المؤلفون: Strizich, Garrett, Gammon, Marilie D, Jacobson, Judith S, Wall, Melanie, Abrahamson, Page, Bradshaw, Patrick T, Terry, Mary Beth, Teitelbaum, Susan, Neugut, Alfred I, Greenlee, Heather

المصدر: BMC Complementary Medicine and Therapies. 15(1)

مصطلحات موضوعية: Health Sciences, Traditional, Complementary and Integrative Medicine, Cancer, Clinical Trials and Supportive Activities, Mind and Body, Prevention, Nutrition, Breast Cancer, Complementary and Integrative Health, Clinical Research, Adult, Age Factors, Aged, Breast Neoplasms, Complementary Therapies, Dietary Supplements, Educational Status, Female, Humans, Middle Aged, Mind-Body Therapies, New York, Patients, Reproducibility of Results, Treatment Outcome, Alternative medicine, Breast cancer, Latent class analysis, Epidemiology, Complementary and Alternative Medicine, Complementary & Alternative Medicine, Traditional, complementary and integrative medicine

الوصف: BackgroundBreast cancer patients commonly report using >1 form of complementary and alternative medicine (CAM). However, few studies have attempted to analyze predictors and outcomes of multiple CAM modalities. We sought to group breast cancer patients by clusters of type and intensity of complementary and alternative medicine (CAM) use following diagnosis.MethodsDetailed CAM use following breast cancer diagnosis was assessed in 2002-2003 among 764 female residents of Long Island, New York diagnosed with breast cancer in 1996-1997. Latent class analysis (LCA) was applied to CAM modalities while taking into account frequency and intensities.ResultsFour distinct latent classes of CAM use emerged: 1) "Low-dose supplement users" (40%), who used only common nutritional supplements; 2) "Vitamin/mineral supplement users" (39%), using an abundance of supplements in addition to other practices; 3) "Mind-body medicine users" (12%), with near-universal use of supplements, mind-body medicine techniques, and massage; and 4) "Multi-modality high-dose users" (9%), who were highly likely to use nearly all types of CAM. Predictors of membership in classes with substantial CAM use included younger age, more education, higher income, Jewish religion, ideal body mass index, higher fruit and vegetable intake, higher levels of physical activity, receipt of adjuvant chemotherapy, and prior use of oral contraceptives.ConclusionsLCA identified important subgroups of breast cancer patients characterized by varying degrees of complementary therapy use. Further research should explore the reproducibility of these classes and investigate the association between latent class membership and breast cancer outcomes.

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URL الوصول: https://escholarship.org/uc/item/4cm127fs

المؤلفون: McDermott, Kelly A, Rao, Mohan Raghavendra, Nagarathna, Raghuram, Murphy, Elizabeth J, Burke, Adam, Nagendra, Ramarao Hongasandra, Hecht, Frederick M

المصدر: BMC Complementary Medicine and Therapies. 14(1)

مصطلحات موضوعية: Health Sciences, Traditional, Complementary and Integrative Medicine, Diabetes, Behavioral and Social Science, Depression, Clinical Trials and Supportive Activities, Prevention, Mental Health, Complementary and Integrative Health, Nutrition, Obesity, Clinical Research, Mind and Body, 3.1 Primary prevention interventions to modify behaviours or promote wellbeing, Prevention of disease and conditions, and promotion of well-being, Metabolic and endocrine, Good Health and Well Being, Adult, Blood Glucose, Blood Pressure, Body Weight, Diabetes Mellitus, Type 2, Female, Humans, India, Insulin, Male, Middle Aged, Pilot Projects, Postprandial Period, Risk Reduction Behavior, Treatment Outcome, Yoga, Prediabetes, Type 2 diabetes, Randomized controlled pilot, Complementary and Alternative Medicine, Complementary & Alternative Medicine, Traditional, complementary and integrative medicine

