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1
المؤلفون: Stefan I. McDonough, Joseph Ligutti, Hongyan Li, Reto Stöcklin, Les P. Miranda, Dong Liu, Justin K. Murray, Leszek Poppe, Philippe Favreau, Bryan D. Moyer, Kristin L. Andrews, Anruo Zou
المصدر: Journal of Medicinal Chemistry. 58:2299-2314
مصطلحات موضوعية: Male, Spectrometry, Mass, Electrospray Ionization, Magnetic Resonance Spectroscopy, Protein Conformation, Stereochemistry, Spider Venoms, Peptide, Venom, Mice, Structure-Activity Relationship, Drug Discovery, Animals, Humans, Voltage-Gated Sodium Channel Blockers, chemistry.chemical_classification, biology, Sodium channel, NAV1.7 Voltage-Gated Sodium Channel, Cystine knot, Antagonist, Spiders, Alanine scanning, biology.organism_classification, Peptide Fragments, High-Throughput Screening Assays, Rats, Electrophysiology, Mice, Inbred C57BL, chemistry, Biochemistry, Molecular Medicine, Female, Selectivity, Grammostola
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2
المؤلفون: Jacinth Naidoo, Andrew A. Pieper, Paula Huntington, Joseph M. Ready, Noelle S. Williams, Sandi Jo Estill, Lorraine Morlock, Thomas J. Mangano, Ruth Starwalt, Héctor De Jesús-Cortés
المصدر: Journal of Medicinal Chemistry
مصطلحات موضوعية: Spectrometry, Mass, Electrospray Ionization, Magnetic Resonance Spectroscopy, Stereochemistry, Carbazoles, Substantia nigra, Neuroprotection, Article, Mice, chemistry.chemical_compound, P7C3, Drug Discovery, Animals, Carbazole, Drug discovery, Neurogenesis, Parkinson Disease, 3. Good health, Mice, Inbred C57BL, Substantia Nigra, Disease Models, Animal, Neuroprotective Agents, chemistry, Area Under Curve, Molecular Medicine, Amine gas treating, Lead compound
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3
المؤلفون: Krista R. Wilson, Carrie Haskell-Luevano, Joseph W. Scott, and Arthur S. Edison, Andrzej Wilczynski
المصدر: Journal of Medicinal Chemistry. 48:3060-3075
مصطلحات موضوعية: Models, Molecular, Agonist, Magnetic Resonance Spectroscopy, medicine.drug_class, Stereochemistry, Peptide, Binding, Competitive, Peptides, Cyclic, Protein Structure, Secondary, Cell Line, Mice, Structure-Activity Relationship, Melanocortin receptor, Drug Discovery, medicine, Animals, Humans, Agouti-Related Protein, Receptor, chemistry.chemical_classification, Receptors, Melanocortin, Proteins, Cyclic peptide, Melanocortin 3 receptor, Amino acid, Biochemistry, chemistry, alpha-MSH, Drug Design, Intercellular Signaling Peptides and Proteins, Receptor, Melanocortin, Type 4, Molecular Medicine, Melanocortin, Oligopeptides, Receptor, Melanocortin, Type 3
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4
المؤلفون: Pál Szabó, Joseph Molnár, Dóra Rédei, Peter Forgo, Alajos Kálmán, Judit Hohmann, Gyula Argay, Ferenc Evanics
المصدر: Journal of Medicinal Chemistry. 45:2425-2431
مصطلحات موضوعية: Models, Molecular, Magnetic Resonance Spectroscopy, Lymphoma, Stereochemistry, Spectrometry, Mass, Fast Atom Bombardment, Pharmacognosy, Crystallography, X-Ray, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Euphorbia, Drug Discovery, Tumor Cells, Cultured, Animals, Euphorbia peplus, ATP Binding Cassette Transporter, Subfamily B, Member 1, P-glycoprotein, Hungary, biology, Chemistry, Absolute configuration, biology.organism_classification, Drug Resistance, Multiple, Terpenoid, Multiple drug resistance, Drug Resistance, Neoplasm, biology.protein, Molecular Medicine, Diterpenes, Drug Screening Assays, Antitumor, Diterpene
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5
المؤلفون: Guosheng Wang, David A. Bellnier, Michael A. J. Rodgers, Joseph R. Missert, Thomas J. Dougherty, Susan H. Camacho, William R. Potter, Barbara W. Henderson, Ravindra K. Pandey, Gang Zheng
المصدر: Journal of Medicinal Chemistry. 44:1540-1559
مصطلحات موضوعية: Chlorophyll, Magnetic Resonance Spectroscopy, Porphyrins, Light, Stereochemistry, Transplantation, Heterologous, Quantitative Structure-Activity Relationship, Chemical synthesis, Mice, chemistry.chemical_compound, Homologous series, In vivo, Drug Discovery, Animals, Scattering, Radiation, Hydroxymethyl, Photosensitizer, Alkyl, chemistry.chemical_classification, Photosensitizing Agents, Singlet Oxygen, Chemistry, Chlorophyll A, Neoplasms, Experimental, Nuclear magnetic resonance spectroscopy, Oxygen, Spectrophotometry, Lipophilicity, Molecular Medicine
