-
101دورية أكاديميةCounteracting Angiotensinogen Small-Interfering RNA-Mediated Antihypertensive Effects With REVERSIR.
المؤلفون: Ye D; Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands (D.Y., E.O.C.-L., R.v.V., I.M.G., A.H.J.D.)., Cruz-López EO; Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands (D.Y., E.O.C.-L., R.v.V., I.M.G., A.H.J.D.)., Veghel RV; Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands (D.Y., E.O.C.-L., R.v.V., I.M.G., A.H.J.D.)., Garrelds IM; Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands (D.Y., E.O.C.-L., R.v.V., I.M.G., A.H.J.D.)., Kasper A; Alnylam Pharmaceuticals, Cambridge, MA (A.K., K.W., H.-C.T., I.Z.)., Wassarman K; Alnylam Pharmaceuticals, Cambridge, MA (A.K., K.W., H.-C.T., I.Z.)., Tu HC; Alnylam Pharmaceuticals, Cambridge, MA (A.K., K.W., H.-C.T., I.Z.)., Zlatev I; Alnylam Pharmaceuticals, Cambridge, MA (A.K., K.W., H.-C.T., I.Z.)., Danser AHJ; Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands (D.Y., E.O.C.-L., R.v.V., I.M.G., A.H.J.D.).
المصدر: Hypertension (Dallas, Tex. : 1979) [Hypertension] 2024 Jul; Vol. 81 (7), pp. 1491-1499. Date of Electronic Publication: 2024 May 01.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Lippincott, Williams & Wilkins Country of Publication: United States NLM ID: 7906255 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4563 (Electronic) Linking ISSN: 0194911X NLM ISO Abbreviation: Hypertension Subsets: MEDLINE
مواضيع طبية MeSH: Angiotensinogen*/genetics , Angiotensinogen*/metabolism , RNA, Small Interfering*/administration & dosage , RNA, Small Interfering*/pharmacology , RNA, Small Interfering*/genetics , Rats, Inbred SHR* , Hypertension*/drug therapy , Hypertension*/genetics , Hypertension*/metabolism , Antihypertensive Agents*/pharmacology, Animals ; Rats ; Male ; Blood Pressure/drug effects ; Disease Models, Animal ; Valsartan/pharmacology ; Renin-Angiotensin System/drug effects
-
102دورية أكاديمية
المؤلفون: Deng F; Institute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, P.R. China., Lei J; Institute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, P.R. China., Chen J; Department of Obstetrics and Gynecology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, P.R. China., Zhao M; Institute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, P.R. China.; Department of Obstetrics and Gynecology, the Third People's Hospital of Bengbu Affiliated to Bengbu Medical College, Bengbu, Anhui, China., Zhao C; Institute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, P.R. China., Fu M; Department of Obstetrics and Gynecology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, P.R. China., Sun M; Institute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, P.R. China., Zhang M; Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China., Qiu J; Department of Oncology and Hematology, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, Jiangsu, P.R. China., Gao Q; Institute for Fetology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, P.R. China.; Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China.
المصدر: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2024 Jun 15; Vol. 38 (11), pp. e23714.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE
مواضيع طبية MeSH: Pre-Eclampsia*/metabolism , Pre-Eclampsia*/genetics , Pre-Eclampsia*/pathology , Angiotensin II*/metabolism , Placenta*/metabolism , 11-beta-Hydroxysteroid Dehydrogenase Type 2*/metabolism , 11-beta-Hydroxysteroid Dehydrogenase Type 2*/genetics , Peptidyl-Dipeptidase A*/metabolism , Peptidyl-Dipeptidase A*/genetics , DNA Methylation*, Pregnancy ; Female ; Humans ; Animals ; Rats ; Adult ; Down-Regulation ; Renin-Angiotensin System/genetics ; Renin-Angiotensin System/physiology ; Hydrocortisone/metabolism ; Rats, Sprague-Dawley
-
103دورية أكاديمية
المؤلفون: Arfsten H; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria., Heitzinger G; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria., Prausmüller S; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria., Weidenhammer A; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria., Goliasch G; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria., Bartko PE; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria., Spinka G; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria., Hülsmann M; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria., Pavo N; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
المصدر: ESC heart failure [ESC Heart Fail] 2024 Jun; Vol. 11 (3), pp. 1748-1757. Date of Electronic Publication: 2024 Mar 08.
