المؤلفون: Ocean AJ; New York Presbyterian Hospital, Weill Cornell Medical College, New York, NY, USA., Christos P, Sparano JA, Matulich D, Kaubish A, Siegel A, Sung M, Ward MM, Hamel N, Espinoza-Delgado I, Yen Y, Lane ME

المصدر: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2011 Aug; Vol. 68 (2), pp. 379-88. Date of Electronic Publication: 2010 Oct 28.

نوع المنشور: Clinical Trial, Phase II; Comparative Study; Journal Article

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7806519 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0843 (Electronic) Linking ISSN: 03445704 NLM ISO Abbreviation: Cancer Chemother Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*therapeutic use , Antineoplastic Combined Chemotherapy Protocols/*therapeutic use , Biliary Tract Neoplasms/*drug therapy , Deoxycytidine/*analogs & derivatives , Enzyme Inhibitors/*therapeutic use , Pyridines/*therapeutic use , Ribonucleotide Reductases/*antagonists & inhibitors , Thiosemicarbazones/*therapeutic use, Adenocarcinoma/complications ; Adenocarcinoma/drug therapy ; Adenocarcinoma/metabolism ; Adenocarcinoma/pathology ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Biliary Tract Neoplasms/complications ; Biliary Tract Neoplasms/metabolism ; Biliary Tract Neoplasms/pathology ; Biopsy, Fine-Needle ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cohort Studies ; Deoxycytidine/administration & dosage ; Deoxycytidine/adverse effects ; Deoxycytidine/therapeutic use ; Enzyme Inhibitors/administration & dosage ; Enzyme Inhibitors/adverse effects ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Hepatic Insufficiency/complications ; Humans ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/metabolism ; Male ; Middle Aged ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Neoplasm Staging ; Neutropenia/chemically induced ; Pyridines/administration & dosage ; Pyridines/adverse effects ; RNA, Messenger/metabolism ; Ribonucleotide Reductases/adverse effects ; Ribonucleotide Reductases/genetics ; Ribonucleotide Reductases/metabolism ; Survival Analysis ; Thiosemicarbazones/administration & dosage ; Thiosemicarbazones/adverse effects ; Gemcitabine

المؤلفون: Ferdinandi ES; Lorus Therapeutics Inc., 2 Meridian Road., Toronto, ON M9W 4Z7, Canada., Vassilakos A, Lee Y, Lightfoot J, Fitsialos D, Wright JA, Young AH

المصدر: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2011 Jul; Vol. 68 (1), pp. 193-205. Date of Electronic Publication: 2010 Oct 01.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7806519 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0843 (Electronic) Linking ISSN: 03445704 NLM ISO Abbreviation: Cancer Chemother Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacokinetics , Antineoplastic Agents/*toxicity , Oligodeoxyribonucleotides/*pharmacokinetics , Oligodeoxyribonucleotides/*toxicity , Phosphorothioate Oligonucleotides/*pharmacokinetics , Phosphorothioate Oligonucleotides/*toxicity , Ribonucleotide Reductases/*genetics, Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/blood ; Base Sequence ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Female ; Humans ; Macaca mulatta ; Male ; Oligodeoxyribonucleotides/administration & dosage ; Oligodeoxyribonucleotides/blood ; Phosphorothioate Oligonucleotides/administration & dosage ; Phosphorothioate Oligonucleotides/blood ; RNA, Messenger/chemistry ; RNA, Messenger/genetics ; Rats ; Rats, Sprague-Dawley ; Ribonucleotide Reductases/metabolism

المؤلفون: Wadler S; Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York, USA., Horowitz R, Rao J, Mao X, Schlesinger K, Schwartz EL

المصدر: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 1996; Vol. 38 (6), pp. 522-8.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, P.H.S.

