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1دورية أكاديمية
المؤلفون: Miyamoto, Yukiko, Aggarwal, Shubhangi, Celaje, Jeff Joseph A, Ihara, Sozaburo, Ang, Jonathan, Eremin, Dmitry B, Land, Kirkwood M, Wrischnik, Lisa A, Zhang, Liangfang, Fokin, Valery V, Eckmann, Lars
المصدر: Journal of Medicinal Chemistry. 64(10)
مصطلحات موضوعية: Sexually Transmitted Infections, Infectious Diseases, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Good Health and Well Being, Animals, Antiprotozoal Agents, Cell Survival, Coordination Complexes, Disease Models, Animal, Drug Resistance, Female, Gold, HeLa Cells, Humans, Mice, Mice, Inbred BALB C, Parasitic Sensitivity Tests, Phosphines, Protein Isoforms, Structure-Activity Relationship, Thioredoxin-Disulfide Reductase, Trichomonas Infections, Trichomonas vaginalis, Trophozoites, Hela Cells, Medicinal and Biomolecular Chemistry, Organic Chemistry, Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry
وصف الملف: application/pdf
URL الوصول: https://escholarship.org/uc/item/99v254ct
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2دورية أكاديمية
المؤلفون: Lowes, David, Pradhan, Anupam, Iyer, Lalitha V, Parman, Toufan, Gow, Jason, Zhu, Fangyi, Furimsky, Anna, Lemoff, Andrew, Guiguemde, W Armand, Sigal, Martina, Clark, Julie A, Wilson, Emily, Tang, Liang, Connelly, Michele C, DeRisi, Joseph L, Kyle, Dennis E, Mirsalis, Jon, Guy, R Kiplin
المصدر: Journal of Medicinal Chemistry. 55(13)
مصطلحات موضوعية: Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Malaria, Rare Diseases, Infectious Diseases, Heart Disease, Orphan Drug, Cardiovascular, Vector-Borne Diseases, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Good Health and Well Being, Administration, Oral, Animals, Antimalarials, Chloroquine, Cytochrome P-450 CYP2D6, Cytochrome P-450 CYP2D6 Inhibitors, Disease Models, Animal, Drug Evaluation, Preclinical, Drug Interactions, Female, HEK293 Cells, Hep G2 Cells, Humans, Mice, Mice, Inbred ICR, Microsomes, Liver, Parasitemia, Plasmodium berghei, Propafenone, Structure-Activity Relationship, Medicinal and Biomolecular Chemistry, Organic Chemistry, Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry, Pharmacology and pharmaceutical sciences, Medicinal and biomolecular chemistry, Organic chemistry
وصف الملف: application/pdf
URL الوصول: https://escholarship.org/uc/item/36c949qc
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3
المؤلفون: Farukh A. Durrani, Richard C. Koya, Heinz Baumann, Erin Tracy, Kevin E. Siters, Joseph Cacaccio, Ramona Watson, Walter A. Tabaczynski, Joseph R. Missert, Ravindra K. Pandey, Ravindra R. Cheruku, Khurshid A. Guru, Mykhaylo Dukh, Pawel Kalinski
المصدر: J Med Chem
مصطلحات موضوعية: Porphyrins, Cell Survival, medicine.medical_treatment, Photodynamic therapy, Mice, SCID, Conjugated system, 01 natural sciences, Article, Erlotinib Hydrochloride, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, 030304 developmental biology, 0303 health sciences, Photosensitizing Agents, Cancer, Stereoisomerism, medicine.disease, Tetrapyrrole, Coculture Techniques, 0104 chemical sciences, Survival Rate, 010404 medicinal & biomolecular chemistry, Photochemotherapy, chemistry, Head and Neck Neoplasms, Cell culture, Cancer research, Molecular Medicine, Female, Erlotinib, medicine.drug, Conjugate
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4
المؤلفون: Shiuhang Yip, Emily Luk, Anwar Murtaza, Yong Zhang, Michael A. Poss, Louis J. Lombardo, Nimmi Raghavan, Zheng Yang, James Kempson, Audris Huang, David R. Tortolani, Jesse Swanson, Xiaoping Hou, Joseph Pawluczyk, James Smalley, Honghe Wan, Karen E. Parrish, Robert M. Borzilleri, Ashok V. Purandare, Karen Augustine-Rauch, Andrew F. Donnell
المصدر: Journal of Medicinal Chemistry. 64:15787-15798
