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    المصدر: Clinical Nutrition. 26:239-244

    الوصف: Summary Background & aims Resveratrol has been reported to have antitumoural effects and recently it has been demonstrated that resveratrol partially blocks skeletal muscle wasting by interfering with NF- κ B activation. We decided to investigate the potential anti-wasting properties of resveratrol on different models of cancer cachexia in experimental animals. Methods and results Incubations of isolated extensor digitorum longus muscles in the presence of 30μM of resveratrol caused a significant decrease in the rate of protein degradation. However, administration of resveratrol in vivo to both rats bearing the Yoshida AH-130 ascites hepatoma (at the dose of 1mg/kg body weight) and mice bearing the Lewis lung carcinoma (at two different doses, 5 and 25mg/kg body weight) had no effect on skeletal muscle mass or body weight in tumour-bearing rodents. In addition, a combination of resveratrol (3mg/kg body weight) and fish oil was also unable to induce any changes in skeletal muscle weights. Conclusions It is therefore concluded from this study that resveratrol is unable to influence muscle mass in vivo and has no potential role as anticachectic agent for the treatment of muscle wasting associated with tumour growth.

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    المصدر: Clinical Nutrition. 5:117-121

    الوصف: To study the potential benefits of hypocaloric peripheral parenteral nutrition (HPPN) in medium to high risk surgical patients we compared this regimen with standard fluid therapy during the postoperative period. Seventy patients were randomised to receive HPPN, consisting of 1 g of amino acids and 2 g of polyols (sorbitol and xylitol) per Kg per day (n = 41), or 1500 ml of 5% glucose and 1500 ml of saline (n = 29). There were no differences in length of hospital stay, postoperative complications or weight loss between the two groups. Concentrations of short and long half-life plasma proteins were similar in both groups. Nitrogen balance was negative and the nitrogen retention was low (60%) in the HPPN group. We conclude that there are no discernible clinical advantages in giving HPPN postoperatively to patients undergoing medium or major severity elective surgery.