المؤلفون: Kelliny S; Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, SA, 5000, Australia.; Faculty of Pharmacy, Assiut University, Assiut, Egypt., Xiong J; Department of Neurology, The Second Affiliated Hospital, Kunming Medical University, Kunming, Yunnan, China., Bobrovskaya L; Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, SA, 5000, Australia., Zhou XF; Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, SA, 5000, Australia. xin-fu.zhou@unisa.edu.au.

المصدر: Neurotoxicity research [Neurotox Res] 2021 Dec; Vol. 39 (6), pp. 1689-1707. Date of Electronic Publication: 2021 Oct 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 100929017 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-3524 (Electronic) Linking ISSN: 10298428 NLM ISO Abbreviation: Neurotox Res Subsets: MEDLINE

مواضيع طبية MeSH: Edaravone/*therapeutic use , Frontotemporal Dementia/*drug therapy , Neuroprotective Agents/*therapeutic use, Administration, Oral ; Animals ; Blotting, Western ; Brain/pathology ; Edaravone/administration & dosage ; Female ; Frontotemporal Dementia/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Morris Water Maze Test ; Neuroprotective Agents/administration & dosage ; Open Field Test ; tau Proteins/metabolism

مستخلص: Oxidative stress is a key factor in the pathogenesis of several neurodegenerative disorders and is involved in the accumulation of amyloid beta plaques and Tau inclusions. Edaravone (EDR) is a free radical scavenger that is approved for motor neuron disease and acute ischemic stroke. EDR alleviates pathologies and cognitive impairment of AD via targeting multiple key pathways in transgenic mice. Herein, we aimed to study the effect of EDR on Tau pathology in P301L mice; an animal model of frontotemporal dementia (FTD), at two age time points representing the early and late stages of the disease. A novel EDR formulation was utilized in the study and the drug was delivered orally in drinking water for 3 months. Then, behavioral tests were conducted followed by animal sacrifice and brain dissection. Treatment with EDR improved the reference memory and accuracy in the probe trial as evaluated in Morris water maze, as well as novel object recognition and significantly alleviated motor deficits in these mice. EDR also reduced the levels of 4-hydroxy-2-nonenal and 3-nitrotyrosine adducts. In addition, immunohistochemistry showed that EDR reduced tau phosphorylation and neuroinflammation and partially rescued neurons against oxidative neurotoxicity. Moreover, EDR attenuated downstream pathologies involved in Tau hyperphosphorylation. These results suggest that EDR may be a potential therapeutic agent for the treatment of FTD.
(© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

المؤلفون: He C; Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.; Key Lab of Environmental Hazard & Health of Shanxi Province, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.; Key Lab of Cellular Physiology of Education Ministry, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.; Department of Anatomy, Shanxi Medical University, Taiyuan, 030001, Shanxi, China., Ji J; Fenyang College, Shanxi Medical University, Fenyang, 032200, Shanxi, China., Zhao X; Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, 030001, Shanxi, China., Lei Y; Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, 030001, Shanxi, China., Li H; Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, 030001, Shanxi, China., Hao Y; Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, 030001, Shanxi, China., Zhang S; Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, 030001, Shanxi, China., Zhang J; Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, 030001, Shanxi, China., Liu C; Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, 030001, Shanxi, China., Nie J; Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, 030001, Shanxi, China. niejisheng@sxmu.edu.cn.; Key Lab of Environmental Hazard & Health of Shanxi Province, Shanxi Medical University, Taiyuan, 030001, Shanxi, China. niejisheng@sxmu.edu.cn.; Key Lab of Cellular Physiology of Education Ministry, Shanxi Medical University, Taiyuan, 030001, Shanxi, China. niejisheng@sxmu.edu.cn., Niu Q; Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan, 030001, Shanxi, China. niuqiao55@163.com.; Key Lab of Environmental Hazard & Health of Shanxi Province, Shanxi Medical University, Taiyuan, 030001, Shanxi, China. niuqiao55@163.com.; Key Lab of Cellular Physiology of Education Ministry, Shanxi Medical University, Taiyuan, 030001, Shanxi, China. niuqiao55@163.com.