الوصف: BackgroundType 2 diabetes is a major health problem in many countries including India. Yoga may be an effective type 2 diabetes prevention strategy in India, particularly given its cultural familiarity.MethodsThis was a parallel, randomized controlled pilot study to collect feasibility and preliminary efficacy data on yoga for diabetes risk factors among people at high risk of diabetes. Primary outcomes included: changes in BMI, waist circumference, fasting blood glucose, postprandial blood glucose, insulin, insulin resistance, blood pressure, and cholesterol. We also looked at measures of psychological well-being including changes in depression, anxiety, positive and negative affect and perceived stress. Forty-one participants with elevated fasting blood glucose in Bangalore, India were randomized to either yoga (n = 21) or a walking control (n = 20). Participants were asked to either attend yoga classes or complete monitored walking 3-6 days per week for eight weeks. Randomization and allocation was performed using computer-generated random numbers and group assignments delivered in sealed, opaque envelopes generated by off-site study staff. Data were analyzed based on intention to treat.ResultsThis study was feasible in terms of recruitment, retention and adherence. In addition, yoga participants had significantly greater reductions in weight, waist circumference and BMI versus control (weight -0.8 ± 2.1 vs. 1.4 ± 3.6, p = 0.02; waist circumference -4.2 ± 4.8 vs. 0.7 ± 4.2, p

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URL الوصول: https://escholarship.org/uc/item/7j04t9j0

المؤلفون: Eisendrath, Stuart J, Gillung, Erin P, Delucchi, Kevin L, Chartier, Maggie, Mathalon, Daniel H, Sullivan, Jude C, Segal, Zindel V, Feldman, Mitchell D

المصدر: BMC Complementary Medicine and Therapies. 14(1)

مصطلحات موضوعية: Health Sciences, Traditional, Complementary and Integrative Medicine, Mind and Body, Clinical Research, Depression, Behavioral and Social Science, Complementary and Integrative Health, Major Depressive Disorder, Clinical Trials and Supportive Activities, Brain Disorders, Rehabilitation, Mental Health, Serious Mental Illness, 6.6 Psychological and behavioural, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Mental health, Good Health and Well Being, Adult, Depressive Disorder, Major, Depressive Disorder, Treatment-Resistant, Female, Humans, Male, Meditation, Mindfulness, Research Design, Treatment-resistant, MBCT, Complementary and Alternative Medicine, Complementary & Alternative Medicine, Traditional, complementary and integrative medicine

الوصف: BackgroundMajor depressive disorder (MDD) is the leading cause of disability in the developed world, yet broadly effective treatments remain elusive. Up to 40% of patients with depression are unresponsive to at least two trials of antidepressant medication and thus have "treatment-resistant depression" (TRD). There is an urgent need for cost-effective, non-pharmacologic, evidence-based treatments for TRD. Mindfulness-Based Cognitive Therapy (MBCT) is an effective treatment for relapse prevention and residual depression in major depression, but has not been previously studied in patients with TRD in a large randomized trial.Methods/designThe purpose of this study was to evaluate whether MBCT is an effective augmentation of antidepressants for adults with MDD who failed to respond to standard pharmacotherapy. MBCT was compared to an active control condition, the Health-Enhancement Program (HEP), which incorporates physical activity, functional movement, music therapy and nutritional advice. HEP was designed as a comparator condition for mindfulness-based interventions to control for non-specific effects. Originally investigated in a non-clinical sample to promote stress reduction, HEP was adapted for a depressed population for this study. Individuals age 18 and older with moderate to severe TRD, who failed to respond to at least two trials of antidepressants in the current episode, were recruited to participate. All participants were taking antidepressants (Treatment as usual; TAU) at the time of enrollment. After signing an informed consent, participants were randomly assigned to either MBCT or HEP condition. Participants were followed for 1 year and assessed at weeks 1-7, 8, 24, 36, and 52. Change in depression severity, rate of treatment response and remission after 8 weeks were the primary outcomes measured by the clinician-rated Hamilton Depression Severity Rating (HAM-D) 17-item scale. The participant-rated Quick Inventory of Depression Symptomology (QIDS-SR) 16-item scale was the secondary outcome measure of depression severity, response, and remission.DiscussionTreatment-resistant depression entails significant morbidity and has few effective treatments. We studied the effect of augmenting antidepressant medication with MBCT, compared with a HEP control, for patients with TRD. Analyses will focus on clinician and patient assessment of depression, participants' clinical global impression change, employment and social functioning scores and quality of life and satisfaction ratings.Trial registrationClincalTrials.gov identifier: NCT01021254.

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URL الوصول: https://escholarship.org/uc/item/5w58d3m8