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1
المؤلفون: Colleen M. Niswender, Meredith J. Noetzel, Michael R. Wood, Patrick R. Gentry, Peter Chase, Masaya Kokubo, Thomas M. Bridges, Emery Smith, P. Jeffrey Conn, Atin Lamsal, Craig W. Lindsley, Peter Hodder, J. Scott Daniels, Hyekyung P. Cho
المصدر: Journal of Medicinal Chemistry
مصطلحات موضوعية: Central Nervous System, Male, Indazoles, Allosteric modulator, Brief Article, Stereochemistry, medicine.drug_class, Allosteric regulation, Drug Evaluation, Preclinical, Carboxamide, Substrate Specificity, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Allosteric Regulation, Piperidines, Drug Discovery, Muscarinic acetylcholine receptor, medicine, Animals, Humans, Potency, 030304 developmental biology, Sulfonamides, 0303 health sciences, Receptor, Muscarinic M5, Trifluoromethyl, Chemistry, Drug discovery, High-Throughput Screening Assays, Rats, 3. Good health, Molecular Medicine, Piperidine, 030217 neurology & neurosurgery
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2
المؤلفون: Jason Manka, Hilde Lavreysen, Colleen M. Niswender, Jon Jacobs, M. Luz Martín-Martín, P. Jeffrey Conn, Meredith J. Noetzel, Han Min Tong, Elizabeth J. Herman, C. David Weaver, Chrysa Malosh, J. Scott Daniels, Susana Conde-Ceide, Paige N. Vinson, Shaun R. Stauffer, Gregor James Macdonald, Claire Mackie, José Manuel Bartolomé-Nebreda, Thomas Steckler, Silvia López, Craig W. Lindsley, Carrie K. Jones, Satyawan Jadhav, Mark Turlington
المصدر: Journal of Medicinal Chemistry. 57:5620-5637
مصطلحات موضوعية: Bicyclic molecule, Metabotropic glutamate receptor 5, Stereochemistry, Chemistry, High-throughput screening, Drug Discovery, Allosteric regulation, Antagonist, Glutamate receptor, Molecular Medicine, Structure–activity relationship, Linker
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3
المؤلفون: Jerri M. Rook, Colleen M. Niswender, Thomas M. Bridges, Jens Meiler, Rocco D. Gogliotti, Karen J. Gregory, J. Scott Daniels, Ya Zhou, Kiran K. Gogi, Paige N. Vinson, P. Jeffrey Conn, Zixiu Xiang, Carrie K. Jones, Shaun R. Stauffer, Aspen Chun, Elizabeth Dong Nguyen, Craig W. Lindsley, Mark Turlington, Meredith J. Noetzel
المصدر: Journal of Medicinal Chemistry. 56:7976-7996
مصطلحات موضوعية: Metabotropic glutamate receptor 5, Chemistry, Stereochemistry, Allosteric regulation, Glutamate receptor, Neurotoxicity, Cooperativity, Ligand (biochemistry), medicine.disease, stomatognathic system, embryonic structures, parasitic diseases, Drug Discovery, medicine, Molecular Medicine, Structure–activity relationship, Metabotropic glutamate receptor 2
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المؤلفون: Mark, Turlington, Chrysa, Malosh, Jon, Jacobs, Jason T, Manka, Meredith J, Noetzel, Paige N, Vinson, Satyawan, Jadhav, Elizabeth J, Herman, Hilde, Lavreysen, Claire, Mackie, José M, Bartolomé-Nebreda, Susana, Conde-Ceide, M Luz, Martín-Martín, Han Min, Tong, Silvia, López, Gregor J, MacDonald, Thomas, Steckler, J Scott, Daniels, C David, Weaver, Colleen M, Niswender, Carrie K, Jones, P Jeffrey, Conn, Craig W, Lindsley, Shaun R, Stauffer
المصدر: Journal of Medicinal Chemistry
مصطلحات موضوعية: Structure-Activity Relationship, HEK293 Cells, Allosteric Regulation, Receptor, Metabotropic Glutamate 5, Microsomes, Liver, Schizophrenia, Animals, Humans, Naphthyridines, Article, Antipsychotic Agents, Rats
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المؤلفون: Laura Iturrino, Satyawan Jadhav, Joaquín Pastor, José Manuel Bartolomé-Nebreda, Thomas Steckler, Francisca Delgado, Frederik J. R. Rombouts, Carola M. Wassvik, Colleen M. Niswender, Meredith J. Noetzel, Craig W. Lindsley, Andrés A. Trabanco, Claire Mackie, Paige N. Vinson, Emily Days, Gregor James Macdonald, Gary Tresadern, P. Jeffrey Conn, Miguel Ángel Pena, Carrie K. Jones, Shaun R. Stauffer, Hilde Lavreysen, Susana Conde-Ceide, Kiran Gogi, C. David Weaver
المصدر: Journal of medicinal chemistry. 56(18)
مصطلحات موضوعية: Male, Receptor, Metabotropic Glutamate 5, Allosteric regulation, Pharmacology, Article, Structure-Activity Relationship, Allosteric Regulation, In vivo, Drug Discovery, Structure–activity relationship, Animals, Humans, Receptor, Behavior, Animal, Dose-Response Relationship, Drug, Chemistry, Metabotropic glutamate receptor 5, Glutamate receptor, Rats, Thiazoles, Metabotropic receptor, Biochemistry, Molecular Medicine, Metabotropic glutamate receptor 2, Locomotion, Antipsychotic Agents
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6دورية أكاديمية
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7دورية أكاديمية
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8دورية أكاديمية
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9دورية أكاديمية
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10دورية أكاديمية
المؤلفون: Gentry, Patrick R., Kokubo, Masaya, Bridges, Thomas M., Noetzel, Meredith J., Cho, Hyekyung P., Lamsal, Atin, Smith, Emery, Chase, Peter, Hodder, Peter S., Niswender, Colleen M., Daniels, J. Scott, Conn, P. Jeffrey, Lindsley, Craig W., Wood, Michael R.
المصدر: Journal of Medicinal Chemistry; Sep2014, Vol. 57 Issue 18, p7804-7810, 7p