المؤلفون: Goodreau SM; Department of Anthropology, University of Washington, Campus Box 353100, Seattle, WA, 98122, USA. goodreau@uw.edu.; Center for Studies in Demography and Ecology, University of Washington, Seattle, WA, USA. goodreau@uw.edu., Barry MP; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Center for AIDS & STD, University of Washington, Seattle, WA, USA., Hamilton DT; Center for Studies in Demography and Ecology, University of Washington, Seattle, WA, USA., Williams AM; Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA., Wang LY; Division of Adolescent and School Health, Centers for Disease Control and Prevention, Atlanta, GA, USA., Sanchez TH; Department of Epidemiology, Emory University, Atlanta, GA, USA., Katz DA; Department of Global Health, University of Washington, Seattle, WA, USA., Delaney KP; Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.

المصدر: AIDS and behavior [AIDS Behav] 2024 May; Vol. 28 (5), pp. 1766-1780. Date of Electronic Publication: 2024 Feb 27.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 9712133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-3254 (Electronic) Linking ISSN: 10907165 NLM ISO Abbreviation: AIDS Behav Subsets: MEDLINE

مواضيع طبية MeSH: Homosexuality, Male*/statistics & numerical data , Homosexuality, Male*/psychology , Pre-Exposure Prophylaxis*/statistics & numerical data , HIV Infections*/prevention & control , HIV Infections*/epidemiology , Sexual Partners* , Unsafe Sex*/statistics & numerical data , Unsafe Sex*/psychology , Condoms*/statistics & numerical data, Humans ; Male ; United States/epidemiology ; Adult ; Adolescent ; Cross-Sectional Studies ; Young Adult ; Middle Aged ; Surveys and Questionnaires ; Sexual Behavior/statistics & numerical data ; Risk-Taking ; Sexual and Gender Minorities/statistics & numerical data ; Sexual and Gender Minorities/psychology ; HIV Seronegativity ; Hispanic or Latino/statistics & numerical data ; Hispanic or Latino/psychology

مستخلص: This study measures changes in condomless anal sex (CAS) among HIV-negative men who have sex with men (MSM) who are not taking pre-exposure prophylaxis (PrEP). It considers the 2014-2019 cycles of the American Men's Internet Survey, a serial, cross-sectional web-based survey of US cisgender MSM aged ≥ 15 years, in which ~ 10% of each year's sample is drawn from the previous year. Among those surveyed for 2 years who remained HIV-negative and off PrEP, reports of having any CAS and of CAS partner number were compared across years. We disaggregated by partner HIV status, and considered demographic predictors. The overall population saw a significant 2.2 percentage-point (pp) increase in reports of any CAS year-over-year. Sub-populations with the largest year-on-year increases were 15-24-year-olds (5.0-pp) and Hispanic respondents (5.1-pp), with interaction (young Hispanic respondents = 12.8-pp). On the relative scale, these numbers correspond to 3.2%, 7.2%, 7.3% and 18.7%, respectively. Absolute increases were concentrated among partners reported as HIV-negative. Multivariable analyses for CAS initiation found effects concentrated among Hispanic and White youth and residents of fringe counties of large metropolitan areas. CAS partner number increases were similarly predicted by Hispanic identity and young age. Although condom use remains more common than PrEP use, increasing CAS among MSM not on PrEP suggests potential new HIV transmission pathways. Concentration of increases among 18-24-year-old MSM portends future increases in the proportion of newly diagnosed HIV that occur among youth. Concentration among young Hispanic MSM will likely expand existing disparities. Although reducing barriers to PrEP remains vital, condom promotion for MSM remains a key public health practice and appears to be missing key audiences. LGBTQ+-inclusive sex education is one avenue for enhancing these efforts.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

المؤلفون: Kamitani E; Division of HIV Prevention, U.S. Centers for Disease Control and Prevention, Atlanta, GA, 30329-4027, USA. ekamitani@cdc.gov., Higa DH; Division of HIV Prevention, U.S. Centers for Disease Control and Prevention, Atlanta, GA, 30329-4027, USA., Crepaz N; Division of HIV Prevention, U.S. Centers for Disease Control and Prevention, Atlanta, GA, 30329-4027, USA., Wichser M; Division of HIV Prevention, U.S. Centers for Disease Control and Prevention, Atlanta, GA, 30329-4027, USA.; SeKON Enterprise, Inc., Atlanta, GA, 30329, USA., Mullins MM; Division of HIV Prevention, U.S. Centers for Disease Control and Prevention, Atlanta, GA, 30329-4027, USA.