مصطلحات موضوعية: Drug, media_common.quotation_subject, Receptor, Transforming Growth Factor-beta Type I, Antineoplastic Agents, Pharmacology, Small Molecule Libraries, Mice, Immune system, Therapeutic index, Drug Stability, Neoplasms, Drug Discovery, Animals, Humans, Prodrugs, Tissue Distribution, Receptor, media_common, Serine protease, Mice, Inbred BALB C, Molecular Structure, biology, Chemistry, Myocardium, Prodrug, Xenograft Model Antitumor Assays, Small molecule, Blockade, Mice, Inbred C57BL, Area Under Curve, biology.protein, Molecular Medicine, Female, Half-Life
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5
المؤلفون: Mian Gao, David J. Shuster, Hai-Yun Xiao, Christine B. Goldstine, Jing Chen, Zhonghui Lu, Victor R. Guarino, Khehyong Ngu, Lisa M. Kopcho, Deepa Calambur, Kurt R. Gregor, Andrew J. Tebben, Jingwu Duan, Luisa Salter-Cid, Hao Lu, Joseph A. Tino, Ning Li, John Hynes, James R. Burke, Joseph Yanchunas, John E. Macor, Steven Sheriff, Dauh-Rurng Wu, Bin Jiang, Patrick J. Shaw, ChiehYing Y. Chang, Jenny Xie, Vojkan Susulic, T. G. Murali Dhar
المصدر: Journal of Medicinal Chemistry. 63:15050-15071
مصطلحات موضوعية: Arthritis, Trimer, Proof of Concept Study, 01 natural sciences, Arthritis, Rheumatoid, Structure-Activity Relationship, 03 medical and health sciences, Pharmacokinetics, In vivo, Drug Discovery, medicine, Animals, Humans, Potency, Structure–activity relationship, Naphthyridines, 030304 developmental biology, 0303 health sciences, Molecular Structure, Tumor Necrosis Factor-alpha, Chemistry, medicine.disease, Arthritis, Experimental, Small molecule, 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Drug Design, Microsomes, Liver, Quinolines, Biophysics, Molecular Medicine, Female, Tumor necrosis factor alpha
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6
المؤلفون: Mark T. Heise, Thomas E. Morrison, Subramaniam Ananthan, Joseph A. Maddry, Sanjay Sarkar, Jessica L. Smith, Kevin J Rodzinak, Nicole N. Haese, Daniel N. Streblow, Nathaniel J. Moorman, Cassilyn E. Streblow, Ashish K. Pathak, Vibha Pathak, Aaron D Streblow, Lynn Rasmussen, Fahim Ahmad, Corinne E. Augelli-Szafran, S Kaleem Ahmed, Victor R. DeFilippis, Robert Bostwick, Craig N. Kreklywich, Mark J. Suto, Sixue Zhang, Robbie Allen, Alec J. Hirsch, Jaden T Cowan, Babu L. Tekwani, Kiley Bonin, Nichole A. Tower, Wes Sander, Valerie J Smith, Mousheng Wu, John M Gerdes, Clayton R. Morrison, Omar Moukha-Chafiq
المصدر: J Med Chem
مصطلحات موضوعية: Male, Oxidoreductases Acting on CH-CH Group Donors, Cell Survival, Dihydroorotate Dehydrogenase, Virus Replication, Antiviral Agents, 01 natural sciences, Article, Virus, Cell Line, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, In vivo, Drug Discovery, Benzene Derivatives, medicine, Animals, Humans, Benzamide, Cytotoxicity, 030304 developmental biology, 0303 health sciences, Binding Sites, Chemistry, virus diseases, Virology, 0104 chemical sciences, Mice, Inbred C57BL, Molecular Docking Simulation, Disease Models, Animal, 010404 medicinal & biomolecular chemistry, Titer, Mechanism of action, Viral replication, Microsomes, Liver, Dihydroorotate dehydrogenase, Chikungunya Fever, Molecular Medicine, Female, medicine.symptom, Chikungunya virus, Half-Life
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7
المؤلفون: Hongchao Zheng, Andrew L. McIver, Surendra Karavadhi, Adam Yasgar, William J. Moore, Li Liu, Zhuyin Li, Carleen Klumpp-Thomas, Ajit Jadhav, Natalia J. Martinez, Kyle R. Brimacombe, Mindy I. Davis, Wei Zhao, Daniel J. Urban, Stephen V. Frye, Anton Simeonov, Xiaodong Wang, Samarjit Patnaik, Rajan Pragani, Mark J. Henderson, Weihe Zhang, Melinda G. Hollingshead, Min Shen, Qingyang Liu, Gordon M. Stott, Tobie D. Lee, Sam Michael, Matthew B. Boxer, Jason M. Rohde, Matthew D. Hall, Yuhong Fang, Joseph M. Covey, Dorian M. Cheff
المصدر: J Med Chem
