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1
المؤلفون: Brandi Soldo, Akshay Buch, John Janusz, Patrick Camilleri
المصدر: Xenobiotica. 51:1110-1121
مصطلحات موضوعية: Stereochemistry, Health, Toxicology and Mutagenesis, Metabolite, Acid Phosphatase, Diol, Toxicology, Biochemistry, Cytochrome P-450 CYP2C8, chemistry.chemical_compound, Tandem Mass Spectrometry, Thiolactone, Thiophene, Sulfamic acid, Humans, Pharmacology, chemistry.chemical_classification, Aniline Compounds, General Medicine, Oxidative Stress, Metabolic pathway, chemistry, Microsomes, Liver, Thiol, Microsome, Sulfonic Acids, Oxidation-Reduction, Chromatography, Liquid
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2
المؤلفون: Yaqin Jia, Yangliu Xia, Yuyi Feng, Zhen Wang, Lili Jiang, Jun Cao, Yong Liu, Zhe Wang, Xiaoyu Wang
المصدر: Toxicology Letters. 348:10-17
مصطلحات موضوعية: Male, 0301 basic medicine, Drug, media_common.quotation_subject, Glucuronidation, Pharmacology, Toxicology, digestive system, 03 medical and health sciences, 0302 clinical medicine, Non-competitive inhibition, In vivo, Humans, Drug Interactions, Osimertinib, Epidermal growth factor receptor, Glucuronosyltransferase, media_common, Acrylamides, Aniline Compounds, biology, Chemistry, General Medicine, In vitro, 030104 developmental biology, Microsomes, Liver, biology.protein, Microsome, 030217 neurology & neurosurgery
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3
المؤلفون: Gabriella Gobbi, Francesca Ferlenghi, Silvia Rivara, Gilberto Spadoni, Fabiola Fanini, Marco Mor, Federica Vacondio, Michele Mari, Gian Marco Elisi, Annalida Bedini, Silvia Bartolucci
المصدر: Chemmedchem
مصطلحات موضوعية: Male, Substituent, Ligands, Biochemistry, Rats, Sprague-Dawley, chemistry.chemical_compound, Amide, Acetamides, Drug Discovery, lipophilicity, melatonin receptors, Animals, Humans, General Pharmacology, Toxicology and Pharmaceutics, Solubility, drug-design, Pharmacology, Aniline Compounds, Aqueous solution, Full Paper, Molecular Structure, Receptor, Melatonin, MT2, Receptor, Melatonin, MT1, Organic Chemistry, Water, Full Papers, Combinatorial chemistry, Rats, Melatonergic, chemistry, Docking (molecular), Lipophilicity, Microsomes, Liver, Thermodynamics, Molecular Medicine, metabolism, pharmacokinetics, Acetamide
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4
المؤلفون: Du Jinfa, Youmei Peng, Yonggang Meng, Kaikai Zhu, Bin Yu, He Huang, Yongfang Yao, Junbiao Chang, Wenquan Yu, Ertong Li, Dongxu Yi, Kai Wang, Chuanjun Song
المصدر: Journal of Medicinal Chemistry. 64:925-937
مصطلحات موضوعية: Indoles, Lung Neoplasms, Metabolite, Phases of clinical research, Antineoplastic Agents, 01 natural sciences, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Dogs, In vivo, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Osimertinib, Epidermal growth factor receptor, Lung cancer, Cell Proliferation, 030304 developmental biology, Acrylamides, 0303 health sciences, Aniline Compounds, biology, Chemistry, Drug discovery, Cell growth, medicine.disease, Xenograft Model Antitumor Assays, Rats, 0104 chemical sciences, ErbB Receptors, 010404 medicinal & biomolecular chemistry, Pyrimidines, Mutation, Microsomes, Liver, Cancer research, biology.protein, Molecular Medicine, Signal Transduction
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5
المؤلفون: Huifen Chen, Matthew L. Landry, S. Cyrus Khojasteh, Shuguang Ma, Wendy B. Young, Chenghong Zhang, James J. Crawford, Jane R. Kenny, Wendy Lee
المصدر: Chemical Research in Toxicology. 33:1950-1959
مصطلحات موضوعية: Pyrimidine, Amine metabolism, 010501 environmental sciences, Toxicology, 01 natural sciences, Activation, Metabolic, Pyridazine, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Phenols, Pyridine, Humans, 030304 developmental biology, 0105 earth and related environmental sciences, 0303 health sciences, Aniline Compounds, Drug discovery, Aryl, General Medicine, Glutathione, Combinatorial chemistry, chemistry, Microsomes, Liver, Amine gas treating, Xenobiotic
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6
المؤلفون: Shengshuang Chen, Xiaolan Hu, Na Li, Yue Zhuo, Shilin Gong, Jian-Lin Wu, Xing-Xing Fan
المصدر: Chemical research in toxicology. 34(11)