المصدر: Neurotoxicity research [Neurotox Res] 2021 Dec; Vol. 39 (6), pp. 2042-2055. Date of Electronic Publication: 2021 Sep 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 100929017 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-3524 (Electronic) Linking ISSN: 10298428 NLM ISO Abbreviation: Neurotox Res Subsets: MEDLINE

مواضيع طبية MeSH: Aluminum/*toxicity , Learning/*drug effects , Memory/*drug effects , Protein Kinase C/*metabolism , Receptors, N-Methyl-D-Aspartate/*metabolism, Animals ; Blotting, Western ; Dose-Response Relationship, Drug ; Hippocampus/drug effects ; Hippocampus/metabolism ; Male ; Morris Water Maze Test/drug effects ; Open Field Test/drug effects ; Protein Kinase C/physiology ; Rats ; Rats, Sprague-Dawley ; Real-Time Polymerase Chain Reaction ; Receptors, N-Methyl-D-Aspartate/physiology

مستخلص: Aluminum is a widespread environmental neurotoxicant that can induce Alzheimer's disease (AD)-like damage, such as neuronal injury and impairment of learning and memory. Several studies have shown that aluminum could reduce the synaptic plasticity, but its molecular mechanism remains unclear. In this study, rats were treated with aluminum maltol (Al(mal) 3 ) to establish a toxic animal model and PMA was used to interfere with the expression of PKC. The Morris water maze and open field test were used to investigate the behavioral changes of the rats. Western blotting and RT-PCR were used to detect the expression levels of NMDAR subunits, PKC and CaMKII. The results showed that Al(mal) 3 damaged learning and memory function and reduced anxiety in rats. During this process, the expression of PKC was downregulated and it inhibited the expression of NMDARs through the phosphorylation of CaMKII.
(© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

المؤلفون: Qu X; Shanghai University of Traditional Chinese Medicine, 1200 Cailun Rd., Shanghai, 201203, China., Liu H; Shanghai University of Traditional Chinese Medicine, 1200 Cailun Rd., Shanghai, 201203, China., Yang Y; Shanghai University of Traditional Chinese Medicine, 1200 Cailun Rd., Shanghai, 201203, China., Liu L; Shanghai University of Traditional Chinese Medicine, 1200 Cailun Rd., Shanghai, 201203, China., Shen X; Shanghai University of Traditional Chinese Medicine, 1200 Cailun Rd., Shanghai, 201203, China. snowysh@hotmail.com., Liu S; Shanghai University of Traditional Chinese Medicine, 1200 Cailun Rd., Shanghai, 201203, China. lskingcn@hotmail.com.

المصدر: Lasers in medical science [Lasers Med Sci] 2021 Mar; Vol. 36 (2), pp. 279-287. Date of Electronic Publication: 2020 Apr 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: England NLM ID: 8611515 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-604X (Electronic) Linking ISSN: 02688921 NLM ISO Abbreviation: Lasers Med Sci Subsets: MEDLINE

مواضيع طبية MeSH: Acupuncture Points* , Behavior, Animal* , Laser Therapy*, Anxiety/*therapy , Gyrus Cinguli/*metabolism , Proto-Oncogene Proteins c-fos/*metabolism , Stress Disorders, Post-Traumatic/*metabolism , Stress Disorders, Post-Traumatic/*therapy, Animals ; Anxiety/blood ; Cell Nucleus/metabolism ; Corticosterone/blood ; Disease Models, Animal ; Elevated Plus Maze Test ; Gyrus Cinguli/radiation effects ; Male ; Open Field Test ; Rats, Sprague-Dawley ; Stress Disorders, Post-Traumatic/blood ; Rats

مستخلص: Post-traumatic stress disorder (PTSD) is a mental disorder that is linked with the onset of multiple anxiety-like behaviors. This study was designed to assess how these behaviors and anterior cingulate cortex (ACC) c-Fos expression were impacted by 10.6-μm laser stimulation at acupoint ST36 a rat model of PTSD. A rat model of PTSD was prepared via prolonged exposure of animals to a stressor, followed by a 7-day period during which animals were allowed to rest undisturbed in their cages. Rats were randomized into four experimental groups (n = 12/group): the control, PTSD, LS, and sham LS groups. Control group animals were not subjected to SPS procedures prior to behavioral testing. LS and sham LS animals were administered LS treatment at bilateral ST36 acupoints or non-acupoints, respectively, for a 7-day period. Animals were then assessed for performance in elevated plus maze (EPM) tests and open-field tests (OFT), and their plasma corticosterone levels were measured. In addition, c-Fos-positive nuclei in the ACC were detected via immunohistochemical staining. Relative to sham LS treatment and PTSD model control rats, LS was associated with increased time spent in both open EPM test arms and in the central area in the OFT (P < 0.05). The PTSD model group exhibited a significant reduction in ACC c-Fox expression, while LS treatment significantly increased this expression (P < 0.001). In addition, a correlation was detected between anxiety-like behaviors and altered ACC neuronal activation. The results of this study indicate that LS at acupoint ST36 can have a previously unreported effect on anxiety-like behaviors in the context of PTSD, with ACC neuronal activation potentially being implicated as a driver of this effect.