مؤلفون مشاركون: U.S. Centers for Disease Control and Prevention’s Prevention Research Synthesis Project

المصدر: AIDS and behavior [AIDS Behav] 2024 Jul; Vol. 28 (7), pp. 2340-2349. Date of Electronic Publication: 2024 May 14.

نوع المنشور: Systematic Review; Journal Article

بيانات الدورية: Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 9712133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-3254 (Electronic) Linking ISSN: 10907165 NLM ISO Abbreviation: AIDS Behav Subsets: MEDLINE

مواضيع طبية MeSH: Pre-Exposure Prophylaxis* , HIV Infections*/prevention & control , Anti-HIV Agents*/therapeutic use , Anti-HIV Agents*/administration & dosage, Humans ; United States ; Medication Adherence ; Male ; Female ; Practice Guidelines as Topic

مستخلص: A qualitative systematic review was conducted to evaluate pre-exposure prophylaxis (PrEP) interventions, describe characteristics of best practices for increasing PrEP use and persistence, and explore research gaps based on current PrEP interventions. We searched CDC's Prevention Research Synthesis (PRS) Project's cumulative HIV database (includes CINAHL, EMBASE, Global Health, MEDLINE, PsycInfo, and Sociological Abstracts) to identify PrEP intervention studies conducted in the U.S., published between 2000 and 2022 (last searched January 2023). Eligibility criteria include studies that evaluated PrEP interventions for persons testing negative for HIV infection, or for healthcare providers who prescribed PrEP; included comparisons between groups or pre/post; and reported at least one relevant PrEP outcome. Each eligible intervention was evaluated on the quality of study design, implementation, analysis, and strength of evidence (PROSPERO registration number: CRD42021256460). Of the 26 eligible interventions, the majority were focused on men who have sex with men (n = 18) and reported PrEP adherence outcomes (n = 12). Nine interventions met the criteria for Best Practices (i.e., evidence-based interventions, evidence-informed interventions). Five were digital health interventions while two implemented individual counseling, one offered motivational interviewing, and one provided integrated medical care with a PrEP peer navigator. Longer intervention periods may provide more time for intervention exposure to facilitate behavioral change, and engaging the community when developing, designing and implementing interventions may be key for effectiveness. For digital health interventions, two-way messaging may help participants feel supported. Research gaps included a lack of Best Practices for several populations (e.g., Black persons, Hispanic/Latino persons, persons who inject drugs, and women of color) and evidence for various intervention strategies (e.g., interventions for promoting provider's PrEP prescription behavior, peer support). These findings call for more collaborative work with communities to develop interventions that work and implement and disseminate Best Practices for increasing PrEP use and persistence in communities.
(© 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)

المؤلفون: Irie WC; Boston College School of Social Work, 140 Commonwealth Avenue, 02467-1037, Chestnut Hill, MA, USA. whitney.irie@bc.edu.; The Fenway Institute, Fenway Health, Boston, MA, USA. whitney.irie@bc.edu., Mayer K; The Fenway Institute, Fenway Health, Boston, MA, USA.; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

المصدر: AIDS and behavior [AIDS Behav] 2024 Jul; Vol. 28 (7), pp. 2175-2182. Date of Electronic Publication: 2024 Apr 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 9712133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-3254 (Electronic) Linking ISSN: 10907165 NLM ISO Abbreviation: AIDS Behav Subsets: MEDLINE

مواضيع طبية MeSH: Pre-Exposure Prophylaxis*/methods , HIV Infections*/prevention & control , Black or African American*/psychology , Anti-HIV Agents*/administration & dosage, Humans ; Female ; United States ; Delayed-Action Preparations ; Injections ; Pyridones ; Diketopiperazines

