المؤلفون: Javadzadeh Y; Krembil Research Institute, University Health Network, Toronto, ON M5S 0T8, Canada.; Institute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 1A1, Canada., Santos A; Krembil Research Institute, University Health Network, Toronto, ON M5S 0T8, Canada., Aquilino MS; Krembil Research Institute, University Health Network, Toronto, ON M5S 0T8, Canada.; Institute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 1A1, Canada., Mylvaganam S; Krembil Research Institute, University Health Network, Toronto, ON M5S 0T8, Canada., Urban K; Avicanna Inc., Toronto, ON M5G 1V2, Canada., Carlen PL; Krembil Research Institute, University Health Network, Toronto, ON M5S 0T8, Canada.; Institute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 1A1, Canada.; Department of Medicine (Neurology), University Health Network, Toronto, ON M5G 2C4, Canada.

المصدر: Cells [Cells] 2024 Mar 07; Vol. 13 (6). Date of Electronic Publication: 2024 Mar 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

مواضيع طبية MeSH: Cannabidiol*/pharmacology , Cannabinoids*/therapeutic use , Neocortex*, Mice ; Animals ; Anticonvulsants/therapeutic use ; Dronabinol ; Receptor, Serotonin, 5-HT1A ; Serotonin

المؤلفون: Wang XF; Krembil Research Institute, University Health Network, Krembil Discovery Tower, 60 Leonard St.,, Toronto, M5T 2O8, ON, Canada.; Institute of Biomedical and Biomaterial Engineering, University of Toronto, 1 King's College circle,, Toronto, M5S 1A8, ON, Canada., Vigouroux R; Krembil Research Institute, University Health Network, Krembil Discovery Tower, 60 Leonard St.,, Toronto, M5T 2O8, ON, Canada.; Department of Physiology, Faculty of Medicine, University of Toronto, 1 King's College circle,, Toronto, M5S 1A8, ON, Canada., Syonov M; Krembil Research Institute, University Health Network, Krembil Discovery Tower, 60 Leonard St.,, Toronto, M5T 2O8, ON, Canada.; Department of Physiology, Faculty of Medicine, University of Toronto, 1 King's College circle,, Toronto, M5S 1A8, ON, Canada., Baglaenko Y; Krembil Research Institute, University Health Network, Krembil Discovery Tower, 60 Leonard St.,, Toronto, M5T 2O8, ON, Canada., Nikolakopoulou AM; Department of Physiology and Neuroscience, The Zilkha Neurogenetic Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA., Ringuette D; Krembil Research Institute, University Health Network, Krembil Discovery Tower, 60 Leonard St.,, Toronto, M5T 2O8, ON, Canada.; Department of Physiology, Faculty of Medicine, University of Toronto, 1 King's College circle,, Toronto, M5S 1A8, ON, Canada., Rus H; University of Maryland, School of Medicine, Department of Neurology, Baltimore, MD, 21201, USA., DiStefano PV; Toronto General Hospital Research Institute, University Health Network, 101 College St. Rm 3-308, Toronto, M5L 1L7, ON, Canada., Dufour S; Krembil Research Institute, University Health Network, Krembil Discovery Tower, 60 Leonard St.,, Toronto, M5T 2O8, ON, Canada., Shabanzadeh AP; Krembil Research Institute, University Health Network, Krembil Discovery Tower, 60 Leonard St.,, Toronto, M5T 2O8, ON, Canada., Lee S; Krembil Research Institute, University Health Network, Krembil Discovery Tower, 60 Leonard St.,, Toronto, M5T 2O8, ON, Canada.; Department of Physiology, Faculty of Medicine, University of Toronto, 1 King's College circle,, Toronto, M5S 1A8, ON, Canada., Mueller BK; BioNTech resano GmbH, An der Goldgrube 12,, 55131, Mainz, Germany., Charish J; Krembil Research Institute, University Health Network, Krembil Discovery Tower, 60 Leonard St.,, Toronto, M5T 2O8, ON, Canada.; Department of Physiology, Faculty of Medicine, University of Toronto, 1 King's College circle,, Toronto, M5S 1A8, ON, Canada., Harada H; Krembil Research Institute, University Health Network, Krembil Discovery Tower, 60 Leonard St.,, Toronto, M5T 2O8, ON, Canada., Fish JE; Toronto General Hospital Research Institute, University Health Network, 101 College St. Rm 3-308, Toronto, M5L 1L7, ON, Canada., Wither J; Krembil Research Institute, University Health Network, Krembil Discovery Tower, 60 Leonard St.,, Toronto, M5T 2O8, ON, Canada., Wälchli T; Krembil Research Institute, University Health Network, Krembil Discovery Tower, 60 Leonard St.,, Toronto, M5T 2O8, ON, Canada.; Group of CNS Angiogenesis and Neurovascular Link, and Physician-Scientist Program, Institute for Regenerative Medicine, Neuroscience Center Zurich, and Division of Neurosurgery, University and University Hospital Zurich, Zurich, Switzerland.; Division of Neurosurgery, University Hospital Zurich, Zurich, Switzerland.; Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University Health Network, Toronto, Canada., Cloutier JF; The Neuro - Montreal Neurological Institute and Hospital, 3801 Rue Université, Montréal, QC, H3A 2B4, Canada., Zlokovic BV; Department of Physiology and Neuroscience, The Zilkha Neurogenetic Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA., Carlen PL; Krembil Research Institute, University Health Network, Krembil Discovery Tower, 60 Leonard St.,, Toronto, M5T 2O8, ON, Canada.; Institute of Biomedical and Biomaterial Engineering, University of Toronto, 1 King's College circle,, Toronto, M5S 1A8, ON, Canada.; Department of Physiology and Neuroscience, The Zilkha Neurogenetic Institute, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA., Monnier PP; Krembil Research Institute, University Health Network, Krembil Discovery Tower, 60 Leonard St.,, Toronto, M5T 2O8, ON, Canada. Philippe.Monnier@uhn.ca.; Institute of Biomedical and Biomaterial Engineering, University of Toronto, 1 King's College circle,, Toronto, M5S 1A8, ON, Canada. Philippe.Monnier@uhn.ca.; Department of Ophthalmology and Vision Sciences, Faculty of Medicine, University of Toronto, 340 College St.,, ON, Toronto, M5T 3A9, Canada. Philippe.Monnier@uhn.ca.

