المؤلفون: Alarcan H; Service de Biochimie et Biologie Moléculaire, CHRU Bretonneau, Tours, France.; UMR 1253 iBrain, Université de Tours, Inserm, Tours, France., Bruno C; Service de Pharmacologie Médicale, CHRU Bretonneau, Tours, France., Emond P; UMR 1253 iBrain, Université de Tours, Inserm, Tours, France.; Laboratoire de Médecine nucléaire in vitro, CHRU Bretonneau, Tours, France., Raoul C; INM, University of Montpellier, INSERM, Montpellier, France.; ALS Reference Center, University of Montpellier, CHU Montpellier, Montpellier, France., Vourc'h P; Service de Biochimie et Biologie Moléculaire, CHRU Bretonneau, Tours, France.; UMR 1253 iBrain, Université de Tours, Inserm, Tours, France., Corcia P; UMR 1253 iBrain, Université de Tours, Inserm, Tours, France.; Service de Neurologie, CHRU Bretonneau, Tours, France., Camu W; INM, University of Montpellier, INSERM, Montpellier, France.; ALS Reference Center, University of Montpellier, CHU Montpellier, Montpellier, France., Veyrune JL; Institute of Human Genetics, University of Montepllier, Montpellier, France., Garlanda C; Department of Biomedical Sciences, Humanitas University, Milan, Italy.; IRCCS Humanitas Research Hospital, Rozzano, Italy., Locati M; IRCCS Humanitas Research Hospital, Rozzano, Italy., Juntas-Morales R; Neuromuscular Diseases Unit, European Reference Network on Rare Neuromuscular Diseases (ERN EURO-NMD), Department of Neurology, Vall d'Hebron University Hospital, Barcelona, Spain., Saker S; Genethon, DNA and Cell bank, Evry, France., Suehs C; Laboratoire de Biostatistique, Epidémiologie clinique, Santé Publique, Innovation et Méthodologie (BESPIM), Université de Nîmes, Nîmes, France., Masseguin C; Delegation for Clinical Research and Innovation, Nîmes University Hospital, Nîmes, France., Kirby J; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK., Shaw P; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK., Malaspina A; UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, Queen Square, London, UK., De Vos J; Department of Cell and Tissue Engineering, University Montpellier, CHU Montpellier, Montpellier, France., Al-Chalabi A; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK., Leigh PN; Brighton and Sussex Medical School, Brighton, UK., Tree T; Department of Computer Science, University of Sheffield, Sheffield, UK., Bensimon G; Laboratoire de Biostatistique, Epidémiologie clinique, Santé Publique, Innovation et Méthodologie (BESPIM), Université de Nîmes, Nîmes, France., Blasco H; Service de Biochimie et Biologie Moléculaire, CHRU Bretonneau, Tours, France.; UMR 1253 iBrain, Université de Tours, Inserm, Tours, France.

المصدر: Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2024 Jun; Vol. 1536 (1), pp. 82-91. Date of Electronic Publication: 2024 May 21.

نوع المنشور: Journal Article; Clinical Trial, Phase II; Randomized Controlled Trial

بيانات الدورية: Publisher: New York Academy of Sciences Country of Publication: United States NLM ID: 7506858 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1749-6632 (Electronic) Linking ISSN: 00778923 NLM ISO Abbreviation: Ann N Y Acad Sci Subsets: MEDLINE

مواضيع طبية MeSH: Amyotrophic Lateral Sclerosis*/drug therapy , Amyotrophic Lateral Sclerosis*/metabolism , Interleukin-2*/administration & dosage , Interleukin-2*/metabolism , Metabolomics*/methods , T-Lymphocytes, Regulatory*/metabolism , T-Lymphocytes, Regulatory*/drug effects , T-Lymphocytes, Regulatory*/immunology, Humans ; Male ; Middle Aged ; Female ; Kynurenine/metabolism ; Aged ; Metabolome/drug effects

المؤلفون: Lim TY; Institute of Liver Studies, King's College Hospital, Medical Research Council (MRC) Centre for Transplantation, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK., Perpiñán E; Institute of Liver Studies, King's College Hospital, Medical Research Council (MRC) Centre for Transplantation, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK., Londoño MC; Institute of Liver Studies, King's College Hospital, Medical Research Council (MRC) Centre for Transplantation, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK; Liver Unit, Hospital Clínic Barcelona, IDIBAPS, CIBERehd, Barcelona, Spain., Miquel R; Institute of Liver Studies, King's College Hospital, Medical Research Council (MRC) Centre for Transplantation, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK; Liver Histopathology Laboratory, King's College Hospital, London, UK., Ruiz P; Institute of Liver Studies, King's College Hospital, Medical Research Council (MRC) Centre for Transplantation, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK., Kurt AS; Institute of Liver Studies, King's College Hospital, Medical Research Council (MRC) Centre for Transplantation, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK., Kodela E; Institute of Liver Studies, King's College Hospital, Medical Research Council (MRC) Centre for Transplantation, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK., Cross AR; Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK., Berlin C; Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK., Hester J; Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK., Issa F; Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK., Douiri A; School of Population Health and Environmental Sciences, King's College London, London, UK., Volmer FH; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany., Taubert R; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany., Williams E; Department of Immunobiology, School of Immunology & Microbial Sciences (SIMS), King's College London, London, UK., Demetris AJ; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA., Lesniak A; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA., Bensimon G; Département de Pharmacologie Clinique, Hôpital de la Pitié-Salpêtrière et UPMC Pharmacologie, Paris-Sorbonne Université, Paris, France; Laboratoire de Biostatistique, Epidémiologie Clinique, Santé Publique Innovation et Méthodologie (BESPIM), CHU-Nîmes, Nîmes, France., Lozano JJ; Bioinformatic Platform, Biomedical Research Center in Hepatic and Digestive Diseases (CIBEREHD), Carlos III Health Institute, Barcelona, Spain., Martinez-Llordella M; Institute of Liver Studies, King's College Hospital, Medical Research Council (MRC) Centre for Transplantation, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK., Tree T; Department of Immunobiology, School of Immunology & Microbial Sciences (SIMS), King's College London, London, UK., Sánchez-Fueyo A; Institute of Liver Studies, King's College Hospital, Medical Research Council (MRC) Centre for Transplantation, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK. Electronic address: sanchez_fueyo@kcl.ac.uk.

المصدر: Journal of hepatology [J Hepatol] 2023 Jan; Vol. 78 (1), pp. 153-164. Date of Electronic Publication: 2022 Sep 07.

