المؤلفون: Petr Džubák, Roman Lesyk, Marian Hajduch, Pavel G. Polishchuk, Anna Kryshchyshyn-Dylevych, Serhiy Holota, Ermin Schadich, Sona Gurska

المصدر: Bioorganicmedicinal chemistry letters. 30(23)

مصطلحات موضوعية: Stereochemistry, Trypanosoma brucei gambiense, Clinical Biochemistry, Thiazolidine, Trypanosoma brucei brucei, Pharmaceutical Science, 01 natural sciences, Biochemistry, Small Molecule Libraries, chemistry.chemical_compound, Structure-Activity Relationship, Parasitic Sensitivity Tests, Drug Discovery, Humans, Leishmania major, Thiazole, Molecular Biology, IC50, Primary (chemistry), biology, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Fibroblasts, biology.organism_classification, Trypanocidal Agents, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Molecular Medicine, Thiazolidines

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01fdc9dd8cdefe7b86932d7d3cdf2791
https://pubmed.ncbi.nlm.nih.gov/33091607

المؤلفون: Rogers Nyamwihura, Olamide O. Crown, Ifedayo Victor Ogungbe, Jasmine T. Collins, Huaisheng Zhang, Oluwatomi Ajayi

المصدر: Bioorg Med Chem Lett

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Trypanosoma brucei brucei, Antiprotozoal Agents, Pharmaceutical Science, Vinyl sulfone, Trypanosoma brucei, Cysteine Proteinase Inhibitors, 01 natural sciences, Biochemistry, Article, chemistry.chemical_compound, Structure-Activity Relationship, Parasitic Sensitivity Tests, Cysteine Proteases, Drug Discovery, parasitic diseases, Sulfones, Molecular Biology, ADME, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Quinoline, Partially saturated, biology.organism_classification, Protozoan parasite, Cysteine protease, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05b5af67b8cabdda146ea7b053539757
https://pubmed.ncbi.nlm.nih.gov/32527539

المؤلفون: Annalise Di Marco, Steven J. Harper, Savina Malancona, Nadia Gennari, Simona Ponzi, Jesus Maria Ontoria Ontoria, Marcel Kaiser, Rita Graziani, Ilaria Biancofiore, Giacomo Paonessa, Alberto Bresciani, Federica Ferrigno, Vincenzo Summa

المساهمون: Ferrigno, F., Biancofiore, I., Malancona, S., Ponzi, S., Paonessa, G., Graziani, R., Bresciani, A., Gennari, N., Di Marco, A., Kaiser, M., Summa, V., Harper, S., Ontoria, J. M.

المصدر: Bioorganicmedicinal chemistry letters. 28(23-24)

مصطلحات موضوعية: 0301 basic medicine, Antiparasitic, medicine.drug_class, 030106 microbiology, Clinical Biochemistry, Plasmodium falciparum, Trypanosoma brucei brucei, Pharmaceutical Science, Trypanosoma brucei, HeLa Cell, Biochemistry, Piperazines, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Sleeping sickne, parasitic diseases, Drug Discovery, medicine, Cytotoxic T cell, Humans, African trypanosomiasis, Malaria, Falciparum, Trypanosoma cruzi, Molecular Biology, Imidazole, Piperazine, biology, 2-(1H-imidazo-2-yl)piperazine, Trypanocidal Agent, Organic Chemistry, Imidazoles, Trypanosoma brucei rhodesiense, medicine.disease, biology.organism_classification, Human African Trypanosomiasis (HAT), Virology, Trypanocidal Agents, 030104 developmental biology, Trypanosomiasis, African, chemistry, Molecular Medicine, Growth inhibition, Human, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf46768ec11c331900bbf1c794ff7cb
https://pubmed.ncbi.nlm.nih.gov/30482621

