-
1
المؤلفون: Julie E Harvey, Christabel Owens, Deborah Duncan, Alyson Dodd, Rod S Taylor, Alexandra Newbold, Thomas R. Lynch, Shelley Norman, Faith Warner, Kim Wright, Mahmood Javaid, Barnaby D. Dunn, Steven Jones, Antonieta Medina-Lara, Fiona C Warren
المصدر: International Journal of Bipolar Disorders, Vol 9, Iss 1, Pp 1-13 (2021)
International Journal of Bipolar Disordersمصطلحات موضوعية: Neurophysiology and neuropsychology, medicine.medical_specialty, Cost effectiveness, Bipolar disorder, medicine.medical_treatment, Mood swing, Population, Neurosciences. Biological psychiatry. Neuropsychiatry, Dialectical behavior therapy, Clinical endpoint, medicine, education, Biological Psychiatry, education.field_of_study, business.industry, Minimal clinically important difference, Research, QP351-495, medicine.disease, C800, B900, Psychiatry and Mental health, Mood, Physical therapy, medicine.symptom, business, RC321-571
الوصف: BackgroundA subgroup of those with bipolar spectrum disorders experience ongoing mood fluctuations outside of full episodes. We conducted a randomised, controlled feasibility study of a Dialectical Behavioural Therapy-informed approach for bipolar mood fluctuations (Therapy for Inter-episode mood Variability in Bipolar [ThrIVe-B]). Our study aimed to examine the feasibility and acceptability of a future definitive trial evaluating the clinical and cost effectiveness of the ThrIVe-B programme. Participants were required to meet diagnostic criteria for a bipolar spectrum disorder and report frequent mood swings outside of acute episodes. They were randomised to treatment as usual (control arm) or the ThrIVe-B intervention plus treatment as usual (intervention arm). Follow-up points were at 3, 6, 9 and 15 months after baseline, with 9 months as the primary end point. To evaluate feasibility and acceptability we examined recruitment and retention rates, completion rates for study measures, adverse events and feedback from participants on their experience of study participation and therapy.ResultsOf the target 48 participants, 43 were recruited (22 in the intervention arm; 21 in the control arm), with a recruitment rate of 3.9 participants per month. At 9 months 74% of participants engaged in research follow-up assessment, exceeding the pre-specified criterion of 60%. There were no serious concerns about the safety of the research procedures or the intervention. On one of the four candidate primary outcome measures, the 95% CI for the between-group mean difference score excluded the null effect and included the minimal clinically important difference, favouring the intervention arm, whilst on no measure was there evidence of deterioration in the intervention arm relative to the control arm. Attendance of the intervention (50% attending at least half of the mandatory sessions) was below the pre-specified continuation criterion of 60%, and qualitative feedback from participants indicated areas that may have hampered or facilitated engagement.ConclusionsIt is broadly feasible to conduct a trial of this design within the population of people with frequent bipolar mood swings. Changes should be made to the therapy to increase uptake, such as simplifying content and considering individual rather than group delivery.Trial registrationISRCTN: ISRCTN54234300. Registered 14th July 2017,http://www.isrctn.com/ISRCTN54234300
وصف الملف: application/pdf
-
2
المؤلفون: Mohammod Mostazir, Thomas R. Lynch, Mahmood Javaid, Kim Wright, Gemma Palmer
المصدر: Pilot and Feasibility Studies, Vol 6, Iss 1, Pp 1-12 (2020)
Pilot and Feasibility Studiesمصطلحات موضوعية: medicine.medical_specialty, lcsh:R5-920, Mood instability, business.industry, Bipolar disorder, Research, Dialectical behaviour therapy, Medicine (miscellaneous), Psychological therapy, Cyclothymic disorder, medicine.disease, 030227 psychiatry, 03 medical and health sciences, Skills training, 0302 clinical medicine, Mood, Intervention (counseling), medicine, Physical therapy, Spectrum disorder, business, lcsh:Medicine (General), 030217 neurology & neurosurgery
الوصف: Background We sought to evaluate the acceptability of a psychological therapy programme (Therapy for Inter-episode Mood Variability in Bipolar Disorder (ThrIVe-B)) for individuals with ongoing bipolar mood instability and the feasibility and acceptability of potential trial procedures. We also evaluated the performance of clinical and process outcome measures and the extent to which the programme potentially represents a safe and effective intervention. Method We conducted an open (uncontrolled) trial in which 12 individuals with a bipolar spectrum diagnosis commenced the ThrIVe-B programme after completing baseline assessments. The programme comprised 16 group skills training sessions plus individual sessions and a supporting smartphone application. Follow-up assessments were at therapy end-point and 