المؤلفون: Ratcliff CG; Department of Psychology, Sam Houston State University, Huntsville, TX, USA. chelsea.ratcliff@shsu.edu.; Department of Psychiatry & Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA. chelsea.ratcliff@shsu.edu., Zepeda SG; Departmnet of Psychology, Our Lady of the Lake University, The Woodlands, TX, USA., Hall MH; Department of Psychology, The University of Pittsburgh, Pittsburgh, PA, USA., Tullos EA; Department of Psychology, Sam Houston State University, Huntsville, TX, USA., Fowler S; Department of Psychology, Sam Houston State University, Huntsville, TX, USA., Chaoul A; Mind, Body, Spirit Institute, The Jung Center, Houston, TX, USA., Spelman A; Office of Protocol Research, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA., Arun B; Department of Breast Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA., Cohen L; Department of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.

المصدر: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2021 May; Vol. 29 (5), pp. 2601-2611. Date of Electronic Publication: 2020 Sep 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 9302957 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-7339 (Electronic) Linking ISSN: 09414355 NLM ISO Abbreviation: Support Care Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Actigraphy/*methods , Breast Neoplasms/*psychology , Quality of Life/*psychology , Sleep Wake Disorders/*etiology, Breast Neoplasms/mortality ; Cancer Survivors ; Female ; Humans ; Middle Aged

مستخلص: Background: Disturbed sleep is common among breast cancer survivors. Identifying patients at risk for disturbed sleep and its sequelae will aid in improving screening and intervention strategies to improve sleep and cancer-related quality of life (QOL).
Methods: Women with stages I-III breast cancer undergoing neoadjuvant or adjuvant chemotherapy (N = 415) reported subjectively assessed sleep quality (PSQI) and actigraphy-assessed wake after sleep onset (AAS-WASO), total sleep time (AAS-TST), and sleep efficiency (AAS-SE), sociodemographic, and clinical characteristics and completed questionnaires assessing physical and mental health QOL at study entry and 3, 6, 12, and 15 months later.
Results: Being from a racially/ethnically underserved population was associated with poorer sleep in all indices (p's < .04). Lower income was associated with poorer subjective sleep and greater AAS-WASO (p's < .02). BMI was associated with lower AAS-SE (p < .001). Baseline subjective sleep complaints were positively associated with depression, fatigue, and health-related QOL and cancer-related symptoms across follow-up (p's < 0.05). Baseline AAS-WASO was positively associated with anxiety and negatively associated with physical health-related QOL at the 3-month follow-up (p's < .001). Baseline AAS-WASO and AAS-SE were associated with mental health-related QOL at the 6-month follow-up (p's < .05).
Conclusions: In keeping with previous health disparity research, racially/ethnically underserved populations, lower household income, and higher BMI were associated with increased risk for disturbed sleep. Sleep disturbance may have long-term effects on multiple aspects of QOL for women undergoing treatment for breast cancer. Results may inform strategies to identify patients at greatest risk for disturbed sleep and its sequelae.

المؤلفون: Trevino KM; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Raghunathan N; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Latte-Naor S; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Polubriaginof FCG; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Jensen C; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Atkinson TM; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Emard N; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Seluzicki CM; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Ostroff JS; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Mao JJ; Memorial Sloan Kettering Cancer Center, New York, NY, USA. maoj@mskcc.org.

المصدر: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2021 Feb; Vol. 29 (2), pp. 543-546. Date of Electronic Publication: 2020 Sep 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 9302957 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-7339 (Electronic) Linking ISSN: 09414355 NLM ISO Abbreviation: Support Care Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Mind-Body Therapies/*statistics & numerical data , Neoplasms/*psychology , Telemedicine/*statistics & numerical data, Anxiety ; COVID-19 ; Disease Outbreaks ; Feasibility Studies ; Humans ; Meditation ; Patient Participation/statistics & numerical data ; Surveys and Questionnaires ; Tai Ji ; Yoga

