المؤلفون: Bagheri S; Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.; Department of Neuroscience, School of Science and Advanced Technologies in Medicine, Hamadan University of Medical Sciences, Hamadan, Iran., Haddadi R; Department of Pharmacology, School of Pharmacy, Hamadan University of Medical Science, Hamadan, Iran., Saki S; Vice-Chancellor for Research and Technology, Hamadan University of Medical Science, Hamadan, Iran., Kourosh-Arami M; Department of Neuroscience, School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran., Komaki A; Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.; Department of Neuroscience, School of Science and Advanced Technologies in Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

المصدر: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience [Int J Dev Neurosci] 2021 Dec; Vol. 81 (8), pp. 669-685. Date of Electronic Publication: 2021 Nov 07.

نوع المنشور: Journal Article; Systematic Review

بيانات الدورية: Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 8401784 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-474X (Electronic) Linking ISSN: 07365748 NLM ISO Abbreviation: Int J Dev Neurosci Subsets: MEDLINE

مواضيع طبية MeSH: Brain/*metabolism , Epilepsy/*metabolism , Multiple Sclerosis/*metabolism , Neurons/*metabolism , Voltage-Gated Sodium Channels/*metabolism, Humans

مستخلص: Neurological and neuronal disorders are associated with structural, biochemical, or electrical abnormalities in the nervous system. Many neurological diseases have not yet been discovered. Interventions used for the treatment of these disorders include avoidance measures, lifestyle changes, physiotherapy, neurorehabilitation, pain management, medication, and surgery. In the sodium channelopathies, alterations in the structure, expression, and function of voltage-gated sodium channels (VGSCs) are considered as the causes of neurological and neuronal diseases. Online databases, including Scopus, Science Direct, Google Scholar, and PubMed were assessed for studies published between 1977 and 2020 using the keywords of review, sodium channels blocker, neurological diseases, and neuronal diseases. VGSCs consist of one α subunit and two β subunits. These subunits are known to regulate the gating kinetics, functional characteristics, and localization of the ion channel. These channels are involved in cell migration, cellular connections, neuronal pathfinding, and neurite outgrowth. Through the VGSC, the action potential is triggered and propagated in the neurons. Action potentials are physiological functions and passage of impermeable ions. The electrophysiological properties of these channels and their relationship with neurological and neuronal disorders have been identified. Subunit mutations are involved in the development of diseases, such as epilepsy, multiple sclerosis, autism, and Alzheimer's disease. Accordingly, we conducted a review of the link between VGSCs and neurological and neuronal diseases. Also, novel therapeutic targets were introduced for future drug discoveries.
(© 2021 International Society for Developmental Neuroscience.)