المؤلفون: Wim G. J. Hol, Erkang Fan, Ranae M. Ranade, Sayaka Shibata, J. Robert Gillespie, Zhongsheng Zhang, Christophe L. M. J. Verlinde, Frederick S. Buckner, Sharon A. Creason, Wenlin Huang, Ximena Barros-Álvarez

المصدر: Bioorganicmedicinal chemistry letters. 27(12)

مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Cell Survival, Clinical Biochemistry, Trypanosoma brucei brucei, Pharmaceutical Science, Methionine-tRNA Ligase, Trypanosoma brucei, 01 natural sciences, Biochemistry, Article, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Methionine, Drug Discovery, Potency, Animals, Humans, Enzyme Inhibitors, Molecular Biology, Binding Sites, biology, Dose-Response Relationship, Drug, Molecular Structure, Fragment (computer graphics), Chemistry, Organic Chemistry, Brain, Hep G2 Cells, biology.organism_classification, Methionyl-tRNA synthetase, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, Molecular Medicine, Linker

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48bcae14585dae656af3cb43827bf3c9
https://pubmed.ncbi.nlm.nih.gov/28465105

المؤلفون: Elena S. Matyugina, Anastasia L. Khandazhinskaya, Katherine L. Seley-Radtke, Harry P. de Koning, Khalid J. Alzahrani, Sergei N. Kochetkov

المصدر: Bioorganicmedicinal chemistry letters. 27(14)

مصطلحات موضوعية: 0301 basic medicine, Pyrimidine, Stereochemistry, Clinical Biochemistry, Leishmania mexicana, Trypanosoma brucei brucei, Antiprotozoal Agents, Drug Resistance, Pharmaceutical Science, Trypanosoma brucei, 01 natural sciences, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Molecular Biology, chemistry.chemical_classification, biology, 010405 organic chemistry, Organic Chemistry, Uracil, biology.organism_classification, Leishmania, Pyrimidine Nucleosides, Uridine, 0104 chemical sciences, 030104 developmental biology, Enzyme, chemistry, Pyrimidine metabolism, Molecular Medicine, Fluorouracil

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d3595414d512614be6a491a0df373e3
https://pubmed.ncbi.nlm.nih.gov/28571825

المؤلفون: Rodrigo Cassio Sola Veneziani, Babu L. Tekwani, Cassia S. Mizuno, Ariana B. Souza, Sérgio Ricardo Ambrósio

المصدر: Bioorganicmedicinal chemistry letters. 25(23)

مصطلحات موضوعية: Clinical Biochemistry, Trypanosoma brucei brucei, Leishmania donovani, Pharmaceutical Science, Trypanosoma brucei, Biochemistry, Copaiba Oil, chemistry.chemical_compound, Inhibitory Concentration 50, parasitic diseases, Drug Discovery, Organic chemistry, Polyalthic acid, Molecular Biology, Biological evaluation, biology, Antiparasitic Agents, Molecular Structure, Organic Chemistry, Neglected Diseases, biology.organism_classification, Trypanocidal Agents, chemistry, Molecular Medicine, Diterpene, Diterpenes

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b4f9c799dcdbc9638de231d9026284
https://pubmed.ncbi.nlm.nih.gov/26520665

المؤلفون: Raphaël Labruère, Casimir Blonski, Stéphanie Pethe, Elodie Jagu, Rachid Djilali, Florence Ramiandrasoa, Philippe M. Loiseau, Sébastien Pomel

المصدر: Bioorganicmedicinal chemistry letters. 25(2)

مصطلحات موضوعية: Stereochemistry, Spermidine, Acylation, Clinical Biochemistry, Trypanosoma brucei brucei, Leishmania donovani, Antiprotozoal Agents, Drug Evaluation, Preclinical, Pharmaceutical Science, Spermine, Trypanosoma brucei, Biochemistry, chemistry.chemical_compound, parasitic diseases, Drug Discovery, Putrescine, Kinetoplastida, Axenic, Molecular Biology, biology, Chemistry, Organic Chemistry, biology.organism_classification, Drug Design, Molecular Medicine, Polyamine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8fde8a4fa42d3dcfe8500b78ea77d9f
https://pubmed.ncbi.nlm.nih.gov/25499437