مستخلص: Introduction: COVID-19 increased stress levels while reducing access to mind-body services in patients with cancer. We describe the rapid deployment of remotely delivered mind-body services to people with cancer during COVID-19, rates of participation, and acceptability from patients' perspectives.
Methods: Eligible participants were patients with cancer age ≥ 18 years enrolled in a single academic cancer center's online patient portal. Interventions included mind-body group therapy sessions in fitness, meditation, yoga, dance, tai chi, and music delivered using Zoom video conferencing. Sessions were 30-45 min and led by an integrative medicine clinician. Following each session, participants were asked to complete a three-item questionnaire assessing (1) satisfaction with the class session, (2) reduction in stress/anxiety, and (3) likelihood of recommending the class to others. Patients could also provide comments in real-time using the Zoom chat function.
Results: Among 5948 unique visits, the most frequently attended classes were fitness (n = 2513, 42.2%) followed by meditation (n = 1176, 19.8%) and yoga (n = 909, 15.3%). Of these visits, 3902 (65.6%) had an associated completed questionnaire. Across class types, a large majority of participants reported being extremely satisfied (n = 3733, 95.7%), experiencing extreme reductions in anxiety/stress (n = 3268, 83.8%), and being extremely likely to recommend the class to others (n = 3605, 92.4%). Fitness had the highest endorsement among class types (all p values < 0.001). Themes from the chat responses included gratitude, expressions of helpfulness, and feelings of connection.
Conclusion: High utilization of and satisfaction with these virtual mind-body services demonstrate the significant potential of remote delivery to facilitate patient access to services.

المؤلفون: Wong CH; Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China., Sundberg T; Musculoskeletal and Sports Injury Epidemiology Center (MUSIC), Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.; Australian Research Centre in Complementary and Integrative Medicine (ARCCIM), Faculty of Health, University of Technology Sydney, Sydney, New South Wales, Australia., Chung VC; Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China.; Australian Research Centre in Complementary and Integrative Medicine (ARCCIM), Faculty of Health, University of Technology Sydney, Sydney, New South Wales, Australia.; School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong, China., Voiss P; Department of Internal and Integrative Medicine, Evang. Kliniken Essen-Mitte, Faculty of Medicine, University of Duisburg-Essen, Am Deimelsberg 34a, 45276, Essen, Germany., Cramer H; Australian Research Centre in Complementary and Integrative Medicine (ARCCIM), Faculty of Health, University of Technology Sydney, Sydney, New South Wales, Australia. h.cramer@kem-med.com.; Department of Internal and Integrative Medicine, Evang. Kliniken Essen-Mitte, Faculty of Medicine, University of Duisburg-Essen, Am Deimelsberg 34a, 45276, Essen, Germany. h.cramer@kem-med.com.

المصدر: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2021 Jan; Vol. 29 (1), pp. 271-278. Date of Electronic Publication: 2020 May 01.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 9302957 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-7339 (Electronic) Linking ISSN: 09414355 NLM ISO Abbreviation: Support Care Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Cancer Survivors/*statistics & numerical data , Chiropractic/*statistics & numerical data , Colorectal Neoplasms/*therapy , Complementary Therapies/*statistics & numerical data , Mind-Body Therapies/*statistics & numerical data, Adolescent ; Adult ; Aged ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Prevalence ; Surveys and Questionnaires ; United States ; Young Adult