مصطلحات موضوعية: Drug, Male, Metabolite, media_common.quotation_subject, Toxicology, Rats, Sprague-Dawley, chemistry.chemical_compound, Pharmacokinetics, In vivo, Tandem Mass Spectrometry, Animals, Chymotrypsin, Humans, Osimertinib, Cysteine, media_common, Acrylamides, Aniline Compounds, Molecular Structure, Hydrolysis, General Medicine, Small molecule, Rats, chemistry, Biochemistry, Liver, Covalent bond, Pharmacodynamics, Microsomes, Liver, Cattle, Female, Chromatography, Liquid
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7
المؤلفون: Weilin, Chen, Xin, Chen, Dongdong, Li, Jianrui, Zhou, Zhengyu, Jiang, Qidong, You, Xiaoke, Guo
المصدر: Journal of medicinal chemistry. 64(12)
مصطلحات موضوعية: Male, Mice, Inbred BALB C, Aniline Compounds, Leukemia, Molecular Structure, Intracellular Signaling Peptides and Proteins, Antineoplastic Agents, Histone-Lysine N-Methyltransferase, Xenograft Model Antitumor Assays, Molecular Docking Simulation, Rats, Sprague-Dawley, Structure-Activity Relationship, Pyrimidines, Drug Stability, Microsomes, Liver, Animals, Humans, Female, Myeloid-Lymphoid Leukemia Protein, Cell Proliferation, Protein Binding
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8
المؤلفون: Jeffry Adiwidjaja, Andrew J. McLachlan, Alan V. Boddy
المساهمون: Adiwidjaja, Jeffry, Boddy, Alan V, McLachlan, Andrew J
المصدر: Pharmaceutical Research. 37
مصطلحات موضوعية: Models, Molecular, Physiologically based pharmacokinetic modelling, Curcumin, Paclitaxel, Pharmaceutical Science, bosutinib, 02 engineering and technology, Pharmacology, Hydroxylation, Models, Biological, 030226 pharmacology & pharmacy, Cytochrome P-450 CYP2C8, 03 medical and health sciences, chemistry.chemical_compound, Glucuronides, 0302 clinical medicine, Pharmacokinetics, Tandem Mass Spectrometry, In vivo, Nitriles, medicine, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme Inhibitors, Humans, curcumin, Drug Interactions, Pharmacology (medical), Chromatography, High Pressure Liquid, natural product-drug interactions, Aniline Compounds, CYP3A4, Organic Chemistry, Imatinib, 021001 nanoscience & nanotechnology, Bioavailability, imatinib, chemistry, modelling and simulation, Imatinib Mesylate, Microsomes, Liver, Quinolines, Molecular Medicine, 0210 nano-technology, Bosutinib, Biotechnology, medicine.drug
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9
المؤلفون: Zhouyang Zhu, Hailey J. Knox, Tae Wook Kim, Jefferson Y. Chan
المصدر: ACS Chemical Biology. 13:1838-1843
مصطلحات موضوعية: Boron Compounds, Hemeproteins, 0301 basic medicine, Concentration dependence, Photoacoustic imaging in biomedicine, 010402 general chemistry, 01 natural sciences, Biochemistry, Photoacoustic Techniques, 03 medical and health sciences, Tissue heterogeneity, Cell Line, Tumor, Neoplasms, medicine, Animals, Image acquisition, Treatment resistance, Fluorescent Dyes, Mice, Inbred BALB C, Oxygen supply, Aniline Compounds, Tumor hypoxia, Chemistry, General Medicine, Hypoxia (medical), Molecular Imaging, Rats, 0104 chemical sciences, 030104 developmental biology, Microsomes, Liver, Tumor Hypoxia, Molecular Medicine, Female, medicine.symptom, Oxidation-Reduction, Biomedical engineering
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10
المؤلفون: John E. Macor, Benjamin M. Johnson, Richard E. Olson, Rex Denton, Michael K. Ahlijanian, Charles F. Albright, Yong-Jin Wu, Antonio Ramirez, Jeremy H. Toyn, Lorin A. Thompson, Xiaoliang Zhuo, Yunhui Zhang, Kenneth M. Boy
المصدر: Bioorganic & Medicinal Chemistry Letters. 30:127530
مصطلحات موضوعية: Pyrimidine, Metabolite, education, Clinical Biochemistry, Pharmaceutical Science, Alcohol, 01 natural sciences, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Drug Discovery, Animals, Humans, Molecular Biology, Gamma secretase, Aniline Compounds, Dose-Response Relationship, Drug, Molecular Structure, Bicyclic molecule, 010405 organic chemistry, digestive, oral, and skin physiology, Organic Chemistry, In vitro, Rats, 0104 chemical sciences, stomatognathic diseases, 010404 medicinal & biomolecular chemistry, Pyrimidines, chemistry, Microsomes, Liver, Microsome, Molecular Medicine, Amyloid Precursor Protein Secretases