مستخلص: The FDA's approval of long-acting injectable cabotegravir pre-exposure prophylaxis (LAI PrEP) as an alternative to daily oral PrEP represents a crucial development in HIV prevention, particularly for American Black cisgender women who face high HIV-1 risks. Yet, uptake may be hindered by racial and gender inequities. Addressing these requires learning from the roll-out of oral PrEP, creating culturally tailored PrEP campaigns, and enhancing provider training to meet Black women's needs. Tools for discussing PrEP within personal relationships and product preference research tailored to Black women's needs are essential for effective LAI PrEP delivery. Deliberative implementation of LAI PrEP must employ strategies that are community-sensitive, -responsive, and -inclusive. It should prioritize the incorporation of Black women's voices in decision-making and should promote community-led strategies. By addressing historical injustices and fostering trust, healthcare systems can enhance LAI PrEP uptake by Black women. Emphasizing a community-centered approach that ensures health equity and acknowledges the crucial role that social media and Black-led organizations play in promoting PrEP awareness and adoption within Black communities is necessary for successful implementation.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

المؤلفون: Merle JL; Department of Population Health Sciences, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, UT, USA. james.merle@utah.edu., Benbow N; Department of Psychiatry and Behavioral Sciences, Northwestern University, Seattle, WA, USA.; Institute for Sexual and Gender Minority Health and Wellbeing, Northwestern University, Seattle, WA, USA., Li DH; Department of Psychiatry and Behavioral Sciences, Northwestern University, Seattle, WA, USA.; Institute for Sexual and Gender Minority Health and Wellbeing, Northwestern University, Seattle, WA, USA., Zapata JP; Institute for Sexual and Gender Minority Health and Wellbeing, Northwestern University, Seattle, WA, USA., Queiroz A; Institute for Sexual and Gender Minority Health and Wellbeing, Northwestern University, Seattle, WA, USA., Zamantakis A; Institute for Sexual and Gender Minority Health and Wellbeing, Northwestern University, Seattle, WA, USA., McKay V; Brown School, Washington University in St. Louis, St. Louis, MO, USA., Keiser B; Department of Family Medicine, University of Washington School of Medicine, Seattle, WA, USA., Villamar JA; Public Health and Epidemiology Unit, Westat, Rockville, MD, USA., Mustanski B; Department of Psychiatry and Behavioral Sciences, Northwestern University, Seattle, WA, USA.; Institute for Sexual and Gender Minority Health and Wellbeing, Northwestern University, Seattle, WA, USA.; Department of Infectious Diseases, Northwestern University, Seattle, WA, USA.; Medical Social Sciences Department, Northwestern University, Seattle, WA, USA., Smith JD; Department of Population Health Sciences, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, UT, USA.

المصدر: AIDS and behavior [AIDS Behav] 2024 Jul; Vol. 28 (7), pp. 2321-2339. Date of Electronic Publication: 2024 Apr 02.

نوع المنشور: Journal Article; Systematic Review

بيانات الدورية: Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 9712133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-3254 (Electronic) Linking ISSN: 10907165 NLM ISO Abbreviation: AIDS Behav Subsets: MEDLINE

مواضيع طبية MeSH: Pre-Exposure Prophylaxis*/methods , HIV Infections*/prevention & control , Anti-HIV Agents*/administration & dosage , Anti-HIV Agents*/therapeutic use, Humans ; United States ; Medication Adherence

مستخلص: Implementation of pre-exposure prophylaxis (PrEP) to prevent HIV transmission is suboptimal in the United States. To date, the literature has focused on identifying determinants of PrEP use, with a lesser focus on developing and testing change methods to improve PrEP implementation. Moreover, the change methods available for improving the uptake and sustained use of PrEP have not been systematically categorized. To summarize the state of the literature, we conducted a systematic review of the implementation strategies used to improve PrEP implementation among delivery systems and providers, as well as the adjunctive interventions used to improve the uptake and persistent adherence to PrEP among patients. Between November 2020 and January 2021, we searched Ovid MEDLINE, PsycINFO, and Web of Science for peer reviewed articles. We identified 44 change methods (18 implementation strategies and 26 adjunctive interventions) across a variety of clinical and community-based service settings. We coded implementation strategies and adjunctive interventions in accordance with established taxonomies and reporting guidelines. Most studies focused on improving patient adherence to PrEP and most conducted pilot trials. Just over one-third of included studies demonstrated a positive effect on outcomes. In order to end the human immunodeficiency virus (HIV) epidemic in the U.S., future, large scale HIV prevention research is needed that develops and evaluates implementation strategies and adjunctive interventions for target populations disproportionately affected by HIV.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