نوع المنشور: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0641 (Electronic) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: MEDLINE

مواضيع طبية MeSH: T-Lymphocytes, Regulatory* , Transplantation Tolerance*, Humans ; Graft Rejection/prevention & control ; Interleukin-2/pharmacology ; Liver ; Tacrolimus/pharmacology

المؤلفون: van Rheenen W; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. w.vanrheenen-2@umcutrecht.nl., van der Spek RAA; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Bakker MK; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., van Vugt JJFA; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Hop PJ; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Zwamborn RAJ; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., de Klein N; Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands., Westra HJ; Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands., Bakker OB; Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands., Deelen P; Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.; Department of Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Shireby G; University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter, UK., Hannon E; University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter, UK., Moisse M; Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven-University of Leuven, Leuven, Belgium.; Laboratory of Neurobiology, VIB, Center for Brain & Disease Research, Leuven, Belgium.; Department of Neurology, University Hospitals Leuven, Leuven, Belgium., Baird D; Translational Biology, Biogen, Boston, MA, USA.; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, University of Bristol, Bristol, UK., Restuadi R; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Dolzhenko E; Illumina, San Diego, CA, USA., Dekker AM; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Gawor K; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Westeneng HJ; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Tazelaar GHP; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., van Eijk KR; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Kooyman M; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Byrne RP; Complex Trait Genomics Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., Doherty M; Complex Trait Genomics Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., Heverin M; Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Al Khleifat A; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Iacoangeli A; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; National Institute for Health Research Biomedical Research Centre and Dementia Unit, South London and Maudsley NHS Foundation Trust and King's College London, London, UK., Shatunov A; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Ticozzi N; Department of Neurology, Stroke Unit and Laboratory of Neuroscience, Istituto Auxologico Italiano IRCCS, Milan, Italy.; Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center, Università degli Studi di Milano, Milan, Italy., Cooper-Knock J; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK., Smith BN; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Gromicho M; Instituto de Fisiologia, Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Chandran S; Euan MacDonald Centre for Motor Neurone Disease Research, Edinburgh, UK.; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK., Pal S; Euan MacDonald Centre for Motor Neurone Disease Research, Edinburgh, UK.; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK., Morrison KE; School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK., Shaw PJ; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK., Hardy J; Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK., Orrell RW; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK., Sendtner M; Institute of Clinical Neurobiology, University Hospital Würzburg, Würzburg, Germany., Meyer T; Charité University Hospital, Humboldt University, Berlin, Germany., Başak N; Koç University, School of Medicine, KUTTAM-NDAL, Istanbul, Turkey., van der Kooi AJ; Department of Neurology, Academic Medical Center, Amsterdam, the Netherlands., Ratti A; Department of Neurology, Stroke Unit and Laboratory of Neuroscience, Istituto Auxologico Italiano IRCCS, Milan, Italy.; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milan, Italy., Fogh I; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Gellera C; Unit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Milan, Italy., Lauria G; 3rd Neurology Unit, Motor Neuron Diseases Center, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', MIlan, Italy.; Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy., Corti S; Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center, Università degli Studi di Milano, Milan, Italy.; Neurology Unit, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Cereda C; Genomic and Post-Genomic Center, IRCCS Mondino Foundation, Pavia, Italy., Sproviero D; Genomic and Post-Genomic Center, IRCCS Mondino Foundation, Pavia, Italy., D'Alfonso S; Department of Health Sciences, University of Eastern Piedmont, Novara, Italy., Sorarù G; Department of Neurosciences, University of Padova, Padova, Italy., Siciliano G; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Filosto M; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Padovani A; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Chiò A; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy.; Neurologia 1, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy., Calvo A; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy.; Neurologia 1, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy., Moglia C; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy.; Neurologia 1, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy., Brunetti M; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy., Canosa A; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy.; Neurologia 1, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy., Grassano M; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy., Beghi E; Laboratory of Neurological Diseases, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Pupillo E; Laboratory of Neurological Diseases, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Logroscino G; Department of Clinical Research in Neurology, University of Bari at 'Pia Fondazione Card G. Panico' Hospital, Bari, Italy., Nefussy B; Neuromuscular Diseases Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Osmanovic A; Department of Neurology, Hannover Medical School, Hannover, Germany.; Essener Zentrum für Seltene Erkrankungen (EZSE), University Hospital Essen, Essen, Germany., Nordin A; Department of Clinical Sciences, Neurosciences, Umeå University, Umeå, Sweden., Lerner Y; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.; Department of Neurology, the Agnes Ginges Center for Human Neurogenetics, Hadassah Medical Center, Jerusalem, Israel., Zabari M; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.; Department of Neurology, the Agnes Ginges Center for Human Neurogenetics, Hadassah Medical Center, Jerusalem, Israel., Gotkine M; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.; Department of Neurology, the Agnes Ginges Center for Human Neurogenetics, Hadassah Medical Center, Jerusalem, Israel., Baloh RH; Center for Neural Science and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Neurology, Neuromuscular Division, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Bell S; Center for Neural Science and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Neurology, Neuromuscular Division, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Vourc'h P; Service de Biochimie et Biologie Moléculaire, CHU de Tours, Tours, France.; UMR 1253, Université de Tours, Inserm, Tours, France., Corcia P; UMR 1253, Université de Tours, Inserm, Tours, France.; Centre de référence sur la SLA, CHU de Tours, Tours, France., Couratier P; Centre de référence sur la SLA, CHRU de Limoges, Limoges, France.; UMR 1094, Université de Limoges, Inserm, Limoges, France., Millecamps S; ICM, Institut du Cerveau, Inserm, CNRS, Sorbonne Université, Hôpital Pitié-Salpêtrière, Paris, France., Meininger V; Hôpital des Peupliers, Ramsay Générale de Santé, Paris, France., Salachas F; ICM, Institut du Cerveau, Inserm, CNRS, Sorbonne Université, Hôpital Pitié-Salpêtrière, Paris, France.; Département de Neurologie, Centre de référence SLA Ile de France, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France., Mora Pardina JS; ALS Unit, Hospital San Rafael, Madrid, Spain., Assialioui A; Functional Unit of Amyotrophic Lateral Sclerosis (UFELA), Service of Neurology, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain., Rojas-García R; MND Clinic, Neurology Department, Hospital de la Santa Creu i Sant Pau de Barcelona, Universitat Autonoma de Barcelona, Barcelona, Spain., Dion PA; Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada., Ross JP; Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada., Ludolph AC; Department of Neurology, Ulm University, Ulm, Germany., Weishaupt JH; Division of Neurodegeneration, Department of Neurology, University Medicine Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Brenner D; Division of Neurodegeneration, Department of Neurology, University Medicine Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Freischmidt A; Department of Neurology, Ulm University, Ulm, Germany.; German Center for Neurodegenerative Diseases (DZNE) Ulm, Ulm, Germany., Bensimon G; Département de Pharmacologie Clinique, Hôpital de la Pitié-Salpêtrière, UPMC Pharmacologie, AP-HP, Paris, France.; Pharmacologie Sorbonne Université, Paris, France.; Institut du Cerveau, Paris Brain Institute ICM, Paris, France.; Laboratoire de Biostatistique, Epidémiologie Clinique, Santé Publique Innovation et Méthodologie (BESPIM), CHU-Nîmes, Nîmes, France., Brice A; Sorbonne Université, Paris Brain Institute, APHP, INSERM, CNRS, Hôpital de la Pitié Salpêtrière, Paris, France., Durr A; Sorbonne Université, Paris Brain Institute, APHP, INSERM, CNRS, Hôpital de la Pitié Salpêtrière, Paris, France., Payan CAM; Département de Pharmacologie Clinique, Hôpital de la Pitié-Salpêtrière, UPMC Pharmacologie, AP-HP, Paris, France., Saker-Delye S; Genethon, CNRS UMR, Evry, France., Wood NW; Department of Clinical and Movement Neuroscience, UCL Institute of Neurology, Queen Square, London, UK., Topp S; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Rademakers R; Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA., Tittmann L; Popgen Biobank and Institute of Epidemiology, Christian Albrechts-University Kiel, Kiel, Germany., Lieb W; Popgen Biobank and Institute of Epidemiology, Christian Albrechts-University