المصدر: Nature communications [Nat Commun] 2024 Feb 03; Vol. 15 (1), pp. 1037. Date of Electronic Publication: 2024 Feb 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Blood-Brain Barrier*/metabolism , Encephalomyelitis, Autoimmune, Experimental*, Animals ; Female ; Mice ; Central Nervous System/metabolism ; Endothelial Cells/metabolism ; Liver/metabolism ; Muscles/metabolism

المؤلفون: Ringuette D; Department of Physiology, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada; Division of Genetics and Development, Krembil Research Institute, 60 Leonard Ave., Toronto, Ontario M5T 2S8, Canada; Krembil Neuroscience, Krembil Research Institute, 60 Leonard Ave., Toronto, Ontario M5T 2S8, Canada. Electronic address: dene.ringuette@mail.utoronto.ca., EbrahimAmini A; Krembil Neuroscience, Krembil Research Institute, 60 Leonard Ave., Toronto, Ontario M5T 2S8, Canada; The Institute Biomedical Engineering, University of Toronto, 164 College St., Toronto, Ontario M5S 3G9, Canada., Sangphosuk W; Krembil Neuroscience, Krembil Research Institute, 60 Leonard Ave., Toronto, Ontario M5T 2S8, Canada., Aquilino MS; The Institute Biomedical Engineering, University of Toronto, 164 College St., Toronto, Ontario M5S 3G9, Canada., Carroll G; The Institute Biomedical Engineering, University of Toronto, 164 College St., Toronto, Ontario M5S 3G9, Canada., Ashley M; Krembil Neuroscience, Krembil Research Institute, 60 Leonard Ave., Toronto, Ontario M5T 2S8, Canada., Bazzigaluppi P; Sunnybrook Health Sciences Center, 2075 Bayview Ave., Toronto, Ontario M4N 3M5, Canada., Dufour S; The Institute Biomedical Engineering, University of Toronto, 164 College St., Toronto, Ontario M5S 3G9, Canada., Droguerre M; Theranexus, 60 Ave. Rockefeller, 69008, Lyon, France., Stefanovic B; Department of Medical Biophysics, University of Toronto, 610 University Ave., Toronto, Ontario M5G 2M9, Canada; Sunnybrook Health Sciences Center, 2075 Bayview Ave., Toronto, Ontario M4N 3M5, Canada., Levi O; The Institute Biomedical Engineering, University of Toronto, 164 College St., Toronto, Ontario M5S 3G9, Canada; The Edward S. Rogers Sr. Department of Electrical and Computer Engineering, University of Toronto, 10 King's College Rd., Toronto, Ontario M5S 3G4, Canada., Charveriat M; Theranexus, 60 Ave. Rockefeller, 69008, Lyon, France., Monnier PP; Department of Physiology, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada; Division of Genetics and Development, Krembil Research Institute, 60 Leonard Ave., Toronto, Ontario M5T 2S8, Canada; Department of Ophthalmology & Vision Science, Faculty of Medicine, University of Toronto, 340 College St., Toronto, Ontario M5T 3A9, Canada., Carlen PL; Department of Physiology, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada; Division of Genetics and Development, Krembil Research Institute, 60 Leonard Ave., Toronto, Ontario M5T 2S8, Canada; Krembil Neuroscience, Krembil Research Institute, 60 Leonard Ave., Toronto, Ontario M5T 2S8, Canada; The Institute Biomedical Engineering, University of Toronto, 164 College St., Toronto, Ontario M5S 3G9, Canada.