6 months post-treatment. Results Nine participants completed treatment. Ten provided end-of-treatment data; of these, nine were satisfied with treatment. Interviews with participants and clinicians indicated that the treatment was broadly feasible and acceptable, with suggestions for improvements to content, delivery and study procedures. Exploration of change in symptoms was consistent with the potential for the intervention to represent a safe and effective intervention. Conclusions Conducting further evaluation of this approach in similar settings is likely to be feasible, whilst patient reports and the pattern of clinical change observed suggest this approach holds promise for this patient group. Future research should include more than one study site and a comparison arm to address additional uncertainties prior to a definitive trial. Trial registration Trial Registration: ClinicalTrials.gov NCT02637401; registered 22.12.15 (retrospectively registered).
-
3
المؤلفون: Robert T. Jones, Andrew Goodspeed, Saswat Mohapatra, Lily Elizabeth Feldman, Mathijs Scholtes, Hedvig Vekony, Annie Jean, Charlene B. Tilton, Michael V. Orman, Cailin Deiter, Nathaniel Xander, Stephanie Araki, Molishree Joshi, Mahmood Javaid, Eric T. Clambey, Ryan Layer, Teemu D. Laajala, Sarah Parker, Tahlita Zuiverloon, Dan Theodorescu, James C. Costello
مصطلحات موضوعية: Cisplatin, medicine.anatomical_structure, Chemistry, In vivo, Protein subunit, Organoid, Cancer research, medicine, Sensitization, In vitro, Function (biology), Intracellular, medicine.drug
الوصف: Despite routine platinum-based chemotherapeutic use in cancer treatment, there remains a need to improve efficacy and patient selection. Using multi-omic assessment of cisplatin responsive and resistant human bladder cancer cell lines and whole-genome CRISPR screens, we identified NPEPPS, the puromycin-sensitive aminopeptidase as a novel driver of cisplatin resistance. Volume-regulated anion channels (VRACs) have been shown to directly import the majority of intracellular cisplatin. Here, we show that the mechanism of NPEPPS-mediated cisplatin resistance is by binding to VRACs and blocking the import of cisplatin into the cell. We show that NPEPPS depletion increased intracellular cisplatin and made cisplatin-resistant cells more responsive to cisplatin in vitro and in vivo. Overexpression of NPEPPS in cisplatin-sensitive cells decreased intracellular cisplatin and resulted in increased treatment resistance. The same results also hold for carboplatin. Our findings describe the first mechanism by which VRACs can be targeted to control the import of cisplatin and carboplatin.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::83a8758e02f98a7d486b5a2a7802c45e
https://doi.org/10.1101/2021.03.04.433676 -
4
المؤلفون: Barnaby D. Dunn, Tamsin Ford, Mahmood Javaid, Merve Yilmaz, Lamprini Psychogiou
المصدر: Behaviour research and therapy. 122
مصطلحات موضوعية: Male, 050103 clinical psychology, Adolescent, media_common.quotation_subject, Happiness, Experimental and Cognitive Psychology, Neuropsychological Tests, Task (project management), Developmental psychology, 03 medical and health sciences, 0302 clinical medicine, Blunt, Intervention (counseling), mental disorders, Sadness, medicine, Humans, 0501 psychology and cognitive sciences, media_common, Recall, 05 social sciences, Anhedonia, Psychiatry and Mental health, Clinical Psychology, Affect, Mental Recall, Female, medicine.symptom, Psychology, psychological phenomena and processes, 030217 neurology & neurosurgery, Positive recall
الوصف: Previous work has shown that dampening appraisals (e.g., thinking "this is too good to last") reduce happiness and enhance sadness when adults recall positive events. In contrast, amplifying appraisals (e.g., thinking "this is the sign of good things to come") do not significantly alter affective experience during the same task. The present study examined whether this pattern holds in adolescence. Eighty-nine adolescents completed an uninstructed positive recall task before being randomized to either dampening, uninstructed control or amplifying instructions during a second positive recall task. Participants experienced a significantly smaller increase in happiness and a significantly less marked reduction in sadness when recalling a positive memory under dampening instructions, relative to both the amplifying and no instruction control conditions. There was no significant difference between the amplifying and control conditions. This broadly replicates adult findings, but the detrimental effects of dampening were less marked in adolescents than adults. Nevertheless, given that elevated dampening appraisals are associated with depressed mood, dampening may partly account for why depressed adolescents struggle to experience positive emotions, and represent a promising target for clinical intervention.
