المؤلفون: Li CY; Department of Environmental and Occupational Health Sciences (C.Y.L., S.L., T.K.B., J.Y.C.), and Department of Pharmaceutics (D.K.B., B.P.), University of Washington, Seattle, Washington; and Pacific Northwest National Laboratory, Sequim, Washington (S.C., L.-J.K., I.R.S.)., Lee S; Department of Environmental and Occupational Health Sciences (C.Y.L., S.L., T.K.B., J.Y.C.), and Department of Pharmaceutics (D.K.B., B.P.), University of Washington, Seattle, Washington; and Pacific Northwest National Laboratory, Sequim, Washington (S.C., L.-J.K., I.R.S.)., Cade S; Department of Environmental and Occupational Health Sciences (C.Y.L., S.L., T.K.B., J.Y.C.), and Department of Pharmaceutics (D.K.B., B.P.), University of Washington, Seattle, Washington; and Pacific Northwest National Laboratory, Sequim, Washington (S.C., L.-J.K., I.R.S.)., Kuo LJ; Department of Environmental and Occupational Health Sciences (C.Y.L., S.L., T.K.B., J.Y.C.), and Department of Pharmaceutics (D.K.B., B.P.), University of Washington, Seattle, Washington; and Pacific Northwest National Laboratory, Sequim, Washington (S.C., L.-J.K., I.R.S.)., Schultz IR; Department of Environmental and Occupational Health Sciences (C.Y.L., S.L., T.K.B., J.Y.C.), and Department of Pharmaceutics (D.K.B., B.P.), University of Washington, Seattle, Washington; and Pacific Northwest National Laboratory, Sequim, Washington (S.C., L.-J.K., I.R.S.)., Bhatt DK; Department of Environmental and Occupational Health Sciences (C.Y.L., S.L., T.K.B., J.Y.C.), and Department of Pharmaceutics (D.K.B., B.P.), University of Washington, Seattle, Washington; and Pacific Northwest National Laboratory, Sequim, Washington (S.C., L.-J.K., I.R.S.)., Prasad B; Department of Environmental and Occupational Health Sciences (C.Y.L., S.L., T.K.B., J.Y.C.), and Department of Pharmaceutics (D.K.B., B.P.), University of Washington, Seattle, Washington; and Pacific Northwest National Laboratory, Sequim, Washington (S.C., L.-J.K., I.R.S.)., Bammler TK; Department of Environmental and Occupational Health Sciences (C.Y.L., S.L., T.K.B., J.Y.C.), and Department of Pharmaceutics (D.K.B., B.P.), University of Washington, Seattle, Washington; and Pacific Northwest National Laboratory, Sequim, Washington (S.C., L.-J.K., I.R.S.)., Cui JY; Department of Environmental and Occupational Health Sciences (C.Y.L., S.L., T.K.B., J.Y.C.), and Department of Pharmaceutics (D.K.B., B.P.), University of Washington, Seattle, Washington; and Pacific Northwest National Laboratory, Sequim, Washington (S.C., L.-J.K., I.R.S.) juliacui@uw.edu.

المصدر: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2017 Nov; Vol. 45 (11), pp. 1197-1214. Date of Electronic Publication: 2017 Sep 01.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE

مواضيع طبية MeSH: Cytochrome P-450 Enzyme System/*metabolism , Environmental Pollutants/*metabolism , Gastrointestinal Microbiome/*physiology , Liver/*enzymology, Animals ; Biotransformation/physiology ; Down-Regulation ; Environmental Pollutants/toxicity ; Halogenated Diphenyl Ethers/metabolism ; Halogenated Diphenyl Ethers/toxicity ; Hydroxylation/physiology ; Male ; Metabolomics ; Mice ; Mice, Inbred C57BL ; Polybrominated Biphenyls/metabolism ; Sequence Analysis, RNA ; Specific Pathogen-Free Organisms ; Up-Regulation