المصدر: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics [Neurotherapeutics] 2024 Jan; Vol. 21 (1), pp. e00298. Date of Electronic Publication: 2023 Dec 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Experimental NeuroTherapeutics Country of Publication: United States NLM ID: 101290381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-7479 (Electronic) Linking ISSN: 18787479 NLM ISO Abbreviation: Neurotherapeutics Subsets: MEDLINE

مواضيع طبية MeSH: Cortical Spreading Depression* , Epilepsy* , Stroke*, Humans ; Potassium/pharmacology ; Multimodal Imaging

المؤلفون: Santos AC; Krembil Research Institute, University Health Network, Toronto, ON M5S 0T8, Canada.; Institute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 1A1, Canada., Nader G; Krembil Research Institute, University Health Network, Toronto, ON M5S 0T8, Canada., El Soufi El Sabbagh D; Krembil Research Institute, University Health Network, Toronto, ON M5S 0T8, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A1, Canada., Urban K; Avicanna Inc., Toronto, ON M5G 1V2, Canada., Attisano L; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A1, Canada.; Donnelly Centre, University of Toronto, Toronto, ON M5S 1A1, Canada., Carlen PL; Krembil Research Institute, University Health Network, Toronto, ON M5S 0T8, Canada.; Institute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 1A1, Canada.

المصدر: Cells [Cells] 2023 Jul 27; Vol. 12 (15). Date of Electronic Publication: 2023 Jul 27.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

مواضيع طبية MeSH: Glucose*/metabolism , Epilepsy*/drug therapy , Epilepsy*/metabolism, Humans ; Solute Carrier Family 12, Member 2/metabolism ; Brain/metabolism ; Organoids/metabolism

المؤلفون: Atiwiwat D; Krembil Research Institute, University of Toronto, Toronto, ON, Canada.; Department of Physiology, University of Toronto, Toronto, ON, Canada.; Biosignal Research Center for Health, Prince of Songkla University, Hat Yai, Songkhla, Thailand.; Division of Health and Applied Sciences, Prince of Songkla University, Hat Yai, Songkhla, Thailand., Aquilino M; Krembil Research Institute, University of Toronto, Toronto, ON, Canada.; Departments of Medicine (Neurology), University of Toronto, Toronto, ON, Canada., Devinsky O; New York University Langone Medical Center, Neurology, New York, NY, United States., Bardakjian BL; Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada., Carlen PL; Krembil Research Institute, University of Toronto, Toronto, ON, Canada.; Department of Physiology, University of Toronto, Toronto, ON, Canada.; Departments of Medicine (Neurology), University of Toronto, Toronto, ON, Canada.; Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.

