المؤلفون: Ruzicka WB; Laboratory for Epigenomics in Human Psychopathology, McLean Hospital, Belmont, MA 02478, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Mohammadi S; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Fullard JF; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Davila-Velderrain J; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Neurogenomics Research Center, Human Technopole, 20157 Milan, Italy., Subburaju S; Laboratory for Epigenomics in Human Psychopathology, McLean Hospital, Belmont, MA 02478, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA., Tso DR; Laboratory for Epigenomics in Human Psychopathology, McLean Hospital, Belmont, MA 02478, USA., Hourihan M; Laboratory for Epigenomics in Human Psychopathology, McLean Hospital, Belmont, MA 02478, USA., Jiang S; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Lee HC; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Bendl J; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Voloudakis G; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Haroutunian V; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Mental Illness Research, Education and Clinical Centers, James J. Peters VA Medical Center, Bronx, NY 10468, USA., Hoffman GE; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Roussos P; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Neurogenomics Research Center, Human Technopole, 20157 Milan, Italy., Kellis M; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

مؤلفون مشاركون: PsychENCODE Consortium§, PsychENCODE Consortium

المصدر: Science (New York, N.Y.) [Science] 2024 May 24; Vol. 384 (6698), pp. eadg5136. Date of Electronic Publication: 2024 May 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Predisposition to Disease* , Neurons*/metabolism , Prefrontal Cortex*/metabolism , Schizophrenia*/genetics , Single-Cell Analysis* , Neuroglia*/metabolism, Adult ; Female ; Humans ; Male ; Cohort Studies ; Risk Factors ; Synapses/metabolism ; Transcriptome ; Young Adult ; Middle Aged ; Aged ; Aged, 80 and over

المؤلفون: McAfee JC; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Lee S; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Lee J; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Bell JL; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Krupa O; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Davis J; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.; UCLA-DOE Institute for Genomics and Proteomics, University of California, Los Angeles, Los Angeles, CA 90095, USA.; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.; Quantitative and Computational Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA., Insigne K; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.; UCLA-DOE Institute for Genomics and Proteomics, University of California, Los Angeles, Los Angeles, CA 90095, USA.; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.; Quantitative and Computational Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA., Bond ML; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Zhao N; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA., Boyle AP; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA., Phanstiel DH; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Love MI; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Stein JL; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Ruzicka WB; Laboratory for Epigenomics in Human Psychopathology, McLean Hospital, Belmont, MA 02141, USA.; Harvard Medical School, Boston, MA 02115, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Davila-Velderrain J; Human Technopole, Viale Rita Levi-Montalcini 1, 20157 Milan, Italy., Kosuri S; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.; UCLA-DOE Institute for Genomics and Proteomics, University of California, Los Angeles, Los Angeles, CA 90095, USA.; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.; Quantitative and Computational Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA., Won H; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

المصدر: Cell genomics [Cell Genom] 2023 Sep 15; Vol. 3 (10), pp. 100404. Date of Electronic Publication: 2023 Sep 15 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 9918284260106676 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-979X (Electronic) Linking ISSN: 2666979X NLM ISO Abbreviation: Cell Genom Subsets: PubMed not MEDLINE

المؤلفون: Huang WC; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Peng Z; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Murdock MH; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Liu L; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Mathys H; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA., Davila-Velderrain J; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA.; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, USA., Jiang X; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Chen M; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Ng AP; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Kim T; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Abdurrob F; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Gao F; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA., Kellis M; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA.; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, USA., Tsai LH; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA.

