يعرض 1 - 10 نتائج من 6,312 نتيجة بحث عن '"medicine"', وقت الاستعلام: 1.45s تنقيح النتائج
  1. 1
    Discovery of Novel Polycyclic Heterocyclic Derivatives from Evodiamine for the Potential Treatment of Triple-Negative Breast Cancer

    المؤلفون: Zhe-Sheng Chen, Shengtao Xu, Jinyi Xu, Manzhen Zhou, Liang Wu, Yangyi Qiu, Hong Yao, Dahong Li, Dong-Hua Yang

    المصدر: Journal of Medicinal Chemistry. 64:17346-17365

    مصطلحات موضوعية: Antineoplastic Agents, Triple Negative Breast Neoplasms, chemistry.chemical_compound, Breast cancer, Heterocyclic Compounds, Evodiamine, In vivo, Cell Line, Tumor, Drug Discovery, medicine, Humans, Polycyclic Compounds, IC50, Triple-negative breast cancer, Cell Proliferation, chemistry.chemical_classification, Reactive oxygen species, biology, Cell growth, Topoisomerase, medicine.disease, chemistry, Quinazolines, Cancer research, biology.protein, Molecular Medicine, Female

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d76ef152e92cada4a4bf77a4f499570c
    https://doi.org/10.1021/acs.jmedchem.1c01411

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  2. 2
    Synthetic Sansanmycin Analogues as Potent Mycobacterium tuberculosis Translocase I Inhibitors

    المؤلفون: Elinor Hortle, David I. Roper, Warwick J. Britton, Richard J. Payne, Gregory M. Cook, Wendy Tran, Paige M. E. Hawkins, Alexander Stoye, Christopher G. Dowson, Rebecca E Audette, Thomas Balle, Jessica L. Ochoa, Gayathri Nagalingam, Daniel J Ford, Ali Saad Kusay, Venugopal Pujari, Roger G. Linington, Chen-Yi Cheung, Dean C. Crick, Eric J. Rubin, Stefan H. Oehlers, Susan A. Charman

    المصدر: Journal of Medicinal Chemistry. 64:17326-17345

    مصطلحات موضوعية: Natural product, Tuberculosis, biology, medicine.drug_class, Isoniazid, bacterial infections and mycoses, Antimycobacterial, biology.organism_classification, medicine.disease, In vitro, Mycobacterium tuberculosis, chemistry.chemical_compound, chemistry, Biochemistry, In vivo, Drug Discovery, biology.protein, medicine, Molecular Medicine, Translocase, medicine.drug

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4e08cda86f6791396aa219a030366f02
    https://doi.org/10.1021/acs.jmedchem.1c01407

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  3. 3
    First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53

    المؤلفون: Eline Hendrix, Anthony Tumber, Klemensas Simelis, Mathew L. Coleman, Nicola Mautone, Akane Kawamura, Catrine Johansson, Alessia Ciogli, Udo Oppermann, Dante Rotili, Lorenzo Antonini, Manuela Sabatino, Daniela Passeri, Antonello Mai, Mohammad Salik Zeya Ansari, Regina Andrijes, Daniela Trisciuoglio, Eidarus Salah, Donatella Del Bufalo, Francesca Romana Pellegrini, Radosław P Nowak, Roberto Pellicciari, Rino Ragno, Christopher J. Schofield

    المصدر: Journal of Medicinal Chemistry
    Journal of medicinal chemistry 64 (2021): 17031–17050. doi:10.1021/acs.jmedchem.1c00605
    info:cnr-pdr/source/autori:Nowak R.P.; Tumber A.; Hendrix E.; Ansari M.S.Z.; Sabatino M.; Antonini L.; Andrijes R.; Salah E.; Mautone N.; Pellegrini F.R.; Simelis K.; Kawamura A.; Johansson C.; Passeri D.; Pellicciari R.; Ciogli A.; Del Bufalo D.; Ragno R.; Coleman M.L.; Trisciuoglio D.; Mai A.; Oppermann U.; Schofield C.J.; Rotili D./titolo:First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53/doi:10.1021%2Facs.jmedchem.1c00605/rivista:Journal of medicinal chemistry/anno:2021/pagina_da:17031/pagina_a:17050/intervallo_pagine:17031–17050/volume:64