المؤلفون: Dai CL; Department of Neurochemistry, Inge Grundke-Iqbal Research Floor, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY, 10314, USA., Li H; Department of Neurochemistry, Inge Grundke-Iqbal Research Floor, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY, 10314, USA.; Department of Anesthesiology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, Guangdong, China., Hu X; Department of Neurochemistry, Inge Grundke-Iqbal Research Floor, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY, 10314, USA., Zhang J; Department of Neurochemistry, Inge Grundke-Iqbal Research Floor, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY, 10314, USA.; Department of Rehabilitation, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, Guangdong, China., Liu F; Department of Neurochemistry, Inge Grundke-Iqbal Research Floor, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY, 10314, USA., Iqbal K; Department of Neurochemistry, Inge Grundke-Iqbal Research Floor, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY, 10314, USA., Gong CX; Department of Neurochemistry, Inge Grundke-Iqbal Research Floor, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY, 10314, USA. chengxin.gong@csi.cuny.edu.

المصدر: Neurotoxicity research [Neurotox Res] 2020 Aug; Vol. 38 (2), pp. 299-311. Date of Electronic Publication: 2020 May 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 100929017 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-3524 (Electronic) Linking ISSN: 10298428 NLM ISO Abbreviation: Neurotox Res Subsets: MEDLINE

مواضيع طبية MeSH: Anesthetics, Inhalation/*toxicity , Cognition/*drug effects , Hypoglycemic Agents/*pharmacology , Insulin/*pharmacology , Sevoflurane/*toxicity, Administration, Intranasal ; Anesthesia, General/adverse effects ; Animals ; Animals, Newborn ; Behavior, Animal/drug effects ; Cognitive Dysfunction ; Conditioning, Psychological/drug effects ; Mice ; Morris Water Maze Test/drug effects ; Open Field Test/drug effects ; Premedication ; tau Proteins/drug effects ; tau Proteins/metabolism

مستخلص: Recent pre-clinical and clinical studies suggest that general anesthesia in infants and children may increase the risk of learning disabilities. Currently, there is no treatment for preventing anesthesia-induced neurotoxicity and potential long-term functional impairment. Animal studies have shown that neonatal exposure to anesthesia can induce acute neurotoxicity and long-term behavioral changes that can be detected a few months later. It is currently unknown whether neonatal exposure, especially repeated exposures, to general anesthesia can induce or increase the risk for cognitive impairment during aging. Here, we report that repeated exposures of neonatal mice (P7-9 days old) to anesthesia with sevoflurane (3 h/day for 3 days) led to cognitive impairment that was detectable at the age of 18-19 months, as assessed by using novel object recognition, Morris water maze, and fear conditioning tests. The repeated neonatal exposures to anesthesia did not result in detectable alterations in neurobehavioral development, in tau phosphorylation, or in the levels of synaptic proteins in the aged mouse brains. Importantly, we found that treatment with intranasal insulin prior to anesthesia exposure can prevent mice from anesthesia-induced cognitive impairment. These results suggest that neonatal exposure to general anesthesia could increase the risk for cognitive impairment during aging. This study also supports pre-treatment with intranasal administration of insulin to be a simple, effective approach to prevent infants and children from the increased risk for age-related cognitive impairment induced by neonatal exposure to general anesthesia.