المؤلفون: Erguera XA; Division of HIV, ID and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.; Department of Public Health, Zuckerberg San Francisco General Hospital, San Francisco, CA, USA., Koester KA; Division of Prevention Science, Department of Medicine, Center for AIDS Prevention Studies, University of California San Francisco, San Francisco, CA, USA., Diaz Tsuzuki M; School of Medicine, University of California San Francisco, San Francisco, CA, USA., Dance KV; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.; Ponce de Leon Center, Grady Health System, Atlanta, GA, USA., Flores R; Department of Family and Community Medicine, College of Medicine, University of Illinois Chicago, Chicago, IL, USA., Kerman J; Cancer Treatment Centers of America, Comprehensive Care and Research Center, City of Hope Chicago, Chicago, IL, USA., McNulty MC; Chicago Center for HIV Elimination, University of Chicago, Chicago, IL, USA.; Section of Infectious Diseases and Global Health, Department of Medicine, University of Chicago, Chicago, IL, USA., Colasanti JA; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.; Ponce de Leon Center, Grady Health System, Atlanta, GA, USA., Collins LF; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.; Ponce de Leon Center, Grady Health System, Atlanta, GA, USA., Montgomery ET; Women's Global Health Imperative, RTI International, Berkeley, CA, USA.; Department of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, San Francisco, CA, USA., Johnson MO; Division of Prevention Science, Department of Medicine, Center for AIDS Prevention Studies, University of California San Francisco, San Francisco, CA, USA., Sauceda JA; Division of Prevention Science, Department of Medicine, Center for AIDS Prevention Studies, University of California San Francisco, San Francisco, CA, USA., Christopoulos KA; Division of HIV, ID and Global Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA. katerina.christopoulos@ucsf.edu.; Department of Public Health, Zuckerberg San Francisco General Hospital, San Francisco, CA, USA. katerina.christopoulos@ucsf.edu.; Division of HIV, Infectious Disease, and Global Medicine, San Francisco General Hospital, 1001 Potrero Avenue, Building 80, Room 424, San Francisco, CA, 94110, USA. katerina.christopoulos@ucsf.edu.

المصدر: AIDS and behavior [AIDS Behav] 2024 Jul; Vol. 28 (7), pp. 2226-2238. Date of Electronic Publication: 2024 Apr 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 9712133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-3254 (Electronic) Linking ISSN: 10907165 NLM ISO Abbreviation: AIDS Behav Subsets: MEDLINE

مواضيع طبية MeSH: HIV Infections*/drug therapy , HIV Infections*/psychology , Patient Acceptance of Health Care*/psychology, Humans ; Female ; Male ; Middle Aged ; Adult ; Interviews as Topic ; Anti-HIV Agents/therapeutic use ; Anti-HIV Agents/administration & dosage ; Qualitative Research ; United States ; Delayed-Action Preparations ; Social Stigma ; Injections ; Chicago ; San Francisco ; White

مستخلص: Understanding the acceptability of long-acting injectable antiretroviral therapy (LAI-ART) among people with HIV (PWH), especially priority populations, is essential for effective implementation. We conducted semi-structured interviews with patients in three Ryan White-funded HIV clinics in San Francisco, Chicago, and Atlanta. We employed maximal variation sampling across age, gender, race, ethnicity, and time living with HIV and oversampled for individuals with suboptimal clinical engagement. An 8-step hybrid deductive and inductive thematic analysis approach guided data analysis. Between August 2020 and July 2021, we conducted 72 interviews. Median age was 46 years; 28% were ciswomen, 7% transwomen, 44% Black/African-American and 35% Latinx, 43% endorsed a psychiatric diagnosis, 35% were experiencing homelessness/unstable housing, and 10% had recent substance use. Approximately 24% were sub-optimally engaged in care. We observed a spectrum of LAI-ART acceptability, ranging from enthusiasm to hesitancy to rejection. We also characterized four emergent orientations towards LAI-ART: innovator, pragmatist, deliberator, and skeptic. Overall, the majority of participants expressed favorable initial reactions towards LAI-ART. Most approached LAI-ART pragmatically, but acceptability was not static, often increasing over the course of the interview. Participants considered their HIV providers as essential for affirming personal relevance. HIV stigma, privacy concerns, and medical mistrust had varied impacts, sometimes facilitating and other times hindering personal relevance. These findings held across priority populations, specifically young adults, cis/trans women, racial/ethnic minorities, and individuals with suboptimal clinical engagement. Further research is needed to explore the transition from hypothetical acceptance to uptake and to confirm the actual benefits and drawbacks of this treatment.
(© 2024. The Author(s).)

