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1
المؤلفون: Maiko Kawashima, Reiko Tanaka, Yuki Mizutani, Takashi Kikuchi, Takeshi Yamada, Naoko Inno, Yoshihide Umebayashi
المصدر: ChemInform. 45
مصطلحات موضوعية: biology, Strain (chemistry), Stereochemistry, Absolute configuration, Trichoderma harzianum, General Medicine, biology.organism_classification, chemistry.chemical_compound, Sponge, Decalin, chemistry, Organic chemistry, Cytotoxicity, Two-dimensional nuclear magnetic resonance spectroscopy, Derivative (chemistry)
الوصف: Tandyukisin (1), a novel decalin derivative with an enolic β-ketoaldehyde, has been isolated from a strain of Trichoderma harzianum OUPS-111D-4 originally derived from the marine sponge Halichondria okadai, and its structure has been elucidated on the basis of spectroscopic analyses using 1D and 2D NMR techniques. In addition, the absolute configuration for 1 was established by the application of CD spectrum to the tribenzoate derivative. This compounds exhibited moderate cytotoxicity against human cancer cell lines.
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2
المؤلفون: Ahmed Toumi, Mejda Daami-Remadi, Hichem Ben Jannet
المصدر: ChemInform. 45
مصطلحات موضوعية: Schiff base, biology, Nitrile, Stereochemistry, Trichoderma harzianum, General Medicine, Carbon-13 NMR, biology.organism_classification, Cycloaddition, chemistry.chemical_compound, Meta, chemistry, Proton NMR, Acetophenone
الوصف: A series of arylaldehydes and acetophenone when treated with 1,2-ethanediamine afford the bis-Schiff bases N,N’bis(arylidene)-ethane-1,2-diamines 1-8, N,N’-bis(arylmethylene)-ethane-1,2-diamines 9-10 and the N,N’-bis(1phenylethylidene)-ethane-1,2-diamine 11. The bis-imines 1-11 on regiospecific 1,3-dipolar cycloaddition with [(4chlorophenyl)methyldyne]azans oxide, prepared in situ, afford the expected new 1,2,4-bis-oxadiazolines 12-22. The target molecules have been identified on the basis of satisfactory analytical results and characterized by spectroscopic means (H NMR, C NMR, UV, IR, HRMS and elemental analyses). All the previously unknown compounds 12-22 have been screened for their antifungal activity towards Trichoderma harzianum, Botrytis cinerea, Fusarium sambucinum and Penicillium sp. using the disc diffusion method. Applied at two concentrations, some of these bis-oxadiazolines exhibit an interesting inhibitory effect against the fungi tested. It is found that compounds, possessing an NO2 group on their aromatic ring, exhibit variable antifungal activity against B. cinerea depending on NO2 position. In fact, the inhibitory activity has been found to be increased when the NO2 group is situated in the meta position.
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3
المؤلفون: Choong Hwan Lee, Yung Hee Kho, Ho Jae Lee, Myung Chul Chung, Hiroyuki Koshino
المصدر: ChemInform. 27
مصطلحات موضوعية: Melanin synthesis, biology, Biochemistry, Chemistry, Trichoderma harzianum, General Medicine, biology.organism_classification
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4
المؤلفون: Yung Hee Kho, Myung Chul Chung, Hiroyuki Koshino, Choong Hwan Lee, Ho Jae Lee
المصدر: ChemInform. 27
مصطلحات موضوعية: chemistry.chemical_compound, biology, Stereochemistry, Chemistry, Organic chemistry, Trichoderma harzianum, General Medicine, biology.organism_classification, Oxazole
الوصف: The ethylacetate extract of Trichoderma harzianum KCTC 0114BP cultures afforded a novel oxazole, MR-93A [1]. The structure of was elucidated as 4-(3,4-dihydroxy-(E)-1-pentenyl)-oxazole by spectroscopic methods.