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7806519 Publication Model: Print Cited Medium: Print ISSN: 0344-5704 (Print) Linking ISSN: 03445704 NLM ISO Abbreviation: Cancer Chemother Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Colonic Neoplasms/*drug therapy , Hydroxyurea/*pharmacology , Interferon-alpha/*pharmacology , Ribonucleotide Reductases/*drug effects, Base Sequence ; Cell Survival/drug effects ; Colonic Neoplasms/enzymology ; Drug Resistance, Neoplasm ; Drug Synergism ; Humans ; Interferon alpha-2 ; RNA, Messenger/analysis ; Recombinant Proteins ; Ribonucleotide Reductases/genetics ; Ribonucleotide Reductases/metabolism ; Tumor Cells, Cultured/drug effects

المؤلفون: Takahashi T; Department of Cancer Chemotherapy, Kyowa Hakko Kogyo Co., Ltd., Shizuoka-ken, Japan., Nakashima A, Kanazawa J, Yamaguchi K, Akinaga S, Tamaoki T, Okabe M

المصدر: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 1998; Vol. 41 (4), pp. 268-74.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7806519 Publication Model: Print Cited Medium: Print ISSN: 0344-5704 (Print) Linking ISSN: 03445704 NLM ISO Abbreviation: Cancer Chemother Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Deoxycytidine/*analogs & derivatives , Ribonucleotide Reductases/*drug effects, Antineoplastic Agents/metabolism ; Deoxycytidine/metabolism ; Deoxycytidine/pharmacology ; Deoxycytidine Kinase/drug effects ; Deoxycytidine Kinase/metabolism ; HeLa Cells ; Humans ; In Vitro Techniques ; Ribonucleotide Reductases/metabolism

المؤلفون: Szekeres T; Institute of Medical Chemistry, University of Vienna, Austria., Gharehbaghi K, Fritzer M, Woody M, Srivastava A, van't Riet B, Jayaram HN, Elford HL

المصدر: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 1994; Vol. 34 (1), pp. 63-6.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7806519 Publication Model: Print Cited Medium: Print ISSN: 0344-5704 (Print) Linking ISSN: 03445704 NLM ISO Abbreviation: Cancer Chemother Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Benzamidines/*pharmacology , Leukemia, Experimental/*drug therapy , Ribonucleotide Reductases/*antagonists & inhibitors, Animals ; Drug Screening Assays, Antitumor ; Female ; Leukemia, Experimental/enzymology ; Male ; Mice ; Mice, Inbred Strains ; Neoplasm Transplantation ; Ribonucleotide Reductases/analysis ; Tumor Cells, Cultured

المؤلفون: Kunos CA; Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD, USA. charles.kunos@nih.gov.; Investigational Drug Branch, Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, MSC 9739, Rockville, MD, 20892-9760, USA. charles.kunos@nih.gov., Chu E; University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Beumer JH; University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Cancer Therapeutics Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.; University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA., Sznol M; Yale University School of Medicine and Yale Cancer Center, New Haven, CT, USA., Ivy SP; Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, MD, USA.

المصدر: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2017 Jan; Vol. 79 (1), pp. 201-207. Date of Electronic Publication: 2016 Nov 22.

نوع المنشور: Clinical Trial, Phase I; Journal Article

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7806519 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0843 (Electronic) Linking ISSN: 03445704 NLM ISO Abbreviation: Cancer Chemother Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Combined Chemotherapy Protocols/*therapeutic use , Neoplasms/*drug therapy , Pyridines/*administration & dosage , Ribonucleotide Reductases/*antagonists & inhibitors , Thiosemicarbazones/*administration & dosage, Adult ; Aged ; Aged, 80 and over ; Cisplatin/administration & dosage ; Cisplatin/adverse effects ; Female ; Humans ; Infusions, Intravenous ; Male ; Middle Aged ; Neoplasm Staging ; Neoplasms/diagnosis ; Pyridines/adverse effects ; Pyridines/pharmacokinetics ; Thiosemicarbazones/adverse effects ; Thiosemicarbazones/pharmacokinetics

المؤلفون: Roman NO; Arizona Cancer Center, University of Arizona, 1515 N. Campbell Ave., Tucson, AZ 85724-5024, USA., Samulitis BK, Wisner L, Landowski TH, Dorr RT

