المؤلفون: Bukofzer S; Ocelot Bio, Inc., Redwood City, CA, USA., Harris G; Ferring Research Institute Inc., San Diego, CA, USA., Cable EE; Ferring Research Institute Inc., San Diego, CA, USA.

المصدر: Current research in pharmacology and drug discovery [Curr Res Pharmacol Drug Discov] 2023 Aug 09; Vol. 5, pp. 100163. Date of Electronic Publication: 2023 Aug 09 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 9918300982506676 Publication Model: eCollection Cited Medium: Internet ISSN: 2590-2571 (Electronic) Linking ISSN: 25902571 NLM ISO Abbreviation: Curr Res Pharmacol Drug Discov Subsets: PubMed not MEDLINE

المؤلفون: Bukofzer S; Ocelot Bio, Inc., San Diego, CA, USA., Harris G; Ferring Research Institute Inc., San Diego, CA, USA., Song S; Ferring Research Institute Inc., San Diego, CA, USA., Cable EE; Ferring Research Institute Inc., San Diego, CA, USA.

المصدر: Journal of experimental pharmacology [J Exp Pharmacol] 2023 Jul 13; Vol. 15, pp. 279-290. Date of Electronic Publication: 2023 Jul 13 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Dove Medical Press Country of Publication: New Zealand NLM ID: 101530345 Publication Model: eCollection Cited Medium: Print ISSN: 1179-1454 (Print) Linking ISSN: 11791454 NLM ISO Abbreviation: J Exp Pharmacol Subsets: PubMed not MEDLINE

المؤلفون: Kouno T; Department of Medicine, University of California San Diego, La Jolla, California, USA., Liu X; Department of Medicine, University of California San Diego, La Jolla, California, USA; Department of Surgery, University of California San Diego, La Jolla, California, USA., Zhao H; Department of Medicine, University of California San Diego, La Jolla, California, USA., Kisseleva T; Department of Surgery, University of California San Diego, La Jolla, California, USA., Cable EE; CymaBay Therapeutics, Newark, California, USA., Schnabl B; Department of Medicine, University of California San Diego, La Jolla, California, USA; Department of Medicine, VA San Diego Healthcare System, San Diego, California, USA. Electronic address: beschnabl@health.ucsd.edu.

المصدر: The Journal of biological chemistry [J Biol Chem] 2022 Jul; Vol. 298 (7), pp. 102056. Date of Electronic Publication: 2022 May 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Acetates*/pharmacology , Bile Acids and Salts*/biosynthesis , Cholesterol 7-alpha-Hydroxylase*/genetics , Cholesterol 7-alpha-Hydroxylase*/metabolism , Fibroblast Growth Factors*/metabolism , PPAR delta*/agonists, Animals ; Hepatocytes/metabolism ; Humans ; Mice ; Signal Transduction

المؤلفون: Chu H; Department of Medicine, University of California San Diego, La Jolla, California; Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Jiang L; Department of Medicine, University of California San Diego, La Jolla, California; Department of Medicine, VA San Diego Healthcare System, San Diego, California., Gao B; Department of Medicine, University of California San Diego, La Jolla, California., Gautam N; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska., Alamoudi JA; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska., Lang S; Department of Medicine, University of California San Diego, La Jolla, California., Wang Y; Department of Medicine, University of California San Diego, La Jolla, California., Duan Y; Department of Medicine, University of California San Diego, La Jolla, California., Alnouti Y; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska., Cable EE; CymaBay Therapeutics, Newark, California., Schnabl B; Department of Medicine, University of California San Diego, La Jolla, California. Electronic address: beschnabl@ucsd.edu.

المصدر: Translational research : the journal of laboratory and clinical medicine [Transl Res] 2021 Jan; Vol. 227, pp. 1-14. Date of Electronic Publication: 2020 Jun 15.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101280339 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1810 (Electronic) Linking ISSN: 18781810 NLM ISO Abbreviation: Transl Res Subsets: MEDLINE

مواضيع طبية MeSH: Homeostasis*, Acetates/*pharmacology , Bile Acids and Salts/*metabolism , Ethanol/*toxicity , Gastrointestinal Microbiome/*drug effects , Liver Diseases, Alcoholic/*prevention & control , PPAR delta/*agonists, Acetates/therapeutic use ; Animals ; Female ; Liver Diseases, Alcoholic/physiopathology ; Mice ; Mice, Inbred C57BL

