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المؤلفون: Ira Fleming, Carolyn Winston, Benjamin Kruft, Alex K. Shalek, Wolfram Goessling, Satdarshan P.S. Monga, Florian Mueller, Sungjin Ko, Udayan Apte, Chad Walesky, Kellie E. Kolb, Jake Henderson
المساهمون: Brigham and Women’s Hospital [Boston, MA], Harvard Medical School [Boston] (HMS), Institute of Medical Engineering & Science [Cambridge, MA] (IMES), Massachusetts Institute of Technology (MIT), Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], Ragon Institute of MGH, MIT and Harvard, Koch Institute for Integrative Cancer Research at MIT [Cambridge, MA], University of Pittsburgh Medical Center [Pittsburgh, PA, États-Unis] (UPMC), Imagerie et Modélisation - Imaging and Modeling, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Department of Pharmacology, Toxicology, and Therapeutics [Kansas City, KS, USA], University of Kansas Medical Center [Kansas City, KS, USA], Harvard-MIT Division of Health Sciences and Technology [Cambridge], Dana-Farber Cancer Institute [Boston], Harvard Stem Cell Institute [Cambridge, USA] (HSCI), Harvard University, Massachusetts General Hospital [Boston, MA, USA], C..W. is supported by F32DK111151, the Cholangiocarcinoma Foundation Research Fellowship, and the American Liver Foundation Charles Trey, MD Memorial Post-doctoral Research Fellowship. W.G. is supported by R01DK090311, R01DK105198, R24OD017870, and the Claudia Adams Barr Program for Excellence in Cancer Research. W.G. is a Pew Scholar in Biomedical Sciences. A.K.S. was supported, in part, by the Searle Scholars Program, the Beckman Young Investigator Program, a Sloan Fellowship in Chemistry, the NIH (1DP2GM1194192 & RM1HG0061931), and the MIT Stem Cell Initiative through Fondation MIT. U.A. is supported by R01DK098414. S.P.M is supported by NIH/NIDDK P30DK120531, Pittsburgh Liver Research Centre Grant, and NIH/NIDDK (DK62277, DK100287, and CA204586)
المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications, 2020, 11 (1), pp.5785. ⟨10.1038/s41467-020-19558-3⟩مصطلحات موضوعية: 0301 basic medicine, MESH: beta Catenin, General Physics and Astronomy, MESH: Cell Cycle, MESH: Mice, Knockout, Biochemistry, Transcriptome, MESH: Hepatocytes, Mice, 0302 clinical medicine, Protein biosynthesis, MESH: Animals, lcsh:Science, Wnt Signaling Pathway, beta Catenin, Mice, Knockout, Multidisciplinary, Fluorescence in situ hybridization, Cell Cycle, MESH: Wnt Signaling Pathway, Wnt signaling pathway, Cell cycle, MESH: Hepatectomy, Liver regeneration, Cell biology, MESH: Wnt Proteins, Liver, 030211 gastroenterology & hepatology, MESH: Liver Regeneration, Reprogramming, Biotechnology, Science, MESH: Acetaminophen, Biology, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, MESH: Gene Expression Profiling, MESH: Mice, Inbred C57BL, MESH: Cell Proliferation, Detoxification, Genetics, Animals, Hepatectomy, Transcriptomics, MESH: Mice, Molecular Biology, Acetaminophen, Cell Proliferation, Mechanism (biology), Gene Expression Profiling, Macrophages, MESH: Macrophages, General Chemistry, Regenerative process, Liver Regeneration, Gene expression profiling, Mice, Inbred C57BL, Wnt Proteins, Disease Models, Animal, 030104 developmental biology, Hepatocytes, lcsh:Q, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Liver function, MESH: Disease Models, Animal, MESH: Liver
