نتائج البحث - "John Rickard"

الوصف: Conduction-system involvement in cardiac amyloidosis (CA) is common. The prevalence, clinical correlates and impact on outcome related to ventricular electrical dyssynchrony in CA remain insufficiently elucidated.Data from a prospectively maintained registry of patients with CA diagnosed in the Cleveland Clinic's amyloidosis clinic was used to determine the frequency of electrical dyssynchrony (defined as a QRS130 msec). The relation with the clinical profile and clinical outcome was assessed. To determine the impact of hypertrophy on QRS prolongation, a QRS-matched cohort without CA was used for comparison of cardiac magnetic resonance imaging.A total of 1140 patients with CA (39% AL, 61% TTR) were evaluated, of whom 230 (20%) had electrical dyssynchrony. The type of conduction block was predominantly a right bundle branch block (BBB, 48%) followed by left BBB (35%) and intraventricular conduction delay (17%). Presence of transthyretin amyloidosis (ATTR-CA), older age, male gender, white race, and coronary artery disease were independently (P0.05 for all) associated with electrical dyssynchrony, and patients were more commonly prescribed a mineralocorticoid receptor antagonist. In ATTR-CA, specifically, every increase in ATTR-CA disease stage was associated with a 1.55-fold (1.23--1.95; P0.001) increased odds for electrical dyssynchrony. In a subset of patients with CA who underwent cardiac magnetic resonance imaging (n = 41), left ventricular mass index was unrelated to the QRS duration (r = 0.187; P = 0.283) in CA, in contrast to a non-CA QRS-matched cohort (r = 0.397; P0.001). Patients with electrical dyssynchrony were more symptomatic at initial presentation, as illustrated by a higher New York Heart Association class (P= 0.041). During a median follow-up of 462 days (IQR:138--996 days), a higher proportion of patients with electrical dyssynchrony died from all-cause death (P= 0.037) or developed a permanent pacing indication (3% vs 10.4%; P0.001) during follow-up.Electrical dyssynchrony is common in CA, especially in ATTR-CA, and is associated with worse functional status and clinical outcome. Given the high rate of permanent pacing indications at follow-up, additional studies are necessary to determine the best monitoring and pacing strategies in CA.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fea5c2f6e889eb76e354b75c1b539a7c
https://doi.org/10.1016/j.cardfail.2022.07.046

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4

Impact of redo ablation for atrial fibrillation on patient‐reported outcomes and quality of life

المصدر: Journal of Cardiovascular Electrophysiology. 34:54-61

مصطلحات موضوعية: Physiology (medical), Cardiology and Cardiovascular Medicine

الوصف: Catheter ablation for atrial fibrillation (AF) is frequently used for the purpose of rhythm control and improved quality of life (QoL). Although success rates are high, a significant proportion of patients require redo ablation. Data are scarce on patient-centered outcomes and QoL in patients undergoing redo AF ablation. We aimed to assess QoL and clinical outcomes using a large prospectively maintained patient-reported outcomes (PRO) registry.All patients undergoing redo AF ablation (2013-2016) at our center were enrolled in a prospective registry for outcomes and assessed for QoL using automated PRO surveys (baseline, 3 and 6 months after ablation, every 6 months thereafter). Data were collected over 3 years of follow-up. The atrial fibrillation symptom severity scale (AFSSS) was used as the main measure for QoL. Additional variables included patient-reported improvement, AF burden, and AF-related healthcare utilization including emergency room (ER) visits and hospitalizations.A total of 848 patients were included (28% females, mean age 63.8, 51% persistent AF). By automated PRO, significant improvement in QoL was noted (baseline median AFSSS of 12 [5-18] and ranged between 2 and 4 on subsequent assessments; p .0001), with ≥70%of patients reported remarkable improvement in their AF-related symptoms. The proportion of patients in AF at the time of baseline survey was 36%, and this decreased to8% across all time points during follow-up (p .0001). AF burden was significantly reduced (including frequency and duration of episodes; p .0001), with an associated decrease in healthcare utilization after 6 months from the time of ablation (including ER visits and hospitalizations; p .0001). The proportion of patients on anticoagulants or antiarrhythmics decreased on follow-up across all time points (p .0001 for all variables).Most patients derive significant QoL benefit from redo AF ablation; with reduction of both AF burden and healthcare utilization.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c87d87fd6f466135c926f18cd2a6f304
https://doi.org/10.1111/jce.15710

