المؤلفون: Kumar P; Natural Products and Medicinal Chemistry Division, CSIR - Indian Institute of Integrative Medicine, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Singh R; Pharmacology Division, CSIR - Indian Institute of Integrative Medicine, Jammu 180001, India., Sharma D; Natural Products and Medicinal Chemistry Division, CSIR - Indian Institute of Integrative Medicine, Jammu 180001, India., Hassan QP; Biotechnology Division, CSIR - Indian Institute of Integrative Medicine, Sanatnagar, Srinagar 190005, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Gopu B; Pharmacology Division, CSIR - Indian Institute of Integrative Medicine, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address: boobalan.g@iiim.res.in., Anal JMH; Natural Products and Medicinal Chemistry Division, CSIR - Indian Institute of Integrative Medicine, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address: hmunshel.jasha@iiim.res.in.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2024 Jul 15; Vol. 107, pp. 129795. Date of Electronic Publication: 2024 May 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Triple Negative Breast Neoplasms*/drug therapy , Triple Negative Breast Neoplasms*/pathology , Triple Negative Breast Neoplasms*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Drug Screening Assays, Antitumor* , Cell Proliferation*/drug effects , Acetamides*/pharmacology , Acetamides*/chemical synthesis , Acetamides*/chemistry , Drug Design* , Apoptosis*/drug effects, Humans ; Structure-Activity Relationship ; Molecular Structure ; Cell Line, Tumor ; Chalcones/pharmacology ; Chalcones/chemistry ; Chalcones/chemical synthesis ; Dose-Response Relationship, Drug ; Chalcone/pharmacology ; Chalcone/chemistry ; Chalcone/chemical synthesis ; Reactive Oxygen Species/metabolism ; Membrane Potential, Mitochondrial/drug effects

المؤلفون: Sharma V; Microbial Biotechnology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), CSIR, New Delhi 110025, India., Singamaneni V; Natural Product Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India., Sharma N; Microbial Biotechnology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), CSIR, New Delhi 110025, India., Kumar A; Instrumentation Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India., Arora D; Microbial Biotechnology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), CSIR, New Delhi 110025, India., Kushwaha M; Microbial Biotechnology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India., Bhushan S; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Indian Pharmacopoeia Commission, Ministry of Health & Family Welfare, Ghaziabad, UP-201002, India., Jaglan S; Microbial Biotechnology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), CSIR, New Delhi 110025, India. Electronic address: sundeepjaglan@iiim.ac.in., Gupta P; Natural Product Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), CSIR, New Delhi 110025, India. Electronic address: guptap@iiim.ac.in.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2018 Jul 01; Vol. 28 (12), pp. 2217-2221. Date of Electronic Publication: 2018 Apr 10.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Bacterial Agents/*pharmacology , Antineoplastic Agents/*pharmacology , Ascomycota/*chemistry , Datura/*microbiology , Peptides, Cyclic/*pharmacology , Valproic Acid/*pharmacology, Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/metabolism ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/metabolism ; Ascomycota/growth & development ; Ascomycota/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Datura/chemistry ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Escherichia coli/drug effects ; Humans ; Microbial Sensitivity Tests ; Molecular Conformation ; Peptides, Cyclic/chemistry ; Peptides, Cyclic/metabolism ; Pseudomonas aeruginosa/drug effects ; Staphylococcus aureus/drug effects ; Structure-Activity Relationship ; Valproic Acid/chemistry