المصدر: Sleep [Sleep] 2023 Apr 12; Vol. 46 (4).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 7809084 Publication Model: Print Cited Medium: Internet ISSN: 1550-9109 (Electronic) Linking ISSN: 01618105 NLM ISO Abbreviation: Sleep Subsets: MEDLINE

مواضيع طبية MeSH: Sleep, REM*/physiology , Theta Rhythm*/physiology, Rats ; Animals ; Solitary Nucleus ; Hippocampus/physiology ; Neurons/physiology

المؤلفون: Saleem A; Krembil Research Institute, 60 Leonard Ave, 7KDT430, Toronto, ON, Canada M5T 0S8.; Institute of Biomedical Engineering, University of Toronto, Rosebrugh Building, 164 College St Room 407, Toronto, ON, Canada, M5S 3G9., Santos AC; Krembil Research Institute, 60 Leonard Ave, 7KDT430, Toronto, ON, Canada M5T 0S8.; Institute of Biomedical Engineering, University of Toronto, Rosebrugh Building, 164 College St Room 407, Toronto, ON, Canada, M5S 3G9., Aquilino MS; Krembil Research Institute, 60 Leonard Ave, 7KDT430, Toronto, ON, Canada M5T 0S8.; Institute of Biomedical Engineering, University of Toronto, Rosebrugh Building, 164 College St Room 407, Toronto, ON, Canada, M5S 3G9., Sivitilli AA; Donnelly Centre, 160 College Street, Room 1008, University of Toronto, Toronto, ON, Canada, M5S 1A8.; Department of Biochemistry, University of Toronto, 1 King's College Circle, Medical Sciences Building, Toronto, ON, Canada., Attisano L; Donnelly Centre, 160 College Street, Room 1008, University of Toronto, Toronto, ON, Canada, M5S 1A8.; Department of Biochemistry, University of Toronto, 1 King's College Circle, Medical Sciences Building, Toronto, ON, Canada., Carlen PL; Krembil Research Institute, 60 Leonard Ave, 7KDT430, Toronto, ON, Canada M5T 0S8.; Institute of Biomedical Engineering, University of Toronto, Rosebrugh Building, 164 College St Room 407, Toronto, ON, Canada, M5S 3G9.; Departments of Medicine and Physiology, University of Toronto, 1 King's College Circle, Medical Sciences Building, Toronto, ON, Canada, M5S 1A8.

المصدر: Heliyon [Heliyon] 2023 Mar 29; Vol. 9 (4), pp. e14999. Date of Electronic Publication: 2023 Mar 29 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101672560 Publication Model: eCollection Cited Medium: Print ISSN: 2405-8440 (Print) Linking ISSN: 24058440 NLM ISO Abbreviation: Heliyon Subsets: PubMed not MEDLINE

المؤلفون: Gravitis AC; Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada., Tufa U; Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada., Zukotynski K; Department of Radiology, McMaster University, Hamilton, ON, Canada.; Department of Electrical and Computer Engineering, University of Toronto, Toronto, ON, Canada., Streiner DL; Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada., Friedman D; Grossman School of Medicine, New York University, New York, NY, United States., Laze J; Grossman School of Medicine, New York University, New York, NY, United States., Chinvarun Y; Department of Medicine, Phramongkutklao Royal Army Hospital, Bangkok, Thailand., Devinsky O; Grossman School of Medicine, New York University, New York, NY, United States., Wennberg R; Department of Medicine (Neurology), University of Toronto, Toronto, ON, Canada., Carlen PL; Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.; Department of Medicine (Neurology), University of Toronto, Toronto, ON, Canada., Bardakjian BL; Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.; Department of Electrical and Computer Engineering, University of Toronto, Toronto, ON, Canada.

المصدر: Frontiers in neurology [Front Neurol] 2023 Mar 13; Vol. 14, pp. 1147576. Date of Electronic Publication: 2023 Mar 13 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101546899 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2295 (Print) Linking ISSN: 16642295 NLM ISO Abbreviation: Front Neurol Subsets: PubMed not MEDLINE

المؤلفون: EbrahimAmini A; Krembil Research Institute, Toronto, ON M5T 0S8, Canada.; Institute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada., Stefanovic B; Sunnybrook Health Sciences Center, Medical Biophysics, Toronto, ON M4N 3M5, Canada., Carlen PL; Krembil Research Institute, Toronto, ON M5T 0S8, Canada.; Institute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada.; Departments of Medicine and Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada.