    مصطلحات موضوعية: Models, Molecular, Oxygenase, Protein Conformation, medical chemistry, Article, Cofactor, Dioxygenases, Substrate Specificity, Hydroxylation, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, solid cancer, Cell Line, Tumor, Drug Discovery, Humans, Enzyme Inhibitors, Transcription factor, MINA53 inhibitors, oncology, Cell Proliferation, 030304 developmental biology, Histone Demethylases, 0303 health sciences, epigenetics, biology, Chemistry, Nuclear Proteins, Active site, Ribosomal RNA, 3. Good health, Biochemistry, 030220 oncology & carcinogenesis, Cancer cell, biology.protein, Molecular Medicine, Demethylase, Crystallization, Ribosomes

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7a2018a4fda17782bb28cfc487a6ff
    https://doi.org/10.1021/acs.jmedchem.1c00605

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  4. 4
    Design, Synthesis, and Pharmacological Evaluation of Biaryl-Containing PD-1/PD-L1 Interaction Inhibitors Bearing a Unique Difluoromethyleneoxy Linkage

    المؤلفون: Zilan Song, Peng Xia, Meiyu Geng, Yi Xu, Jing Ai, Ao Zhang, Wangting Gu, Yiming Sun, Bo Liu, Xing Li

    المصدر: Journal of Medicinal Chemistry. 64:16687-16702

    مصطلحات موضوعية: Cell signaling, Stereochemistry, T cell, Programmed Cell Death 1 Receptor, CD8-Positive T-Lymphocytes, B7-H1 Antigen, Interferon-gamma, Mice, Cell Line, Tumor, PD-L1, Drug Discovery, medicine, Animals, Humans, Potency, Immune Checkpoint Inhibitors, IC50, biology, Chemistry, Xenograft Model Antitumor Assays, Immune checkpoint, Mice, Inbred C57BL, Molecular Docking Simulation, medicine.anatomical_structure, Design synthesis, Drug Design, biology.protein, Molecular Medicine, CD8, Signal Transduction

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220b689939f9baf537334387aef46bce
    https://doi.org/10.1021/acs.jmedchem.1c01422

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  5. 5
    Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L

    المؤلفون: Anthony J. O’Donoghue, Michael C Yoon, Max J. Bedding, Vivian Hook, Pavla Fajtová, Arthur H Tang, Mark Larance, Linfeng Li, Chien-Te Tseng, Stuart Turville, James H. McKerrow, Dustin Pwee, Laura Beretta, Alexander Stoye, Danielle E. Skinner, William H. Gerwick, Anneliese S. Ashhurst, Thomas D. Meek, Anupriya Aggarwal, Aleksandra Drelich, Richard J. Payne

    المصدر: bioRxiv

    مصطلحات موضوعية: Proteomics, Proteases, Cathepsin L, medicine.medical_treatment, Molecular Conformation, Microbial Sensitivity Tests, Cysteine Proteinase Inhibitors, Antiviral Agents, Article, Serine, Structure-Activity Relationship, chemistry.chemical_compound, Viral entry, Chlorocebus aethiops, Drug Discovery, medicine, Animals, Humans, Vero Cells, Cathepsin, Biological Products, Protease, Natural product, Dose-Response Relationship, Drug, biology, SARS-CoV-2, COVID-19, Cysteine protease, COVID-19 Drug Treatment, Coronavirus, chemistry, Biochemistry, A549 Cells, biology.protein, Molecular Medicine, Antimicrobial Cationic Peptides

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e9010452bb0a2bc93e68d7e3db2d8a
    https://doi.org/10.1021/acs.jmedchem.1c01494

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  6. 6
    Immune Modulating Antibody–Drug Conjugate (IM-ADC) for Cancer Immunotherapy

    المؤلفون: He Lei, Hui Chen, Tiantian Li, Liangliang Wang, Yaning Zhang, Xuebin Liao, Zhisong Wang, Juanjuan Du, Dimiter S. Dimitrov, Zeping Hu

    المصدر: Journal of Medicinal Chemistry. 64:15716-15726

    مصطلحات موضوعية: Antibody-drug conjugate, Immunoconjugates, medicine.medical_treatment, Programmed Cell Death 1 Receptor, B7-H1 Antigen, Epigenesis, Genetic, Immune system, Cancer immunotherapy, Cell Line, Tumor, Neoplasms, Drug Discovery, Tumor Microenvironment, medicine, Humans, biology, Chemistry, TLR7, Immune checkpoint, Blockade, body regions, Toll-Like Receptor 7, Toll-Like Receptor 8, biology.protein, Cancer research, Molecular Medicine, Immunotherapy, Antibody, Signal transduction, Signal Transduction

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::904a807456550bff7cc318f34c288103
    https://doi.org/10.1021/acs.jmedchem.1c00961