المؤلفون: Kota KK; Division of HIV Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, MS H18-3, Atlanta, GA, USA. qel3@cdc.gov.; Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA. qel3@cdc.gov., Gelaude D; Division of HIV Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, MS H18-3, Atlanta, GA, USA., Carnes N; Division of HIV Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, MS H18-3, Atlanta, GA, USA., Schoua-Glusberg A; Research Support Services, Inc., Evanston, IL, USA., Frew PM; Emory University School of Medicine, Atlanta, GA, USA.; Emory University Rollins School of Public Health, Atlanta, GA, USA.; Merck & Co., Inc., Kenilworth, NJ, USA., Randall L; Emory University School of Medicine, Atlanta, GA, USA.; Emory University Rollins School of Public Health, Atlanta, GA, USA., Gale B; American Institutes for Research, Arlington, VA, USA., Betley V; American Institutes for Research, Arlington, VA, USA., Mansergh G; Division of HIV Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, MS H18-3, Atlanta, GA, USA.

المصدر: AIDS and behavior [AIDS Behav] 2024 Jun; Vol. 28 (6), pp. 1845-1857. Date of Electronic Publication: 2024 Mar 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 9712133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-3254 (Electronic) Linking ISSN: 10907165 NLM ISO Abbreviation: AIDS Behav Subsets: MEDLINE

مواضيع طبية MeSH: Pre-Exposure Prophylaxis* , HIV Infections*/prevention & control , Homosexuality, Male*/psychology , Homosexuality, Male*/statistics & numerical data , Anti-HIV Agents*/therapeutic use , Anti-HIV Agents*/administration & dosage , Sexual Partners* , Focus Groups*, Humans ; Male ; Adult ; Chicago ; Sexual Behavior ; Health Knowledge, Attitudes, Practice ; Sexual and Gender Minorities/psychology ; Sexual and Gender Minorities/statistics & numerical data ; Middle Aged ; Interviews as Topic ; Treatment Refusal/statistics & numerical data ; Treatment Refusal/psychology ; Young Adult ; United States ; Qualitative Research ; Risk-Taking ; Self Concept

مستخلص: Pre-exposure prophylaxis (PrEP) reduces sexual risk for HIV transmission by 99% when used appropriately, but remains underutilized among gay, bisexual, and other men who have sex with men (MSM). In this mixed-method study, we describe reasons for PrEP refusal associated with low self-perceived need for PrEP among MSM who recently declined daily oral PrEP when offered by a provider. Data are from a quantitative behavioral survey of MSM (N = 93) living in Atlanta, Chicago, and Raleigh-Durham, who also either responded to an in-depth interview (n = 51) or participated in one of 12 focus groups (n = 42). Themes of low self-perceived need for PrEP were: low self-perceived risk for HIV acquisition (33% of respondents); confidence in remaining HIV-negative (35%); using condoms (81%); limiting number of partners and choosing partners carefully (48%); asking partners about their HIV status before having sex (45%); engaging in safer sexual positions or oral sex (28%); being in a monogamous relationship or exclusivity with one partner (26%); and regular HIV testing (18%). Low self-perceived risk for HIV acquisition and high confidence in other prevention strategies were important factors related to low self-perceived need in MSM refusing daily oral PrEP when offered. Providers should continue to discuss the benefits of PrEP as a safe and highly effective option for HIV prevention.
(© 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)

المؤلفون: Okafor CN; Department of Medicine, Division of Infectious Diseases, Long School of Medicine, University of Texas Health Science Center San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas, 78229-3900, USA. Okaforcn@uthscsa.edu., Eaton L; Department of Human Development and Family Sciences, University of Connecticut, Storrs, CT, USA., Watson R; Department of Human Development and Family Sciences, University of Connecticut, Storrs, CT, USA.