المؤلفون: Srinivas M; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180 001, India; Academy of Scientific and Innovative Research, Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110 001, India., Singh Pathania A; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180 001, India; Academy of Scientific and Innovative Research, Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110 001, India., Mahajan P; Discovery Informatics Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180 001, India; Academy of Scientific and Innovative Research, Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110 001, India., Verma PK; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180 001, India., Chobe SS; Department of Chemistry, Loknete Vyankatrao Hiray Arts, Science and Commerce College, Nashik (M.S.), India., Malik FA; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180 001, India; Academy of Scientific and Innovative Research, Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110 001, India., Nargotra A; Discovery Informatics Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180 001, India; Academy of Scientific and Innovative Research, Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110 001, India., Vishwakarma RA; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180 001, India; Academy of Scientific and Innovative Research, Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110 001, India., Sawant SD; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180 001, India; Academy of Scientific and Innovative Research, Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110 001, India. Electronic address: sdsawant@iiim.ac.in.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2018 Apr 01; Vol. 28 (6), pp. 1005-1010. Date of Electronic Publication: 2018 Feb 16.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design* , Phosphoinositide-3 Kinase Inhibitors*, Antineoplastic Agents/*pharmacology , Protein Kinase Inhibitors/*pharmacology , Quinazolinones/*pharmacology , Triazoles/*pharmacology, Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Class Ib Phosphatidylinositol 3-Kinase/metabolism ; Cycloaddition Reaction ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Quinazolinones/chemical synthesis ; Quinazolinones/chemistry ; Structure-Activity Relationship ; Triazoles/chemical synthesis ; Triazoles/chemistry

المؤلفون: Sharma R; Natural Products Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific & Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India., Gatchie L; Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK., Williams IS; Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK., Jain SK; Natural Products Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific & Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India., Vishwakarma RA; Academy of Scientific & Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India., Chaudhuri B; Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK. Electronic address: bchaudhuri@dmu.ac.in., Bharate SB; Academy of Scientific & Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India. Electronic address: sbharate@iiim.ac.in.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2017 Dec 15; Vol. 27 (24), pp. 5400-5403. Date of Electronic Publication: 2017 Nov 07.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Cytochrome P-450 CYP1B1/*antagonists & inhibitors , Drug Resistance, Neoplasm/*drug effects , Enzyme Inhibitors/*chemistry , Glycyrrhiza/*chemistry , Plant Extracts/*chemistry , Quercetin/*pharmacology, Binding Sites ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cisplatin/pharmacology ; Cytochrome P-450 CYP1B1/metabolism ; Enzyme Inhibitors/pharmacology ; Female ; Glycyrrhiza/metabolism ; Humans ; Inhibitory Concentration 50 ; Molecular Docking Simulation ; Plant Extracts/pharmacology ; Protein Structure, Tertiary ; Triple Negative Breast Neoplasms/metabolism ; Triple Negative Breast Neoplasms/pathology

المؤلفون: Singh H; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab 143005, India., Singh JV; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab 143005, India., Gupta MK; Lloyd Institute of Management and Technology, Greater Noida, UP, India., Saxena AK; Indian Institute of Integrative Medicine, Jammu, India., Sharma S; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab 143005, India. Electronic address: ss.gq2009@gmail.com., Nepali K; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab 143005, India., Bedi PMS; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab 143005, India.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2017 Sep 01; Vol. 27 (17), pp. 3974-3979. Date of Electronic Publication: 2017 Jul 29.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design*, Antineoplastic Agents/*pharmacology , Coumarins/*pharmacology , Isatin/*pharmacology , Triazoles/*pharmacology, Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Coumarins/chemistry ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Isatin/chemistry ; Molecular Docking Simulation ; Molecular Structure ; Structure-Activity Relationship ; Triazoles/chemistry

المؤلفون: Williams IS; Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK; CYP Design Limited, Innovation Centre, 49 Oxford Street, Leicester LE1 5XY, UK., Joshi P; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific & Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India., Gatchie L; Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK; CYP Design Limited, Innovation Centre, 49 Oxford Street, Leicester LE1 5XY, UK., Sharma M; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India., Satti NK; Natural Product Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India., Vishwakarma RA; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific & Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India., Chaudhuri B; Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK; CYP Design Limited, Innovation Centre, 49 Oxford Street, Leicester LE1 5XY, UK. Electronic address: bchaudhuri@dmu.ac.uk., Bharate SB; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific & Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India. Electronic address: sbharate@iiim.ac.in.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2017 Aug 15; Vol. 27 (16), pp. 3683-3687. Date of Electronic Publication: 2017 Jul 04.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*chemical synthesis , Antineoplastic Agents/*pharmacology , Chalcones/*chemical synthesis , Chalcones/*pharmacology , Cytochrome P-450 CYP1B1/*antagonists & inhibitors , Drug Resistance, Neoplasm/*drug effects, Antineoplastic Agents/chemistry ; Binding Sites ; Cell Line, Tumor ; Cell Survival/drug effects ; Cisplatin/pharmacology ; Cytochrome P-450 CYP1B1/genetics ; Cytochrome P-450 CYP1B1/metabolism ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; HEK293 Cells ; Humans ; Inhibitory Concentration 50 ; Molecular Dynamics Simulation ; Protein Isoforms/antagonists & inhibitors ; Protein Isoforms/metabolism ; Pyrroles/chemical synthesis ; Pyrroles/pharmacology ; Structure-Activity Relationship