المؤلفون: Schaeffer EA; Department of Psychology, Northern Illinois University, DeKalb, IL, 60115, USA. eschaeffer2@niu.edu., Campbell N; Department of Psychology, Northern Illinois University, DeKalb, IL, 60115, USA., Sampson H; Department of Psychology, Northern Illinois University, DeKalb, IL, 60115, USA., Osterlund Oltmanns JR; Department of Psychology, Northern Illinois University, DeKalb, IL, 60115, USA., Lake R; Department of Psychology, Northern Illinois University, DeKalb, IL, 60115, USA., Clark BJ; Department of Psychology, University of New Mexico Albuquerque, Albuquerque, NM, USA., Wallace DG; Department of Psychology, Northern Illinois University, DeKalb, IL, 60115, USA.

المصدر: Animal cognition [Anim Cogn] 2023 Jun; Vol. 26 (3), pp. 861-883. Date of Electronic Publication: 2022 Dec 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 9814573 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-9456 (Electronic) Linking ISSN: 14359448 NLM ISO Abbreviation: Anim Cogn Subsets: MEDLINE

مواضيع طبية MeSH: Cues* , Spatial Navigation*, Mice ; Animals ; Exploratory Behavior

مستخلص: The nature of the representation guiding spatial navigation has been investigated extensively; however, most of this work has used behavioral tasks that involved learning the location of food reward or an escape platform. In contrast, relatively few studies have focused on the spatial representation of a home base, a ubiquitous feature of open-field behavior, and its ability to be encoded relative to environmental cues. The current set of experiments investigated acquisition and retention of the location of home base establishment. In general, proximal cues anchored the position of the home base during acquisition sessions across all four experiments. Although mice established a home base during retention sessions, previous experience did not influence its position during retention sessions. These observations demonstrate that stimulus control of home base position depends on access to proximal cues. Further work is needed to determine the extent that home base establishment may provide a framework to encode goal-directed spatial behaviors.
(© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

المؤلفون: Hagbi Z; School of Zoology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, 69978, Ramat-Aviv, Israel., Gielman S; School of Zoology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, 69978, Ramat-Aviv, Israel., Dorfman A; School of Zoology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, 69978, Ramat-Aviv, Israel., Eilam D; School of Zoology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, 69978, Ramat-Aviv, Israel. eilam@tauex.tau.ac.il.

المصدر: Animal cognition [Anim Cogn] 2023 Mar; Vol. 26 (2), pp. 655-666. Date of Electronic Publication: 2022 Nov 01.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 9814573 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-9456 (Electronic) Linking ISSN: 14359448 NLM ISO Abbreviation: Anim Cogn Subsets: MEDLINE

مواضيع طبية MeSH: Exploratory Behavior* , Spatial Behavior*, Rats ; Animals ; Rodentia ; Sensation ; Space Perception

مستخلص: We tested rats on a 'bi-level open-field' whose two halves were separated vertically by an 8-cm step that the rats could easily ascend/descend. We sought to determine what might be the factors that shape traveling in three-dimensional environments; what makes an environment perceived as multileveled; and how are multileveled environments explored compared to two-dimensional environments? We found that rats on the bi-level open-field traveled a greater distance on the lower level compared to the upper one. They also spent a long time at the foot of the step before ascending to the upper level. They established a home-base on one level and a local base on the other one, and explored each level separately. We could not find a particular factor that accounted for the preference for the lower level. We suggest that the momentary egocentric sensation of moving vertically, together with an overall area large enough for exploration, result in perceiving an environment as multilevel. Exploration of such environments is fragmented, and each level is explored relatively independently, as has also been shown in other studies. Regarding the unanswered question of earlier studies concerning what integrates fragmented representations, this is the first study that suggests that in rats, and perhaps also in other rodent species, such integration is achieved by means of home-base behavior, resulting in the establishment of a single comprehensive representation of the multilevel environment.
(© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

المؤلفون: Kisipan ML; Department of Experimental Medicine, University of Copenhagen, Copenhagen, Denmark. kisipanm@gmail.com.; Department of Veterinary Anatomy and Physiology, Egerton University, Njoro, Kenya. kisipanm@gmail.com., Ojoo RO; Department of Veterinary Anatomy and Physiology, University of Nairobi, Nairobi, Kenya., Kanui TI; Department of Agricultural Sciences, South Eastern Kenya University, Kitui, Kenya., Abelson KSP; Department of Experimental Medicine, University of Copenhagen, Copenhagen, Denmark.