مستخلص: Background: In the USA, colorectal cancer is among the top diagnosed cancers. The current study specifically targets the US adult population that have a history of colorectal cancer.
Methods: We used the 2017 National Health Interview Survey (NHIS) to investigate the prevalence and predictors of colorectal cancer survivors using complementary medicine in the past 12 months in a representative sample of the US population (N = 26,742). We descriptively analyzed the 12-month prevalence of any complementary medicine use separately for individuals with a prior diagnosis of colorectal cancer and those without. Using chi-squared tests and backward stepwise multiple logistic regression analyses, we identified predictors of complementary medicine use in the past 12 months.
Results: A weighted total of 1,501,481 US adults (0.6%) had a history of colorectal cancer. More individuals without (weighted n = 76,550,503; 31.2%) than those with a history of colorectal cancer (weighted n = 410,086; 27.3%) had used complementary medicine. The most commonly used complementary medicine among colorectal cancer patients was mind-body medicine, followed by chiropractic. A higher prevalence of complementary medicine use was associated with being female, higher educated and/or living in the US Midwest or South.
Conclusions: In this study, over one fourth of the US colorectal cancer survivors had used complementary medicine. Mind-body medicine was found to be the most commonly used. With evidence supporting the effectiveness and safety of mind-body medicine use among colorectal cancer patients, promoting the use of evidence-based mind-body medicine for colorectal cancer management could be considered.

المؤلفون: Liou KT; Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1429 First Avenue, New York, NY, 10021, USA. liouk@mskcc.org., Mao JJ; Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1429 First Avenue, New York, NY, 10021, USA.

المصدر: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2021 Jan; Vol. 29 (1), pp. 5. Date of Electronic Publication: 2020 Oct 28.

نوع المنشور: Letter; Comment

بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 9302957 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-7339 (Electronic) Linking ISSN: 09414355 NLM ISO Abbreviation: Support Care Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Acupuncture Therapy* , Cancer Pain*/drug therapy , Neoplasms*/complications , Neoplasms*/drug therapy, Humans ; Pain Management

المؤلفون: Bischoff KE; Division of Palliative Medicine, Department of Medicine, University of California, San Francisco, Box 0131, 533 Parnassus Avenue, San Francisco, CA, 94143, USA. kara.bischoff@ucsf.edu., Zapata C; Division of Palliative Medicine, Department of Medicine, University of California, San Francisco, Box 0131, 533 Parnassus Avenue, San Francisco, CA, 94143, USA., Sedki S; Division of Palliative Medicine, Department of Medicine, University of California, San Francisco, Box 0131, 533 Parnassus Avenue, San Francisco, CA, 94143, USA., Ursem C; Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco and San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA., O'Riordan DL; Division of Palliative Medicine, Department of Medicine, University of California, San Francisco, Box 0131, 533 Parnassus Avenue, San Francisco, CA, 94143, USA., England AE; Department of Psychology, Central Michigan University, Mount Pleasant, MI, USA., Thompson N; Osher Center for Integrative Medicine, Department of Medicine, University of California. San Francisco, San Francisco, CA, USA., Alfaro A; Division of Hematology and Oncology, Department of Medicine and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA., Rabow MW; Division of Palliative Medicine, Department of Medicine, University of California, San Francisco, Box 0131, 533 Parnassus Avenue, San Francisco, CA, 94143, USA., Atreya CE; Division of Hematology and Oncology, Department of Medicine and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.

المصدر: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2020 Dec; Vol. 28 (12), pp. 5995-6010. Date of Electronic Publication: 2020 Apr 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 9302957 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-7339 (Electronic) Linking ISSN: 09414355 NLM ISO Abbreviation: Support Care Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Advance Directives/*statistics & numerical data , Colorectal Neoplasms/*therapy , Hospice and Palliative Care Nursing/*methods , Palliative Care/*methods, Advance Care Planning ; Caregivers ; Cohort Studies ; Colorectal Neoplasms/pathology ; Female ; Humans ; Male ; Middle Aged ; Pilot Projects ; Quality of Life/psychology ; Surveys and Questionnaires

