المؤلفون: Harini Natarajan, Shiwei Xu, Andrew R. Crowley, Savannah E. Butler, Joshua A. Weiner, Evan M. Bloch, Kirsten Littlefield, Sarah E. Benner, Ruchee Shrestha, Olivia Ajayi, Wendy Wieland-Alter, David Sullivan, Shmuel Shoham, Thomas C. Quinn, Arturo Casadevall, Andrew Pekosz, Andrew D. Redd, Aaron A. R. Tobian, Ruth I. Connor, Peter F. Wright, Margaret E. Ackerman

المصدر: BMC Immunology, Vol 23, Iss 1, Pp 1-11 (2022)

مصطلحات موضوعية: SARS-CoV-2, IgG, IgM, IgA, Neutralization, Effector function, Immunologic diseases. Allergy, RC581-607

الوصف: Abstract Background While antibodies can provide significant protection from SARS-CoV-2 infection and disease sequelae, the specific attributes of the humoral response that contribute to immunity are incompletely defined. Methods We employ machine learning to relate characteristics of the polyclonal antibody response raised by natural infection to diverse antibody effector functions and neutralization potency with the goal of generating both accurate predictions of each activity based on antibody response profiles as well as insights into antibody mechanisms of action. Results To this end, antibody-mediated phagocytosis, cytotoxicity, complement deposition, and neutralization were accurately predicted from biophysical antibody profiles in both discovery and validation cohorts. These models identified SARS-CoV-2-specific IgM as a key predictor of neutralization activity whose mechanistic relevance was supported experimentally by depletion. Conclusions Validated models of how different aspects of the humoral response relate to antiviral antibody activities suggest desirable attributes to recapitulate by vaccination or other antibody-based interventions.

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1471-2172

URL الوصول: https://doaj.org/article/034c463115724341925f58490be90688

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