المصدر: Biomedicines [Biomedicines] 2022 Jul 01; Vol. 10 (7). Date of Electronic Publication: 2022 Jul 01.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101691304 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9059 (Print) Linking ISSN: 22279059 NLM ISO Abbreviation: Biomedicines Subsets: PubMed not MEDLINE

المؤلفون: Whyte-Fagundes P; Department of Biology, York University, Toronto, ON, M3J1P3, Canada. whytefp@yorku.ca.; Center of Vision Research (CVR), York University, Toronto, ON, M3J1P3, Canada. whytefp@yorku.ca.; Krembil Research Institute, University Health Network, 60 Leonard Ave, Toronto, ON, M5T 1M8, Canada. whytefp@yorku.ca., Taskina D; Department of Biology, York University, Toronto, ON, M3J1P3, Canada.; Center of Vision Research (CVR), York University, Toronto, ON, M3J1P3, Canada., Safarian N; Department of Biology, York University, Toronto, ON, M3J1P3, Canada.; Center of Vision Research (CVR), York University, Toronto, ON, M3J1P3, Canada., Zoidl C; Department of Biology, York University, Toronto, ON, M3J1P3, Canada.; Center of Vision Research (CVR), York University, Toronto, ON, M3J1P3, Canada., Carlen PL; Krembil Research Institute, University Health Network, 60 Leonard Ave, Toronto, ON, M5T 1M8, Canada.; Department of Medicine, Physiology and BME, University of Toronto, 399 Bathurst St., 5w442, Toronto, ON, M5T 2S8, Canada., Donaldson LW; Department of Biology, York University, Toronto, ON, M3J1P3, Canada., Zoidl GR; Department of Biology, York University, Toronto, ON, M3J1P3, Canada. gzoidl@yorku.ca.; Center of Vision Research (CVR), York University, Toronto, ON, M3J1P3, Canada. gzoidl@yorku.ca.; Krembil Research Institute, University Health Network, 60 Leonard Ave, Toronto, ON, M5T 1M8, Canada. gzoidl@yorku.ca.

المصدر: Communications biology [Commun Biol] 2022 May 18; Vol. 5 (1), pp. 472. Date of Electronic Publication: 2022 May 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE

مواضيع طبية MeSH: Connexins*/metabolism , Receptors, Purinergic P2X7*/metabolism , Xenopus Proteins*/metabolism, Adenosine Triphosphate/metabolism ; Animals ; Nerve Tissue Proteins/metabolism ; Seizures/genetics ; Seizures/metabolism ; Signal Transduction ; Zebrafish

المؤلفون: Tufa U; Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada., Gravitis A; Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada., Zukotynski K; Edward S. Rogers Sr. Department of Electrical and Computer Engineering, University of Toronto, Toronto, ON, Canada.; Department of Radiology and Medicine, McMaster University, Hamilton, ON, Canada., Chinvarun Y; Comprehensive Epilepsy Program and Neurology Unit, Phramongkutklao Hospital, Bangkok, Thailand., Devinsky O; Department of Neurology, New York University School of Medicine, New York, NY, United States., Wennberg R; Division of Neurology, Toronto Western Hospital, Toronto, ON, Canada., Carlen PL; Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.; Department of Neurology, New York University School of Medicine, New York, NY, United States.; Department of Physiology, University of Toronto, Toronto, ON, Canada., Bardakjian BL; Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.; Edward S. Rogers Sr. Department of Electrical and Computer Engineering, University of Toronto, Toronto, ON, Canada.

المصدر: Frontiers in network physiology [Front Netw Physiol] 2022 Apr 26; Vol. 2, pp. 866540. Date of Electronic Publication: 2022 Apr 26 (Print Publication: 2022).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 9918334487406676 Publication Model: eCollection Cited Medium: Internet ISSN: 2674-0109 (Electronic) Linking ISSN: 26740109 NLM ISO Abbreviation: Front Netw Physiol Subsets: PubMed not MEDLINE