المؤلفون: Bobkov V; Division of Medicinal Chemistry, Amsterdam Institute for Molecules Medicines and Systems, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands (V.B., M.A., A.Z., T.W.M.D.G., M.J.S.); and argenx BVBA, Zwijnaarde, Belgium (V.B., B.W., H.H.)., Arimont M; Division of Medicinal Chemistry, Amsterdam Institute for Molecules Medicines and Systems, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands (V.B., M.A., A.Z., T.W.M.D.G., M.J.S.); and argenx BVBA, Zwijnaarde, Belgium (V.B., B.W., H.H.)., Zarca A; Division of Medicinal Chemistry, Amsterdam Institute for Molecules Medicines and Systems, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands (V.B., M.A., A.Z., T.W.M.D.G., M.J.S.); and argenx BVBA, Zwijnaarde, Belgium (V.B., B.W., H.H.)., De Groof TWM; Division of Medicinal Chemistry, Amsterdam Institute for Molecules Medicines and Systems, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands (V.B., M.A., A.Z., T.W.M.D.G., M.J.S.); and argenx BVBA, Zwijnaarde, Belgium (V.B., B.W., H.H.)., van der Woning B; Division of Medicinal Chemistry, Amsterdam Institute for Molecules Medicines and Systems, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands (V.B., M.A., A.Z., T.W.M.D.G., M.J.S.); and argenx BVBA, Zwijnaarde, Belgium (V.B., B.W., H.H.)., de Haard H; Division of Medicinal Chemistry, Amsterdam Institute for Molecules Medicines and Systems, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands (V.B., M.A., A.Z., T.W.M.D.G., M.J.S.); and argenx BVBA, Zwijnaarde, Belgium (V.B., B.W., H.H.)., Smit MJ; Division of Medicinal Chemistry, Amsterdam Institute for Molecules Medicines and Systems, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands (V.B., M.A., A.Z., T.W.M.D.G., M.J.S.); and argenx BVBA, Zwijnaarde, Belgium (V.B., B.W., H.H.) mj.smit@vu.nl.

المصدر: Molecular pharmacology [Mol Pharmacol] 2019 Dec; Vol. 96 (6), pp. 753-764. Date of Electronic Publication: 2019 Sep 03.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0035623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0111 (Electronic) Linking ISSN: 0026895X NLM ISO Abbreviation: Mol Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal/*administration & dosage , Antibodies, Monoclonal/*metabolism , Receptors, CXCR/*metabolism , Receptors, CXCR4/*metabolism , Single-Domain Antibodies/*administration & dosage , Single-Domain Antibodies/*metabolism, Animals ; Drug Delivery Systems/methods ; Humans ; Receptors, CXCR/antagonists & inhibitors ; Receptors, CXCR4/antagonists & inhibitors

المؤلفون: Brunn ND; Biologics DMPK and Disposition (N.D.B., D.W., D.H., E.E.), Immuno-oncology (S.M., D.G., R.U., A.M.B.), and Bioanalytics Department (S.Z.), Merck Research Laboratories, Merck & Co. Inc., Palo Alto, California., Mauze S; Biologics DMPK and Disposition (N.D.B., D.W., D.H., E.E.), Immuno-oncology (S.M., D.G., R.U., A.M.B.), and Bioanalytics Department (S.Z.), Merck Research Laboratories, Merck & Co. Inc., Palo Alto, California., Gu D; Biologics DMPK and Disposition (N.D.B., D.W., D.H., E.E.), Immuno-oncology (S.M., D.G., R.U., A.M.B.), and Bioanalytics Department (S.Z.), Merck Research Laboratories, Merck & Co. Inc., Palo Alto, California., Wiswell D; Biologics DMPK and Disposition (N.D.B., D.W., D.H., E.E.), Immuno-oncology (S.M., D.G., R.U., A.M.B.), and Bioanalytics Department (S.Z.), Merck Research Laboratories, Merck & Co. Inc., Palo Alto, California., Ueda R; Biologics DMPK and Disposition (N.D.B., D.W., D.H., E.E.), Immuno-oncology (S.M., D.G., R.U., A.M.B.), and Bioanalytics Department (S.Z.), Merck Research Laboratories, Merck & Co. Inc., Palo Alto, California., Hodges D; Biologics DMPK and Disposition (N.D.B., D.W., D.H., E.E.), Immuno-oncology (S.M., D.G., R.U., A.M.B.), and Bioanalytics Department (S.Z.), Merck Research Laboratories, Merck & Co. Inc., Palo Alto, California., Beebe AM; Biologics DMPK and Disposition (N.D.B., D.W., D.H., E.E.), Immuno-oncology (S.M., D.G., R.U., A.M.B.), and Bioanalytics Department (S.Z.), Merck Research Laboratories, Merck & Co. Inc., Palo Alto, California., Zhang S; Biologics DMPK and Disposition (N.D.B., D.W., D.H., E.E.), Immuno-oncology (S.M., D.G., R.U., A.M.B.), and Bioanalytics Department (S.Z.), Merck Research Laboratories, Merck & Co. Inc., Palo Alto, California., Escandón E; Biologics DMPK and Disposition (N.D.B., D.W., D.H., E.E.), Immuno-oncology (S.M., D.G., R.U., A.M.B.), and Bioanalytics Department (S.Z.), Merck Research Laboratories, Merck & Co. Inc., Palo Alto, California Enrique.escandon@merck.com.