مستخلص: Purpose: Palliative care is recommended for patients with metastatic cancer, but there has been limited research about embedded palliative care for specific patient populations. We describe the impact of a pilot program that provided routine, early, integrated palliative care to patients with metastatic colorectal cancer.
Methods: Mixed methods pre-post intervention cohort study at an academic cancer center. Thirty control then 30 intervention patients with metastatic colorectal cancer were surveyed at baseline and 1, 3, 6, 9, and 12 months thereafter about symptoms, quality-of-life, and likelihood of cure. We compared survey responses, trends over time, rates of advance care planning, and healthcare utilization between groups. Patients, family caregivers, and clinicians were interviewed.
Results: Patients in the intervention group were followed for an average of 6.5 months and had an average of 3.5 palliative care visits. At baseline, symptoms were mild (average 1.85/10) and 78.2% of patients reported good/excellent quality-of-life. Half (50.9%) believed they were likely to be cured of cancer. Over time, symptoms and quality-of-life metrics remained similar between groups, however intervention patients were more realistic about their likelihood of cure (p = 0.008). Intervention patients were more likely to have a surrogate documented (83.3% vs. 26.7%, p < 0.0001), an advance directive completed (63.3% vs. 13.3%, p < 0.0001), and non-full code status (43.3% vs. 16.7%, p < 0.03). All patients and family caregivers would recommend the program to others with cancer.
Conclusions: We describe the impact of an embedded palliative care program for patients with metastatic colorectal cancer, which improved prognostic awareness and rates of advance care planning.

المؤلفون: Guo Y; Department of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1414, Houston, TX, 77030, USA. yguo@mdanderson.org., Molinares D; Department of Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1414, Houston, TX, 77030, USA.; Department of Physical Medicine, Sylvester Comprehensive Cancer Center, 1120 NW 14th Street, 9th Floor, Miami, FL, 33136, USA.

المصدر: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2020 Sep; Vol. 28 (9), pp. 3981-3982. Date of Electronic Publication: 2019 Dec 11.

نوع المنشور: Letter; Comment

بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 9302957 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-7339 (Electronic) Linking ISSN: 09414355 NLM ISO Abbreviation: Support Care Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Meditation* , Neoplasms*/therapy , Yoga*, Humans

المؤلفون: Filbet M; Centre de Soins Palliatifs, Centre Hospitalier Lyon Sud, Lyon Sud, France., Schloss J; Office of Research, Endeavour College of Natural Health, Brisbane, QLD, Australia., Maret JB; Centre de Soins Palliatifs, Centre Hospitalier Lyon Sud, Lyon Sud, France., Diezel H; Office of Research, Endeavour College of Natural Health, Brisbane, QLD, Australia., Palmgren PJ; Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, Stockholm, Sweden., Steel A; Office of Research, Endeavour College of Natural Health, Brisbane, QLD, Australia. amie.steel@uts.edu.au.; Australian Research Centre in Complementary and Integrative Medicine, Faculty of Health, University of Technology Sydney, Level 8, Building 10 235-253 Jones St, Ultimo, NSW, 2006, Australia. amie.steel@uts.edu.au.

المصدر: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2020 Sep; Vol. 28 (9), pp. 4405-4412. Date of Electronic Publication: 2020 Jan 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 9302957 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-7339 (Electronic) Linking ISSN: 09414355 NLM ISO Abbreviation: Support Care Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Complementary Therapies/*standards , Palliative Care/*methods, Cross-Sectional Studies ; Female ; France ; Humans ; Male ; Middle Aged ; Prevalence

مستخلص: Purpose: Palliative care for cancer deals with physical, psychosocial, and spiritual issues faced by cancer patients, their families, communities, and healthcare providers. Research on complementary medicine (CM) use in France is limited despite high rates of reported CM use in other countries including by palliative patients. This study describes the use of CM by individuals receiving palliative care in Lyon, France.
Design: This study employed an observational cross-sectional survey design.
Setting/participants: The study was conducted in three palliative care centers in Lyon, France; two tertiary hospitals and one palliative care unit (3 sites). Inpatients and outpatients visiting the palliative care clinic with a primary diagnosis of cancer at each study site were invited to participate.
Results: Of 138 eligible patients, 100 completed the survey (RR 72.4%). The majority (90.7%) reported using CM in the previous 6 months or since their primary cancer diagnosis. Participant CM use was either the same (20.7%) or increased since their primary cancer diagnosis (33.7%). Average out-of-pocket expenses associated with CM use in the previous 6 months or since diagnosis were €157.40 (SD €330.15). The most common CM health professional visited was an aromatherapist (72.7%), a Coupeurs de feu (38.6%), osteopath (28.6%) and naturopath (15.3%). The most common CM used were aromatherapy oils (33.7%), homeopathy (30.0%), and vitamins (29.4%).
Conclusion: This second survey on CM use in France; is the first conducted in palliative care centers. Results show people with cancer in Lyon, France, have a very high prevalence of CM utilization.