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5
المؤلفون: Steven E. Klohr, Richard A. Dalterio, Jingfang Qian-Cutrone, Li-Ping Chang, Susan E. Lowe, Stella Huang, Robert Hugill, Kathleen F. Kadow, Dolores M. Pirnik, M. Alam
المصدر: ChemInform. 28
مصطلحات موضوعية: Bioassay guided fractionation, biology, viruses, Butanol, Human immunodeficiency virus (HIV), RNA, Trichoderma harzianum, General Medicine, Harziphilone, medicine.disease_cause, biology.organism_classification, chemistry.chemical_compound, chemistry, Biochemistry, Cell culture, medicine, Cytotoxicity
الوصف: During the screening of the natural products for their ability to inhibit the binding of REV (regulation of virion expression) protein to [33P] labeled RRE (REV responsive element) RNA, two novel fungal metabolites, harziphilone and fleephilone, were isolated from the butanol - methanol (1:1) extract of the fermentation broth of Trichoderma harzianum by bioassay guided fractionation. The structures of these two new compounds were established by spectroscopic methods. Harziphilone and fleephilone showed inhibitory activity against the binding of REV-protein to RRE RNA with IC50 values of 2.0μM and 7.6μM, respectively. However both compounds did not protect CEM-SS cells from acute HIV infection at concentration levels up to 200μg/ml using an XTT dye reduction assay. In addition, harziphilone demonstrated cytotoxicity at 38μM against the murine tumor cell line M-109.
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6
المؤلفون: Isabelle Augeven-Bour, Bernard Bodo, Christophe Goulard, Yann Prigent, Catherine Auvin, Sylvie Rebuffat
المصدر: ChemInform. 28
مصطلحات موضوعية: chemistry.chemical_classification, biology, Stereochemistry, Peptaibol, Trichoderma harzianum, General Medicine, Tripeptide, biology.organism_classification, High-performance liquid chromatography, Amino acid, chemistry.chemical_compound, Residue (chemistry), chemistry, Membrane activity, Proton NMR
الوصف: Harzianin HB I is a minor component of the peptaibol mixture biosynthesized by a Trichoderma harzianum strain. It is isolated by a multi-step chromatography procedure, including HPLC; its sequence has been elucidated by LSIMS and two-dimensional 1H NMR experiments. This 11-residue peptaibol is an analogue of the 14-residue peptaibol harzianin HC IX, resulting from the deletion of the tripeptide Aib-Pro-Ala. The CD and NMR data (NOE data and amide proton temperature coefficients) are similar to those of HC IX, suggesting a right-handed helix-type conformation for the two peptides. Harzianin HB I was synthesized by the solution-phase method using BOP as coupling reagent. The membrane properties examined on liposomes are compared with those of other known peptaibols.
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7
المؤلفون: Michel Becchi, Delphine Duval, Christophe Goulard, Bernard Bodo, Yann Prigent, Sylvie Rebuffat
المصدر: ChemInform. 28
مصطلحات موضوعية: chemistry.chemical_classification, biology, medicine.drug_class, Sequence analysis, Antibiotics, Trichoderma harzianum, Peptide, General Medicine, Isolation (microbiology), biology.organism_classification, Amino acid, Microbiology, chemistry, medicine
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8
المؤلفون: M. C. Chung, Y. H. Kho, C. H. Lee, J. S. Yoo, J. K. Hong, H. J. Lee, Hiroyuki Koshino
المصدر: ChemInform. 28
مصطلحات موضوعية: biology, Stereochemistry, Chemistry, Organic chemistry, Trichoderma harzianum, General Medicine, biology.organism_classification, Melanin Synthesis Inhibitors
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9
المؤلفون: T. Kikuchi, Q. Huang, Yasuhiro Tezuka, Yasumaru Hatanaka, M. Tasaki
المصدر: ChemInform. 29
مصطلحات موضوعية: Terpene, chemistry.chemical_compound, chemistry, biology, Botany, Trichoderma harzianum, General Medicine, Fungus, Sesquiterpene, biology.organism_classification
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10
المؤلفون: Katsuhiko Minoura, Tadayoshi Ito, Atsushi Numata, Yoshihide Usami, Taro Amagata
المصدر: ChemInform. 29
مصطلحات موضوعية: Sponge, biology, Strain (chemistry), Chemistry, Trichoderma harzianum, Fungal strain, General Medicine, Cytotoxic substances, biology.organism_classification, Cytotoxicity, Microbiology, Halichondria okadai
الوصف: Five novel metabolites, trichodenones A-C (1-3), harzialactone A (4) and B (5), have been isolated together with known R-mevalonolactone (6) from the culture broth of a strain of Trichoderma harzianum OUPS-N115 originally separated from the sponge Halichondria okadai. Their structures have been elucidated by spectral evidence. Among them, 1-3 exhibited significant cytotoxicity against cultured P388 cells.
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