المصدر: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2016 Mar; Vol. 356 (3), pp. 574-86. Date of Electronic Publication: 2015 Dec 15.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal/*pharmacokinetics , Antineoplastic Agents/*pharmacokinetics , Drug Delivery Systems/*methods , Glucocorticoid-Induced TNFR-Related Protein/*agonists , Glucocorticoid-Induced TNFR-Related Protein/*metabolism, Animals ; Antibodies, Monoclonal/administration & dosage ; Antineoplastic Agents/administration & dosage ; Cell Line, Tumor ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Tissue Distribution/drug effects ; Tissue Distribution/physiology ; Xenograft Model Antitumor Assays/methods

المؤلفون: McCarron PA; School of Pharmacy, Queen's University Belfast, BT9 7BL, UK., Olwill SA, Marouf WM, Buick RJ, Walker B, Scott CJ

المصدر: Molecular interventions [Mol Interv] 2005 Dec; Vol. 5 (6), pp. 368-80.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 101093789 Publication Model: Print Cited Medium: Print ISSN: 1534-0384 (Print) Linking ISSN: 15340384 NLM ISO Abbreviation: Mol Interv Subsets: MEDLINE

مواضيع طبية MeSH: Drug Delivery Systems*, Antibodies, Monoclonal/*chemistry , Drug Carriers/*chemistry , Immunoconjugates/*administration & dosage , Peptides/*administration & dosage , Recombinant Proteins/*administration & dosage, Animals ; Antibodies, Monoclonal/therapeutic use ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/therapeutic use ; Humans ; Immunoconjugates/chemistry ; Immunoconjugates/therapeutic use ; Immunotherapy ; Immunotoxins/administration & dosage ; Immunotoxins/chemistry ; Immunotoxins/therapeutic use ; Mice ; Nanostructures ; Peptides/chemistry ; Peptides/therapeutic use ; Radioisotopes/therapeutic use ; Recombinant Proteins/chemistry ; Recombinant Proteins/therapeutic use

المؤلفون: Scherpereel A; Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6068, USA., Rome JJ, Wiewrodt R, Watkins SC, Harshaw DW, Alder S, Christofidou-Solomidou M, Haut E, Murciano JC, Nakada M, Albelda SM, Muzykantov VR

المصدر: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2002 Mar; Vol. 300 (3), pp. 777-86.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print Cited Medium: Print ISSN: 0022-3565 (Print) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

مواضيع طبية MeSH: Drug Delivery Systems*, Antibodies, Monoclonal/*pharmacology , Coronary Circulation/*drug effects , Platelet Endothelial Cell Adhesion Molecule-1/*immunology , Pulmonary Circulation/*drug effects, Animals ; Animals, Newborn ; Antibodies, Monoclonal/pharmacokinetics ; Biotin/chemistry ; Cross Reactions ; Endothelium, Vascular/cytology ; Endothelium, Vascular/metabolism ; Immunoglobulin G/chemistry ; Immunoglobulin G/immunology ; Immunohistochemistry ; Infusions, Intravenous ; Iodine Radioisotopes ; Isotope Labeling ; Lung/cytology ; Lung/metabolism ; Myocardium/cytology ; Myocardium/metabolism ; Organ Specificity ; Platelet Endothelial Cell Adhesion Molecule-1/metabolism ; Swine ; Tissue Distribution ; beta-Galactosidase/pharmacokinetics