Kiel, Kiel, Germany., Franke A; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany., Ripke S; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany., Braun A; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany., Kraft J; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany., Whiteman DC; Cancer Control Group, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Olsen CM; Cancer Control Group, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Uitterlinden AG; Department of Internal Medicine, Genetics Laboratory, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Epidemiology, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands., Hofman A; Department of Epidemiology, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands., Rietschel M; Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.; Central Institute of Mental Health, Mannheim, Germany., Cichon S; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life and Brain Center, Bonn, Germany.; Division of Medical Genetics, University Hospital Basel and Department of Biomedicine, University of Basel, Basel, Switzerland.; Institute of Neuroscience and Medicine INM-1, Research Center Juelich, Juelich, Germany., Nöthen MM; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life and Brain Center, Bonn, Germany., Amouyel P; INSERM UMR1167-RID-AGE LabEx DISTALZ-Risk Factors and Molecular Determinants of Aging-Related Diseases, University of Lille, Centre Hospitalier of the University of Lille, Institut Pasteur de Lille, Lille, France., Traynor BJ; Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, Porter Neuroscience Research Center, Bethesda, MD, USA.; Department of Neurology, Johns Hopkins University, Baltimore, MD, USA., Singleton AB; Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, Porter Neuroscience Research Center, Bethesda, MD, USA., Mitne Neto M; Universidade de São Paulo, São Paulo, Brazil., Cauchi RJ; Centre for Molecular Medicine and Biobanking and Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta., Ophoff RA; University Medical Center Utrecht, Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, Utrecht, the Netherlands.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA., Wiedau-Pazos M; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Lomen-Hoerth C; Department of Neurology, University of California, San Francisco, CA, USA., van Deerlin VM; Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Grosskreutz J; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany.; Precision Neurology Unit, Department of Neurology, University Hospital Schleswig-Holstein, University of Luebeck, Luebeck, Germany., Roediger A; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Gaur N; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Jörk A; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Barthel T; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Theele E; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Ilse B; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Stubendorff B; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Witte OW; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Steinbach R; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Hübner CA; Institute of Human Genetics, Jena University Hospital, Jena, Germany., Graff C; Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden., Brylev L; Department of Neurology, Bujanov Moscow Clinical Hospital, Moscow, Russia.; Moscow Research and Clinical Center for Neuropsychiatry of the Healthcare Department, Moscow, Russia.; Department of Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology Russian Academy of Sciences, Moscow, Russia., Fominykh V; Department of Neurology, Bujanov Moscow Clinical Hospital, Moscow, Russia.; Department of Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology Russian Academy of Sciences, Moscow, Russia., Demeshonok V; ALS-Care Center, 'GAOORDI', Medical Clinic of the St. Petersburg, St. Petersburg, Russia., Ataulina A; Department of Neurology, Bujanov Moscow Clinical Hospital, Moscow, Russia., Rogelj B; Department of Biotechnology, Jožef Stefan Institute, Ljubljana, Slovenia.; Biomedical Research Institute BRIS, Ljubljana, Slovenia.; Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, Slovenia., Koritnik B; Ljubljana ALS Centre, Institute of Clinical Neurophysiology, University Medical Centre Ljubljana, Ljubljana, Slovenia., Zidar J; Ljubljana ALS Centre, Institute of Clinical Neurophysiology, University Medical Centre Ljubljana, Ljubljana, Slovenia., Ravnik-Glavač M; Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia., Glavač D; Department of Molecular Genetics, Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia., Stević Z; Clinic of Neurology, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia., Drory V; Neuromuscular Diseases Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Povedano M; Functional Unit of Amyotrophic Lateral Sclerosis (UFELA), Service of Neurology, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain., Blair IP; Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia., Kiernan MC; Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia., Benyamin B; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.; Australian Centre for Precision Health and Allied Health and Human Performance, University of South Australia, Adelaide, South Australia, Australia., Henderson RD; Centre for Clinical Research, Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Queensland, Australia.; Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia., Furlong S; Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia., Mathers S; Calvary Health Care Bethlehem, Parkdale, Victoria, Australia., McCombe PA; Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia., Needham M; Fiona Stanley Hospital, Perth, Western Australia, Australia.; Notre Dame University, Fremantle, Western Australia, Australia.; Centre for Molecular Medicine and Innovative Therapeutics, Health Futures Institute, Murdoch University, Perth, Western Australia, Australia., Ngo ST; Centre for Clinical Research, Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Queensland, Australia.; Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia., Nicholson GA; Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia.; Northcott Neuroscience Laboratory, ANZAC Research Institute, Concord, New South Wales, Australia.; Molecular Medicine Laboratory, Concord Repatriation General Hospital, Concord, New South Wales, Australia., Pamphlett R; Discipline of Pathology and Department of Neuropathology, Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia., Rowe DB; Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia., Steyn FJ; Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.; The School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia., Williams KL; Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia., Mather KA; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.; Neuroscience Research Australia Institute, Randwick, New South Wales, Australia., Sachdev PS; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.; Neuropsychiatric Institute, the Prince of Wales Hospital, UNSW, Randwick, New South Wales, Australia., Henders AK; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Wallace L; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., de Carvalho M; Instituto de Fisiologia, Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Pinto S; Instituto de Fisiologia, Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Petri S; Department of Neurology, Hannover Medical School, Hannover, Germany., Weber M; Neuromuscular Diseases Unit/ALS Clinic, Kantonsspital St. Gallen, St. Gallen, Switzerland., Rouleau GA; Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada., Silani V; Department of Neurology, Stroke Unit and Laboratory of Neuroscience, Istituto Auxologico Italiano IRCCS, Milan, Italy.; Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center, Università degli Studi di Milano, Milan, Italy., Curtis CJ; Social Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.; NIHR BioResource Centre Maudsley, NIHR Maudsley Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation Trust (SLaM) & Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK., Breen G; Social Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.; NIHR BioResource Centre Maudsley, NIHR Maudsley Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation Trust (SLaM) & Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK., Glass JD; Department Neurology, Emory University School of Medicine, Atlanta, GA, USA., Brown RH Jr; Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA., Landers JE; Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA., Shaw CE; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Andersen PM; Department of Clinical Sciences, Neurosciences, Umeå University, Umeå, Sweden., Groen EJN; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., van Es MA; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Pasterkamp RJ; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Fan D; Department of Neurology, Third Hospital, Peking University, Beijing, China., Garton FC; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., McRae AF; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Davey Smith G; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, University of Bristol, Bristol, UK.; Population Health Science, Bristol Medical School, Bristol, UK., Gaunt TR; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, University of Bristol, Bristol, UK.; Population Health Science, Bristol Medical School, Bristol, UK., Eberle MA; Illumina, San Diego, CA, USA., Mill J; University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter, UK., McLaughlin RL; Complex Trait Genomics Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., Hardiman O; Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Kenna KP; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Wray NR; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia., Tsai E; Translational Biology, Biogen, Boston, MA, USA., Runz H; Translational Biology, Biogen, Boston, MA, USA., Franke L; Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands., Al-Chalabi A; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; King's College Hospital, London, UK., Van Damme P; Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven-University of Leuven, Leuven, Belgium.; Laboratory of Neurobiology, VIB, Center for Brain & Disease Research, Leuven, Belgium.; Department of Neurology, University Hospitals Leuven, Leuven, Belgium., van den Berg LH; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Veldink JH; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. j.h.veldink@umcutrecht.nl.