نوع المنشور: Journal Article; Observational Study
بيانات الدورية: Publisher: John Wiley & Sons Ltd on behalf of the European Society of Cardiology Country of Publication: England NLM ID: 101669191 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2055-5822 (Electronic) Linking ISSN: 20555822 NLM ISO Abbreviation: ESC Heart Fail Subsets: MEDLINE
مواضيع طبية MeSH: Renin*/blood , Heart Failure*/physiopathology , Heart Failure*/blood , Stroke Volume*/physiology, Humans ; Female ; Male ; Prospective Studies ; Aged ; Middle Aged ; Biomarkers/blood ; Renin-Angiotensin System/physiology ; Follow-Up Studies ; Registries ; Echocardiography ; Ventricular Dysfunction, Right/physiopathology ; Ventricular Dysfunction, Right/blood ; Ventricular Function, Right/physiology ; Peptide Fragments ; Natriuretic Peptide, Brain
-
104دورية أكاديمية
عنوان ترانسليتريتد: Nouveautés dans la prise en charge de l’hyperkaliémie.
المؤلفون: Lefevre F; Centre de néphrologie et transplantation rénale, hôpital de la Conception, AP-HM, 147, boulevard Baille, 13005 Marseille, France., Mousseaux C; Sorbonne université, CORAKID, Inserm UMR_S1155, hôpital Tenon, Paris, France; Soins intensifs néphrologiques-Rein Aigu, hôpital Tenon, AP-HP, Paris, France., Bobot M; Centre de néphrologie et transplantation rénale, hôpital de la Conception, AP-HM, 147, boulevard Baille, 13005 Marseille, France; Aix-Marseille université, C2VN, Inserm 1263, INRAE 1260, CERIMED, Marseille, France. Electronic address: mickael.bobot@ap-hm.fr.
المصدر: La Revue de medecine interne [Rev Med Interne] 2024 Jun; Vol. 45 (6), pp. 350-353. Date of Electronic Publication: 2024 Jan 13.
نوع المنشور: Journal Article; Review; English Abstract
بيانات الدورية: Publisher: Elsevier Country of Publication: France NLM ID: 8101383 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3122 (Electronic) Linking ISSN: 02488663 NLM ISO Abbreviation: Rev Med Interne Subsets: MEDLINE
مواضيع طبية MeSH: Hyperkalemia*/therapy , Hyperkalemia*/etiology , Hyperkalemia*/diagnosis, Humans ; Polystyrenes/therapeutic use ; Polystyrenes/adverse effects ; Renin-Angiotensin System/drug effects ; Renin-Angiotensin System/physiology ; Potassium/blood ; Potassium/therapeutic use ; Renal Insufficiency, Chronic/complications ; Polymers/therapeutic use
-
105دورية أكاديمية
المؤلفون: Bell DSH; University of Alabama Medical School and Southside Endocrinology, Irondale, Alabama, USA., Jerkins T; Midstate Endocrine Associates, Lipscomb University, Nashville, Tennessee, USA.
المصدر: Diabetes, obesity & metabolism [Diabetes Obes Metab] 2024 Jun; Vol. 26 (6), pp. 2046-2053. Date of Electronic Publication: 2024 Mar 22.
نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 100883645 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1463-1326 (Electronic) Linking ISSN: 14628902 NLM ISO Abbreviation: Diabetes Obes Metab Subsets: MEDLINE
مواضيع طبية MeSH: Diabetic Nephropathies*/drug therapy , Diabetic Nephropathies*/prevention & control , Angiotensin-Converting Enzyme Inhibitors*/therapeutic use , Sodium-Glucose Transporter 2 Inhibitors*/therapeutic use , Drug Therapy, Combination* , Mineralocorticoid Receptor Antagonists*/therapeutic use, Humans ; Disease Progression ; Renin-Angiotensin System/drug effects ; Treatment Outcome ; Angiotensin Receptor Antagonists/therapeutic use ; Glucagon-Like Peptide 1/agonists ; Glucagon-Like Peptide 1/therapeutic use ; Hypoglycemic Agents/therapeutic use ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/complications ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use
-
106دورية أكاديمية
المؤلفون: Higashihara E; Department of Urology, Kyorin University School of Medicine, Mitaka, Japan., Harada T; Department of Renal and Cardiovascular Research, Otsuka Pharmaceutical Co. Ltd, Tokushima, Japan., Fukuhara H; Department of Urology, Kyorin University School of Medicine, Mitaka, Japan.
المصدر: Expert opinion on pharmacotherapy [Expert Opin Pharmacother] 2024 May; Vol. 25 (7), pp. 819-832. Date of Electronic Publication: 2024 May 22.
