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المؤلفون: David Martin, Adrian S. Dunne, Eoin A. Murphy, Fergal Boyle
المساهمون: Technological University Dublin, Fiosraigh Scholarship
المصدر: Articles
مصطلحات موضوعية: In-stent restenosis, Materials science, Intimal hyperplasia, medicine.medical_treatment, 0206 medical engineering, Biomedical Engineering, Biological Transport, Active, 02 engineering and technology, Computational fluid dynamics, 030204 cardiovascular system & hematology, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Restenosis, Coronary Circulation, Coronary stent, medicine, Animals, Humans, Hypoxia, Biomedical Engineering and Bioengineering, Oxygen transport, Models, Cardiovascular, Stent, Blood flow, medicine.disease, 020601 biomedical engineering, Coronary Vessels, Coronary arteries, Oxygen, medicine.anatomical_structure, Stents, Biomedical engineering
الوصف: Oxygen deficiency, known as hypoxia, in arterial walls has been linked to increased intimal hyperplasia, which is the main adverse biological process causing in-stent restenosis. Stent implantation has significant effects on the oxygen transport into the arterial wall. Elucidating these effects is critical to optimizing future stent designs. In this study the most advanced oxygen transport model developed to date was assessed in two test cases and used to compare three coronary stent designs. Additionally, the predicted results from four simplified blood oxygen transport models are compared in the two test cases. The advanced model showed good agreement with experimental measurements within the mass-transfer boundary layer and at the luminal surface; however, more work is needed in predicting the oxygen transport within the arterial wall. Simplifying the oxygen transport model within the blood flow produces significant errors in predicting the oxygen transport in arteries. This study can be used as a guide for all future numerical studies in this area and the advanced model could provide a powerful tool in aiding design of stents and other cardiovascular devices.
وصف الملف: application/pdf
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