مؤلفون مشاركون: SLALOM Consortium, PARALS Consortium, SLAGEN Consortium, SLAP Consortium

المصدر: Nature genetics [Nat Genet] 2022 Mar; Vol. 54 (3), pp. 361.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: van Rheenen W; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. w.vanrheenen-2@umcutrecht.nl., van der Spek RAA; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Bakker MK; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., van Vugt JJFA; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Hop PJ; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Zwamborn RAJ; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., de Klein N; Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands., Westra HJ; Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands., Bakker OB; Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands., Deelen P; Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.; Department of Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Shireby G; University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter, UK., Hannon E; University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter, UK., Moisse M; Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven-University of Leuven, Leuven, Belgium.; Laboratory of Neurobiology, VIB, Center for Brain & Disease Research, Leuven, Belgium.; Department of Neurology, University Hospitals Leuven, Leuven, Belgium., Baird D; Translational Biology, Biogen, Boston, MA, USA.; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, University of Bristol, Bristol, UK., Restuadi R; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Dolzhenko E; Illumina, San Diego, CA, USA., Dekker AM; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Gawor K; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Westeneng HJ; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Tazelaar GHP; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., van Eijk KR; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Kooyman M; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Byrne RP; Complex Trait Genomics Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., Doherty M; Complex Trait Genomics Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., Heverin M; Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Al Khleifat A; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Iacoangeli A; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; National Institute for Health Research Biomedical Research Centre and Dementia Unit, South London and Maudsley NHS Foundation Trust and King's College London, London, UK., Shatunov A; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Ticozzi N; Department of Neurology, Stroke Unit and Laboratory of Neuroscience, Istituto Auxologico Italiano IRCCS, Milan, Italy.; Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center, Università degli Studi di Milano, Milan, Italy., Cooper-Knock J; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK., Smith BN; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Gromicho M; Instituto de Fisiologia, Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Chandran S; Euan MacDonald Centre for Motor Neurone Disease Research, Edinburgh, UK.; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK., Pal S; Euan MacDonald Centre for Motor Neurone Disease Research, Edinburgh, UK.; UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK., Morrison KE; School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK., Shaw PJ; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK., Hardy J; Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK., Orrell RW; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK., Sendtner M; Institute of Clinical Neurobiology, University Hospital Würzburg, Würzburg, Germany., Meyer T; Charité University Hospital, Humboldt University, Berlin, Germany., Başak N; Koç University, School of Medicine, KUTTAM-NDAL, Istanbul, Turkey., van der Kooi AJ; Department of Neurology, Academic Medical Center, Amsterdam, the Netherlands., Ratti A; Department of Neurology, Stroke Unit and Laboratory of Neuroscience, Istituto Auxologico Italiano IRCCS, Milan, Italy.; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milan, Italy., Fogh I; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Gellera C; Unit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Milan, Italy., Lauria G; 3rd Neurology Unit, Motor Neuron Diseases Center, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', MIlan, Italy.; Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy., Corti S; Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center, Università degli Studi di Milano, Milan, Italy.; Neurology Unit, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Cereda C; Genomic and Post-Genomic Center, IRCCS Mondino Foundation, Pavia, Italy., Sproviero D; Genomic and Post-Genomic Center, IRCCS Mondino Foundation, Pavia, Italy., D'Alfonso S; Department of Health Sciences, University of Eastern Piedmont, Novara, Italy., Sorarù G; Department of Neurosciences, University of Padova, Padova, Italy., Siciliano G; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Filosto M; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Padovani A; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Chiò A; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy.; Neurologia 1, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy., Calvo A; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy.; Neurologia 1, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy., Moglia C; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy.; Neurologia 1, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy., Brunetti M; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy., Canosa A; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy.; Neurologia 1, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, Turin, Italy., Grassano M; 'Rita Levi Montalcini' Department of Neuroscience, ALS Centre, University of Torino, Turin, Italy., Beghi E; Laboratory of Neurological Diseases, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Pupillo E; Laboratory of Neurological Diseases, Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Logroscino G; Department of Clinical Research in Neurology, University of Bari at 'Pia Fondazione Card G. Panico' Hospital, Bari, Italy., Nefussy B; Neuromuscular Diseases Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Osmanovic A; Department of Neurology, Hannover Medical School, Hannover, Germany.; Essener Zentrum für Seltene Erkrankungen (EZSE), University Hospital Essen, Essen, Germany., Nordin A; Department of Clinical Sciences, Neurosciences, Umeå University, Umeå, Sweden., Lerner Y; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.; Department of Neurology, the Agnes Ginges Center for Human Neurogenetics, Hadassah Medical Center, Jerusalem, Israel., Zabari M; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.; Department of Neurology, the Agnes Ginges Center for Human Neurogenetics, Hadassah Medical Center, Jerusalem, Israel., Gotkine M; Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.; Department of Neurology, the Agnes Ginges Center for Human Neurogenetics, Hadassah Medical Center, Jerusalem, Israel., Baloh RH; Center for Neural Science and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Neurology, Neuromuscular Division, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Bell S; Center for Neural Science and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Neurology, Neuromuscular Division, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Vourc'h P; Service de Biochimie et Biologie Moléculaire, CHU de Tours, Tours, France.; UMR 1253, Université de Tours, Inserm, Tours, France., Corcia P; UMR 1253, Université de Tours, Inserm, Tours, France.; Centre de référence sur la SLA, CHU de Tours, Tours, France., Couratier P; Centre de référence sur la SLA, CHRU de Limoges, Limoges, France.; UMR 1094, Université de Limoges, Inserm, Limoges, France., Millecamps S; ICM, Institut du Cerveau, Inserm, CNRS, Sorbonne Université, Hôpital Pitié-Salpêtrière, Paris, France., Meininger V; Hôpital des Peupliers, Ramsay Générale de Santé, Paris, France., Salachas F; ICM, Institut du Cerveau, Inserm, CNRS, Sorbonne Université, Hôpital Pitié-Salpêtrière, Paris, France.; Département de Neurologie, Centre de référence SLA Ile de France, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France., Mora Pardina JS; ALS Unit, Hospital San Rafael, Madrid, Spain., Assialioui A; Functional Unit of Amyotrophic Lateral Sclerosis (UFELA), Service of Neurology, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain., Rojas-García R; MND Clinic, Neurology Department, Hospital de la Santa Creu i Sant Pau de Barcelona, Universitat Autonoma de Barcelona, Barcelona, Spain., Dion PA; Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada., Ross JP; Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada., Ludolph AC; Department of Neurology, Ulm University, Ulm, Germany., Weishaupt JH; Division of Neurodegeneration, Department of Neurology, University Medicine Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Brenner D; Division of Neurodegeneration, Department of Neurology, University Medicine Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Freischmidt A; Department of Neurology, Ulm University, Ulm, Germany.; German Center for Neurodegenerative Diseases (DZNE) Ulm, Ulm, Germany., Bensimon G; Département de Pharmacologie Clinique, Hôpital de la Pitié-Salpêtrière, UPMC Pharmacologie, AP-HP, Paris, France.; Pharmacologie Sorbonne Université, Paris, France.; Institut du Cerveau, Paris Brain Institute ICM, Paris, France.; Laboratoire de Biostatistique, Epidémiologie Clinique, Santé Publique Innovation et Méthodologie (BESPIM), CHU-Nîmes, Nîmes, France., Brice A; Sorbonne Université, Paris Brain Institute, APHP, INSERM, CNRS, Hôpital de la Pitié Salpêtrière, Paris, France., Durr A; Sorbonne Université, Paris Brain Institute, APHP, INSERM, CNRS, Hôpital de la Pitié Salpêtrière, Paris, France., Payan CAM; Département de Pharmacologie Clinique, Hôpital de la Pitié-Salpêtrière, UPMC Pharmacologie, AP-HP, Paris, France., Saker-Delye S; Genethon, CNRS UMR, Evry, France., Wood NW; Department of Clinical and Movement Neuroscience, UCL Institute of Neurology, Queen Square, London, UK., Topp S; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Rademakers R; Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA., Tittmann L; Popgen Biobank and Institute of Epidemiology, Christian Albrechts-University Kiel, Kiel, Germany., Lieb W; Popgen Biobank and Institute of Epidemiology, Christian Albrechts-University Kiel, Kiel, Germany., Franke A; Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany., Ripke S; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany., Braun A; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany., Kraft J; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany., Whiteman DC; Cancer Control Group, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Olsen CM; Cancer Control Group, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Uitterlinden AG; Department of Internal Medicine, Genetics Laboratory, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Epidemiology, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands., Hofman A; Department of Epidemiology, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands., Rietschel M; Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.; Central Institute of Mental Health, Mannheim, Germany., Cichon S; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life and Brain Center, Bonn, Germany.; Division of Medical Genetics, University Hospital Basel and Department of Biomedicine, University of Basel, Basel, Switzerland.; Institute of Neuroscience and Medicine INM-1, Research Center Juelich, Juelich, Germany., Nöthen MM; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Department of Genomics, Life and Brain Center, Bonn, Germany., Amouyel P; INSERM UMR1167-RID-AGE LabEx DISTALZ-Risk Factors and Molecular Determinants of Aging-Related Diseases, University of Lille, Centre Hospitalier of the University of Lille, Institut Pasteur de Lille, Lille, France., Traynor BJ; Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, Porter Neuroscience Research Center, Bethesda, MD, USA.; Department of Neurology, Johns Hopkins University, Baltimore, MD, USA., Singleton AB; Molecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, Porter Neuroscience Research Center, Bethesda, MD, USA., Mitne Neto M; Universidade de São Paulo, São Paulo, Brazil., Cauchi RJ; Centre for Molecular Medicine and Biobanking and Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta., Ophoff RA; University Medical Center Utrecht, Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, Utrecht, the Netherlands.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA., Wiedau-Pazos M; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Lomen-Hoerth C; Department of Neurology, University of California, San Francisco, CA, USA., van Deerlin VM; Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Grosskreutz J; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany.; Precision Neurology Unit, Department of Neurology, University Hospital Schleswig-Holstein, University of Luebeck, Luebeck, Germany., Roediger A; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Gaur N; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Jörk A; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Barthel T; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Theele E; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Ilse B; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Stubendorff B; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Witte OW; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Steinbach R; Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany., Hübner CA; Institute of Human Genetics, Jena University Hospital, Jena, Germany., Graff C; Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden., Brylev L; Department of Neurology, Bujanov Moscow Clinical Hospital, Moscow, Russia.; Moscow Research and Clinical Center for Neuropsychiatry of the Healthcare Department, Moscow, Russia.; Department of Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology Russian Academy of Sciences, Moscow, Russia., Fominykh V; Department of Neurology, Bujanov Moscow Clinical Hospital, Moscow, Russia.; Department of Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology Russian Academy of Sciences, Moscow, Russia., Demeshonok V; ALS-Care Center, 'GAOORDI', Medical Clinic of the St. Petersburg, St. Petersburg, Russia., Ataulina A; Department of Neurology, Bujanov Moscow Clinical Hospital, Moscow, Russia., Rogelj B; Department of Biotechnology, Jožef Stefan Institute, Ljubljana, Slovenia.; Biomedical Research Institute BRIS, Ljubljana, Slovenia.; Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, Slovenia., Koritnik B; Ljubljana ALS Centre, Institute of Clinical Neurophysiology, University Medical Centre Ljubljana, Ljubljana, Slovenia., Zidar J; Ljubljana ALS Centre, Institute of Clinical Neurophysiology, University Medical Centre Ljubljana, Ljubljana, Slovenia., Ravnik-Glavač M; Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia., Glavač D; Department of Molecular Genetics, Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia., Stević Z; Clinic of Neurology, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia., Drory V; Neuromuscular Diseases Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Povedano M; Functional Unit of Amyotrophic Lateral Sclerosis (UFELA), Service of Neurology, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain., Blair IP; Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia., Kiernan MC; Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia., Benyamin B; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.; Australian Centre for Precision Health and Allied Health and Human Performance, University of South Australia, Adelaide, South Australia, Australia., Henderson RD; Centre for Clinical Research, Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Queensland, Australia.; Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia., Furlong S; Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia., Mathers S; Calvary Health Care Bethlehem, Parkdale, Victoria, Australia., McCombe PA; Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia., Needham M; Fiona Stanley Hospital, Perth, Western Australia, Australia.; Notre Dame University, Fremantle, Western Australia, Australia.; Centre for Molecular Medicine and Innovative Therapeutics, Health Futures Institute, Murdoch University, Perth, Western Australia, Australia., Ngo ST; Centre for Clinical Research, Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Queensland, Australia.; Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia., Nicholson GA; Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia.; Northcott Neuroscience Laboratory, ANZAC Research Institute, Concord, New South Wales, Australia.; Molecular Medicine Laboratory, Concord Repatriation General Hospital, Concord, New South Wales, Australia., Pamphlett R; Discipline of Pathology and Department of Neuropathology, Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia., Rowe DB; Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia., Steyn FJ; Department of Neurology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.; The School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia., Williams KL; Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales, Australia., Mather KA; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.; Neuroscience Research Australia Institute, Randwick, New South Wales, Australia., Sachdev PS; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.; Neuropsychiatric Institute, the Prince of Wales Hospital, UNSW, Randwick, New South Wales, Australia., Henders AK; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Wallace L; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., de Carvalho M; Instituto de Fisiologia, Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Pinto S; Instituto de Fisiologia, Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Petri S; Department of Neurology, Hannover Medical School, Hannover, Germany., Weber M; Neuromuscular Diseases Unit/ALS Clinic, Kantonsspital St. Gallen, St. Gallen, Switzerland., Rouleau GA; Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada., Silani V; Department of Neurology, Stroke Unit and Laboratory of Neuroscience, Istituto Auxologico Italiano IRCCS, Milan, Italy.; Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center, Università degli Studi di Milano, Milan, Italy., Curtis CJ; Social Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.; NIHR BioResource Centre Maudsley, NIHR Maudsley Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation Trust (SLaM) & Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK., Breen G; Social Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.; NIHR BioResource Centre Maudsley, NIHR Maudsley Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation Trust (SLaM) & Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK., Glass JD; Department Neurology, Emory University School of Medicine, Atlanta, GA, USA., Brown RH Jr; Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA., Landers JE; Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA., Shaw CE; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Andersen PM; Department of Clinical Sciences, Neurosciences, Umeå University, Umeå, Sweden., Groen EJN; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., van Es MA; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Pasterkamp RJ; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Fan D; Department of Neurology, Third Hospital, Peking University, Beijing, China., Garton FC; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., McRae AF; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Davey Smith G; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, University of Bristol, Bristol, UK.; Population Health Science, Bristol Medical School, Bristol, UK., Gaunt TR; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, University of Bristol, Bristol, UK.; Population Health Science, Bristol Medical School, Bristol, UK., Eberle MA; Illumina, San Diego, CA, USA., Mill J; University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter, UK., McLaughlin RL; Complex Trait Genomics Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., Hardiman O; Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Kenna KP; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Wray NR; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia., Tsai E; Translational Biology, Biogen, Boston, MA, USA., Runz H; Translational Biology, Biogen, Boston, MA, USA., Franke L; Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands., Al-Chalabi A; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.; King's College Hospital, London, UK., Van Damme P; Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven-University of Leuven, Leuven, Belgium.; Laboratory of Neurobiology, VIB, Center for Brain & Disease Research, Leuven, Belgium.; Department of Neurology, University Hospitals Leuven, Leuven, Belgium., van den Berg LH; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Veldink JH; Department of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. j.h.veldink@umcutrecht.nl.