نوع المنشور: Journal Article; Review
بيانات الدورية: Publisher: Informa Healthcare Country of Publication: England NLM ID: 100897346 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-7666 (Electronic) Linking ISSN: 14656566 NLM ISO Abbreviation: Expert Opin Pharmacother Subsets: MEDLINE
مواضيع طبية MeSH: Homeostasis*/drug effects , Renal Insufficiency, Chronic*/drug therapy , Renal Insufficiency, Chronic*/metabolism , Juxtaglomerular Apparatus*/metabolism , Sodium-Glucose Transporter 2 Inhibitors*/therapeutic use , Sodium-Glucose Transporter 2 Inhibitors*/pharmacology , Tolvaptan*/therapeutic use , Tolvaptan*/pharmacology, Humans ; Animals ; Disease Progression ; Polycystic Kidney, Autosomal Dominant/drug therapy ; Polycystic Kidney, Autosomal Dominant/metabolism ; Polycystic Kidney, Autosomal Dominant/physiopathology ; Renin-Angiotensin System/drug effects ; Sodium/metabolism ; Antidiuretic Hormone Receptor Antagonists/therapeutic use ; Antidiuretic Hormone Receptor Antagonists/pharmacology
-
107دورية أكاديمية
المؤلفون: Gutierrez Del Arroyo A; Translational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK., Patel A; Translational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK., Abbott TEF; Translational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK., Begum S; Translational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK., Dias P; Translational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK., Somanath S; County Durham and Darlington NHS Foundation Trust, Durham, UK., Middleditch A; University Hospitals Bristol NHS Foundation Trust, Bristol, UK., Cleland S; University Hospitals Plymouth NHS Trust, Plymouth, UK., Brealey D; Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK; UCL Hospitals NHS Foundation Trust, London, UK., Pearse RM; Translational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK., Ackland GL; Translational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK. Electronic address: g.ackland@qmul.ac.uk.
مؤلفون مشاركون: SPACE trial investigators
المصدر: British journal of anaesthesia [Br J Anaesth] 2024 May; Vol. 132 (5), pp. 857-866. Date of Electronic Publication: 2024 Feb 09.
نوع المنشور: Randomized Controlled Trial; Multicenter Study; Clinical Trial, Phase II; Journal Article
بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 0372541 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-6771 (Electronic) Linking ISSN: 00070912 NLM ISO Abbreviation: Br J Anaesth Subsets: MEDLINE
مواضيع طبية MeSH: Natriuretic Peptide, Brain* , Heart Injuries*, Female ; Humans ; Aged ; Male ; Troponin T ; Renin-Angiotensin System ; Biomarkers ; Peptide Fragments
-
108دورية أكاديمية
المؤلفون: Judd E; Department of Medicine, Division of Nephrology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA., Kumar V; Department of Medicine, Division of Nephrology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA., Porrett PM; Department of Surgery, Division of Transplantation, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA., Hyndman KA; Department of Medicine, Division of Nephrology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA., Anderson DJ; Department of Surgery, Division of Transplantation, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA., Jones-Carr ME; Department of Surgery, Division of Transplantation, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA., Shunk A; Legacy of Hope, Birmingham, Alabama, USA., Epstein DR; Department of Surgery, Division of Transplantation, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA., Fatima H; Department of Pathology, Division of Anatomic Pathology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA., Katsurada A; Department of Physiology and Hypertension and Renal Center, Tulane University, New Orleans, Louisianna, USA., Satou R; Department of Physiology and Hypertension and Renal Center, Tulane University, New Orleans, Louisianna, USA., Navar LG; Department of Physiology and Hypertension and Renal Center, Tulane University, New Orleans, Louisianna, USA., Locke JE; Department of Surgery, Division of Transplantation, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA. Electronic address: jlocke@uabmc.edu.