المؤلفون: Luu KT; Clinical Pharmacology-Oncology Business Unit, Pfizer Global Research and Development, La Jolla, California, USA. kenneth.luu@pfizer.com, Bergqvist S, Chen E, Hu-Lowe D, Kraynov E

المصدر: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2012 Jun; Vol. 341 (3), pp. 702-8. Date of Electronic Publication: 2012 Mar 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

مواضيع طبية MeSH: Computer Simulation* , Models, Biological*, Antibodies, Monoclonal/*pharmacokinetics, Activin Receptors, Type I/immunology ; Animals ; Antibodies, Monoclonal, Humanized ; Clinical Trials, Phase I as Topic ; Dose-Response Relationship, Drug ; Drug Delivery Systems ; Drug Evaluation, Preclinical ; Endothelium, Vascular/metabolism ; Enzyme-Linked Immunosorbent Assay ; Flow Cytometry ; Haplorhini ; Humans ; Immunoglobulin G/immunology ; Mice ; Surface Plasmon Resonance ; Umbilical Veins

المؤلفون: Gu W; Department of Metabolic Disorders, Amgen Inc, Thousand Oaks, California 91320, USA., Lloyd DJ, Chinookswong N, Komorowski R, Sivits G Jr, Graham M, Winters KA, Yan H, Boros LG, Lindberg RA, Véniant MM

المصدر: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2011 Jul; Vol. 338 (1), pp. 70-81. Date of Electronic Publication: 2011 Apr 06.

نوع المنشور: Comparative Study; Journal Article

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal/*administration & dosage , Blood Glucose/*drug effects , Energy Metabolism/*drug effects , Glucagon-Like Peptide 1/*analogs & derivatives , Homeostasis/*drug effects , Obesity/*metabolism , Receptors, Glucagon/*antagonists & inhibitors, Animals ; Blood Glucose/physiology ; Body Weight/drug effects ; Body Weight/physiology ; Dietary Fats/administration & dosage ; Drug Delivery Systems/methods ; Energy Metabolism/physiology ; Glucagon-Like Peptide 1/administration & dosage ; Glucagon-Like Peptide 1/physiology ; Glucagon-Like Peptide-1 Receptor ; Homeostasis/physiology ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Obesity/drug therapy ; Receptors, Glucagon/physiology

المؤلفون: Lee HJ; Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA., Engelhardt B, Lesley J, Bickel U, Pardridge WM

المصدر: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2000 Mar; Vol. 292 (3), pp. 1048-52.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print Cited Medium: Print ISSN: 0022-3565 (Print) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

مواضيع طبية MeSH: Blood-Brain Barrier*, Antibodies, Monoclonal/*pharmacokinetics , Receptors, Transferrin/*immunology, Animals ; Brain/metabolism ; Drug Delivery Systems ; Mice ; Mice, Inbred BALB C ; Rats ; Tissue Distribution

المؤلفون: Granholm AC; Department of Basic Science, University of Colorado School of Dentistry, Denver., Bäckman C, Bloom F, Ebendal T, Gerhardt GA, Hoffer B, Mackerlova L, Olson L, Söderström S, Walus LR, et. al.

المصدر: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 1994 Jan; Vol. 268 (1), pp. 448-59.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print Cited Medium: Print ISSN: 0022-3565 (Print) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal/*pharmacology , Hippocampus/*cytology , Nerve Growth Factors/*pharmacology , Neurons/*transplantation , Receptors, Transferrin/*immunology, Adrenal Glands/metabolism ; Animals ; Antibody Formation ; Blood-Brain Barrier ; Brain/blood supply ; Drug Delivery Systems ; Enzyme-Linked Immunosorbent Assay ; Epinephrine/metabolism ; Female ; Hippocampus/metabolism ; Immunohistochemistry ; Mice ; Nerve Growth Factors/administration & dosage ; Nerve Growth Factors/immunology ; Neurons/drug effects ; Neurons/metabolism ; Norepinephrine/metabolism ; Ophthalmologic Surgical Procedures ; Rats ; Rats, Sprague-Dawley ; Receptors, Cholinergic/metabolism ; Receptors, Transferrin/metabolism