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المؤلفون: Guinn S; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland., Kinny-Köster B; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Surgery, New York University Grossman School of Medicine, New York, New York., Tandurella JA; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland., Mitchell JT; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland., Sidiropoulos DN; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland., Loth M; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland., Lyman MR; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland., Pucsek AB; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland., Zabransky DJ; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland., Lee JW; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland., Kartalia E; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland., Ramani M; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland., Seppälä TT; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere University Hospital, Tampere, Finland., Cherry C; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Translational Tissue Engineering Center, Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, Maryland.; Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland., Suri R; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Zlomke H; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Patel J; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., He J; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Wolfgang CL; Department of Surgery, New York University Grossman School of Medicine, New York, New York., Yu J; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Zheng L; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland., Ryan DP; The Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Ting DT; The Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Kimmelman A; Department of Radiation Oncology at New York University Grossman School of Medicine, NYU Langone Health, New York, New York., Gupta A; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Danilova L; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland., Elisseeff JH; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Translational Tissue Engineering Center, Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, Maryland.; Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland., Wood LD; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland., Stein-O'Brien G; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, Maryland., Kagohara LT; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland., Jaffee EM; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland., Burkhart RA; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Fertig EJ; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland.; Department of Applied Mathematics and Statistics, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland., Zimmerman JW; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Bloomberg Kimmel Immunology Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.

المصدر: Cancer research [Cancer Res] 2024 May 02; Vol. 84 (9), pp. 1517-1533.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Epithelial-Mesenchymal Transition* , Carcinoma, Pancreatic Ductal*/pathology , Carcinoma, Pancreatic Ductal*/metabolism , Carcinoma, Pancreatic Ductal*/genetics , Cancer-Associated Fibroblasts*/metabolism , Cancer-Associated Fibroblasts*/pathology , Pancreatic Neoplasms*/pathology , Pancreatic Neoplasms*/metabolism , Pancreatic Neoplasms*/genetics , Inflammation*/pathology , Inflammation*/metabolism , Tumor Microenvironment* , Integrin beta1*/metabolism , Integrin beta1*/genetics , Coculture Techniques* , Single-Cell Analysis*, Humans ; Organoids/pathology ; Organoids/metabolism ; Vascular Endothelial Growth Factor A/metabolism ; Vascular Endothelial Growth Factor A/genetics ; Neuropilin-1/metabolism ; Neuropilin-1/genetics ; Gene Expression Regulation, Neoplastic ; Cell Line, Tumor ; Cell Communication