مصطلحات موضوعية: IDH1, Pyridines, Pyridones, Mutant, Drug Evaluation, Preclinical, Glycine, Mice, Nude, 01 natural sciences, Article, Single oral dose, Mice, Structure-Activity Relationship, 03 medical and health sciences, Cell Line, Tumor, Neoplasms, Drug Discovery, medicine, Animals, Humans, Enzyme Inhibitors, 030304 developmental biology, 0303 health sciences, Chemistry, Brain, Myeloid leukemia, Cancer, medicine.disease, Xenograft Model Antitumor Assays, Molecular biology, Isocitrate Dehydrogenase, Rats, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Isocitrate dehydrogenase, Microsomes, Liver, Mutagenesis, Site-Directed, Molecular Medicine, Female, Half-Life
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8
المؤلفون: Roderick A. Porter, James Edward John Mills, Paul Blaney, Paul Alan Glossop, Matthew J. Tozer, Jean-Olivier Zirimwabagabo, Karl Richard Gibson, Ameera B. A. Jailani, Paris Avgoustou, Ning Wang, Joseph P. A. Harrity, Timothy M. Skerry, Gareth O. Richards
المصدر: Journal of Medicinal Chemistry
مصطلحات موضوعية: Antineoplastic Agents, Triple Negative Breast Neoplasms, Pharmacology, 01 natural sciences, Article, Small Molecule Libraries, Structure-Activity Relationship, 03 medical and health sciences, Cell Line, Tumor, Drug Discovery, Animals, Humans, Receptors, Adrenomedullin, Calcitonin receptor, Receptor, 030304 developmental biology, G protein-coupled receptor, Mice, Inbred BALB C, 0303 health sciences, Chemistry, Drug discovery, 0104 chemical sciences, 3. Good health, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Calcitonin, RAMP2, RAMP1, RAMP3, Molecular Medicine, Female
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9
المؤلفون: Agustin Casimiro-Garcia, Christophe Allais, Agnes Brennan, Chulho Choi, Gabriela Dower, Kathleen A. Farley, Margaret Fleming, Andrew Flick, Richard K. Frisbie, Justin Hall, David Hepworth, Hannah Jones, John D. Knafels, Steve Kortum, Frank E. Lovering, John P. Mathias, Sashi Mohan, Paul M. Morgan, Chuenlei Parng, Kevin Parris, Nick Pullen, Franklin Schlerman, John Stansfield, Joseph W. Strohbach, Felix F. Vajdos, Fabien Vincent, Hong Wang, Xiaolun Wang, Robert Webster, Stephen W. Wright
المصدر: Journal of medicinal chemistry. 65(1)
مصطلحات موضوعية: Models, Molecular, Mice, Inbred BALB C, Pyridines, Dextran Sulfate, Ketones, Colitis, Crystallography, X-Ray, GPI-Linked Proteins, Amidohydrolases, High-Throughput Screening Assays, Rats, Mice, Structure-Activity Relationship, Dogs, Drug Discovery, Molecular Medicine, Animals, Female
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10
المؤلفون: Courtney G. Havens, Correa Matthew D, Rama K. Narla, Frans Baculi, Kercher Timothy S, Thomas O. Daniel, Roy L. Harris, Brian E. Cathers, Matt Alexander, Mehran F. Moghaddam, Grant Virginia Heather Sharron, Veronique Plantevin, James Carmichael, Katalin Ebinger, Antonia Lopez-Girona, Gody Khambatta, Derek Mendy, Lawrence G Hamann, Joshua Hansen, Katerina Leftheris, Brandon Wade Whitefield, Joseph Piccotti, Nagy Mark A, Rupert Vessey, Yang Tang, Laurie LeBrun, Jim Leisten, Dehua Huang
المصدر: Journal of Medicinal Chemistry. 63:6648-6676
مصطلحات موضوعية: Oncology, medicine.medical_specialty, Ubiquitin-Protein Ligases, Antineoplastic Agents, Protein degradation, 01 natural sciences, Inhibitory Concentration 50, Mice, 03 medical and health sciences, Refractory, Recurrence, Cell Line, Tumor, Internal medicine, Drug Discovery, medicine, Animals, Humans, Treatment Failure, Multiple myeloma, Adaptor Proteins, Signal Transducing, Cell Proliferation, 030304 developmental biology, Lenalidomide, 0303 health sciences, biology, Chemistry, Cereblon, Stereoisomerism, Pomalidomide, medicine.disease, Xenograft Model Antitumor Assays, 0104 chemical sciences, Ubiquitin ligase, 010404 medicinal & biomolecular chemistry, Proteasome, biology.protein, Molecular Medicine, Female, Multiple Myeloma, medicine.drug
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