المؤلفون: Gravier AL; Department of Palliative Care, Rehabilitation and Integrative Medicine, Unit 414, University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA., Shamieh O; Department of Palliative Care, King Hussein Cancer Center, Amman, Jordan., Paiva CE; Department of Medical Oncology, Barretos Cancer Hospital, Barretos, Brazil., Perez-Cruz PE; Departamento Medicina Interna, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile., Muckaden MA; Department of Palliative Care, Tata Memorial Center, Mumbai, India., Park M; Department of Biostatistics, MD Anderson Cancer Center, Houston, TX, USA., Bruera E; Department of Palliative Care, Rehabilitation and Integrative Medicine, Unit 414, University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA., Hui D; Department of Palliative Care, Rehabilitation and Integrative Medicine, Unit 414, University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA. dhui@mdanderson.org.

المصدر: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2020 Aug; Vol. 28 (8), pp. 3927-3934. Date of Electronic Publication: 2019 Dec 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 9302957 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-7339 (Electronic) Linking ISSN: 09414355 NLM ISO Abbreviation: Support Care Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Existentialism*, Neoplasms/*psychology, Adult ; Aged ; Aged, 80 and over ; Anxiety/etiology ; Anxiety/psychology ; Cultural Characteristics ; Fatigue/etiology ; Fatigue/psychology ; Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Multivariate Analysis ; Observational Studies as Topic ; Prospective Studies ; Quality of Life ; Spirituality ; Young Adult

مستخلص: Background: Few studies have examined meaning in life, a novel existential outcome, in patients with advanced cancer across countries.
Objectives: We examined differences in meaning in life across 5 countries and identified factors associated with meaning in life.
Methods: This is a pre-planned secondary analysis of a prospective longitudinal multicenter observational study of patients with advanced cancer. Meaning in life was assessed using a validated scale which examined four domains of meaning: values, purpose, goals, and reflection. The total score ranged from 8 to 32, with a higher score indicating greater meaning in life.
Results: Among 728 patients, the median meaning in life score was 25/32 (interquartile range 23, 28). There was no significant difference in the total meaning in life score among 5 countries (P = 0.11), though there were differences in domain sub-scores. In the univariate analysis, patients with higher intensity of physical symptoms by ESAS score (pain, fatigue, drowsiness, dyspnea, insomnia), depression, anxiety, spiritual pain, and financial distress had significantly lower meaning in life. However, patients with higher levels of education, who were married, and who had higher optimism had significantly higher meaning in life. In the multivariate analysis, higher total meaning in life scores were significantly associated with greater optimism (multivariate estimate = 0.33, p < 0.001), lower depression (- 0.26, < 0.001), spiritual pain (- 0.19, < 0.001), and financial distress (- 0.16, < 0.001).
Conclusion: Country of origin was not a determinant of meaning in life. However, meaning in life was significantly associated with optimism, depression, spiritual pain, and financial distress, underscoring the multidimensional nature of this construct and potential opportunities for improvement in addressing meaning in life of patients with advanced cancer.

المؤلفون: Steel A; Australian Research Centre in Complementary and Integrative Medicine, Faculty of Health, University of Technology Sydney, 235-253 Jones St, Ultimo, NSW, Australia. Amie.steel@uts.edu.au., Palmgren P; Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, Stockholm, Sweden., Schloss J; Australian Research Centre in Complementary and Integrative Medicine, Faculty of Health, University of Technology Sydney, 235-253 Jones St, Ultimo, NSW, Australia.; Office of Research, Endeavour College of Natural Health, QLD, Brisbane, Australia., Diezel H; Office of Research, Endeavour College of Natural Health, QLD, Brisbane, Australia., Filbet M; Centre de Soins Palliatif, Centre Hospitalier Lyon-Sud, Lyon-Sud, France.