المصدر: Science translational medicine [Sci Transl Med] 2023 Apr 19; Vol. 15 (692), pp. eabq1019. Date of Electronic Publication: 2023 Apr 19.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

مواضيع طبية MeSH: Alzheimer Disease*/pathology, Mice ; Humans ; Animals ; Mammillary Bodies/metabolism ; Mammillary Bodies/pathology ; Mice, Transgenic ; Neurons/metabolism ; Brain/metabolism ; Memory Disorders/pathology ; Disease Models, Animal ; Amyloid beta-Peptides/metabolism

المؤلفون: Blanchard JW; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.; Nash Family Department of Neuroscience, Black Family Stem Cell Institute, Ronald M. Loeb Center for Alzheimer's Disease, Friedman Brain Institute, Icahn School of Medicine at Mt Sinai, New York, NY, USA., Akay LA; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA., Davila-Velderrain J; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA.; Human Technopole, Milan, Italy., von Maydell D; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA., Mathys H; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA., Davidson SM; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA., Effenberger A; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Chen CY; Department of Medicine, Emory Integrated Metabolomics and Lipidomics Core, Emory University School of Medicine, Atlanta, GA, USA., Maner-Smith K; Department of Medicine, Emory Integrated Metabolomics and Lipidomics Core, Emory University School of Medicine, Atlanta, GA, USA., Hajjar I; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA., Ortlund EA; Department of Medicine, Emory Integrated Metabolomics and Lipidomics Core, Emory University School of Medicine, Atlanta, GA, USA.; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA., Bula M; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Agbas E; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Ng A; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Jiang X; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Kahn M; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Blanco-Duque C; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Lavoie N; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Liu L; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Reyes R; Nash Family Department of Neuroscience, Black Family Stem Cell Institute, Ronald M. Loeb Center for Alzheimer's Disease, Friedman Brain Institute, Icahn School of Medicine at Mt Sinai, New York, NY, USA., Lin YT; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Ko T; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., R'Bibo L; Nash Family Department of Neuroscience, Black Family Stem Cell Institute, Ronald M. Loeb Center for Alzheimer's Disease, Friedman Brain Institute, Icahn School of Medicine at Mt Sinai, New York, NY, USA., Ralvenius WT; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Cam HP; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Kellis M; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA. manoli@mit.edu.; Broad Institute of Harvard and MIT, Cambridge, MA, USA. manoli@mit.edu., Tsai LH; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA. lhtsai@mit.edu.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA. lhtsai@mit.edu.; Broad Institute of Harvard and MIT, Cambridge, MA, USA. lhtsai@mit.edu.

المصدر: Nature [Nature] 2022 Nov; Vol. 611 (7937), pp. 769-779. Date of Electronic Publication: 2022 Nov 16.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Apolipoprotein E4*/genetics , Apolipoprotein E4*/metabolism , Brain*/metabolism , Brain*/pathology , Cholesterol*/metabolism , Oligodendroglia*/metabolism , Oligodendroglia*/pathology , Nerve Fibers, Myelinated*/metabolism , Nerve Fibers, Myelinated*/pathology, Animals ; Humans ; Mice ; Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Autopsy ; Induced Pluripotent Stem Cells ; Neurons/metabolism ; Neurons/pathology ; Heterozygote ; Biological Transport ; Homeostasis ; Single-Cell Analysis ; Memory ; Aging/genetics ; Gene Expression Profiling ; Myelin Sheath/metabolism ; Myelin Sheath/pathology

المؤلفون: Welch GM; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Boix CA; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA., Schmauch E; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Davila-Velderrain J; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA., Victor MB; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Dileep V; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Bozzelli PL; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Su Q; Departments of Computational Biology and Biology and Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA, USA., Cheng JD; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Lee A; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Leary NS; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Pfenning AR; Departments of Computational Biology and Biology and Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA, USA., Kellis M; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Tsai LH; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.

المصدر: Science advances [Sci Adv] 2022 Sep 30; Vol. 8 (39), pp. eabo4662. Date of Electronic Publication: 2022 Sep 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

مواضيع طبية MeSH: DNA Breaks, Double-Stranded* , Microglia*/metabolism, Animals ; Antiviral Agents/metabolism ; DNA/metabolism ; Humans ; Mice ; NF-kappa B/metabolism ; Neurons/metabolism

المؤلفون: Singh N; Department of Neuroscience, UConn Health, Farmington, CT 06030-3401, USA., Benoit MR; Department of Neuroscience, UConn Health, Farmington, CT 06030-3401, USA., Zhou J; Department of Neuroscience, UConn Health, Farmington, CT 06030-3401, USA., Das B; Department of Neuroscience, UConn Health, Farmington, CT 06030-3401, USA., Davila-Velderrain J; Human Technopole, Viale Rita Levi-Montalcini 1, 20157, Milan, Italy.; Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA 02138, USA.; Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02138, USA., Kellis M; Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, Cambridge, MA 02138, USA.; Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02138, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02138, USA., Tsai LH; Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02138, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02138, USA., Hu X; Department of Neuroscience, UConn Health, Farmington, CT 06030-3401, USA., Yan R; Department of Neuroscience, UConn Health, Farmington, CT 06030-3401, USA.