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المؤلفون: Troy L. Mitchell, Yang Li, Tom Z. Yuan, Meghah Vuppalapaty, Nikita Tripuraneni, Fowler Tristan William, Sung-Jin Lee, Jingjing Ye, Haili Zhang, Erica S. Rego, Hui Chen, Archana Dilip, Liqin Xie, Helene Baribault, Janda Claudia Yvonne, Wen-Chen Yeh, Shengjiang Tu, Maureen Newman, Brian Ouyang, Devin Mutha
المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
مصطلحات موضوعية: 0301 basic medicine, Frizzled, Aging, Science, Osteoporosis, Drug Evaluation, Preclinical, General Physics and Astronomy, 030209 endocrinology & metabolism, Regenerative medicine, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Mice, Young Adult, 0302 clinical medicine, In vivo, Bone Density, Medicine, Animals, Humans, Femur, Bone Resorption, Wnt Signaling Pathway, Osteoporosis, Postmenopausal, Aged, Bone mineral, Phenocopy, Multidisciplinary, Bone Density Conservation Agents, Diphosphonates, business.industry, Wnt signaling pathway, Increased Bone Density, Drug Synergism, General Chemistry, medicine.disease, Wnt Proteins, Disease Models, Animal, 030104 developmental biology, Cancer research, Drug Therapy, Combination, Female, business, Femoral Fractures
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المؤلفون: Hoon Ki Sung, Tae-Hee Kim, Sammy Shun Wai Shi, Lijiang Fei, Noah A. Hahn, Ji-Eun Kim, Wen-Chi Yin, Abilasha Rao-Bhatia, Ju Hee Lee, Xiaoyun Zhang, Chi-chung Hui, Sabrina Coquenlorge, Wasi Rizvi, Kyoung-Han Kim, Guoji Guo
المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communicationsمصطلحات موضوعية: 0301 basic medicine, Male, Stromal cell, Science, Cell, General Physics and Astronomy, Biology, Zinc Finger Protein Gli2, Ligands, General Biochemistry, Genetics and Molecular Biology, Article, Transcriptome, 03 medical and health sciences, Mice, 0302 clinical medicine, Single-cell analysis, Telocyte, medicine, Animals, Homeostasis, Regeneration, Genetic Testing, Telocytes, Cell Self Renewal, Stem Cell Niche, lcsh:Science, Wnt Signaling Pathway, Mice, Knockout, Multidisciplinary, Wnt signaling pathway, Epithelial Cells, General Chemistry, Cell biology, Gastrointestinal Tract, Wnt Proteins, 030104 developmental biology, medicine.anatomical_structure, lcsh:Q, Pericyte, Stem cell, Stromal Cells, 030217 neurology & neurosurgery, Stem-cell niche
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المؤلفون: Jamie A. Hackett, Ufuk Günesdogan, Yun Huang, M. Azim Surani, Kristjan A. Gretarsson, Toshihiro Kobayashi
المساهمون: Surani, Azim [0000-0002-8640-4318], Hackett, Jamie [0000-0002-6237-3684], Apollo - University of Cambridge Repository
المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communicationsمصطلحات موضوعية: 0301 basic medicine, Pluripotent Stem Cells, endocrine system, Somatic cell, Chromosomal Proteins, Non-Histone, Science, Population, Green Fluorescent Proteins, Gene regulatory network, General Physics and Astronomy, Embryonic Development, Receptors, Cytoplasmic and Nuclear, Mice, Transgenic, Cell fate determination, Biology, General Biochemistry, Genetics and Molecular Biology, Germline, 03 medical and health sciences, Mice, 0302 clinical medicine, Genes, Reporter, medicine, Basic Helix-Loop-Helix Transcription Factors, CRISPR, Animals, Clustered Regularly Interspaced Short Palindromic Repeats, education, lcsh:Science, 030304 developmental biology, 0303 health sciences, education.field_of_study, Multidisciplinary, Wnt signaling pathway, Gene Expression Regulation, Developmental, General Chemistry, Publisher Correction, 3. Good health, Cell biology, DNA-Binding Proteins, Repressor Proteins, Wnt Proteins, 030104 developmental biology, medicine.anatomical_structure, Epiblast, lcsh:Q, Positive Regulatory Domain I-Binding Factor 1, 030217 neurology & neurosurgery, Germ cell
