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101
المؤلفون: Joseph Chabenne, Richard D. DiMarchi, John P. Mayer, Piotr A. Mroz
المصدر: Journal of Medicinal Chemistry. 63:3447-3460
مصطلحات موضوعية: medicine.medical_treatment, Carbohydrate metabolism, Hypoglycemia, Bioinformatics, 01 natural sciences, Glucagon, Structure-Activity Relationship, 03 medical and health sciences, Drug Delivery Systems, Protein stability, Diabetes mellitus, Drug Discovery, medicine, Animals, Humans, Amino Acid Sequence, Acute hypoglycemia, 030304 developmental biology, 0303 health sciences, Molecular Structure, Protein Stability, Chemistry, Insulin, Emergency rescue, medicine.disease, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Solubility, Molecular Medicine
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102
المؤلفون: Joseph Openy, Adriaan P. IJzerman, Burak Dogan, Ya-Yun Hsiao, Eelke B. Lenselink, Jacobus P. D. van Veldhoven, Natalia V. Ortiz Zacarías, Laura H. Heitman, Lisa S den Hollander
المصدر: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 62(24), 11035-11053مصطلحات موضوعية: CCR2, Receptors, CCR5, Receptors, CCR2, animal diseases, Antineoplastic Agents, Bone Neoplasms, Pharmacology, Ligands, 01 natural sciences, Article, Radioligand Assay, Structure-Activity Relationship, 03 medical and health sciences, Chemokine receptor, parasitic diseases, Drug Discovery, Tumor Cells, Cultured, Humans, Structure–activity relationship, Binding site, Receptor, Cell Proliferation, 030304 developmental biology, Osteosarcoma, 0303 health sciences, Binding Sites, Molecular Structure, Chemistry, hemic and immune systems, Biological activity, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Purines, Molecular Medicine, Intracellular, Protein Binding
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103دورية أكاديمية
لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل. -
104
المؤلفون: Harley Green, Lydia Barnes, Jolyon Matthews-Wright, Rachel Szpara, Luke Francis, Nuria S. Lima, Hollie Blaber, Carrie K. W. Wong, Alexander Seal, Charlotte S. Payne, Matthew F. Meehan, C. Elizabeth Killalea, Rohan J. Trainor, Katherine Wood, Jack M. J. Grace, Oliver Williams, Liam Cochrane, Edmund J. P. Hogarth, Katherine Louise Jones, Zoe J. Lee, Shusha Mahdy, Anna Gruszka, Lisa Morrison, Freya Taday, Leyla Jusu, Oliver King, May-Li Mackinnon, Joe Stillibrand, Daniel Buckley, Edward Cooney, Z.A. Henley, Simon J. F. Macdonald, Christina L. Long, Daniel Fu He, Craig Pike, Zoe C. Byron, Keenan M. Smith, Ian Edward David Smith, Antony M. Threadgould, Lewis Byers, Kamile Stanelyte, Hal R. I. Parke, Nick Barton, Rosa Cookson, James E. Rowedder, Andrew Nortcliffe, Aaron J. Senior, Alan Nadin, Makenzie J. Millward, Joseph Lambert, Lawrence Payne, David T. K. Brooks, Christopher Merrett, Heather A. Damian, Jordan Waters, Richard G. Chilvers
المصدر: Journal of Medicinal Chemistry. 62:10402-10422
مصطلحات موضوعية: 0303 health sciences, Phosphoinositide 3-kinase, biology, Cell growth, Chemistry, Regulator, N methylation, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Transformation (genetics), Biochemistry, Drug Discovery, biology.protein, Molecular Medicine, PI3K/AKT/mTOR pathway, 030304 developmental biology
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105
المؤلفون: Carolyn A. Weigelt, Sha Li, David Marcoux, Georgia Cornelius, Qihong Zhao, Mary Ellen Cvijic, John E. Macor, Jingwu Duan, Melissa Yarde, Muthalagu Vetrichelvan, David J. Shuster, Qingjie Liu, Richard Rampulla, Kim W. McIntyre, Mary T. Obermeier, Shiuhang Yip, Purnima Khandelwal, Sureshbabu Vishwakrishnan, Anuradha Gupta, Virna Borowski, Peng Li, Kevin Stefanski, Sridharan Ramlingam, Myra Beaudoin-Bertrand, Nageswara Maddala, Sridhar Vanteru, Percy H. Carter, Arvind Mathur, Aberra Fura, Max Ruzanov, John Hynes, Dauh-Rurng Wu, Jinhong Wang, Luisa Salter-Cid, John S. Sack, Cornelius Lyndon A M, Anurag S. Srivastava, Robert J. Cherney, Kumaravel Selvakumar, Mushkin Basha, Arun Kumar Gupta, Douglas G. Batt, Rex Denton, Sukhen Karmakar, Qing Shi, Ananta Karmakar, Naveen Manjunath, Javed Khan, Jenny Xie, Joseph A. Tino, T. G. Murali Dhar