مؤلفون مشاركون: SLALOM Consortium, PARALS Consortium, SLAGEN Consortium, SLAP Consortium

المصدر: Nature genetics [Nat Genet] 2021 Dec; Vol. 53 (12), pp. 1636-1648. Date of Electronic Publication: 2021 Dec 06.

نوع المنشور: Journal Article; Meta-Analysis

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE

مواضيع طبية MeSH: Genome-Wide Association Study* , Mutation*, Amyotrophic Lateral Sclerosis/*genetics , Neurons/*metabolism, Amyotrophic Lateral Sclerosis/metabolism ; Brain/metabolism ; Cholesterol/blood ; Disease Progression ; Female ; Glutamine/metabolism ; Humans ; Male ; Mendelian Randomization Analysis ; Microsatellite Repeats ; Neurodegenerative Diseases/genetics ; Quantitative Trait Loci ; RNA-Seq ; Risk Factors

المؤلفون: Giovannelli I; Department of Neuroscience, Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK., Bayatti N; Department of Neuroscience, Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK., Brown A; Department of Neuroscience, Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK., Wang D; Department of Neuroscience, Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.; Department of Neuroscience, Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK., Mickunas M; Department of Computer Science, University of Sheffield, Sheffield S1 4DP, UK., Camu W; Department of Immunobiology, Faculty of Life Science and Medicine, King's College London, London SE1 9RT, UK., Veyrune JL; Clinique du Motoneurone, CHU Gui de Chaliac, University of Montpellier, Montpellier 34295, France., Payan C; Department of Cell and Tissue Engineering, University of Montpellier, CHU Montpellier, Montpellier 34000, France.; Department of Biostatistics, Clinical Epidemiology, Public Health and Innovation in Methodology (BESPIM), Nîmes University Hospital, Nîmes 30029, France., Garlanda C; Department of Pharmacology, AP-HP Sorbonne University, Pitié-Salpêtrière Hospital, F-75013 Paris, 75013 France.; Humanitas Clinical & Research Center-IRCCS, Milan 20089, Italy., Locati M; Humanitas University, Pieve Emanuele, Milan 20090, Italy.; Department of Medical Biotechnologies and Translational Medicine, University Milan, Milan 20133, Italy., Juntas-Morales R; Department of Immunobiology, Faculty of Life Science and Medicine, King's College London, London SE1 9RT, UK., Pageot N; Department of Immunobiology, Faculty of Life Science and Medicine, King's College London, London SE1 9RT, UK., Malaspina A; Department of Neuroimmunology, Barts and the London School of Medicine and Dentistry, Neuroscience and Trauma Centre, Institute of Cell and Molecular Medicine, London E1 2AT, UK., Andreasson U; Department of Psychiatry & Neurochemistry, University of Gothenburg, Mölndal 41345, Sweden., Suehs C; Department of Biostatistics, Clinical Epidemiology, Public Health and Innovation in Methodology (BESPIM), Nîmes University Hospital, Nîmes 30029, France.; Department of Medical Information, University of Montpellier, CHU Montpellier, Montpellier, France.; Department of Respiratory Diseases, University of Montpellier, CHU Montpellier, Montpellier 34090, France., Saker S; DNA and Cell Bank, Genethon, Evry 91000, France., Masseguin C; Delegation for Clinical Research and Innovation, Nîmes University Hospital, Nîmes 30029, France., de Vos J; Clinique du Motoneurone, CHU Gui de Chaliac, University of Montpellier, Montpellier 34295, France., Zetterberg H; Department of Psychiatry & Neurochemistry, University of Gothenburg, Mölndal 41345, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal 43180, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.; UK Dementia Research Institute at UCL, London WC1E 6BT, UK., Al-Chalabi A; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London SE5 9RX, UK.; Department of Neurology, King's College Hospital, London SE5 9RS, UK., Leigh PN; Brighton and Sussex Medical School, The Trafford Centre for Biomedical Research, Falmer, Brighton BN1 9RY, UK., Tree T; Department of Computer Science, University of Sheffield, Sheffield S1 4DP, UK.; NIHR Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust and King's College London, London SE1 9RT, UK., Bensimon G; Department of Cell and Tissue Engineering, University of Montpellier, CHU Montpellier, Montpellier 34000, France.; Department of Biostatistics, Clinical Epidemiology, Public Health and Innovation in Methodology (BESPIM), Nîmes University Hospital, Nîmes 30029, France.; Department of Pharmacology, Sorbonne University Médecine, F-75013 Paris 75013, France., Heath PR; Department of Neuroscience, Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK., Shaw PJ; Department of Neuroscience, Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK., Kirby J; Department of Neuroscience, Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.