المصدر: Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology [J Comp Physiol A Neuroethol Sens Neural Behav Physiol] 2022 Jul; Vol. 208 (4), pp. 493-504. Date of Electronic Publication: 2022 Jun 22.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 101141792 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1351 (Electronic) Linking ISSN: 03407594 NLM ISO Abbreviation: J Comp Physiol A Neuroethol Sens Neural Behav Physiol Subsets: MEDLINE

مواضيع طبية MeSH: Lipopolysaccharides*/pharmacology , Mole Rats*/physiology, Animals ; Body Weight ; Inflammation/chemically induced ; Locomotion

مستخلص: The naked mole rat has unique biologic characteristics that include atypical inflammatory responses. Lipopolysaccharide induces inflammation which triggers brain centers controlling feeding, and behavior to result in "sick animal behavior". We characterized the bodyweight, locomotor, and other behavioral responses of this rodent to lipopolysaccharide administration. Lipopolysaccharide caused weight losses, which were not prevented by TAK 242. In the open field test, lipopolysaccharide did not depress locomotion, while urination, defecation, and activity freezing were rare. The animals exhibited walling but not rearing and fast backward movements that were unaffected by lipopolysaccharide. Failure to depress locomotion suggests either a unique immunity-brain crosstalk or motor responses/centers that tolerate depressive effects of inflammation. The absence of activity freezing and rarity of urination and defecation suggests that novel environments or lipopolysaccharide do not induce anxiety, or that anxiety is expressed differently in the animal. The absence of rearing could be due to the design of the animal's locomotor apparatus while fast backward movement could be a mechanism for quick escape from threats in the tunnels of their habitat. Our results elucidate the unique biology of this rodent, which elicits interest in the animal as a model for inflammatory research, although the findings require mechanistic corroborations.
(© 2022. The Author(s).)

المؤلفون: Sizemore BA; Department of Psychology, Bowling Green State University, Bowling Green, OH, 43403, USA. brsizemo@iu.edu.; J. P. Scott Center for Neuroscience, Mind, and Behavior, Bowling Green State University, Bowling Green, OH, 43403, USA. brsizemo@iu.edu.; School of Social Sciences, Indiana University Southeast, 4201 Grant Line Road, New Albany, IN, 47150, USA. brsizemo@iu.edu., Bausher A; Northwestern University, Evanston, IL, USA., Paul E; The Ohio State University, Columbus, OH, USA., Russell M; Department of Psychology, Bowling Green State University, Bowling Green, OH, 43403, USA., Bingman VP; Department of Psychology, Bowling Green State University, Bowling Green, OH, 43403, USA.; J. P. Scott Center for Neuroscience, Mind, and Behavior, Bowling Green State University, Bowling Green, OH, 43403, USA.

المصدر: Learning & behavior [Learn Behav] 2022 Mar; Vol. 50 (1), pp. 99-112. Date of Electronic Publication: 2021 Dec 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 101155056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-4508 (Electronic) Linking ISSN: 15434494 NLM ISO Abbreviation: Learn Behav Subsets: MEDLINE

مواضيع طبية MeSH: Columbidae* , Hippocampus*/pathology, Animals ; Learning ; Reward ; Space Perception

مستخلص: David Sherry has been a pioneer in investigating the avian hippocampal formation (HF) and spatial memory. Following on his work and observations that HF is sensitive to the occurrence of reward (food), we were interested in carrying out an exploratory study to investigate possible HF involvement in the representation goal value and risk. Control sham-lesioned and hippocampal-lesioned pigeons were trained in an open field to locate one food bowl containing a constant two food pellets on all trials, and two variable bowls with one containing five pellets on 75% (High Variable) and another on 25% (Low Variable) of their respective trials (High-Variable and Low-Variable bowls were never presented together). One pairing of pigeons learned bowl locations (space); another bowl colors (feature). Trained to color, hippocampal-lesioned pigeons performed as rational agents in their bowl choices and were indistinguishable from the control pigeons, a result consistent with HF regarded as unimportant for non-spatial memory. By contrast, when trained to location, hippocampal-lesioned pigeons differed from the control pigeons. They made more first-choice errors to bowls that never contained food, consistent with a role of HF in spatial memory. Intriguingly, the hippocampal-lesioned pigeons also made fewer first choices to both variable bowls, suggesting that hippocampal lesions resulted in the pigeons becoming more risk averse. Acknowledging that the results are preliminary and further research is needed, the data nonetheless support the general hypothesis that HF-dependent memory representations of space capture properties of reward value and risk, properties that contribute to decision making when confronted with a choice.
(© 2021. The Psychonomic Society, Inc.)