المصدر: Kidney international [Kidney Int] 2024 May; Vol. 105 (5), pp. 971-979. Date of Electronic Publication: 2024 Jan 28.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0323470 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-1755 (Electronic) Linking ISSN: 00852538 NLM ISO Abbreviation: Kidney Int Subsets: MEDLINE
مواضيع طبية MeSH: Renin* , Renal Insufficiency*, Adult ; Humans ; Animals ; Swine ; Transplantation, Heterologous ; Kidney/physiology ; Renin-Angiotensin System ; Aldosterone ; Homeostasis ; Parathyroid Hormone ; Water
-
109دورية أكاديمية
المؤلفون: Silva-Velasco DL; Departamento de Farmacobiología, Cinvestav-Coapa, Czda. de los Tenorios 235, Col. Granjas-Coapa, Alcaldía Tlalpan C.P. 14330, Mexico., Beltran-Ornelas JH; Departamento de Farmacobiología, Cinvestav-Coapa, Czda. de los Tenorios 235, Col. Granjas-Coapa, Alcaldía Tlalpan C.P. 14330, Mexico., Tapia-Martínez J; Departamento de Farmacobiología, Cinvestav-Coapa, Czda. de los Tenorios 235, Col. Granjas-Coapa, Alcaldía Tlalpan C.P. 14330, Mexico., Sánchez-López A; Departamento de Farmacobiología, Cinvestav-Coapa, Czda. de los Tenorios 235, Col. Granjas-Coapa, Alcaldía Tlalpan C.P. 14330, Mexico., de la Cruz SH; Departamento de Farmacobiología, Cinvestav-Coapa, Czda. de los Tenorios 235, Col. Granjas-Coapa, Alcaldía Tlalpan C.P. 14330, Mexico., Cervantes-Pérez LG; Departamento de Farmacología, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No.1, Col. Sección XVI, Alcaldía Tlalpan C.P. 14080, Mexico., Del Valle-Mondragón L; Departamento de Farmacología, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No.1, Col. Sección XVI, Alcaldía Tlalpan C.P. 14080, Mexico., Sánchez-Mendoza A; Departamento de Farmacología, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No.1, Col. Sección XVI, Alcaldía Tlalpan C.P. 14080, Mexico. Electronic address: alicia.sanchez@cardiologia.org.mx., Centurión D; Departamento de Farmacobiología, Cinvestav-Coapa, Czda. de los Tenorios 235, Col. Granjas-Coapa, Alcaldía Tlalpan C.P. 14330, Mexico. Electronic address: dcenturi@cinvestav.mx.
المصدر: Peptides [Peptides] 2023 Jun; Vol. 164, pp. 171001. Date of Electronic Publication: 2023 Mar 27.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: Elsevier Science Inc Country of Publication: United States NLM ID: 8008690 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5169 (Electronic) Linking ISSN: 01969781 NLM ISO Abbreviation: Peptides Subsets: MEDLINE
مواضيع طبية MeSH: Renin-Angiotensin System* , Hyperglycemia*/chemically induced , Hyperglycemia*/drug therapy , Hyperglycemia*/metabolism, Rats ; Male ; Animals ; Angiotensin II/metabolism ; Angiotensin-Converting Enzyme 2/metabolism ; Blood Glucose ; Streptozocin/pharmacology ; Rats, Wistar ; Peptidyl-Dipeptidase A/metabolism ; Angiotensin I/pharmacology
-
110دورية أكاديمية
المؤلفون: Wang YN; School of Pharmacy, Zhejiang Chinese Medical University, No. 548 Binwen Road, Hangzhou, Zhejiang 310053, China., Miao H; School of Pharmacy, Zhejiang Chinese Medical University, No. 548 Binwen Road, Hangzhou, Zhejiang 310053, China., Hua MR; School of Pharmacy, Zhejiang Chinese Medical University, No. 548 Binwen Road, Hangzhou, Zhejiang 310053, China., Yang JZ; Guangdong Nephrotic Drug Engineering Technology Research Center, Guangdong Consun Pharmaceutical Group, Institute of Consun Co. for Chinese Medicine in Kidney Diseases, No. 71 Dongpeng avenue, Guangzhou, Guangdong 510530, China., Pei M; Department of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, No. 88 Changling Road, Tianjin 300073, China., Yu HX; Department of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, No. 88 Changling Road, Tianjin 300073, China., Wei LJ; Department of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, No. 88 Changling Road, Tianjin 300073, China., Zou L; School of Food and Bioengineering, Chengdu University, No. 2025 Chengluo Avenue, Chengdu, Sichuan 610106, China., Zhang YM; Key disciplines of clinical pharmacy, Clinical Genetics Laboratory, Affiliated Hospital & Clinical Medical College of Chengdu University, No. 82 The Second Section of North 2nd Ring Road, Chengdu, Sichuan 610081, China., Cao G; School of Pharmacy, Zhejiang Chinese Medical University, No. 548 Binwen Road, Hangzhou, Zhejiang 310053, China. Electronic address: caogang33@163.com., Zhao YY; School of Pharmacy, Zhejiang Chinese Medical University, No. 548 Binwen Road, Hangzhou, Zhejiang 310053, China; Key disciplines of clinical pharmacy, Clinical Genetics Laboratory, Affiliated Hospital & Clinical Medical College of Chengdu University, No. 82 The Second Section of North 2nd Ring Road, Chengdu, Sichuan 610081, China. Electronic address: zhaoyybr@163.com.
المصدر: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2023 Jun; Vol. 114, pp. 154763. Date of Electronic Publication: 2023 Mar 15.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE
مواضيع طبية MeSH: Renin-Angiotensin System* , Glomerulonephritis, Membranous*, Rats ; Animals ; beta Catenin/metabolism ; Proteinuria ; Wnt Signaling Pathway