المؤلفون: Fernández-Varo G; Biochemistry and Molecular Genetics Service, Hospital Clínic i Provincial de Barcelona, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain.; Department Ciencies Fisiologiques I, University of Barcelona, Barcelona, Spain., Oró D; Biochemistry and Molecular Genetics Service, Hospital Clínic i Provincial de Barcelona, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain., Cable EE; Ferring Research Institute Inc., San Diego, CA., Reichenbach V; Biochemistry and Molecular Genetics Service, Hospital Clínic i Provincial de Barcelona, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain., Carvajal S; Biochemistry and Molecular Genetics Service, Hospital Clínic i Provincial de Barcelona, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain., de la Presa BG; Biochemistry and Molecular Genetics Service, Hospital Clínic i Provincial de Barcelona, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain., Wiśniewski K; Ferring Research Institute Inc., San Diego, CA., Ginés P; Liver Unit, Hospital Clínic i Provincial de Barcelona, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain., Harris G; Ferring Research Institute Inc., San Diego, CA., Jiménez W; Biochemistry and Molecular Genetics Service, Hospital Clínic i Provincial de Barcelona, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain.; Department Ciencies Fisiologiques I, University of Barcelona, Barcelona, Spain.

المصدر: Hepatology (Baltimore, Md.) [Hepatology] 2016 Jan; Vol. 63 (1), pp. 207-16. Date of Electronic Publication: 2015 Nov 04.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 8302946 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-3350 (Electronic) Linking ISSN: 02709139 NLM ISO Abbreviation: Hepatology Subsets: MEDLINE

مواضيع طبية MeSH: Ascites/*drug therapy , Ascites/*metabolism , Hypertension, Portal/*drug therapy , Hypertension, Portal/*metabolism , Liver Cirrhosis/*metabolism , Receptors, Vasopressin/*agonists , Sodium/*metabolism, Animals ; Ascites/etiology ; Hypertension, Portal/etiology ; Liver Cirrhosis/complications ; Male ; Rats ; Rats, Wistar

المؤلفون: Gómez-Galeno JE; Metabasis Therapeutics, Inc., La Jolla, California 92037., Dang Q; Metabasis Therapeutics, Inc., La Jolla, California 92037., Nguyen TH; Metabasis Therapeutics, Inc., La Jolla, California 92037., Boyer SH; Metabasis Therapeutics, Inc., La Jolla, California 92037., Grote MP; Metabasis Therapeutics, Inc., La Jolla, California 92037., Sun Z; Metabasis Therapeutics, Inc., La Jolla, California 92037., Chen M; Metabasis Therapeutics, Inc., La Jolla, California 92037., Craigo WA; Metabasis Therapeutics, Inc., La Jolla, California 92037., van Poelje PD; Metabasis Therapeutics, Inc., La Jolla, California 92037., MacKenna DA; Metabasis Therapeutics, Inc., La Jolla, California 92037., Cable EE; Metabasis Therapeutics, Inc., La Jolla, California 92037., Rolzin PA; Metabasis Therapeutics, Inc., La Jolla, California 92037., Finn PD; Metabasis Therapeutics, Inc., La Jolla, California 92037., Chi B; Metabasis Therapeutics, Inc., La Jolla, California 92037., Linemeyer DL; Metabasis Therapeutics, Inc., La Jolla, California 92037., Hecker SJ; Metabasis Therapeutics, Inc., La Jolla, California 92037., Erion MD; Metabasis Therapeutics, Inc., La Jolla, California 92037.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2010 Aug 30; Vol. 1 (9), pp. 478-82. Date of Electronic Publication: 2010 Aug 30 (Print Publication: 2010).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Cable EE; Metabasis Therapeutics, Inc, La Jolla, CA 92037, USA. edwardc@mbasis.com, Finn PD, Stebbins JW, Hou J, Ito BR, van Poelje PD, Linemeyer DL, Erion MD

المصدر: Hepatology (Baltimore, Md.) [Hepatology] 2009 Feb; Vol. 49 (2), pp. 407-17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 8302946 Publication Model: Print Cited Medium: Internet ISSN: 1527-3350 (Electronic) Linking ISSN: 02709139 NLM ISO Abbreviation: Hepatology Subsets: MEDLINE