المصدر: AIDS and behavior [AIDS Behav] 2024 Jun; Vol. 28 (6), pp. 2166-2174. Date of Electronic Publication: 2024 Mar 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 9712133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-3254 (Electronic) Linking ISSN: 10907165 NLM ISO Abbreviation: AIDS Behav Subsets: MEDLINE

مواضيع طبية MeSH: Hispanic or Latino*/psychology , Hispanic or Latino*/statistics & numerical data , HIV Infections*/prevention & control , HIV Infections*/ethnology , Sexual and Gender Minorities*/psychology , Sexual and Gender Minorities*/statistics & numerical data , Pre-Exposure Prophylaxis* , Anti-HIV Agents*/administration & dosage , Anti-HIV Agents*/therapeutic use , Black or African American*/psychology , Black or African American*/statistics & numerical data , Patient Acceptance of Health Care*/psychology , Patient Acceptance of Health Care*/ethnology , Patient Acceptance of Health Care*/statistics & numerical data, Humans ; Male ; Female ; Adult ; United States/epidemiology ; Young Adult ; Adolescent ; Social Stigma ; Delayed-Action Preparations ; Medication Adherence/statistics & numerical data ; Medication Adherence/psychology

مستخلص: In December 2021, long-acting injectable pre-exposure prophylaxis (LAI-PrEP) was approved for the prevention of HIV in at-risk adults and adolescents. LAI-PrEP may address adherence issues of daily oral daily PrEP and PrEP stigma. However, studies assessing LAI-PrEP willingness among PrEP naive Black and Hispanic sexual and gender minority (SGM) persons- a group disproportionately impacted by the HIV epidemic in the United States - is rare. To assess the extent of and characteristics of willingness to use LAI-PrEP in a national sample of Black and Hispanic SGM who are self-reported that they have never used PrEP. We analyzed data from a national sample of Black and Hispanic SGM collected between March and August 2020. We used log-binomial regression models to assess characteristics associated with willingness to use LAI-PrEP. Of the overall sample (N = 380), the mean age was 24 (SD = 2.8) and the majority of the sample (54%, n = 205) reported willingness to use LAI-PrEP. In multivariable log-binomial regression models, PrEP stigma was independently associated with less [prevalence ratio (PR) = 0.7, 95% confidence interval (CI) = 0.6, 0.9], while number of sexual partners in the past 12 months was associated with a more willingness to use LAI-PrEP (PR = 1.1, 95% CI = 1.0, 1.2). Our findings highlight the persistence of PrEP stigma as a potential barrier to willingness to use LAI-PrEP in this sample of Black and Hispanic SGM who have never used PrEP. Additional work needs to be done to reduce PrEP stigma more broadly.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

المؤلفون: Guo Y; Graduate School of Public Health and Health Policy, City University of New York, 55 W 125th St, 7th Floor mailroom, New York, NY, 10027, USA.; Institute for Implementation Science in Population Health, City University of New York, New York, NY, USA., Westmoreland DA; Department of Epidemiology, College of Medicine & College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA., D'Angelo AB; Graduate School of Public Health and Health Policy, City University of New York, 55 W 125th St, 7th Floor mailroom, New York, NY, 10027, USA.; Institute for Implementation Science in Population Health, City University of New York, New York, NY, USA., Mirzayi C; Graduate School of Public Health and Health Policy, City University of New York, 55 W 125th St, 7th Floor mailroom, New York, NY, 10027, USA.; Institute for Implementation Science in Population Health, City University of New York, New York, NY, USA., Dearolf M; Graduate School of Public Health and Health Policy, City University of New York, 55 W 125th St, 7th Floor mailroom, New York, NY, 10027, USA.; Institute for Implementation Science in Population Health, City University of New York, New York, NY, USA., Ray M; Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA., Carneiro PB; Graduate School of Public Health and Health Policy, City University of New York, 55 W 125th St, 7th Floor mailroom, New York, NY, 10027, USA., Pantalone DW; Department of Psychology, University of Massachusetts Boston, Boston, MA, USA.; The Fenway Institute, Fenway Health, Boston, MA, USA., Carrico AW; Department of Health Promotion & Disease Prevention, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL, USA., Patel VV; Division of General Internal Medicine, Department of Medicine, Albert Einstein College of Medicine, Montefiore Health System Bronx, Miami, NY, USA., Golub SA; Hunter HIV/AIDS Research Team, Department of Psychology, Hunter College, City University of New York, New York, NY, USA., Hirshfield S; Department of Medicine, STAR Program, SUNY Downstate Health Sciences University, Brooklyn, NY, USA., Hoover DR; Department of Statistics and Biostatistics, Rutgers University, New Brunswick, NJ, USA., Nash D; Institute for Implementation Science in Population Health, City University of New York, New York, NY, USA., Grov C; Graduate School of Public Health and Health Policy, City University of New York, 55 W 125th St, 7th Floor mailroom, New York, NY, 10027, USA. christian.grov@sph.cuny.edu.; Institute for Implementation Science in Population Health, City University of New York, New York, NY, USA. christian.grov@sph.cuny.edu.