المؤلفون: Michael P. Pollastri, Charles Tapley Hoyt, Robert K. Campbell, Nicholas D. Bland, Emanuele Amata, Luca Settimo

المصدر: Bioorganicmedicinal chemistry letters. 24(17)

مصطلحات موضوعية: Antiprotozoal agents, Cyclohexanecarboxylic Acids, Phosphodiesterase Inhibitors, Clinical Biochemistry, Trypanosoma brucei brucei, Protozoan Proteins, Pharmaceutical Science, Pharmacology, Trypanosoma brucei, Biochemistry, Article, TbrPDEB1 Trypanosoma brucei, Structure-Activity Relationship, Trypanosomiasis, Cilomilast, Drug Discovery, parasitic diseases, Nitriles, medicine, Structure–activity relationship, Humans, Molecular Biology, Cell Proliferation, biology, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Drug Repositioning, Tropical disease, Phosphodiesterase, Neglected Diseases, medicine.disease, biology.organism_classification, Antiprotozoal agents, Cilomilast, Phosphodiesterase inhibitors, TbrPDEB1 Trypanosoma brucei, Cyclic Nucleotide Phosphodiesterases, Type 4, Drug repositioning, 3',5'-Cyclic-AMP Phosphodiesterases, Drug Design, Neglected tropical diseases, Molecular Medicine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d37ae38eaed523d558bec498590dd9f
https://pubmed.ncbi.nlm.nih.gov/25127163

المؤلفون: Shabber Mohammed, Ram A. Vishwakarma, Ikhlas A. Khan, Babu L. Tekwani, Surendra Jain, Sandip B. Bharate, Shabana I. Khan, Sudhakar Manda

المصدر: Bioorganicmedicinal chemistry letters. 24(15)

مصطلحات موضوعية: Swine, Clinical Biochemistry, Trypanosoma brucei brucei, Leishmania donovani, Antiprotozoal Agents, Pharmaceutical Science, Trypanosoma brucei, Pharmacology, Biochemistry, Cell Line, Structure-Activity Relationship, Parasitic Sensitivity Tests, Drug Discovery, Chlorocebus aethiops, medicine, Cytotoxic T cell, Animals, Humans, Axenic, Amastigote, Molecular Biology, IC50, Vero Cells, biology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Macrophages, Organic Chemistry, Hep G2 Cells, biology.organism_classification, medicine.disease, In vitro, Visceral leishmaniasis, Molecular Medicine, Carbolines

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f105cc7e140d558379c306bc77b01d5e
https://pubmed.ncbi.nlm.nih.gov/24980054

المؤلفون: Robert K. Campbell, Michael P. Pollastri, Jennifer L. Woodring, Nicholas D. Bland, Stefan O. Ochiana

المصدر: Bioorganicmedicinal chemistry letters. 23(21)

مصطلحات موضوعية: Models, Molecular, Pyridines, Clinical Biochemistry, Trypanosoma brucei brucei, Catechols, Protozoan Proteins, Pharmaceutical Science, Trypanosoma brucei, Pharmacology, Biochemistry, Article, chemistry.chemical_compound, Phosphodiesterase-4, Drug Discovery, medicine, Humans, African trypanosomiasis, Molecular Biology, Trypanocidal agent, Catechol, biology, Drug discovery, Organic Chemistry, Phosphodiesterase, biology.organism_classification, medicine.disease, Trypanocidal Agents, Trypanosomiasis, African, chemistry, 3',5'-Cyclic-AMP Phosphodiesterases, Benzamides, Molecular Medicine, Phosphodiesterase 4 Inhibitors, Piclamilast

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7fd105b9ea1f9531782275ba723f427
https://pubmed.ncbi.nlm.nih.gov/24042005