المصدر: Brain communications [Brain Commun] 2021 Jun 29; Vol. 3 (3), pp. fcab141. Date of Electronic Publication: 2021 Jun 29 (Print Publication: 2021).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 101755125 Publication Model: eCollection Cited Medium: Internet ISSN: 2632-1297 (Electronic) Linking ISSN: 26321297 NLM ISO Abbreviation: Brain Commun Subsets: PubMed not MEDLINE

المؤلفون: Camu W; Clinique du Motoneurone, CHU Gui de Chauliac, University of Montpellier, Montpellier, France., Mickunas M; Department Immunobiology, Faculty of Life Sciences and Medicine, King's College London, London, UK; NIHR Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK., Veyrune JL; Department of Cell and Tisue Engineering, University of Montpellier, CHU Montpellier, Montpellier France., Payan C; Department of Biostatistics, Clinical Epidemiology, Public Health and Innovation in Methodology (BESPIM), Nîmes University Hospital, Nîmes, France; Department of Pharmacology, AP-HP.Sorbonne Université, Pitié-Salpêtrière Hospital, 47, Bd de l'Hôpital, F-75013 Paris, France., Garlanda C; IRCCS Humanitas Clinical & Research Institute, Milan, Italy; Humanitas University, Pieve Emanuele, Milan, Italy., Locati M; IRCCS Humanitas Clinical & Research Institute, Milan, Italy; Department of Medical Biotechnologies and Translational Medicine, University Milan, Milan Italy., Juntas-Morales R; Clinique du Motoneurone, CHU Gui de Chauliac, University of Montpellier, Montpellier, France., Pageot N; Clinique du Motoneurone, CHU Gui de Chauliac, University of Montpellier, Montpellier, France., Malaspina A; Neuroscience and Trauma Centre, Institute of Cell and Molecular Medicine, Department of Neuroimmunology, Barts and the London School of Medicine and Dentistry, London, UK., Andreasson U; Department of Psychiatry & Neurochemistry, University of Gothenburg, Mölndal, Sweden., Kirby J; Sheffield Institute for Translational Neuroscience, Department of Neuroscience, University of Sheffield, Sheffield, UK., Suehs C; Departments of Medical Information and Respiratory Diseases, University of Montpellier, CHU Montpellier, Montpellier, France., Saker S; DNA and Cell Bank, Genethon, Evry, France., Masseguin C; Delegation for Clinical Research and Innovation, Nîmes University Hospital, Nîmes, France., De Vos J; Department of Cell and Tisue Engineering, University of Montpellier, CHU Montpellier, Montpellier France., Zetterberg H; Department of Psychiatry & Neurochemistry, University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK; UK Dementia Research Institute at UCL, London, UK., Shaw PJ; Sheffield Institute for Translational Neuroscience, Department of Neuroscience, University of Sheffield, Sheffield, UK., Al-Chalabi A; Institute of Psychiatry Psychology and Neuroscience, Department of Basic and Clinical Neuroscience, King's College London, London, UK; Department of Neurology, King's College Hospital, London, UK., Leigh PN; The Trafford Centre for Biomedical Research, Brighton and Sussex Medical School, Falmer, Brighton BN1 9RY, UK., Tree T; Department Immunobiology, Faculty of Life Sciences and Medicine, King's College London, London, UK; NIHR Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, UK. Electronic address: timothy.tree@kcl.ac.uk., Bensimon G; Department of Biostatistics, Clinical Epidemiology, Public Health and Innovation in Methodology (BESPIM), Nîmes University Hospital, Nîmes, France; Department of Pharmacology, AP-HP.Sorbonne Université, Pitié-Salpêtrière Hospital, 47, Bd de l'Hôpital, F-75013 Paris, France; Department of Pharmacology, Sorbonne Université Médecine, F-75013 Paris, France. Electronic address: gbensimon.psl@gmail.com.

المصدر: EBioMedicine [EBioMedicine] 2020 Sep; Vol. 59, pp. 102844. Date of Electronic Publication: 2020 Jul 07.

نوع المنشور: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial

بيانات الدورية: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE

مواضيع طبية MeSH: Amyotrophic Lateral Sclerosis/*drug therapy , Antineoplastic Agents/*administration & dosage , Interleukin-2/*analogs & derivatives, Aged ; Aged, 80 and over ; Amyotrophic Lateral Sclerosis/diagnosis ; Amyotrophic Lateral Sclerosis/etiology ; Amyotrophic Lateral Sclerosis/metabolism ; Biomarkers ; Chemokines ; Cytokines ; Female ; Humans ; Immunophenotyping ; Interleukin-2/administration & dosage ; Interleukin-2/metabolism ; Male ; Middle Aged ; Recombinant Proteins/administration & dosage ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; Treatment Outcome

المؤلفون: Chen Z; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK., Chen JA; Interdepartmental Program in Bioinformatics, David Geffen School of Medicine, University of California, Los Angeles, California, USA., Shatunov A; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK., Jones AR; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK., Kravitz SN; Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, California, USA., Huang AY; Interdepartmental Program in Bioinformatics, David Geffen School of Medicine, University of California, Los Angeles, California, USA., Lawrence L; Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, California, USA., Lowe JK; Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, California, USA., Lewis CM; Social, Genetic and Developmental Psychiatry Centre, and Department of Medical and Molecular Genetics, King's College London, UK., Payan CAM; Département de Pharmacologie Clinique, Hôpital de la Pitié-Salpétrière, Assistance Publique Hôpitaux de Paris, Paris; Pharmacologie, Universités Paris-Sorbonne, UPMC Paris 06, Paris, France., Lieb W; Institute of Epidemiology and Biobank Popgen, Christian Albrechts Universitat zu Kiel, Kiel, Germany., Franke A; Institute of Clinical Molecular Biology, Christian Albrechts Universitat zu Kiel, Kiel, Germany., Deloukas P; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK., Amouyel P; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Risk Factor and Molecular Determinants of Aging Diseases, Labex-Distalz, Lille, France., Tzourio C; University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, UMR-1219, CHU Bordeaux, France., Dartigues JF; University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, UMR-1219, CHU Bordeaux, France., Ludolph A; Department of Neurology, University of Ulm, Oberer Eselsberg, Ulm, Germany., Bensimon G; Département de Pharmacologie Clinique, Hôpital de la Pitié-Salpétrière, Assistance Publique Hôpitaux de Paris, Paris; Pharmacologie, Universités Paris-Sorbonne, UPMC Paris 06, Paris, France., Leigh PN; Trafford Centre for Biomedical Research, Brighton and Sussex Medical School, University of Sussex, Falmer, Brighton, UK., Bronstein JM; Program in Movement Disorders, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, California, USA., Coppola G; Interdepartmental Program in Bioinformatics, David Geffen School of Medicine, University of California, Los Angeles, California, USA.; Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, California, USA.; Center for Neurobehavioral Genetics, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, California, USA., Geschwind DH; Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, California, USA.; Social, Genetic and Developmental Psychiatry Centre, and Department of Medical and Molecular Genetics, King's College London, UK.; Department of Human Genetics, University of California, Los Angeles, California, USA., Al-Chalabi A; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK.