-
5
المؤلفون: Magid Eltayeb, Shah Jehan, Mohammad Muddassir Mahmood Javaid
المصدر: Clinics in Orthopedic Surgery
مصطلحات موضوعية: Reverse, Adult, Male, Reoperation, medicine.medical_specialty, Shoulder, medicine.medical_treatment, Deltoid curve, Replacement, Young Adult, Postoperative Complications, Arthropathy, Medicine, Humans, Orthopedics and Sports Medicine, Rotator cuff, Arthroplasty, Replacement, Aged, Retrospective Studies, Aged, 80 and over, Polarity, business.industry, Shoulder Joint, Retrospective cohort study, Middle Aged, medicine.disease, Surgery, Pulmonary embolism, medicine.anatomical_structure, Delta, Shoulder joint, Original Article, Female, business, Complication, Shoulder replacement, Follow-Up Studies
الوصف: Background The delta reverse shoulder replacement system was developed for the treatment of rotator cuff arthropathy so that the deltoid can substitute for the deficient rotator cuff. To evaluate the results of delta reverse shoulder replacement for functional improvement and complications in a consecutive series by a single surgeon over a period of six years with a minimum follow-up of 2 years. Methods The data were collected retrospectively from electronic theatre records. Over a period of 6 years (2006-2012), 46 cases that fulfilled the inclusion criteria were identified. There were 34 females and 12 males. The average age of patients was 76.2 years (range, 58 to 87 years). A single surgeon performed all procedures using the anterosuperior approach. The mean follow-up time was 49 months (range, 24 to 91 months). All cases had preoperative and postoperative Constant scores. We collected the data on indications, hospital stay, and change in the Constant score, complications, and reoperation rates. Results The main indication for surgery was rotator cuff arthropathy (52.2%), followed by massive rotator cuff tear (28.3%), osteoarthritis (8.7%), fractures (6.5%), and rheumatoid arthritis (4.3%). Also, 65.2% of the cases were referred by general practitioners, 26% of the cases were referred by other consultants, and 8.8% of the cases were already under the care of a shoulder surgeon. The average preoperative Constant score was 23.5 (range, 8 to 59). The average Constant score at the final follow-up was 56 (range, 22 to 83). On average, there was an improvement of 33 points in the Constant score. The improvement in the Constant score was significant (p < 0.001). We observed complications in four patients (8.6%). Three of four patients (6.5%) needed reoperation. The first complication was pulmonary embolism in the early postoperative period. The other complications included dissociation of the glenosphere from the metaglene, deltoid detachment, and stitch abscess. Conclusions This is a single-surgeon, single-approach series of 46 cases with a minimum follow-up of 2 years. At this stage, the results are encouraging with no cases of loosening, dislocation, or nerve injury.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f77cc777c5b0a4c9bd2f43c6bcb54e
http://europepmc.org/articles/PMC4553285 -
6