المصدر: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2011 Jan; Vol. 67 (1), pp. 183-92. Date of Electronic Publication: 2010 Mar 26.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7806519 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0843 (Electronic) Linking ISSN: 03445704 NLM ISO Abbreviation: Cancer Chemother Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Combined Chemotherapy Protocols/*pharmacology , Pancreatic Neoplasms/*drug therapy , Ribonucleotide Reductases/*antagonists & inhibitors, Animals ; Antineoplastic Combined Chemotherapy Protocols/pharmacokinetics ; Area Under Curve ; Cell Line, Tumor ; Deoxycytidine/administration & dosage ; Deoxycytidine/analogs & derivatives ; Drug Synergism ; Female ; Hexanones/administration & dosage ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, SCID ; Pancreatic Neoplasms/pathology ; Xenograft Model Antitumor Assays ; Gemcitabine

المؤلفون: Eley HL; Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham, UK., McDonald PS, Russell ST, Tisdale MJ

المصدر: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2009 Mar; Vol. 63 (4), pp. 651-9. Date of Electronic Publication: 2008 Jun 14.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7806519 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0843 (Electronic) Linking ISSN: 03445704 NLM ISO Abbreviation: Cancer Chemother Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Neoplasms, Experimental/*pathology , Protein Kinase Inhibitors/*pharmacology , RNA, Double-Stranded/*drug effects , eIF-2 Kinase/*antagonists & inhibitors, Animals ; Antimetabolites, Antineoplastic/pharmacology ; Blotting, Western ; Cell Proliferation ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/pharmacology ; Electrophoretic Mobility Shift Assay ; Enzyme Activation/drug effects ; Fluorouracil/pharmacology ; Mice ; NF-kappa B/metabolism ; Neoplasms, Experimental/enzymology ; Neoplasms, Experimental/genetics ; Phosphorylation/drug effects ; Proteasome Endopeptidase Complex/genetics ; Proteasome Endopeptidase Complex/metabolism ; Protein Biosynthesis ; Ribonucleotide Reductases/antagonists & inhibitors ; Gemcitabine

المؤلفون: Nomura N; Department of Surgery II, Nagoya University, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. sjypy948@yahoo.co.jp, Kasuya H, Watanabe I, Shikano T, Shirota T, Misawa M, Sugimoto H, Kanazumi N, Nomoto S, Takeda S, Nakao A

المصدر: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2009 Jan; Vol. 63 (2), pp. 321-30. Date of Electronic Publication: 2008 Jun 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7806519 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0843 (Electronic) Linking ISSN: 03445704 NLM ISO Abbreviation: Cancer Chemother Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Herpesvirus 1, Human/*genetics , Liver Neoplasms/*secondary , Liver Neoplasms/*therapy, Animals ; Cell Line, Tumor ; Chlorocebus aethiops ; Endothelial Cells/enzymology ; Endothelial Cells/virology ; Genetic Vectors ; Hepatocytes/enzymology ; Hepatocytes/virology ; Herpesvirus 1, Human/immunology ; Herpesvirus 1, Human/physiology ; Humans ; Immunoglobulin G/blood ; Injections, Intravenous ; Lac Operon ; Liver Neoplasms/enzymology ; Mice ; Mice, Inbred BALB C ; Polymerase Chain Reaction ; Ribonucleotide Reductases/biosynthesis ; Vero Cells ; Virus Replication ; Xenograft Model Antitumor Assays

المؤلفون: Okusaka T; Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. tokusaka@ncc.go.jp, Ishii H, Funakoshi A, Yamao K, Ohkawa S, Saito S, Saito H, Tsuyuguchi T

المصدر: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2006 May; Vol. 57 (5), pp. 647-53. Date of Electronic Publication: 2005 Sep 02.

نوع المنشور: Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7806519 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0344-5704 (Print) Linking ISSN: 03445704 NLM ISO Abbreviation: Cancer Chemother Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Adenocarcinoma/*drug therapy , Antimetabolites, Antineoplastic/*therapeutic use , Biliary Tract Neoplasms/*drug therapy , Deoxycytidine/*analogs & derivatives, Adenocarcinoma/mortality ; Adenocarcinoma/secondary ; Adult ; Aged ; Biliary Tract Neoplasms/mortality ; Biliary Tract Neoplasms/pathology ; Deoxycytidine/therapeutic use ; Female ; Humans ; Male ; Maximum Tolerated Dose ; Middle Aged ; Ribonucleotide Reductases/antagonists & inhibitors ; Survival Rate ; Gemcitabine