المؤلفون: Zhuang T; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China; Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China., Xiong J; School of Medicine, Guangxi University of Science and Technology, Liuzhou, 545005, China., Ren X; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China., Liang L; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China., Qi Z; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China., Zhang S; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China., Du W; Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China., Chen Y; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China. Electronic address: 2019000015@jou.edu.cn., Liu X; Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China. Electronic address: xliu@mail.hust.edu.cn., Zhang G; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China; Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China. Electronic address: gszhang@mail.hust.edu.cn.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2022 Nov 05; Vol. 241, pp. 114649. Date of Electronic Publication: 2022 Aug 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Analgesics*/pharmacology , Neuralgia* , Receptors, Opioid, mu*/agonists , Receptors, Opioid, mu*/antagonists & inhibitors , Receptors, sigma*/agonists , Receptors, sigma*/antagonists & inhibitors, Animals ; Ligands ; Mice ; Naloxone/pharmacology ; Rats ; Sigma-1 Receptor

المؤلفون: Liao LS; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, PR China., Tan LJ; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, PR China., Chen Y; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, PR China., Yang QY; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, PR China., Choudhary MI; International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 74270, Pakistan., Pan YM; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, PR China., Tang HT; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, PR China., Su GF; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, PR China. Electronic address: gfysglgx@163.com., Liang H; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, PR China. Electronic address: hliang@gxnu.edu.cn., Chen ZF; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, PR China. Electronic address: chenzf@gxnu.edu.cn.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2022 Mar 05; Vol. 231, pp. 114141. Date of Electronic Publication: 2022 Jan 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents*, Animals ; Apoptosis ; Cell Cycle Checkpoints ; Cell Line, Tumor ; Cell Proliferation ; Drug Screening Assays, Antitumor ; Humans ; Mice ; Mitochondria ; S Phase

المؤلفون: Xiong J; Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China., Zhuang T; Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China., Ma Y; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China., Xu J; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China., Ye J; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China., Ma R; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China., Zhang S; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China., Liu X; Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China., Liu BF; Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China., Hao C; Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China. Electronic address: d201880507@hust.edu.cn., Zhang G; Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China. Electronic address: gszhang@mail.hust.edu.cn., Chen Y; Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China. Electronic address: 2019000015@jou.edu.cn.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2021 Dec 15; Vol. 226, pp. 113879. Date of Electronic Publication: 2021 Oct 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Amides/*pharmacology , Neuralgia/*drug therapy , Piperidines/*pharmacology , Receptors, Opioid, mu/*agonists , Receptors, sigma/*antagonists & inhibitors, Acetic Acid ; Amides/chemical synthesis ; Amides/chemistry ; Animals ; Behavior, Animal/drug effects ; Dose-Response Relationship, Drug ; Formaldehyde ; Guinea Pigs ; Mice ; Mice, Inbred ICR ; Molecular Dynamics Simulation ; Molecular Structure ; Neuralgia/chemically induced ; Neuralgia/metabolism ; Pain Measurement ; Piperidines/chemical synthesis ; Piperidines/chemistry ; Rats ; Rats, Sprague-Dawley ; Receptors, Opioid, mu/metabolism ; Receptors, sigma/metabolism ; Structure-Activity Relationship ; Sigma-1 Receptor

المؤلفون: Zhuang T; Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China., Xiong J; Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China., Hao S; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China., Du W; Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China., Liu Z; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China. Electronic address: zmliu@bjmu.edu.cn., Liu B; Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China., Zhang G; Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China. Electronic address: gszhang@mail.hust.edu.cn., Chen Y; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China. Electronic address: 2019000015@jou.edu.cn.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2021 Nov 05; Vol. 223, pp. 113658. Date of Electronic Publication: 2021 Jun 18.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Analgesics, Opioid/*chemistry , Receptors, Opioid, delta/*antagonists & inhibitors , Receptors, Opioid, mu/*agonists, Analgesics, Opioid/adverse effects ; Analgesics, Opioid/metabolism ; Analgesics, Opioid/therapeutic use ; Benzopyrans/chemistry ; Benzopyrans/metabolism ; Humans ; Ligands ; Pain/drug therapy ; Piperazines/chemistry ; Piperazines/metabolism ; Receptors, Opioid, delta/metabolism ; Receptors, Opioid, mu/metabolism ; Receptors, sigma/antagonists & inhibitors ; Receptors, sigma/metabolism ; Sigma-1 Receptor