المؤلفون: Christabel Owens, Mahmood Javaid, Thomas R. Lynch, Julie E Harvey, Antonieta Medina-Lara, Alexandra Newbold, Alyson Dodd, Rod S Taylor, Barney Dunn, Fiona C Warren, Kim Wright, Steven Jones
المصدر: Trials
Trials, Vol 19, Iss 1, Pp 1-11 (2018)مصطلحات موضوعية: medicine.medical_specialty, Bipolar Disorder, Time Factors, Cost effectiveness, Mood swing, Cost-Benefit Analysis, Psychological intervention, Medicine (miscellaneous), Dialectical Behavior Therapy, 03 medical and health sciences, Study Protocol, 0302 clinical medicine, Clinical Trials, Phase II as Topic, Intervention (counseling), Clinical endpoint, Medicine, Humans, Multicenter Studies as Topic, Pharmacology (medical), Spectrum disorder, Bipolar disorder, Randomized Controlled Trials as Topic, lcsh:R5-920, Primary Health Care, business.industry, Cyclothymic disorder, Health Care Costs, medicine.disease, United Kingdom, C800, 030227 psychiatry, Affect, Mood, Treatment Outcome, Dialectical behaviour therapy, Physical therapy, Psychological therapy, Feasibility Studies, medicine.symptom, lcsh:Medicine (General), business, 030217 neurology & neurosurgery
الوصف: Background In bipolar spectrum disorder, some individuals experience ongoing, frequent fluctuations in mood outside of affective episodes. There are currently no evidence-based psychological interventions designed to address this. This feasibility study is a phase II evaluation of a dialectical behavioural therapy-informed approach (Therapy for Inter-episode mood Variability in Bipolar [ThrIVe-B]). It seeks to examine the feasibility and acceptability of a future definitive trial evaluating the clinical and cost effectiveness of the ThrIVe-B programme. Methods/design Patients will be randomised 1:1 to either treatment as usual only (control arm) or the ThrIVe-B intervention plus treatment as usual (intervention arm). Follow-up points will be at 3, 6, 9 and 15 months after baseline, with 9 months as the primary end point for the candidate primary outcome measures. We aim to recruit 48 individuals meeting diagnostic criteria for a bipolar spectrum disorder and reporting frequent mood swings outside of acute episodes, through primary and secondary care services and self-referral. To evaluate feasibility and acceptability, we will examine recruitment and retention rates, completion rates for study measures and feedback from participants on their experience of study participation and therapy. Discussion Proceeding to a definitive trial will be indicated if the following criteria are met: (1) trial participation does not lead to serious negative consequences for our participants; (2) any serious concerns about the acceptability and feasibility of the trial procedures can be rectified prior to a definitive trial; (3) follow-up data at 9 months are available for at least 60% of participants; (4) at least 60% of patients in the ThrIVe-B arm complete treatment. Trial registration ISRCTN, ISRCTN54234300. Registered on 20 July 2017. Electronic supplementary material The online version of this article (10.1186/s13063-018-2926-7) contains supplementary material, which is available to authorized users.