المؤلفون: Grigoryan GA; Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia., Pavlova IV; Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia., Zaichenko MI; Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia.

المصدر: Neuroscience and behavioral physiology [Neurosci Behav Physiol] 2022; Vol. 52 (5), pp. 722-738. Date of Electronic Publication: 2022 Sep 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 0330471 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-899X (Electronic) Linking ISSN: 00970549 NLM ISO Abbreviation: Neurosci Behav Physiol Subsets: PubMed not MEDLINE

مستخلص: This review describes the role of social isolation in the development of anxiety and depression-like behavior in rodents. The duration of social isolation, age from onset of social isolation, sex, species, and strain of animals, the nature of the model used, and other factors have been shown to have influences. The molecular-cellular mechanisms of development of anxiety and depression-like behavior under the influence of social isolation and the roles of the HHAS, oxidative and nitrosative stress, neuroinflammation, BDNF, neurogenesis, synaptic plasticity, as well as monoamines in these mechanisms are discussed. This review presents data on sex differences in the effects of social isolation, along with the effects of interactions with other types of stress, and the roles of an enriched environment and other factors in ameliorating the negative sequelae of social isolation.
(© Springer Nature Switzerland AG 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)

المؤلفون: Akosman MS; Department of Anatomy, Faculty of Veterinary Medicine, Afyon Kocatepe University, 03200, Afyon, Turkey., Türkmen R; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Afyon Kocatepe University, 03200, Afyon, Turkey. ruhiturkmen@gmail.com., Demirel HH; Bayat Vocational School, Afyon Kocatepe University, 03200, Afyon, Turkey.

المصدر: Environmental science and pollution research international [Environ Sci Pollut Res Int] 2021 Dec; Vol. 28 (46), pp. 65872-65884. Date of Electronic Publication: 2021 Jul 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 9441769 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1614-7499 (Electronic) Linking ISSN: 09441344 NLM ISO Abbreviation: Environ Sci Pollut Res Int Subsets: MEDLINE

مواضيع طبية MeSH: Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/therapeutic use , Schizophrenia*/chemically induced , Schizophrenia*/drug therapy, Animals ; Disease Models, Animal ; Dizocilpine Maleate/pharmacology ; Mice ; Resveratrol

مستخلص: Increasing evidence supports the view that oxidative stress and brain demyelination play an important role in the pathogenesis of schizophrenia. Resveratrol is a powerful antioxidant with neuroprotective effects. This study aimed to assess the effect of resveratrol on schizophrenia-like behaviors and possible brain demyelination induced by MK-801, an N-methyl-D-aspartate glutamate receptor antagonist, and the underlying neuroprotective mechanism. Resveratrol (40 mg/kg/day/, intraperitoneal) was administered to mice for 14 days. MK-801 (1 mg/kg/day, intraperitoneal) was injected into the mice 4 h after the resveratrol administration for 14 days. The open-field and elevated-plus maze tests were performed to detect behavior changes on the 15th day. Following the behavioral tests, the expression of the myelin basic protein (MBP) was measured with the real-time PCR (RT-PCR) method, while total oxidant capacity (TOS) and total antioxidant capacity (TAS), which are the biomarkers of oxidative damage, were measured with the ELISA method. Hematoxylin-eosin staining was also used to identify stereological and pathological changes in the brain. According to the results obtained, this study showed for the first time that resveratrol prevented glial cell infiltration induced in the brain by MK-801 and shrinkage of nerve cell nuclei in the hippocampus and corpus callosum. However, the resveratrol administrations did not correct behavioral disorders and demyelination of schizophrenia. Although resveratrol partially prevented oxidative damage in the brain in the mice that were injected with MK-801, it was determined that this effect was not statistically significant. These results showed that resveratrol administration partially protects tissues against MK-801-induced neurodegeneration, and resveratrol may be used in combination with different antioxidants or at different doses in future studies.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)