المؤلفون: Zhiguang Yan, Hongyuan Gao, Yanping Kuang, Li Wang, Wenya Guo, Xi Shen, Hui Long, Yun Wang, Shaozhen Zhang, Qifeng Lyu, Wei Jin, Renfei Cai

المصدر: Frontiers in Endocrinology
Frontiers in Endocrinology, Vol 10 (2019)

مصطلحات موضوعية: mature oocyte rate, 0301 basic medicine, medicine.medical_specialty, medicine.drug_class, Endocrinology, Diabetes and Metabolism, media_common.quotation_subject, 030209 endocrinology & metabolism, Stimulation, lcsh:Diseases of the endocrine glands. Clinical endocrinology, ovulation trigger–OPU interval, 03 medical and health sciences, Endocrinology, 0302 clinical medicine, medicine, Ovarian reserve, implantation rate, Ovulation, Original Research, media_common, Gynecology, lcsh:RC648-665, business.industry, Retrospective cohort study, Oocyte, live birth rate, 030104 developmental biology, medicine.anatomical_structure, progestin-primed ovarian stimulation (PPOS) protocol, Propensity score matching, Live birth, business, Progestin

الوصف: Background: To investigate the optimal ovulation trigger–oocyte pickup (OPU) interval of a progestin-primed ovarian stimulation (PPOS) protocol.Method: Patients with normal ovarian reserve in their first PPOS OPU cycle were enrolled in this retrospective cohort study between July 2013 and April 2018. This retrospective cohort study included two parts. In part I, we studied the regression trend of mature oocyte rate, implantation rate, and live birth rate within the whole ovulation trigger–OPU interval of 7,258 patients. To homogenize some clinical characters that were key regulators of OPU time, in part II, we used propensity score matching to auto-select patients among trigger–OPU interval group 1 (35.6–36.4 h), group 2 (36.4–37.1 h), and group 3 (37.1–37.8 h) and analyzed clinical outcomes.Results: Study part I showed that the whole ovulation trigger–OPU interval (33–39.5 h) of PPOS protocol had a trend of a high mature oocyte rate (>80%), increasing implantation rate, and high live birth rate. Propensity score matching of patients with homogeneous clinical characteristics further indicated that the trigger–OPU interval within groups 2 and 3 (36.4–37.8 h) had significantly higher mature oocyte rates (84.54% vs. 84.60% vs. 82.34%, P = 0.002) and implantation rates (34.17% vs. 34.37% vs. 29.61%, P < 0.05) than group 1. The same tend was observed in the live birth rate.Conclusions: The ovulation trigger–OPU interval of 36.4–37.8 h is optimal for most patients using a PPOS protocol.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ecd63310c434256dd95dd268b74c42
https://doi.org/10.3389/fendo.2019.00694

المؤلفون: Haihui Sheng, Wei Jin, Xiuxiu Su, Xiang Gao, Zhijun Wu, Lin Lu

المصدر: Frontiers in Endocrinology
Frontiers in Endocrinology, Vol 9 (2018)

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Single-nucleotide polymorphism, 030204 cardiovascular system & hematology, lcsh:Diseases of the endocrine glands. Clinical endocrinology, genetic risk score, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Diabetes mellitus, Internal medicine, medicine, Myocardial infarction, mediation analysis, Original Research, lcsh:RC648-665, business.industry, Case-control study, Odds ratio, medicine.disease, metabolic disease, Confidence interval, 030104 developmental biology, myocardial infarction, Quartile, diabetes mellitus, business

الوصف: Background: Previous genome-wide association studies revealed that the chromosome 9p21.3 locus is associated with an increased risk of myocardial infarction (MI) and diabetes mellitus (DM). However, it is unclear whether the 9p21.3-MI association is direct or mediated by pathways related to DM. Study Design: We applied mediation analysis to examine the potential mediating effect of DM on the association between the 9p21.3 genetic risk score (GRS; ranged from 0 to 8) and MI in a case-control study of 865 MI patients and 927 controls without coronary artery disease (CAD). The GRS combining 4 lead 9p21.3 single nucleotide polymorphisms (rs1333040, rs4987574, rs2383207, and rs1333049) was constructed. Results: Each 1 unit increase in weighted 9p21.3 GRS was associated with a 9% increased DM risk (95% confidence interval (CI) 1.00, 1.19) in the control group and a 14% increased MI risk (95% CI 1.09, 1.20). Mediation analyses yielded a direct-effect odds ratio (OR) of 1.06 (95% CI 1.04, 1.08) and an indirect-effect OR of 1.00 (95% CI 0.99, 1.01) for weighted GRS. DM mediated 4.40% (95% CI 3.42, 6.52) of the total association between the weighted GRS and MI risk. Individuals with the highest quartile of 9p21.3 GRS and DM had a 6-fold higher MI risk than those with the lowest quartile of 9p21.3 GRS and non-DM (OR 6.03, 95% CI 3.48, 10.5). Conclusion: DM is a weak mediator that explains a small fraction of the 9p21. 3-MI association in Chinese adults. Nevertheless, there is a strong synergistic effect between DM and the 9p21.3 GRS on MI risk.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c793f7968da023d3516af0f4fb1565c3
http://europepmc.org/articles/PMC6058023