مواضيع طبية MeSH: Fatty Liver/*drug therapy , Receptors, Thyroid Hormone/*agonists, Acetates/therapeutic use ; Adipose Tissue/drug effects ; Adipose Tissue/metabolism ; Animals ; Cytochrome P-450 CYP3A/metabolism ; Epididymis ; Fatty Acids, Nonesterified/metabolism ; Hepatocytes/drug effects ; Hepatocytes/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Oxidation-Reduction ; Phenols/therapeutic use ; Phenyl Ethers/therapeutic use ; Phenylacetates/therapeutic use ; Rats ; Rats, Sprague-Dawley

المؤلفون: Ito BR; Department of Biological Sciences, Metabasis Therapeutics, Inc., La Jolla, CA, USA. ito@mbasis.com, Zhang BH, Cable EE, Song X, Fujitaki JM, MacKenna DA, Wilker CE, Chi B, van Poelje PD, Linemeyer DL, Erion MD

المصدر: British journal of pharmacology [Br J Pharmacol] 2009 Feb; Vol. 156 (3), pp. 454-65. Date of Electronic Publication: 2009 Jan 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Anticholesteremic Agents/*therapeutic use , Cholesterol/*blood , Heptanoic Acids/*therapeutic use , Organophosphonates/*therapeutic use , Phenols/*therapeutic use , Prodrugs/*therapeutic use , Pyrroles/*therapeutic use , Thyroid Hormone Receptors beta/*agonists, Animals ; Anticholesteremic Agents/administration & dosage ; Anticholesteremic Agents/pharmacokinetics ; Atorvastatin ; Dogs ; Dose-Response Relationship, Drug ; Drug Synergism ; Drug Therapy, Combination ; Female ; Heptanoic Acids/administration & dosage ; Heptanoic Acids/pharmacokinetics ; Hypercholesterolemia/blood ; Hypercholesterolemia/drug therapy ; Macaca fascicularis ; Male ; Organophosphonates/administration & dosage ; Organophosphonates/pharmacokinetics ; Phenols/administration & dosage ; Phenols/pharmacokinetics ; Prodrugs/administration & dosage ; Prodrugs/pharmacokinetics ; Pyrroles/administration & dosage ; Pyrroles/pharmacokinetics ; Rabbits

المؤلفون: Boyer SH; Departments of Medicinal Chemistry and Biosciences, Metabasis Therapeutics, Inc., 11119 North Torrey Pines Road, La Jolla, California 92037, USA. boyer@mbasis.com, Jiang H, Jacintho JD, Reddy MV, Li H, Li W, Godwin JL, Schulz WG, Cable EE, Hou J, Wu R, Fujitaki JM, Hecker SJ, Erion MD

المصدر: Journal of medicinal chemistry [J Med Chem] 2008 Nov 27; Vol. 51 (22), pp. 7075-93.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Liver/*drug effects , Organophosphonates/*chemical synthesis , Organophosphonates/*pharmacology , Prodrugs/*chemical synthesis , Prodrugs/*pharmacology , Receptors, Thyroid Hormone/*agonists, Animals ; Cholesterol/administration & dosage ; Cholesterol/blood ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Design ; Drug Evaluation, Preclinical ; Glycerolphosphate Dehydrogenase/metabolism ; Hypercholesterolemia/drug therapy ; Ligands ; Liver/metabolism ; Molecular Structure ; Organophosphonates/chemistry ; Prodrugs/chemistry ; Rats ; Rats, Sprague-Dawley ; Stereoisomerism ; Structure-Activity Relationship

المؤلفون: Fujitaki JM; Department of Biological Sciences, Metabasis Therapeutics, Inc., 11119 North Torrey Pines Rd., La Jolla, CA 92037, USA. fujitaki@mbasis.com, Cable EE, Ito BR, Zhang BH, Hou J, Yang C, Bullough DA, Ferrero JL, van Poelje PD, Linemeyer DL, Erion MD

المصدر: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2008 Nov; Vol. 36 (11), pp. 2393-403. Date of Electronic Publication: 2008 Aug 14.

نوع المنشور: Comparative Study; Journal Article

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE

مواضيع طبية MeSH: Organophosphonates/*pharmacokinetics , Prodrugs/*pharmacokinetics , Receptors, Thyroid Hormone/*agonists , Receptors, Thyroid Hormone/*metabolism, Animals ; Dogs ; Drug Delivery Systems/methods ; Drug Evaluation, Preclinical/methods ; Female ; Humans ; Macaca fascicularis ; Male ; Mice ; Mice, Inbred ICR ; Microsomes, Liver/drug effects ; Microsomes, Liver/metabolism ; Organophosphonates/administration & dosage ; Prodrugs/administration & dosage ; Rabbits ; Rats ; Rats, Sprague-Dawley