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6
المؤلفون: Umesh B. Gangadharmath, Hartmuth C. Kolb, Otmar Schober, Klaus Kopka, Michael Schäfers, Joseph C. Walsh, Artem Y. Lebedev, Sven Hermann, Verena Hugenberg, Stefan Wagner, Burkhard Riemann, Wei Zhang, Katrin Szardenings
المصدر: Journal of medicinal chemistry. 56(17)
مصطلحات موضوعية: 1,2,3-Triazole, Magnetic Resonance Spectroscopy, Stereochemistry, Matrix metalloproteinase inhibitor, Triazole, Drug Evaluation, Preclinical, Alkyne, Matrix metalloproteinase, In Vitro Techniques, Hydroxamic Acids, Mass Spectrometry, chemistry.chemical_compound, Mice, In vivo, Drug Discovery, Animals, Protease Inhibitors, Tissue Distribution, chemistry.chemical_classification, Triazoles, In vitro, Matrix Metalloproteinases, Mice, Inbred C57BL, chemistry, Molecular Medicine, Azide
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7α2 Adrenoceptor Agonists as Potential Analgesic Agents. 1. (Imidazolylmethyl)oxazoles and -thiazoles
المؤلفون: B Reynolds, Joseph Francis Gardocki, A L Kirifides, Robert E. Boyd, Debra J. Bennett, Jeffery B. Press, Chris Royce Rasmussen, E. E. Codd, Robert B. Raffa, J T Hortenstein, Allen B. Reitz, Charlene D. Connelly
المصدر: Journal of Medicinal Chemistry. 42:5064-5071
مصطلحات موضوعية: Male, Magnetic Resonance Spectroscopy, Adrenergic receptor, Analgesic, Alpha (ethology), Pharmacology, Analgesic agents, Mice, chemistry.chemical_compound, Dogs, Receptors, Adrenergic, alpha-2, In vivo, Drug Discovery, Animals, Imidazole, Rats, Wistar, Thiazole, Oxazoles, Analgesics, Molecular Structure, Chemistry, Adrenergic alpha-2 Receptor Antagonists, Rats, Thiazoles, Molecular Medicine, Alpha-2 adrenergic receptor, Adrenergic alpha-Agonists
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8
المؤلفون: I Uchida, Smith Rl, A K Judd, C K Hiebert, R G Almquist, Waud Wr, Dousman L, Joseph I. DeGraw
المصدر: Journal of Medicinal Chemistry. 40:2398-2406
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Ketone, medicine.drug_class, Stereochemistry, Peptide, Spectrometry, Mass, Fast Atom Bombardment, Pentapeptide repeat, Chemical synthesis, Aminoketone, Mice, Radioligand Assay, chemistry.chemical_compound, Adjuvants, Immunologic, Drug Stability, Isomerism, Drug Discovery, Peptide synthesis, medicine, Animals, Humans, Peptide bond, Thymopentin, chemistry.chemical_classification, Ketones, chemistry, Molecular Medicine, Oligopeptides, Half-Life, medicine.drug
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9
المؤلفون: Joseph G. Cory, Tai-Shun Lin, M.‐C. Liu, and Ann H. Cory, Alan C. Sartorelli
المصدر: Journal of Medicinal Chemistry. 39:2586-2593
مصطلحات موضوعية: DNA Replication, Thiosemicarbazones, Magnetic Resonance Spectroscopy, Ribonucleoside Diphosphate Reductase, Methanesulfonyl chloride, Cell Survival, Pyridines, Stereochemistry, Antineoplastic Agents, Medicinal chemistry, Chemical synthesis, Mice, chemistry.chemical_compound, Morpholine, Drug Discovery, Pyridine, Tumor Cells, Cultured, Animals, Enzyme Inhibitors, Leukemia L1210, Semicarbazone, Molecular Structure, Acetal, Raney nickel, Acetic anhydride, chemistry, Molecular Medicine, Cell Division
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10
المؤلفون: Jeffrey M. Besterman, Dallas K. Croom, Daniel D. Sternbach, Gordon McIntyre, Alain Vuong, Evans Michael G, Julie C. Yates, Karen Lackey, Michael Joseph Luzzio, Peter Leitner, David L. Emerson
المصدر: Journal of Medicinal Chemistry. 39:713-719
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Stereochemistry, Mice, Nude, Antineoplastic Agents, Adenocarcinoma, Mass Spectrometry, Methylenedioxy, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Nude mouse, Drug Discovery, Tumor Cells, Cultured, medicine, Animals, Humans, Cytotoxicity, Ethylenedioxy, Ovarian Neoplasms, chemistry.chemical_classification, biology, Topoisomerase, Water, Aromatic amine, biology.organism_classification, Solubility, chemistry, Biochemistry, Colonic Neoplasms, biology.protein, Molecular Medicine, Camptothecin, Female, Topotecan, Topoisomerase I Inhibitors, medicine.drug