وصف الملف: application/pdf
-
7
المصدر: Appetite. 130:309
مصطلحات موضوعية: 0301 basic medicine, 03 medical and health sciences, 030109 nutrition & dietetics, Nutrition and Dietetics, Snacking, business.industry, Applied psychology, Training (meteorology), Medicine, business, General Psychology, Response inhibition
-
8
المؤلفون: Natalia S, Lawrence, Jamie, O'Sullivan, David, Parslow, Mahmood, Javaid, Rachel C, Adams, Christopher D, Chambers, Katarina, Kos, Frederick, Verbruggen
المصدر: Appetite
مصطلحات موضوعية: Adult, Male, Research Report, Weight loss, digestive, oral, and skin physiology, Food liking, Feeding Behavior, Middle Aged, Overweight, Disinhibition, Diet Records, Food Preferences, Inhibition, Psychological, Young Adult, Double-Blind Method, Behavior Therapy, Cognitive training, Response inhibition, Humans, Female, Energy intake, Obesity, Snacks, Aged
الوصف: The majority of adults in the UK and US are overweight or obese due to multiple factors including excess energy intake. Training people to inhibit simple motor responses (key presses) to high-energy density food pictures reduces intake in laboratory studies. We examined whether online response inhibition training reduced real-world food consumption and weight in a community sample of adults who were predominantly overweight or obese (N = 83). Participants were allocated in a randomised, double-blind design to receive four 10-min sessions of either active or control go/no-go training in which either high-energy density snack foods (active) or non-food stimuli (control) were associated with no-go signals. Participants' weight, energy intake (calculated from 24-h food diaries), daily snacking frequency and subjective food evaluations were measured for one week pre- and post-intervention. Participants also provided self-reported weight and monthly snacking frequency at pre-intervention screening, and one month and six months after completing the study. Participants in the active relative to control condition showed significant weight loss, reductions in daily energy intake and a reduction in rated liking of high-energy density (no-go) foods from the pre-to post-intervention week. There were no changes in self-reported daily snacking frequency. At longer-term follow-up, the active group showed significant reductions in self-reported weight at six months, whilst both groups reported significantly less snacking at one- and six-months. Excellent rates of adherence (97%) and positive feedback about the training suggest that this intervention is acceptable and has the potential to improve public health by reducing energy intake and overweight.
Graphical abstract
Highlights • We examine whether response inhibition training alters real-world eating behaviour. • Food no-go training (active) reduces energy intake, weight and food liking. • Non-food no-go training (control) has no effect pre-to post-intervention. • Both groups show reduced snacking at one and six-month follow-ups. • Active training is associated with self-reported weight loss at six-months. -
9
المؤلفون: Frederick Verbruggen, Natalia Lawrence, Lucy Porter, Mahmood Javaid
المصدر: Appetite. 107:689
مصطلحات موضوعية: 03 medical and health sciences, 0302 clinical medicine, Nutrition and Dietetics, 030225 pediatrics, media_common.quotation_subject, 030212 general & internal medicine, Child obesity, Temptation, Psychology, General Psychology, Clinical psychology, media_common
-
10
المؤلفون: Tony J. Prescott, Mathew H. Evans, Tom Stafford, Craig Bertram, Mahmood Javaid
المصدر: Biomimetic and Biohybrid Systems ISBN: 9783642398018
Living Machinesمصطلحات موضوعية: InformationSystems_INFORMATIONINTERFACESANDPRESENTATION(e.g.,HCI), business.industry, Computer science, Active sensing, Sensory system, Somatosensory system, Accelerometer, Haptic display, Arduino, Computer vision, Artificial intelligence, Human operator, business, Tactile sensor
الوصف: The Tactile Helmet is designed to augment a wearer's senses with a long range sense of touch. Tactile specialist animals such as rats and mice are capable of rapidly acquiring detailed information about their environment from their whiskers by using task-sensitive strategies. Providing similar information about the nearby environment, in tactile form, to a human operator could prove invaluable for search and rescue operations, or for partially-sighted people. Two key aspects of the Tactile Helmet are sensory augmentation, and active sensing. A haptic display is used to provide the user with ultrasonic range information. This can be interpreted in addition to, rather than instead of, visual or auditory information. Active sensing systems "are purposive and information-seeking sensory systems, involving task specific control of the sensory apparatus" [1]. The integration of an accelerometer allows the device to actively gate the delivery of sensory information to the user, depending on their movement. Here we describe the hardware, sensory transduction and characterisation of the Tactile Helmet device, before outlining potential use cases and benefits of the system.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5fcb3a440fd84a8fb34b6d69780b9508
https://doi.org/10.1007/978-3-642-39802-5_3
إعادة تعيين المنقحات
عرض المنقحات (%%عد%%)
Find this article in full text from Springer Verlag.