المصدر: Science advances [Sci Adv] 2022 Jun 17; Vol. 8 (24), pp. eabo1286. Date of Electronic Publication: 2022 Jun 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Barker SJ; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Raju RM; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA., Milman NEP; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Wang J; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Davila-Velderrain J; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Gunter-Rahman F; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Parro CC; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Bozzelli PL; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Abdurrob F; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Abdelaal K; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA., Kellis M; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Tsai LH; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

المصدر: Science translational medicine [Sci Transl Med] 2021 Nov 03; Vol. 13 (618), pp. eabd7695. Date of Electronic Publication: 2021 Nov 03.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

مواضيع طبية MeSH: MEF2 Transcription Factors*/genetics , MEF2 Transcription Factors*/metabolism , Neurodegenerative Diseases*/genetics, Animals ; Brain/metabolism ; Cognition/physiology ; Gene Regulatory Networks ; Humans ; Mice

المؤلفون: Caldu-Primo JL; Instituto de Ecología, Universidad Nacional Autónoma de México, Cd. Universitaria, CDMX., 04510, México., Verduzco-Martínez JA; Departamento de Biología Celular y Genética, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, San Nicolás de los Garza, Nuevo León, 66400, México., Alvarez-Buylla ER; Instituto de Ecología, Universidad Nacional Autónoma de México, Cd. Universitaria, CDMX., 04510, México., Davila-Velderrain J; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, USA.

المصدر: NAR genomics and bioinformatics [NAR Genom Bioinform] 2021 Jul 13; Vol. 3 (3), pp. lqab063. Date of Electronic Publication: 2021 Jul 13 (Print Publication: 2021).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 101756213 Publication Model: eCollection Cited Medium: Internet ISSN: 2631-9268 (Electronic) Linking ISSN: 26319268 NLM ISO Abbreviation: NAR Genom Bioinform Subsets: PubMed not MEDLINE

المؤلفون: He L; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA. liang.he@duke.edu., Davila-Velderrain J; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA, USA., Sumida TS; Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT, USA.; Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan., Hafler DA; Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT, USA., Kellis M; Broad Institute of MIT and Harvard, Cambridge, MA, USA. manoli@mit.edu.; Computer Science and Artificial Intelligence Laboratory, MIT, Cambridge, MA, USA. manoli@mit.edu., Kulminski AM; Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA. alexander.kulminski@duke.edu.

المصدر: Communications biology [Commun Biol] 2021 May 26; Vol. 4 (1), pp. 629. Date of Electronic Publication: 2021 May 26.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE

مواضيع طبية MeSH: Computational Biology/*methods , Gene Expression Profiling/*methods , Single-Cell Analysis/*methods, Alzheimer Disease/genetics ; Apolipoproteins E/genetics ; Binomial Distribution ; Gene Expression/genetics ; Humans ; Microglia/metabolism ; Models, Statistical

المؤلفون: Blanchard JW; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Bula M; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Davila-Velderrain J; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Akay LA; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Zhu L; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Frank A; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Victor MB; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Bonner JM; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Mathys H; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Lin YT; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Ko T; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Cam HP; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA., Kellis M; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Tsai LH; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA. lhtsai@mit.edu.; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA. lhtsai@mit.edu.; Broad Institute of Harvard and MIT, Cambridge, MA, USA. lhtsai@mit.edu.

المصدر: Nature medicine [Nat Med] 2021 Feb; Vol. 27 (2), pp. 356.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: PubMed not MEDLINE; MEDLINE