المصدر: AIDS and behavior [AIDS Behav] 2024 Jun; Vol. 28 (6), pp. 2078-2086. Date of Electronic Publication: 2024 Mar 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 9712133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-3254 (Electronic) Linking ISSN: 10907165 NLM ISO Abbreviation: AIDS Behav Subsets: MEDLINE

مواضيع طبية MeSH: Methamphetamine*/administration & dosage , HIV Infections*/prevention & control , HIV Infections*/epidemiology , Sexual and Gender Minorities*/statistics & numerical data , Pre-Exposure Prophylaxis*/statistics & numerical data, Humans ; Male ; Adult ; Prospective Studies ; United States/epidemiology ; Female ; Anti-HIV Agents/therapeutic use ; Amphetamine-Related Disorders/epidemiology ; Amphetamine-Related Disorders/ethnology ; Homosexuality, Male/statistics & numerical data ; Homosexuality, Male/psychology ; Homosexuality, Male/ethnology ; Risk Factors ; Young Adult ; Middle Aged

مستخلص: Methamphetamine use is on the rise among sexual and gender minority people who have sex with men (SGMSM), escalating their HIV risk. Despite pre-exposure prophylaxis (PrEP) being an effective biomedical HIV prevention tool, its uptake in relation to methamphetamine use patterns in SGMSM has not been studied. In a U.S. cohort study from 2017 to 2022, 6,253 HIV-negative SGMSM indicated for but not using PrEP were followed for four years. Methamphetamine use was categorized (i.e., newly initiated, persistently used, never used, used but quit), and PrEP uptake assessed using generalized estimating equation (GEE), adjusted for attrition. Participants had a median age of 29, with 51.9% White, 11.1% Black, 24.5% Latinx, and 12.5% other races/ethnicities. Over the four years, PrEP use increased from 16.3 to 27.2%. GEE models identified risk factors including housing instability and food insecurity. In contrast, older age, health insurance, clinical indications, and prior PrEP use increased uptake. Notably, Latinx participants were more likely to use PrEP than Whites. Regarding methamphetamine use, those who newly initiated it were more likely to use PrEP compared to non-users. However, those who quit methamphetamine and those who persistently used it had PrEP usage rates comparable to those of non-users. Though PrEP uptake increased, it remained low in SGMSM. Methamphetamine use was associated with PrEP uptake. Healthcare providers should assess methamphetamine use for harm reduction. Prioritizing younger, uninsured SGMSM and addressing basic needs can enhance PrEP uptake and reduce HIV vulnerabilities.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

المؤلفون: Ahmed M; University of Texas Southwestern Medical School, Dallas, TX, USA., Nijhawan AE; Department of Internal Medicine, Division of Infectious Diseases and Geographic Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA., Gao A; Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA., Ahn C; Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA., Chow JY; Department of Internal Medicine, Division of Infectious Diseases and Geographic Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA. jeremy.chow@utsouthwestern.edu.; Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA. jeremy.chow@utsouthwestern.edu.