المؤلفون: Hussain A; Microbial Biotechnology Division, CSIR - Indian Institute of Integrative Medicine, Sanatnagar, Srinagar, Jammu & Kashmir 190005, India; Academy of Scientific and Innovative Research, CSIR - Indian Institute of Integrative Medicine, Canal Road, Jammu Tawi, 180001, India., Rather MA; Clinical Microbiology and PK/PD Division, CSIR - Indian Institute of Integrative Medicine, Sanatnagar, Srinagar, Jammu & Kashmir 190005, India., Dar MS; Cancer Pharmacology Division, CSIR - Indian Institute of Integrative Medicine, Jammu Tawi, 180001, India., Aga MA; Medicinal Chemistry Division, CSIR - Indian Institute of Integrative Medicine, Sanatnagar, Srinagar, Jammu & Kashmir 190005, India., Ahmad N; Medicinal Chemistry Division, CSIR - Indian Institute of Integrative Medicine, Sanatnagar, Srinagar, Jammu & Kashmir 190005, India., Manzoor A; Microbial Biotechnology Division, CSIR - Indian Institute of Integrative Medicine, Sanatnagar, Srinagar, Jammu & Kashmir 190005, India., Qayum A; Cancer Pharmacology Division, CSIR - Indian Institute of Integrative Medicine, Jammu Tawi, 180001, India., Shah A; Microbial Biotechnology Division, CSIR - Indian Institute of Integrative Medicine, Sanatnagar, Srinagar, Jammu & Kashmir 190005, India., Mushtaq S; Microbial Biotechnology Division, CSIR - Indian Institute of Integrative Medicine, Sanatnagar, Srinagar, Jammu & Kashmir 190005, India., Ahmad Z; Clinical Microbiology and PK/PD Division, CSIR - Indian Institute of Integrative Medicine, Sanatnagar, Srinagar, Jammu & Kashmir 190005, India., Hassan QP; Microbial Biotechnology Division, CSIR - Indian Institute of Integrative Medicine, Sanatnagar, Srinagar, Jammu & Kashmir 190005, India; Academy of Scientific and Innovative Research, CSIR - Indian Institute of Integrative Medicine, Canal Road, Jammu Tawi, 180001, India. Electronic address: qphassan@iiim.ac.in.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2017 Jun 01; Vol. 27 (11), pp. 2579-2582. Date of Electronic Publication: 2017 Mar 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Actinobacteria/*chemistry , Anti-Bacterial Agents/*chemistry , Antineoplastic Agents/*chemistry , Sesquiterpenes, Eudesmane/*chemistry, Actinobacteria/metabolism ; Anti-Bacterial Agents/isolation & purification ; Anti-Bacterial Agents/pharmacology ; Antineoplastic Agents/isolation & purification ; Antineoplastic Agents/toxicity ; Cell Line, Tumor ; Cell Survival/drug effects ; Gram-Negative Bacteria/drug effects ; Gram-Positive Bacteria/drug effects ; Humans ; Magnetic Resonance Spectroscopy ; Microbial Sensitivity Tests ; Molecular Conformation ; Sesquiterpenes, Eudesmane/isolation & purification ; Sesquiterpenes, Eudesmane/pharmacology ; Spectrometry, Mass, Electrospray Ionization ; Spectroscopy, Fourier Transform Infrared