المصدر: Journal of Medicinal Chemistry. 62:9931-9946
مصطلحات موضوعية: Models, Molecular, Pyrrolidines, Drug Inverse Agonism, Protein Conformation, Pharmacology, 01 natural sciences, Jurkat Cells, Mice, Structure-Activity Relationship, 03 medical and health sciences, Psoriatic arthritis, RAR-related orphan receptor gamma, In vivo, Drug Discovery, medicine, Animals, Humans, Inverse agonist, Structure–activity relationship, Tissue Distribution, 030304 developmental biology, 0303 health sciences, Chemistry, Nuclear Receptor Subfamily 1, Group F, Member 3, medicine.disease, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Nuclear receptor, Drug Design, Molecular Medicine
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106دورية أكاديمية
لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل. -
107دورية أكاديمية
لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل. -
108
المؤلفون: Robert F. Bruns, Qi Chen, Paloma Vidal, John Mehnert Schaus, Charles R. Yang, Stephen N. Mitchell, Steven Marc Massey, Nuria Diaz, Xushan Wang, David Andrew Coates, Rebecca A. Wright, Beverly A. Heinz, Kevin Matthew Gardinier, Greg Stephenson, James P. Beck, Rajni M. Bhardwaj, Julie F. Falcone, Bruce A. Dressman, Deanna L Maren, Anette M. Johansson, David Michael Remick, Jeff W. Cramer, Cohen Michael Philip, Brian Morgan Watson, Jeffery Richardson, Kjell Svensson, Xin Zhou, Erik James Hembre, Serge Louis Boulet, Reinhard Matthew Robert, Daniel S. Richards, Junliang Hao, David M. Bender, Guy Carter, Christopher David Beadle, Brian G. Getman, Wolfangel Craig Daniel, Diseroad Benjamin Alan, Jason K. Myers, Joseph H. Krushinski, David Edward Tupper
المصدر: Journal of Medicinal Chemistry. 62:8711-8732
مصطلحات موضوعية: 0303 health sciences, Catechol, Allosteric modulator, Stereochemistry, Subtype selective, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, Dopamine receptor D1, chemistry, Dopamine, Drug Discovery, medicine, Molecular Medicine, Hydroxymethyl, 030304 developmental biology, medicine.drug
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109
المؤلفون: Joseph E. Pero, Dennis A. Holt, Carl Brooks, Matthews Jay M, Melissa H. Costell, Raynold Shenje, John J. McAtee, David J. Behm, Ralph A. Rivero, Larry J. Jolivette, Sanchez Robert, Brent W. Mccleland, Lamont Roscoe Terrell, Jaclyn R. Patterson, Edward J. Brnardic, Theresa J. Roethke, Brian G. Lawhorn, Linda S. Barton
المصدر: Journal of Medicinal Chemistry. 62:9270-9280
مصطلحات موضوعية: Pyrrolidines, Metabolite, Drug Evaluation, Preclinical, Administration, Oral, TRPV Cation Channels, 01 natural sciences, Pyrrolidine, Rats, Sprague-Dawley, Inhibitory Concentration 50, Structure-Activity Relationship, 03 medical and health sciences, Transient receptor potential channel, chemistry.chemical_compound, Pharmacokinetics, In vivo, Drug Discovery, Animals, Humans, Structure–activity relationship, Moiety, 030304 developmental biology, Sulfonamides, 0303 health sciences, Chemistry, In vitro, Rats, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Solubility, Biophysics, Molecular Medicine, Half-Life
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110
المؤلفون: William A. Denny, Stephen M. F. Jamieson, Christian K. Miller, Kate H. Gartlan, Julie Ann Spicer, Jiney Jose, Karshing Chang, Matthew Bull, Hedieh Akhlaghi, Joseph A. Trapani, Jagdish K. Jaiswal, Geoff R. Hill, Patrick D. O'Connor, Anna C. Giddens
المصدر: Journal of Medicinal Chemistry. 63:2229-2239
مصطلحات موضوعية: Graft Rejection, Male, chemical and pharmacologic phenomena, Context (language use), 01 natural sciences, Cell Line, Bone Marrow Stem Cell Transplantation, Mice, 03 medical and health sciences, In vivo, Drug Discovery, Animals, Cytotoxic T cell, Bone Marrow Transplantation, 030304 developmental biology, Mice, Inbred BALB C, Sulfonamides, 0303 health sciences, biology, Perforin, Chemistry, 3. Good health, 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Granzyme, Cell culture, biology.protein, Cancer research, Molecular Medicine, Stem cell, Stem Cell Transplantation