المؤلفون: Tajima K; UCSF Diabetes Center, San Francisco, CA, 94143, USA.; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, San Francisco, CA, 94143, USA.; Department of Cell and Tissue Biology, University of California, San Francisco, CA, 94143, USA., Ikeda K; UCSF Diabetes Center, San Francisco, CA, 94143, USA.; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, San Francisco, CA, 94143, USA.; Department of Cell and Tissue Biology, University of California, San Francisco, CA, 94143, USA.; Department of Molecular Endocrinology and Metabolism, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan., Tanabe Y; Department of Electrical Engineering, Stanford University, Stanford, CA, 94305, USA., Thomson EA; Department of Electrical Engineering, Stanford University, Stanford, CA, 94305, USA., Yoneshiro T; UCSF Diabetes Center, San Francisco, CA, 94143, USA.; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, San Francisco, CA, 94143, USA.; Department of Cell and Tissue Biology, University of California, San Francisco, CA, 94143, USA., Oguri Y; UCSF Diabetes Center, San Francisco, CA, 94143, USA.; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, San Francisco, CA, 94143, USA.; Department of Cell and Tissue Biology, University of California, San Francisco, CA, 94143, USA., Ferro MD; Department of Materials Science and Engineering, Stanford University, Stanford, CA, 94305, USA., Poon ASY; Department of Electrical Engineering, Stanford University, Stanford, CA, 94305, USA. adapoon@stanford.edu.; Chan Zuckerberg Biohub, San Francisco, CA, 94158, USA. adapoon@stanford.edu., Kajimura S; UCSF Diabetes Center, San Francisco, CA, 94143, USA. shingo.kajimura@ucsf.edu.; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, San Francisco, CA, 94143, USA. shingo.kajimura@ucsf.edu.; Department of Cell and Tissue Biology, University of California, San Francisco, CA, 94143, USA. shingo.kajimura@ucsf.edu.

المصدر: Nature communications [Nat Commun] 2020 Apr 07; Vol. 11 (1), pp. 1730. Date of Electronic Publication: 2020 Apr 07.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Adipocytes/*metabolism , Adipose Tissue/*metabolism , Channelrhodopsins/*metabolism , Obesity/*therapy , Optogenetics/*instrumentation , Sarcoplasmic Reticulum Calcium-Transporting ATPases/*metabolism , Thermogenesis/*radiation effects, Adipocytes/radiation effects ; Adipose Tissue/radiation effects ; Animals ; Body Weight/physiology ; Body Weight/radiation effects ; Calcium/metabolism ; Cells, Cultured ; Channelrhodopsins/radiation effects ; Channelrhodopsins/therapeutic use ; Diet ; Energy Metabolism/radiation effects ; Locomotion ; Male ; Mice ; Mice, Knockout ; Obesity/metabolism ; Optogenetics/methods ; Oxygen Consumption ; Receptors, Adrenergic, beta/metabolism ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/genetics ; Thermogenesis/physiology

المؤلفون: Joslin AC; Department of Human Genetics, University of Chicago, Chicago, IL, USA. acjoslin@gmail.com., Sobreira DR; Department of Human Genetics, University of Chicago, Chicago, IL, USA. deborarsobreira@gmail.com., Hansen GT; Department of Human Genetics, University of Chicago, Chicago, IL, USA., Sakabe NJ; Department of Human Genetics, University of Chicago, Chicago, IL, USA., Aneas I; Department of Human Genetics, University of Chicago, Chicago, IL, USA., Montefiori LE; Department of Human Genetics, University of Chicago, Chicago, IL, USA., Farris KM; Department of Human Genetics, University of Chicago, Chicago, IL, USA., Gu J; Department of Human Genetics, University of Chicago, Chicago, IL, USA., Lehman DM; Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Ober C; Department of Human Genetics, University of Chicago, Chicago, IL, USA., He X; Department of Human Genetics, University of Chicago, Chicago, IL, USA., Nóbrega MA; Department of Human Genetics, University of Chicago, Chicago, IL, USA. nobrega@uchicago.edu.

المصدر: Nature communications [Nat Commun] 2021 Sep 06; Vol. 12 (1), pp. 5253. Date of Electronic Publication: 2021 Sep 06.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Enhancer Elements, Genetic* , Genetic Pleiotropy*, Adipocytes/*physiology , Obesity/*genetics, Adipocytes/cytology ; Arrhythmias, Cardiac/genetics ; Arrhythmias, Cardiac/pathology ; Genetic Diseases, X-Linked/genetics ; Genetic Diseases, X-Linked/pathology ; Genome-Wide Association Study ; Gigantism/genetics ; Gigantism/pathology ; Heart Defects, Congenital/genetics ; Heart Defects, Congenital/pathology ; Humans ; Hypothalamus/physiology ; Intellectual Disability/genetics ; Intellectual Disability/pathology ; MAP Kinase Kinase 5/genetics ; Neurons/cytology ; Neurons/physiology ; Polymorphism, Single Nucleotide ; Protein Kinases/genetics ; Quantitative Trait Loci ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/genetics ; Transcription Factors/genetics ; Transcriptome

SCR Disease Name: Simpson-Golabi-Behmel syndrome