المؤلفون: Jin J; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China., Zhang K; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China., Dou F; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China., Hao C; Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China., Zhang Y; Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China., Cao X; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, Jiangsu, China., Gao L; Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China., Xiong J; Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China., Liu X; Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China., Liu BF; Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China., Zhang G; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China; Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China. Electronic address: gszhang@mail.hust.edu.cn., Chen Y; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China. Electronic address: 2019000015@jou.edu.cn.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2020 Dec 01; Vol. 207, pp. 112709. Date of Electronic Publication: 2020 Aug 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antipsychotic Agents/*pharmacology , Dopamine Agents/*pharmacology , Isoquinolines/*pharmacology , Receptors, Dopamine D2/*metabolism , Serotonin/*metabolism , Serotonin Agents/*pharmacology, Animals ; Antipsychotic Agents/chemical synthesis ; Antipsychotic Agents/chemistry ; CHO Cells ; Cricetulus ; Dopamine Agents/chemical synthesis ; Dopamine Agents/chemistry ; Drug Design ; HEK293 Cells ; Humans ; Isoquinolines/chemical synthesis ; Isoquinolines/chemistry ; Mice ; Rats, Sprague-Dawley ; Serotonin Agents/chemical synthesis ; Serotonin Agents/chemistry ; Structure-Activity Relationship

المؤلفون: Xiong J; Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China., Jin J; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China., Gao L; Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China., Hao C; Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China., Liu X; Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China., Liu BF; Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China., Chen Y; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China. Electronic address: 2019000015@jou.edu.cn., Zhang G; Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China; Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China. Electronic address: gszhang@mail.hust.edu.cn.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2020 Apr 01; Vol. 191, pp. 112144. Date of Electronic Publication: 2020 Feb 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Amides/*pharmacology , Neuralgia/*drug therapy , Piperidines/*pharmacology , Receptors, Opioid, mu/*agonists , Receptors, sigma/*antagonists & inhibitors, Amides/administration & dosage ; Amides/chemistry ; Animals ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Formaldehyde ; Guinea Pigs ; Injections, Subcutaneous ; Mice ; Mice, Inbred ICR ; Molecular Structure ; Neuralgia/chemically induced ; Neuralgia/pathology ; Piperidines/administration & dosage ; Piperidines/chemistry ; Rats ; Rats, Sprague-Dawley ; Sciatic Nerve/drug effects ; Sciatic Nerve/pathology ; Structure-Activity Relationship ; Sigma-1 Receptor

المؤلفون: Chen Y; State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China., Zheng Y; State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China., Jiang Q; State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China; School of Pharmacy and Sichuan Province College Key Laboratory of Structure-Specific Small Molecule Drugs, Chengdu Medical College, Chengdu 610500, China., Qin F; State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China., Zhang Y; Collaborative Innovation Center for Biotherapy, School of Medicine, Tsinghua University, Beijing 100084, China., Fu L; State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China. Electronic address: leilei_fu@163.com., He G; State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China. Electronic address: hegu@scu.edu.cn.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2017 Feb 15; Vol. 127, pp. 997-1011. Date of Electronic Publication: 2016 Nov 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Computational Biology*, Antineoplastic Agents/*pharmacology , Breast Neoplasms/*pathology , Drug Discovery/*methods , Extracellular Signal-Regulated MAP Kinases/*antagonists & inhibitors , Phosphatidylethanolamine Binding Protein/*antagonists & inhibitors , Protein Kinase Inhibitors/*pharmacology, Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/metabolism ; Drug Design ; Extracellular Signal-Regulated MAP Kinases/chemistry ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Humans ; MCF-7 Cells ; Mitochondria/drug effects ; Mitochondria/metabolism ; Molecular Docking Simulation ; Phosphatidylethanolamine Binding Protein/chemistry ; Phosphatidylethanolamine Binding Protein/metabolism ; Protein Domains ; Sequence Homology, Amino Acid