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5

2023 HRS / APHRS / LAHRS guideline on cardiac physiologic pacing for the avoidance and mitigation of heart failure

المؤلفون: Mina K. Chung, Kristen K. Patton, Chu‐Pak Lau, Alexander R. J. Dal Forno, Sana M. Al‐Khatib, Vanita Arora, Ulrika Maria Birgersdotter‐Green, Yong‐Mei Cha, Eugene H. Chung, Edmond M. Cronin, Anne B. Curtis, Iwona Cygankiewicz, Gopi Dandamudi, Anne M. Dubin, Douglas P. Ensch, Taya V. Glotzer, Michael R. Gold, Zachary D. Goldberger, Rakesh Gopinathannair, Eiran Z. Gorodeski, Alejandra Gutierrez, Juan C. Guzman, Weijian Huang, Peter B. Imrey, Julia H. Indik, Saima Karim, Peter P. Karpawich, Yaariv Khaykin, Erich L. Kiehl, Jordana Kron, Valentina Kutyifa, Mark S. Link, Joseph E. Marine, Wilfried Mullens, Seung‐Jung Park, Ratika Parkash, Manuel F. Patete, Rajeev Kumar Pathak, Carlos A. Perona, John Rickard, Mark H. Schoenfeld, Swee‐Chong Seow, Win‐Kuang Shen, Morio Shoda, Jagmeet P. Singh, David J. Slotwiner, Arun Raghav M. Sridhar, Uma N. Srivatsa, Eric C. Stecker, Tanyanan Tanawuttiwat, W. H. Wilson Tang, Carlos Andres Tapias, Cynthia M. Tracy, Gaurav A. Upadhyay, Niraj Varma, Kevin Vernooy, Pugazhendhi Vijayaraman, Sarah Ann Worsnick, Wojciech Zareba, Emily P. Zeitler

المصدر: Journal of Arrhythmia.

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::fc6a04cfd9982a27372d65ba420317e6
https://doi.org/10.1002/joa3.12872

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6

Atrial Fibrillation Ablation in Young Adults: Measuring Quality of Life Using Patient-Reported Outcomes Over 5 Years

المؤلفون: Brett M. Johnson, Oussama M. Wazni, Medhat Farwati, Walid I. Saliba, Pasquale Santangeli, Ruth Madden, Patricia Bouscher, Mina Chung, Mohamed Kanj, Thomas J. Dresing, Thomas D. Callahan, Mandeep Bhargava, Bryan Baranowski, John Rickard, Daniel J. Cantillon, Patrick J. Tchou, Jakub Sroubek, Hiroshi Nakagawa, Ayman A. Hussein

المصدر: Circulation: Arrhythmia and Electrophysiology.

مصطلحات موضوعية: Physiology (medical), Cardiology and Cardiovascular Medicine

الوصف: BACKGROUND: Ablation is used for both rhythm control and improved quality of life (QoL) in atrial fibrillation (AF). It has been suggested that young adults may experience high recurrence rates after ablation and data remain lacking regarding QoL benefits. We aimed to investigate AF ablation outcomes and QoL benefits in young adults undergoing AF ablation using a large prospectively maintained registry and automated patient-reported outcomes (PRO). METHODS: All patients undergoing AF ablation (2013–2016) at our center were prospectively enrolled. Patients aged 50 years or younger were included. For PROs, QoL measures and symptoms were assessed at baseline, 3 months after ablation, and every 6 months thereafter. The AF severity score served as the main assessment of QoL. RESULTS: A total of 241 young adults (age, 16–50 years) were included (17% female, 40.3% persistent AF). In all, 77.2% of patients remained arrhythmia-free during the first year of follow-up (80% in nonstructural AF and 66% in structural AF). Using PROs, 90% of patients reported improvement in QoL throughout all survey time points up to 5 years postablation ( P P P CONCLUSIONS: Ablation remains an effective rhythm-control strategy in young adults with AF. Young adults also experience significant improvement in QoL with reduction of the frequency and duration of AF episodes and AF-related healthcare utilization.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7f86c8bcd9b8d5b2ac4836d8be6b0cfd
https://doi.org/10.1161/circep.122.011565

