المؤلفون: Guo ZN; Stroke Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China.; Neuroscience Research Centre, The First Hospital of Jilin University, Changchun, China., Qu Y; Stroke Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China., Gao Y; Department of Cardiac Surgery, The First Hospital of Jilin University, Changchun, China., Xing Y; Center for Neurovascular Ultrasound, Department of Neurology, The First Hospital of Jilin University, Changchun, China., Ma H; Stroke Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China., Liu J; Laboratory for Engineering and Scientific Computing, Institute of Advanced Computing and Digital Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China., Guo YZ; Stroke Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China., Chang J; Center for Protein and Cell-Based Drugs, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China., Zhang P; Stroke Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China., Jin H; Stroke Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China., Sun X; Stroke Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China., Han K; Cerebrovascular Disease Research Center, Department of Neurology, Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China., Hu HH; Cerebrovascular Treatment and Research Center, College of Medicine, Taipei Medical University, Taipei, Taiwan., He Q; Stroke Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China., Simpson DM; Institute of Sound and Vibration Research, University of Southampton, Southampton, UK., Yang Y; Stroke Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China.; Neuroscience Research Centre, The First Hospital of Jilin University, Changchun, China.

المصدر: CNS neuroscience & therapeutics [CNS Neurosci Ther] 2023 Oct; Vol. 29 (10), pp. 3031-3042. Date of Electronic Publication: 2023 May 08.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101473265 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1755-5949 (Electronic) Linking ISSN: 17555930 NLM ISO Abbreviation: CNS Neurosci Ther Subsets: MEDLINE

مواضيع طبية MeSH: Foramen Ovale, Patent*/surgery , Migraine Disorders* , Stroke*/etiology, Humans ; Becaplermin ; Treatment Outcome ; Cardiac Catheterization/adverse effects ; Biomarkers

مستخلص: Aims: This study aimed to investigate changes in dynamic cerebral autoregulation (dCA), 20 stroke-related blood biomarkers, and autonomic regulation after patent foramen ovale (PFO) closure in severe migraine patients.
Methods: Patent foramen ovale severe migraine patients, matched non-PFO severe migraine patients, and healthy controls were included. dCA and autonomic regulation were evaluated in each participant at baseline, and within 48-h and 30 days after closure in PFO migraineurs. A panel of stroke-related blood biomarkers was detected pre-surgically in arterial-and venous blood, and post-surgically in the arterial blood in PFO migraineurs.
Results: Forty-five PFO severe migraine patients, 50 non-PFO severe migraine patients, and 50 controls were enrolled. The baseline dCA function of PFO migraineurs was significantly lower than that of non-PFO migraineurs and controls but was rapidly improved with PFO closure, remaining stable at 1-month follow-up. Arterial blood platelet-derived growth factor-BB (PDGF-BB) levels were higher in PFO migraineurs than in controls, which was immediately and significantly reduced after closure. No differences in autonomic regulation were observed among the three groups.
Conclusion: Patent foramen ovale closure can improve dCA and alter elevated arterial PDGF-BB levels in migraine patients with PFO, both of which may be related to the preventive effect of PFO closure on stroke occurrence/recurrence.
(© 2023 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd.)