المؤلفون: Cao X; Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China., Chen Y; Jiangsu Nhwa Pharmaceutical Co., Ltd., 69 Democratic South Road, Xuzhou, Jiangsu 221116, China., Zhang Y; Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China., Qiu Y; Jiangsu Nhwa Pharmaceutical Co., Ltd., 69 Democratic South Road, Xuzhou, Jiangsu 221116, China., Yu M; Jiangsu Nhwa Pharmaceutical Co., Ltd., 69 Democratic South Road, Xuzhou, Jiangsu 221116, China., Xu X; Jiangsu Nhwa Pharmaceutical Co., Ltd., 69 Democratic South Road, Xuzhou, Jiangsu 221116, China., Liu X; Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China., Liu BF; Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China., Zhang G; Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China; Jiangsu Nhwa Pharmaceutical Co., Ltd., 69 Democratic South Road, Xuzhou, Jiangsu 221116, China. Electronic address: gszhang@mail.hust.edu.cn.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2016 Nov 29; Vol. 124, pp. 713-728. Date of Electronic Publication: 2016 Sep 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Nitroimidazoles/*chemical synthesis , Nitroimidazoles/*pharmacology, Animals ; Antipsychotic Agents/chemical synthesis ; Antipsychotic Agents/chemistry ; Antipsychotic Agents/pharmacology ; Binding Sites ; Drug Delivery Systems/trends ; Drug Design ; Mice ; Molecular Structure ; Nitroimidazoles/chemistry ; Protein Binding/drug effects ; Pyridazines/chemical synthesis ; Pyridazines/chemistry ; Pyridazines/pharmacology ; Rats ; Receptor, Serotonin, 5-HT1A/metabolism ; Receptor, Serotonin, 5-HT2A/metabolism

المؤلفون: Zhang H; Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China., Xu X; Jiangsu Nhwa Pharmaceutical Co., Ltd., 69 Democratic South Road, Xuzhou, Jiangsu 221116, China., Chen Y; Jiangsu Nhwa Pharmaceutical Co., Ltd., 69 Democratic South Road, Xuzhou, Jiangsu 221116, China., Qiu Y; Jiangsu Nhwa Pharmaceutical Co., Ltd., 69 Democratic South Road, Xuzhou, Jiangsu 221116, China., Liu X; Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China., Liu BF; Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China., Zhang G; Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China; Jiangsu Nhwa Pharmaceutical Co., Ltd., 69 Democratic South Road, Xuzhou, Jiangsu 221116, China. Electronic address: gszhang@mail.hust.edu.cn.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2015 Jan 07; Vol. 89, pp. 524-39. Date of Electronic Publication: 2014 Oct 28.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Acetates/*chemistry , Acetates/*pharmacology , Fluorine/*chemistry , Hypnotics and Sedatives/*chemistry , Hypnotics and Sedatives/*pharmacology , Phenols/*chemistry , Phenols/*pharmacology , Reflex/*drug effects, Animals ; Dose-Response Relationship, Drug ; Hypnotics and Sedatives/chemical synthesis ; Molecular Structure ; Rats ; Rats, Sprague-Dawley ; Receptors, GABA-A/metabolism ; Receptors, N-Methyl-D-Aspartate/metabolism ; Structure-Activity Relationship

المؤلفون: Lan Y; Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China., Chen Y; Jiangsu Nhwa Pharmaceutical Co., Ltd. 69 Democratic South Road, Xuzhou, Jiangsu 221116, China., Xu X; Jiangsu Nhwa Pharmaceutical Co., Ltd. 69 Democratic South Road, Xuzhou, Jiangsu 221116, China., Qiu Y; Jiangsu Nhwa Pharmaceutical Co., Ltd. 69 Democratic South Road, Xuzhou, Jiangsu 221116, China., Liu S; Jiangsu Nhwa Pharmaceutical Co., Ltd. 69 Democratic South Road, Xuzhou, Jiangsu 221116, China., Liu X; Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China., Liu BF; Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China., Zhang G; Systems Biology Theme, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China; Jiangsu Nhwa Pharmaceutical Co., Ltd. 69 Democratic South Road, Xuzhou, Jiangsu 221116, China. Electronic address: gszhang@mail.hust.edu.cn.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2014 May 22; Vol. 79, pp. 216-30. Date of Electronic Publication: 2014 Apr 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Analgesics/*pharmacology , Hydroquinones/*pharmacology , Nociceptive Pain/*prevention & control , Receptors, sigma/*antagonists & inhibitors, Analgesics/chemical synthesis ; Analgesics/chemistry ; Animals ; Brain/drug effects ; Dose-Response Relationship, Drug ; Formaldehyde/administration & dosage ; Guinea Pigs ; Hydroquinones/chemical synthesis ; Hydroquinones/chemistry ; Mice ; Mice, Inbred Strains ; Molecular Structure ; Nociceptive Pain/chemically induced ; Pain Measurement ; Structure-Activity Relationship ; Sigma-1 Receptor