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2023 HRS/APHRS/LAHRS guideline on cardiac physiologic pacing for the avoidance and mitigation of heart failure

المؤلفون: Mina K. Chung, Kristen K. Patton, Chu-Pak Lau, Alexander R.J. Dal Forno, Sana M. Al-Khatib, Vanita Arora, Ulrika Maria Birgersdotter-Green, Yong-Mei Cha, Eugene H. Chung, Edmond M. Cronin, Anne B. Curtis, Iwona Cygankiewicz, Gopi Dandamudi, Anne M. Dubin, Douglas P. Ensch, Taya V. Glotzer, Michael R. Gold, Zachary D. Goldberger, Rakesh Gopinathannair, Eiran Z. Gorodeski, Alejandra Gutierrez, Juan C. Guzman, Weijian Huang, Peter B. Imrey, Julia H. Indik, Saima Karim, Peter P. Karpawich, Yaariv Khaykin, Erich L. Kiehl, Jordana Kron, Valentina Kutyifa, Mark S. Link, Joseph E. Marine, Wilfried Mullens, Seung-Jung Park, Ratika Parkash, Manuel F. Patete, Rajeev Kumar Pathak, Carlos A. Perona, John Rickard, Mark H. Schoenfeld, Swee-Chong Seow, Win-Kuang Shen, Morio Shoda, Jagmeet P. Singh, David J. Slotwiner, Arun Raghav M. Sridhar, Uma N. Srivatsa, Eric C. Stecker, Tanyanan Tanawuttiwat, W.H. Wilson Tang, Carlos Andres Tapias, Cynthia M. Tracy, Gaurav A. Upadhyay, Niraj Varma, Kevin Vernooy, Pugazhendhi Vijayaraman, Sarah Ann Worsnick, Wojciech Zareba, Emily P. Zeitler

المصدر: Heart Rhythm.

مصطلحات موضوعية: Physiology (medical), Cardiology and Cardiovascular Medicine

الوصف: Cardiac physiologic pacing (CPP), encompassing cardiac resynchronization therapy (CRT) and conduction system pacing (CSP), has emerged as a pacing therapy strategy that may mitigate or prevent the development of heart failure (HF) in patients with ventricular dyssynchrony or pacing-induced cardiomyopathy. This clinical practice guideline is intended to provide guidance on indications for CRT for HF therapy and CPP in patients with pacemaker indications or HF, patient selection, pre-procedure evaluation and preparation, implant procedure management, follow-up evaluation and optimization of CPP response, and use in pediatric populations. Gaps in knowledge, pointing to new directions for future research, are also identified.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de1481cf4f7160c465c015ade41d8255
https://doi.org/10.1016/j.hrthm.2023.03.1538

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8

LB-456640-3 FIRST-IN-MAN EXPERIENCE WITH THE IMPELLA 5.0/5.5 HEMODYNAMIC SUPPORT DEVICE FOR HIGH-RISK PATIENTS WITH ADVANCED HEART FAILURE UNDERGOING VT ABLATION

المؤلفون: Jakub Sroubek, Ramya Vajapey, Joseph Sipko, Edward Soltesz, Aaron Weiss, Elad Anter, Thomas D. Callahan, Thomas J. Dresing, Ayman A. Hussein, Mohamed Kanj, John Rickard, Walid I. Saliba, Oussama M. Wazni, Pasquale Santangeli

المصدر: Heart Rhythm.