المؤلفون: Kumar A; Academy of Scientific and Innovative Research, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, Jammu and Kashmir 180001, India; Natural Product Microbes, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, Jammu and Kashmir 180001, India., Qayum A; Academy of Scientific and Innovative Research, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, Jammu and Kashmir 180001, India; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, Jammu and Kashmir 180001, India., Sharma PR; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, Jammu and Kashmir 180001, India., Singh SK; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, Jammu and Kashmir 180001, India. Electronic address: sksingh@iiim.ac.in., Shah BA; Academy of Scientific and Innovative Research, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, Jammu and Kashmir 180001, India; Natural Product Microbes, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi, Jammu and Kashmir 180001, India. Electronic address: bashah@iiim.ac.in.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2016 Jan 01; Vol. 26 (1), pp. 76-81. Date of Electronic Publication: 2015 Nov 11.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*chemical synthesis , Antineoplastic Agents/*pharmacology , Apoptosis/*drug effects , Triterpenes/*chemistry , Triterpenes/*pharmacology, Antineoplastic Agents/chemistry ; Antineoplastic Agents/metabolism ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; HCT116 Cells ; Humans ; Molecular Conformation ; Structure-Activity Relationship ; Triterpenes/chemical synthesis

المؤلفون: Hyder I; NPC Division, CSIR - Indian Institute of Chemical Technology, Hyderabad 500007, India; Academy of Scientific and Innovative Research, CSIR - Indian Institute of Chemical Technology, Hyderabad 500007, India., Yedlapudi D; Centre for Chemical Biology Division, CSIR - Indian Institute of Chemical Technology, Hyderabad 500007, India., Kalivendi SV; Centre for Chemical Biology Division, CSIR - Indian Institute of Chemical Technology, Hyderabad 500007, India. Electronic address: kalivendi@iict.res.in., Khazir J; Medicinal Chemistry Division, Indian Institute of Integrative Medicine, Jammu 180001, India., Ismail T; Medicinal Chemistry Division, Indian Institute of Integrative Medicine, Jammu 180001, India., Nalla N; NPC Division, CSIR - Indian Institute of Chemical Technology, Hyderabad 500007, India., Miryala S; NPC Division, CSIR - Indian Institute of Chemical Technology, Hyderabad 500007, India; Academy of Scientific and Innovative Research, CSIR - Indian Institute of Chemical Technology, Hyderabad 500007, India., Sampath Kumar HM; NPC Division, CSIR - Indian Institute of Chemical Technology, Hyderabad 500007, India; Academy of Scientific and Innovative Research, CSIR - Indian Institute of Chemical Technology, Hyderabad 500007, India. Electronic address: sampath@iict.res.in.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Jul 15; Vol. 25 (14), pp. 2860-3. Date of Electronic Publication: 2015 May 05.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*chemical synthesis , Antineoplastic Agents/*pharmacology , Podophyllotoxin/*chemistry , Podophyllotoxin/*pharmacology, Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; HeLa Cells ; Humans ; Structure-Activity Relationship ; Tubulin/chemistry ; Tubulin/metabolism ; Tubulin Modulators/chemical synthesis ; Tubulin Modulators/pharmacology

المؤلفون: Sharma S; Natural Product Microbes, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi 180001, J&K, India., Ahmad M; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi 180001, J&K, India., Bhat JA; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi 180001, J&K, India., Kumar A; Natural Product Microbes, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi 180001, J&K, India; Academy of Scientific and Innovative Research, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi 180001, J&K, India., Kumar M; Natural Product Microbes, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi 180001, J&K, India., Zargar MA; Department of Biochemistry, University of Kashmir, Srinagar, India., Hamid A; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi 180001, J&K, India. Electronic address: ahdar@iiim.ac.in., Shah BA; Natural Product Microbes, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi 180001, J&K, India; Academy of Scientific and Innovative Research, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-Tawi 180001, J&K, India. Electronic address: bashah@iiim.ac.in.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2014 Oct 01; Vol. 24 (19), pp. 4729-4734. Date of Electronic Publication: 2014 Aug 14.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design*, Antineoplastic Agents/*pharmacology , Histone Deacetylase Inhibitors/*pharmacology , Histone Deacetylases/*metabolism , Triterpenes/*pharmacology, Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Cycle/drug effects ; Cell Death/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; HCT116 Cells ; HL-60 Cells ; Histone Deacetylase Inhibitors/chemical synthesis ; Histone Deacetylase Inhibitors/chemistry ; Humans ; MCF-7 Cells ; Models, Molecular ; Molecular Structure ; Structure-Activity Relationship ; Triterpenes/chemical synthesis ; Triterpenes/chemistry