المؤلفون: Oshima F; Department of Neurology, Japanese Red Cross Kyoto Daiichi Hospital, Japan. oshima-fumiko@kyoto1-jrc.org, Yokozeki M, Hamanaka M, Imai K, Makino M, Kimura M, Fujimoto Y, Fujiu-Kurachi M

المصدر: Internal medicine (Tokyo, Japan) [Intern Med] 2013; Vol. 52 (12), pp. 1325-31.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Japanese Society of Internal Medicine Country of Publication: Japan NLM ID: 9204241 Publication Model: Print Cited Medium: Internet ISSN: 1349-7235 (Electronic) Linking ISSN: 09182918 NLM ISO Abbreviation: Intern Med Subsets: MEDLINE

مواضيع طبية MeSH: Deglutition Disorders/*etiology , Lateral Medullary Syndrome/*complications, Adult ; Aged ; Aged, 80 and over ; Deglutition/physiology ; Deglutition Disorders/diagnostic imaging ; Deglutition Disorders/physiopathology ; Female ; Fluoroscopy ; Humans ; Lateral Medullary Syndrome/pathology ; Lateral Medullary Syndrome/physiopathology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Prognosis ; Video Recording

مستخلص: Objective: In order to identify the factors that influence the swallowing function in patients who develop Wallenberg syndrome (WS) following lateral medullary infarction (LMI), we examined various patient characteristics, including the passage pattern abnormality (PPA) of a bolus through the upper esophageal sphincter (UES).
Methods: Fifty-four pure LMI patients with dysphagia participated in this study. PPA, defined as the failure of bolus passage through the UES corresponding to the intact side of the medulla, was identified during videofluorographic swallowing evaluations of each patient. On brain magnetic resonance imaging, the subjects' lesions were classified vertically into three levels and horizontally into seven levels in relation to the involvement of the ambiguous and/or solitary nuclei. Logistic regression analyses were performed for age, sex, PPA and the vertical and horizontal sites of the lesions.
Results: In terms of severity, 15 subjects were categorized as having mild dysphagia, 26 subjects were categorized as having moderate dysphagia and 13 were categorized as having severe dysphagia. Subjects with cephalic lesions, greater vertical spread of the lesion and PPA were more likely to have severe dysphagia. PPA and a greater vertical spread of the lesion were related to the severity of the functional outcome (p<0.01). The horizontal extent of the lesion was not strongly related to the prognosis.
Conclusion: The presence of PPA in LMI patients is suggestive of abnormalities in the swallowing pattern and, in turn, damage to the medullary central pattern generator. The presence of PPA and a greater vertical spread of the lesion can be useful predictors of severe dysphagia.