المؤلفون: Xin-rui Qiao, Tao Feng, Dong Zhang, Li-li Zhi, Jin-tao Zhang, Xiao-fei Liu, Yun Pan, Jia-wei Xu, Wen-Jing Cui, Liang Dong

المصدر: Pharmaceutical Biology, Vol 61, Iss 1, Pp 165-176 (2023)

مصطلحات موضوعية: Airway inflammation, Therapeutics. Pharmacology, RM1-950

الوصف: AbstractContext Luteolin can affect multiple biological functions, such as anti-inflammatory, antioxidant and immune enhancement processes. Luteolin can inhibit inflammation of T2-high asthma, but its role in neutrophilic asthma has been insufficently studied.Objective This study determines the effect of luteolin on IL-36γ secretion-mediated MAPK pathway signalling in neutrophilic asthma.Materials and methods The asthma model was established by using ovalbumin/lipopolysaccharide (OVA/LPS). Female 6–8-week-old C57BL/6 mice were divided into control, asthma, luteolin (20 mg/kg) and asthma + luteolin (20 mg/kg) groups. To explore the mechanism of anti-inflammatory effects of luteolin in neutrophilic asthma, Beas-2B cells were treated with luteolin (20 µmol/L), LPS (100 ng/mL), recombinant human IL-36γ protein (rhIL-36γ; 100 ng/mL) or IL-36γ siRNA.Results IL-36γ secretion and MAPK/IL-1β signalling were significantly increased in the asthma mouse model compared with the control (p

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1388-0209; https://doaj.org/toc/1744-5116

URL الوصول: https://doaj.org/article/961bb74c67e74890b6c65c182c687c67

المؤلفون: Chong⁃zhu FAN, Hai⁃nan LI, Shao⁃qiang XU, Da⁃biao DENG, Zhen⁃bin ZHANG, YANG Li LI Zhi

المصدر: Chinese Journal of Contemporary Neurology and Neurosurgery, Vol 20, Iss 4, Pp 330-337 (2020)

مصطلحات موضوعية: meningeal carcinomatosis, lung neoplasms, meningioma, immunohistochemistry, Neurology. Diseases of the nervous system, RC346-429

الوصف: Objective To investigate the clinicopathological features of pulmonary adenocarcinoma ⁃ to ⁃ meningioma metastasis with meningeal carcinomatosis, and to reduce the rate of missed diagnosis of this disease. Methods and Results A 58⁃year⁃old female was admitted to hospital due to repeated headaches for 4 years and increased dizziness and vomiting for 2 months. Head MRI showed a space ⁃ occupying lesion in left apical petrous cross middle posterior fossa (mainly in the posterior fossa). Microscopy showed the tumor was mainly composed of meningothelial meningioma. In addition, the implantation of adenocarcinoma cells on the surface of arachnoid, and the small tumor adenocarcinoma nests in the meningioma were found. The cerebrospinal fluid cytology found heterotypic tumor cells. Immunohistochemical staining showed meningioma components expressed progesterone receptor (PR), somatostatin receptor 2 (SSTR2), Ki ⁃ 67 proliferation index was 3% ; adenocarcinoma components express cytokeratin (CK), cytokeratin 7 (CK7), thyroid transcription factor ⁃ 1 (TTF ⁃ 1), aspartic protease A (Napsin A), Ki⁃67 proliferation index was 30% . Epithelial membrane antigen (EMA) was stained of two components. Final pathological diagnosis was pulmonary adenocarcinoma ⁃ to ⁃ meningioma metastasis with meningeal carcinomatosis. Conclusions Pulmonary adenocarcinoma⁃to⁃meningoma metastasis is uncommon, So far, there are 20 cases reported. It is common in the elderly, mostly in women, with poor prognosis. Accurate diagnosis depends on histopathological, and should be combined with clinical, imaging, cerebrospinal fluid cytology, multidisciplinary diagnosis can avoid missed diagnosis. DOI：10.3969/j.issn.1672⁃6731.2020.04.013

وصف الملف: electronic resource

Relation: http://www.cjcnn.org/index.php/cjcnn/article/view/2127; https://doaj.org/toc/1672-6731

URL الوصول: https://doaj.org/article/a1b92218293a4f6380676e781b3220e9