المصدر: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2020 Jul; Vol. 28 (7), pp. 2997-2998. Date of Electronic Publication: 2020 Apr 14.

نوع المنشور: Letter; Comment

بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 9302957 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-7339 (Electronic) Linking ISSN: 09414355 NLM ISO Abbreviation: Support Care Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Complementary Therapies* , Hospice and Palliative Care Nursing*, Cross-Sectional Studies ; France ; Humans ; Palliative Care

المؤلفون: Chow R; Department of Epidemiology and Biostatistics, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada. rchow48@uwo.ca.; Division of Radiation Oncology, Department of Oncology, London Regional Cancer Program, University of Western Ontario, London, Ontario, Canada. rchow48@uwo.ca., Bruera E; Department of Palliative, Rehabilitation and Integrative Medicine, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Temel JS; Division of Hematology and Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Krishnan M; Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Harvard University, Boston, MA, USA., Im J; Department of Epidemiology and Biostatistics, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada., Lock M; Division of Radiation Oncology, Department of Oncology, London Regional Cancer Program, University of Western Ontario, London, Ontario, Canada.

المصدر: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2020 May; Vol. 28 (5), pp. 2071-2078. Date of Electronic Publication: 2020 Jan 03.

نوع المنشور: Journal Article; Meta-Analysis; Systematic Review

بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 9302957 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-7339 (Electronic) Linking ISSN: 09414355 NLM ISO Abbreviation: Support Care Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Health Personnel/*statistics & numerical data , Karnofsky Performance Status/*statistics & numerical data , Neoplasms/*mortality , Neoplasms/*psychology , Terminal Care/*psychology, Hospices ; Humans ; Neoplasms/therapy ; Prognosis ; Reproducibility of Results

مستخلص: Introduction: Survival prediction for patients with incurable malignancies is invaluable information during end-of-life discussions, as it helps the healthcare team to appropriately recommend treatment options and consider hospice enrolment. Assessment of performance status may differ between different healthcare professionals (HCPs), which could have implications in predicting prognosis. The aim of this systematic review and meta-analysis is to update a prior systematic review with recent articles, as well as conduct a meta-analysis to quantitatively compare performance status scores.
Methods: A literature search was carried out in Ovid MEDLINE, Embase, and Cochrane Central Register of Controlled Trials, from the earliest date until the first week of August 2019. Studies were included if they reported on (1) Karnofsky Performance Status (KPS), Eastern Cooperative Oncology Group (ECOG) Performance Status, and/or Palliative Performance Scale (PPS) and (2) assessment of performance status by multiple HCPs for the same patient sets. The concordance statistics (Kappa, Krippendorff's alpha, Kendall correlation, Spearman rank correlation, Pearson correlation) were extracted into a summary table for narrative review, and Pearson correlation coefficients were calculated for each study and meta-analyzed with a random effects analysis model. Analyses were conducted using Comprehensive Meta-Analysis (Version 3) by Biostat.
Results: Fourteen articles were included, with a cumulative sample size of 2808 patients. The Pearson correlation coefficient was 0.787 (95% CI: 0.661, 0.870) for KPS, 0.749 (95% CI: 0.716, 0.779) for PPS, and 0.705 (95% CI: 0.536, 0.819) for ECOG. Four studies compared different tools head-to-head; KPS was favored in three studies. The quality of evidence was moderate, as determined by the GRADE tool.
Conclusions: The meta-analysis's Pearson correlation coefficient ranged from 0.705 to 0.787; there is notable correlation of performance status scores, with no one tool statistically superior to others. KPS is, however, descriptively better and favored in head-to-head trials. Future studies could now examine the accuracy of KPS assessment in prognostication and focus on model-building around KPS.