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  7. 7
    Functionalized Dioxonaphthoimidazoliums: A Redox Cycling Chemotype with Potent Bactericidal Activities against Mycobacterium tuberculosis

    المؤلفون: Dereje Abate Negatu, Yulin Lam, Gregory M. Cook, Ming Li, Thomas Dick, Mei-Lin Go, Kevin T. Fridianto, Kiel Hards

    المصدر: Journal of Medicinal Chemistry. 64:15991-16007

    مصطلحات موضوعية: chemistry.chemical_classification, Reactive oxygen species, Programmed cell death, biology, Chemistry, Isoniazid, NADH dehydrogenase, biology.organism_classification, Quinone, Mycobacterium tuberculosis, Biochemistry, Drug Discovery, biology.protein, medicine, Molecular Medicine, Mode of action, Bacteria, medicine.drug

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e79dd47ebaccd46030c6592c1d5f62cf
    https://doi.org/10.1021/acs.jmedchem.1c01383

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  8. 8
    Discovery of 1-Amino-1H-imidazole-5-carboxamide Derivatives as Highly Selective, Covalent Bruton’s Tyrosine Kinase (BTK) Inhibitors

    المؤلفون: Zhang Shuting, Xu Guiqing, Longfei Mao, Ma Chunhua, Zhang Dandan, Zhao Minghao, Liang Zhu, Dingding Gao, Yuqin Jiang, Yang Shouning, Ding Qingjie, Jie Zhao, Li Qingyun, Wei Li, Goujie Fan

    المصدر: Journal of Medicinal Chemistry. 64:16242-16270

    مصطلحات موضوعية: biology, Chemistry, medicine.drug_class, Kinase, Carboxamide, chemistry.chemical_compound, immune system diseases, In vivo, Covalent bond, hemic and lymphatic diseases, Ibrutinib, Drug Discovery, biology.protein, medicine, Cancer research, Molecular Medicine, Bruton's tyrosine kinase, Imidazole, Tyrosine kinase

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bdbbffe90a321bd495483037e442d671
    https://doi.org/10.1021/acs.jmedchem.1c01559

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  9. 9
    Structure–Activity Relationship of USP5 Inhibitors

    المؤلفون: Rachel Harding, M.K. Mann, Ahmed Aman, Carlos Zepeda-Velázquez, Brian J. Wilson, Taira Kiyota, Cheryl H. Arrowsmith, Peter Loppnau, Rima Al-awar, Matthieu Schapira, Héctor González-Álvarez, Yanjun Li, Aiping Dong

    المصدر: Journal of Medicinal Chemistry. 64:15017-15036

    مصطلحات موضوعية: Ubiquitin binding, Cleavage (embryo), Deubiquitinating enzyme, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Endopeptidases, Drug Discovery, Humans, Structure–activity relationship, Enzyme Inhibitors, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Substrate (chemistry), In vitro, 3. Good health, Enzyme, Biochemistry, biology.protein, Molecular Medicine, 030217 neurology & neurosurgery, Function (biology)

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0f2b58e16e289efc68af8b3a1671546
    https://doi.org/10.1021/acs.jmedchem.1c00889

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  10. 10
    Discovery of Reldesemtiv, a Fast Skeletal Muscle Troponin Activator for the Treatment of Impaired Muscle Function

    المؤلفون: Aaron C. Hinken, Morgan Bradley P, Bing Yao, Jeffrey Warrington, Antonio A. Romero, Kevin Lu, David J. Morgans, Jeffrey Gardina, James J. Hartman, Chihyuan Chuang, Anna Marquez, Gustave Bergnes, Alexander Muci, Darren T. Hwee, Luke W. Ashcraft, Donghong Xu, Julia Schaletzky, Marc Garard, Ellen Valkevich, Nickie Durham, Pu-Ping Lu, Fady I. Malik, Chris R. Jamison, Scott Collibee, Wenyue Wang

    المصدر: Journal of Medicinal Chemistry. 64:14930-14941

    مصطلحات موضوعية: medicine.medical_specialty, Dose-Response Relationship, Drug, Molecular Structure, biology, Activator (genetics), Chemistry, Skeletal muscle, Phases of clinical research, Stimulation, medicine.disease, Troponin, Structure-Activity Relationship, medicine.anatomical_structure, Endocrinology, In vivo, Internal medicine, Drug Discovery, medicine, biology.protein, Humans, Molecular Medicine, Potency, Amyotrophic lateral sclerosis, Muscle, Skeletal

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668cbb454d32e106e7cbf776cf29af68
    https://doi.org/10.1021/acs.jmedchem.1c01067

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