مؤلفون مشاركون: NNIPPS and BBBIPPS Study Groups

المصدر: Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2019 Jul; Vol. 34 (7), pp. 1049-1059. Date of Electronic Publication: 2019 May 06.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8610688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-8257 (Electronic) Linking ISSN: 08853185 NLM ISO Abbreviation: Mov Disord Subsets: MEDLINE

مواضيع طبية MeSH: Genotype*, DNA Copy Number Variations/*genetics , Supranuclear Palsy, Progressive/*genetics , tau Proteins/*genetics, Adult ; Age of Onset ; Aged ; Aged, 80 and over ; Female ; Genome-Wide Association Study ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide/genetics

المؤلفون: Chen JA; Interdepartmental Program in Bioinformatics, University of California, Los Angeles, CA, 90095, USA., Chen Z; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, King's College London, London, SE5 9RX, UK., Won H; Program in Neurogenetics, Department of Neurology and Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA., Huang AY; Interdepartmental Program in Bioinformatics, University of California, Los Angeles, CA, 90095, USA., Lowe JK; Program in Neurogenetics, Department of Neurology and Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA., Wojta K; Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, 90095, USA., Yokoyama JS; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, 94158, USA., Bensimon G; BESPIM, CHU-Nîmes, Nîmes, France.; Dept Pharmacologie Clinique, Pitié-Salpêtrière Hospital, AP-PH, Paris, France.; Pharmacology UPMC-Paris VI, Universite Paris-Sorbonne, Paris, France., Leigh PN; Trafford Centre for Biomedical Research, Brighton and Sussex Medical School, University of Sussex, Falmer, Brighton, UK., Payan C; BESPIM, CHU-Nîmes, Nîmes, France.; Dept Pharmacologie Clinique, Pitié-Salpêtrière Hospital, AP-PH, Paris, France., Shatunov A; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, King's College London, London, SE5 9RX, UK., Jones AR; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, King's College London, London, SE5 9RX, UK., Lewis CM; Medical Research Council Social, Genetic and Developmental Psychiatry Centre, and Department of Medical and Molecular Genetics, King's College London, London, SE5 8AF, UK., Deloukas P; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK., Amouyel P; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Risk Factor and molecular determinants of aging diseases, Labex-Distalz, F-59000, Lille, France., Tzourio C; Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, CHU Bordeaux, F-33000 Bordeaux, France., Dartigues JF; Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, CHU Bordeaux, F-33000 Bordeaux, France., Ludolph A; Department of Neurology, University of Ulm, Oberer Eselsberg, Ulm, Germany., Boxer AL; Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, 94158, USA., Bronstein JM; Program in Neurogenetics, Department of Neurology and Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA., Al-Chalabi A; Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, King's College London, London, SE5 9RX, UK., Geschwind DH; Interdepartmental Program in Bioinformatics, University of California, Los Angeles, CA, 90095, USA.; Program in Neurogenetics, Department of Neurology and Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA., Coppola G; Interdepartmental Program in Bioinformatics, University of California, Los Angeles, CA, 90095, USA. gcoppola@ucla.edu.; Program in Neurogenetics, Department of Neurology and Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA. gcoppola@ucla.edu.; Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, 90095, USA. gcoppola@ucla.edu.; Departments of Psychiatry and Neurology, David Geffen School of Medicine, University of California, Los Angeles, 695 Charles E Young Dr. South, Gonda Bldg, Rm 1524, Los Angeles, CA, 90095, USA. gcoppola@ucla.edu.

المصدر: Molecular neurodegeneration [Mol Neurodegener] 2018 Aug 08; Vol. 13 (1), pp. 41. Date of Electronic Publication: 2018 Aug 08.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium: Internet ISSN: 1750-1326 (Electronic) Linking ISSN: 17501326 NLM ISO Abbreviation: Mol Neurodegener Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Predisposition to Disease/*genetics , Neurodegenerative Diseases/*genetics , Supranuclear Palsy, Progressive/*genetics, Female ; Genome-Wide Association Study ; Genotype ; Humans ; Male ; Polymorphism, Single Nucleotide

المؤلفون: Al-Chalabi A; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 9RS, UK; King's College Hospital, London SE5 9RS, UK. Electronic address: ammar.al-chalabi@kcl.ac.uk., Fang T; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 9RS, UK., Khleifat AA; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 9RS, UK., Meurgey JH; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 9RS, UK., Jones A; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 9RS, UK., Leigh PN; Department of Neurology, Brighton and Sussex Medical School, Sussex, UK., Bensimon G; Department of Pharmacology, Pitié-Salpêtrière Hospital, Paris, France.

المصدر: The Lancet. Neurology [Lancet Neurol] 2018 Jul; Vol. 17 (7), pp. 579-580.

نوع المنشور: Letter; Comment

بيانات الدورية: Publisher: Lancet Pub. Group Country of Publication: England NLM ID: 101139309 Publication Model: Print Cited Medium: Internet ISSN: 1474-4465 (Electronic) Linking ISSN: 14744422 NLM ISO Abbreviation: Lancet Neurol Subsets: MEDLINE

مواضيع طبية MeSH: Amyotrophic Lateral Sclerosis* , Riluzole*, Data Collection ; Humans ; Retrospective Studies

SCR Disease Name: Amyotrophic Lateral Sclerosis 2, Juvenile

المؤلفون: Fang T; King's College London, Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, London, UK., Al Khleifat A; King's College London, Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, London, UK., Meurgey JH; King's College London, Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, London, UK., Jones A; King's College London, Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, London, UK., Leigh PN; Department of Neurology, Brighton and Sussex Medical School, Sussex, UK., Bensimon G; Department of Pharmacology, Hôpital Pitié-Salpêtrière, Paris, France., Al-Chalabi A; King's College London, Maurice Wohl Clinical Neuroscience Institute, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, London, UK; King's College Hospital, Denmark Hill, London, UK. Electronic address: ammar.al-chalabi@kcl.ac.uk.

المصدر: The Lancet. Neurology [Lancet Neurol] 2018 May; Vol. 17 (5), pp. 416-422. Date of Electronic Publication: 2018 Mar 07.

نوع المنشور: Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Lancet Pub. Group Country of Publication: England NLM ID: 101139309 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-4465 (Electronic) Linking ISSN: 14744422 NLM ISO Abbreviation: Lancet Neurol Subsets: MEDLINE

مواضيع طبية MeSH: Disease Progression* , Outcome Assessment, Health Care* , Severity of Illness Index* , Survival Analysis*, Amyotrophic Lateral Sclerosis/*drug therapy , Excitatory Amino Acid Antagonists/*administration & dosage , Riluzole/*administration & dosage, Amyotrophic Lateral Sclerosis/mortality ; Dose-Response Relationship, Drug ; Humans ; Retrospective Studies ; Time Factors