z.). Further funding was provided by the German Ministry for Education and Research (BMBF) (e:Med/Multiscale HCC), the German Universities Excellence Initiative (third funding line: ‘future concept’), the German Center for Translational Cancer Research (DKTK), the German-Israeli Cooperation in Cancer Research (DKFZ-MOST) (to L.Z.) and the Intramural Research Program of the Centre for Cancer Research, National Cancer Institute, National Institutes of Health (to X.W.W.). The group of O.B. is supported by grants from ANR-BMFT, Fondation ARC pour la recherche sur le Cancer, INSERM, and the National Cancer Institute of the National Institutes of Health under Award Number R01CA136533. O.B. is a CNRS fellow., We thank E. Rist, P. Schiemann, C. Fellmeth, C.-J. Hsieh, D. Heide and J. Hetzer for technical help or assistance. We thank A. Weber for providing TLR2 and TLR4 knockout mice and W. S. Alexander and The Walter and Eliza Hall Institute of Medical Research for providing Mlklfl/fl mice. The Cas9n–p19Arf sgRNA vector was provided by W. Xue. We thank the c.ATG facility of Tuebingen University and CeGaT Tuebingen for exome sequencing and data analysis., Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Rheinisch-Westfälische Technische Hochschule Aachen University (RWTH), University of Zurich, Zender, Lars
المصدر: Nature
Nature, Nature Publishing Group, 2018, 562 (7725), pp.69-75. ⟨10.1038/s41586-018-0519-y⟩
Nature, 2018, 562 (7725), pp.69-75. ⟨10.1038/s41586-018-0519-y⟩مصطلحات موضوعية: 0301 basic medicine, MESH: Necrosis*/genetics, Cellular differentiation, MESH: Cell Lineage*/genetics, MESH: Carcinoma, Hepatocellular/pathology, MESH: Tumor Microenvironment, 10239 Institute of Laboratory Animal Science, MESH: Animals, Cancer epigenetics, MESH: Apoptosis*/genetics, MESH: Transcription Factors/metabolism, MESH: Proto-Oncogene Proteins c-akt/genetics, Multidisciplinary, MESH: Carcinoma, Hepatocellular/genetics, MESH: Cyclin-Dependent Kinase Inhibitor p16/deficiency, 3. Good health, MESH: Carcinogenesis/genetics, MESH: Cholangiocarcinoma/genetics, MESH: Mosaicism, MESH: T-Box Domain Proteins/genetics, Liver cancer, Cancer microenvironment, MESH: Cell Differentiation, Necroptosis, MESH: Cholangiocarcinoma/pathology, MESH: Liver Neoplasms/pathology, Context (language use), 610 Medicine & health, [SDV.CAN]Life Sciences [q-bio]/Cancer, Biology, MESH: DNA-Binding Proteins/metabolism, Article, 03 medical and health sciences, MESH: DNA Transposable Elements/genetics, MESH: Gene Expression Profiling, MESH: Hepatocytes/metabolism, medicine, MESH: Transcription Factors/genetics, MESH: Mice, MESH: Genes, myc, MESH: Liver Neoplasms/genetics, Tumor microenvironment, 1000 Multidisciplinary, MESH: DNA-Binding Proteins/genetics, MESH: Humans, Epigenome, medicine.disease, MESH: Male, digestive system diseases, MESH: Genes, ras, 030104 developmental biology, MESH: Hepatocytes/pathology, Cancer research, Hepatic stellate cell, 570 Life sciences, biology, MESH: Epigenesis, Genetic/genetics, MESH: Cytokines/metabolism, MESH: Disease Models, Animal, MESH: Female, MESH: T-Box Domain Proteins/metabolism
وصف الملف: Seehawer_2018_NATURE_Necroptosis_liver.pdf - application/pdf
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