المؤلفون: Skrivankova VW; Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland., Richmond RC; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom., Woolf BAR; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.; Department of Psychological Science, University of Bristol, Bristol, United Kingdom., Yarmolinsky J; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom., Davies NM; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Norway., Swanson SA; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands., VanderWeele TJ; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts., Higgins JPT; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.; NIHR Bristol Biomedical Research Centre, Bristol, United Kingdom., Timpson NJ; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom., Dimou N; Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France., Langenberg C; MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany., Golub RM; JAMA , Chicago, Illinois.; Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Loder EW; Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts.; BMJ , London, United Kingdom., Gallo V; Campus Fryslân, University of Groningen, Leeuwarden, the Netherlands.; Institute of Population Health Sciences, Queen Mary, University of London, London, United Kingdom.; Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, United Kingdom., Tybjaerg-Hansen A; Section for Molecular Genetics, Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Davey Smith G; Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.; NIHR Bristol Biomedical Research Centre, Bristol, United Kingdom., Egger M; Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.; Centre for Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, South Africa., Richards JB; Departments of Medicine, Human Genetics, Epidemiology, & Biostatistics, Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Quebec, Canada.; Department of Twin Research and Genetic Epidemiology, King's College London, University of London, London, United Kingdom.

المصدر: JAMA [JAMA] 2021 Oct 26; Vol. 326 (16), pp. 1614-1621.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE

مواضيع طبية MeSH: Checklist* , Epidemiology* , Guidelines as Topic* , Observational Studies as Topic*, Mendelian Randomization Analysis/*methods, Bias ; Genome-Wide Association Study ; Humans ; Information Dissemination ; Pilot Projects ; Social Media

المؤلفون: Yarmolinsky J; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom., Bull CJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.; School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom., Vincent EE; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.; School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom., Robinson J; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom., Walther A; Bristol Cancer Institute, University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom., Smith GD; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom., Lewis SJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom., Relton CL; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom., Martin RM; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.; National Institute for Health Research Bristol Biomedical Research Centre, University of Bristol, University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom.

المصدر: JAMA [JAMA] 2020 Feb 18; Vol. 323 (7), pp. 646-655.

نوع المنشور: Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE

مواضيع طبية MeSH: Polymorphism, Single Nucleotide*, Carcinoma, Ovarian Epithelial/*prevention & control , Hydroxymethylglutaryl CoA Reductases/*genetics , Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use , Ovarian Neoplasms/*prevention & control, Adult ; Carcinoma, Ovarian Epithelial/genetics ; Case-Control Studies ; Cholesterol, LDL/blood ; Female ; Genes, BRCA1 ; Genes, BRCA2 ; Humans ; Membrane Transport Proteins/genetics ; Mendelian Randomization Analysis ; Middle Aged ; Mutation ; Odds Ratio ; Ovarian Neoplasms/genetics ; Proprotein Convertase 9/genetics ; Retrospective Studies ; Risk