المصدر: AIDS and behavior [AIDS Behav] 2024 May; Vol. 28 (5), pp. 1731-1740. Date of Electronic Publication: 2024 Feb 16.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 9712133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-3254 (Electronic) Linking ISSN: 10907165 NLM ISO Abbreviation: AIDS Behav Subsets: MEDLINE

مواضيع طبية MeSH: HIV Infections*/diagnosis , HIV Infections*/psychology , Substance-Related Disorders*/epidemiology , Continuity of Patient Care* , Mental Disorders*/diagnosis , Mental Disorders*/epidemiology , Mass Screening*/methods, Humans ; Male ; Female ; Adult ; Retrospective Studies ; Middle Aged ; Risk Factors ; Retention in Care/statistics & numerical data ; United States/epidemiology

مستخلص: Mental illness (MI) and substance use (SU) are highly prevalent among people with HIV (PWH) and impact care outcomes. The Substance Abuse and Mental Illness Symptoms Screener (SAMISS) is a validated screener for MI and SU, but it is unknown how screening results at entry to care correlate with subsequent HIV outcomes. This is a retrospective chart review of individuals newly diagnosed with HIV between 2016 and 2019 in a Southern US, safety-net clinic. Baseline demographics, HIV risk factors, socioeconomic variables, and SAMISS screening scores were collected. Outcomes included retention in care, achieving virologic suppression (VS), and continuous VS. Data analyses included stepwise Cox and logistic multivariate regression modeling. Among the 544 newly diagnosed PWH, mean age was 35, 76% were male, 46% non-Hispanic Black, 40% Hispanic/other. Overall, 35% screened positive for SU and 41% for MI. A positive SU (odds ratio (OR) 0.66, p = 0.04) or MI (OR 0.65, p = 0.03) SAMISS screening was associated with lower retention in care in univariate analysis, but was not statistically significant after adjusting for other variables. Positive SAMISS screening for SU and MI were both associated with reduced continuous VS in univariate and multivariate analyses (SU: adjusted OR (aOR) 0.67, p = 0.05; MI: aOR 0.66, p = 0.03). SAMISS is a useful tool for prospectively identifying individuals at risk for low retention in care and for not achieving sustained VS. Future interventions guided by SAMISS may improve HIV care continuum outcomes.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

المؤلفون: Rubtsova AA; Department of Behavioral, Social, and Health Education Sciences, Emory University Rollins School of Public Health, 1518 Clifton Rd, Atlanta, GA, 30322, USA. grubtso@emory.edu., Taylor TN; College of Medicine, Division of Infectious Diseases, State University of New York Downstate Health Sciences University, Brooklyn, NY, USA., Wingood G; Department of Sociomedical Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA., Ofotokun I; Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA., Gustafson D; Department of Neurology, State University of New York Downstate Health Sciences University, Brooklyn, NY, USA., Vance DE; The University of Alabama at Birmingham School of Nursing, Birmingham, AL, USA., Holstad M; Emory University Nell Hodgson Woodruff School of Nursing, Atlanta, GA, USA.

المصدر: AIDS and behavior [AIDS Behav] 2024 May; Vol. 28 (5), pp. 1581-1593. Date of Electronic Publication: 2024 Jan 17.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 9712133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-3254 (Electronic) Linking ISSN: 10907165 NLM ISO Abbreviation: AIDS Behav Subsets: MEDLINE

مواضيع طبية MeSH: HIV Infections*/psychology , Aging*/psychology , Focus Groups* , Qualitative Research* , Interviews as Topic*, Humans ; Female ; Middle Aged ; Aged ; Adaptation, Psychological ; Quality of Life ; United States/epidemiology

مستخلص: Successful aging (SA) is an important target for HIV care. However, we have insufficient understanding of how older women living with HIV (OWLH) in the US define SA. We explored conceptions of SA by OWLH and older women at risk of HIV and examined whether SA conceptions differed by (1) HIV serostatus, and (2) participation in the Women's Interagency HIV Study (WIHS). These analyses were part of a larger mixed-methods study with a sequential design. Participants were recruited at two clinical WIHS sites. We enrolled both WIHS participants and non-WIHS clinic patients. Our sample was 84% Black and included 29 OWLH and 15 older women at risk of HIV. We conducted 21 semi-structured interviews and four focus groups. The dataset was analyzed using descriptive, comparative, and relational analysis. We found four interlinked themes: life course perspective, accepting and celebrating aging, taking care of yourself, and looking good. The life course perspective was a core theme: participants assessed their aging in comparison to their earlier life hardships. These themes were similarly present among OWLH and older women at risk of HIV, although OWLH emphasized taking care of HIV. SA conceptualizations by OWLH did not differ whether or not they participated in the WIHS. Women living with or at risk of HIV may experience severe hardships throughout their lives. Overcoming these hardships may be linked to SA. Assessing the needs and connecting women to resources and programs are critical for SA promotion.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)