المؤلفون: Leftheris K; Departments of Discovery Chemistry, Bristol-Myers Squibb, PO Box 4000, Princeton, New Jersey 08543-4000, USA. katerina.leftheris@bms.com, Ahmed G, Chan R, Dyckman AJ, Hussain Z, Ho K, Hynes J Jr, Letourneau J, Li W, Lin S, Metzger A, Moriarty KJ, Riviello C, Shimshock Y, Wen J, Wityak J, Wrobleski ST, Wu H, Wu J, Desai M, Gillooly KM, Lin TH, Loo D, McIntyre KW, Pitt S, Shen DR, Shuster DJ, Zhang R, Diller D, Doweyko A, Sack J, Baldwin J, Barrish J, Dodd J, Henderson I, Kanner S, Schieven GL, Webb M

المصدر: Journal of medicinal chemistry [J Med Chem] 2004 Dec 02; Vol. 47 (25), pp. 6283-91.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Amides/*chemical synthesis , Aniline Compounds/*chemical synthesis , Anti-Inflammatory Agents, Non-Steroidal/*chemical synthesis , Benzamides/*chemical synthesis , Triazines/*chemical synthesis , p38 Mitogen-Activated Protein Kinases/*antagonists & inhibitors, Administration, Oral ; Amides/chemistry ; Amides/pharmacology ; Aniline Compounds/chemistry ; Aniline Compounds/pharmacology ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Arthritis, Experimental/drug therapy ; Arthritis, Experimental/pathology ; Benzamides/chemistry ; Benzamides/pharmacology ; Crystallography, X-Ray ; Female ; Humans ; In Vitro Techniques ; Mice ; Mice, Inbred BALB C ; Microsomes, Liver/drug effects ; Microsomes, Liver/metabolism ; Models, Molecular ; Molecular Structure ; Monocytes/drug effects ; Monocytes/metabolism ; Rats ; Rats, Inbred Lew ; Structure-Activity Relationship ; Triazines/chemistry ; Triazines/pharmacology ; Tumor Necrosis Factor-alpha/biosynthesis ; p38 Mitogen-Activated Protein Kinases/chemistry