مصطلحات موضوعية: Physiology (medical), Cardiology and Cardiovascular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a4c7e98cbd7477622c535c158c5de0bb
https://doi.org/10.1016/j.hrthm.2023.04.050

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9

Predictors and outcome of electrical storm–induced cardiogenic shock

المؤلفون: Cameron Incognito, Pieter Martens, Jeffrey Hedley, Joshua D Parker, Kristine Posadas, Shravani Gangidi, Oussama Wazni, Venu Menon, John Rickard, Ayman Hussein, Wai Hong Wilson Tang

المصدر: European Heart Journal. Acute Cardiovascular Care. 11:906-915

مصطلحات موضوعية: General Medicine, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine

الوصف: Aim Limited information is available about the short- and long-term outcomes in electrical storm (ES)-induced cardiogenic shock (CS) and its predictors. Methods and results This is a retrospective, single-centre cohort study of consecutive patients with ES admitted to the Cardiac Intensive Care Unit between 2015 and 2020. The proportion of ES patients who developed CS was adjudicated, and clinical predictors of in-hospital ventricular arrhythmia (VA)-related mortality and 1-year all-cause mortality were investigated. Of the 214 patients with ES, 33.6% developed CS. Left-ventricular ejection fraction, admission lactate, absence of an implantable cardioverter defibrillator, and admission central venous pressure were independently associated with development of CS (P < 0.03 for all). Based on these variables, a FLIC score was developed (https://riskcalc.org/FLICscore/) to predict ES-induced CS [area under the curve (AUC) = 0.949, with AUC = 0.954 in a validation cohort, both P < 0.001]. Patients who developed CS had a 11.3-fold [95% confidence interval (CI) 2.7–12.8] increased odds for in-hospital VA-related mortality and 9.4-fold (95% CI 4.0–22.4) increased odds for in-hospital all-cause mortality. A FLIC score above 0.62 was associated with a 6.2- and 5.8-fold increased odds for respectively similar endpoints. Patients with ES-induced CS received more treatment modalities to manage the ES (4.5 ± 1.8 vs. 2.3 ± 1.2, P < 0.001) and had longer length of stay [14 (8–27) vs. 8 (5–13), P < 0.001] than patients without CS. Interestingly, if patients with ES-induced CS survived to discharge, their outcomes were similar to those without CS at 1 year. Conclusion Cardiogenic shock in ES is a frequent and potentially life-threatening complication with high short-term mortality. A novel risk score could identify patient at risk, generating a potential for early risk-based interventions.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a9718f98228ebe301fa573ea3cb9265
https://doi.org/10.1093/ehjacc/zuac121

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Acute pericarditis after atrial fibrillation ablation: Incidence, characteristics, and risk factors

المؤلفون: Shady, Nakhla, Amgad, Mentias, Christopher, Rymer, Ayman, Hussein, Oussama, Wazni, John, Rickard, Bryan, Baranowski, Daniel, Cantillon, Allan L, Klein, Paul C, Cremer, Tyler L, Taigen

المصدر: Heart Rhythm O2. 3:248-251

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الوصف: Little is known about the incidence and risk factors for the development of acute pericarditis after ablation for atrial fibrillation (AF).The purpose of this retrospective cohort study was to describe the occurrence of and associations with suspected acute pericarditis after AF ablation.All patients undergoing AF ablation in our center were enrolled in a prospectively maintained registry. Suspected acute pericarditis was defined as pericardial chest pain treated with disease specific anti-inflammatories within 3 months of AF ablation.Among 2215 patients with AF ablations between January 1, 2018, and December 31, 2019, 226 (10.2%) had suspected acute pericarditis. Treatments included colchicine in 149 patients (65.9%), prednisone in 66 (29.2%), and high-dose ibuprofen in 43 (19.0%). Multiple anti-inflammatory therapies were used in 57 patients (25%). At baseline, a lower CHADSSuspected acute pericarditis is common after AF ablation and is associated with a younger age. Systematic assessments for acute pericarditis after AF ablation should be considered.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce4cd31de6a8cc69440160da00645b4
https://doi.org/10.1016/j.hroo.2022.02.008

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