وصف الملف: application/pdf
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المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communicationsمصطلحات موضوعية: 0301 basic medicine, food.ingredient, animal structures, Science, General Physics and Astronomy, nematostella-vectensis, Nematostella, ctenophore mnemiopsis-leidyi, Biology, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, food, evolution, Animals, hydra, animal-vegetal axis, Hox gene, genome, Bilateria, Body Patterning, Multidisciplinary, Gastrulation, Genes, Homeobox, Wnt signaling pathway, Gene Expression Regulation, Developmental, Starlet sea anemone, sea-anemone, homeobox genes, General Chemistry, Blastula, biology.organism_classification, Wnt Proteins, Sea Anemones, 030104 developmental biology, fate, Evolutionary biology, embryonic structures, oral-aboral axis, Homeobox, 030217 neurology & neurosurgery, Signal Transduction
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المؤلفون: Riccardo Bocchi, Patrick Salmon, Charles Quairiaux, Michael Boitard, Kristof Egervari, Mathias De Roo, Jozsef Zoltan Kiss, Suzanne Oskouie, Laura Carol-Perdiguer, Beatrice Viale
المصدر: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications
Nature Communications, Vol. 8, No 1 (2017) P. 1158مصطلحات موضوعية: Male, 0301 basic medicine, Neurogenesis, Science, Regulator, General Physics and Astronomy, Biology, Somatosensory system, Article, General Biochemistry, Genetics and Molecular Biology, Corpus Callosum, Membrane Potentials, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Cell Movement, Image Processing, Computer-Assisted, Animals, Humans, Premovement neuronal activity, Rats, Wistar, lcsh:Science, Social Behavior, Cerebrum, Wnt Signaling Pathway, Neurons, Multidisciplinary, Behavior, Animal, Sequence Analysis, RNA, HEK 293 cells, Wnt signaling pathway, Brain, Somatosensory Cortex, General Chemistry, ddc:616.8, Rats, Cortex (botany), Wnt Proteins, HEK293 Cells, Phenotype, 030104 developmental biology, lcsh:Q, Female, Neuroglia, Neuroscience, 030217 neurology & neurosurgery
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المؤلفون: Fang Yin Lo, Domenico Coppola, Gabriel A. Bien-Willner, Danielle M. Greenawalt, Andrey Loboda, Mingli Yang, Anup Madan, Michael Nebozhyn, Timothy J. Yeatman, Binglin Yue, Jamie K. Teer, Alvaro N.A. Monteiro, Michael J. Schell
المصدر: Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Nature Communicationsمصطلحات موضوعية: 0301 basic medicine, Mutation rate, Colorectal cancer, Science, Adenomatous Polyposis Coli Protein, General Physics and Astronomy, Disease, Kaplan-Meier Estimate, Biology, medicine.disease_cause, Bioinformatics, General Biochemistry, Genetics and Molecular Biology, Article, Statistics, Nonparametric, 03 medical and health sciences, 0302 clinical medicine, Mutation Rate, medicine, Humans, Neoplasm Metastasis, Wnt Signaling Pathway, beta Catenin, Proportional Hazards Models, Cell Nucleus, Multidisciplinary, Staining and Labeling, Proportional hazards model, Cancer, Microsatellite instability, General Chemistry, medicine.disease, Prognosis, 3. Good health, Wnt Proteins, 030104 developmental biology, 030220 oncology & carcinogenesis, Mutation (genetic algorithm), Mutation, Cancer research, Microsatellite Instability, KRAS, Colorectal Neoplasms, Genes, Neoplasm