المؤلفون: Joshua D. G. Leach, Nikola Vlahov, Petros Tsantoulis, Rachel A. Ridgway, Dustin J. Flanagan, Kathryn Gilroy, Nathalie Sphyris, Ester G. Vázquez, David F. Vincent, William J. Faller, Michael C. Hodder, Alexander Raven, Sigrid Fey, Arafath K. Najumudeen, Douglas Strathdee, Colin Nixon, Mark Hughes, William Clark, Robin Shaw, S:CORT consortium, Sander R. van Hooff, David J. Huels, Jan Paul Medema, Simon T. Barry, Margaret C. Frame, Asier Unciti-Broceta, Simon J. Leedham, Gareth J. Inman, Rene Jackstadt, Barry J. Thompson, Andrew D. Campbell, Sabine Tejpar, Owen J. Sansom

المساهمون: Center of Experimental and Molecular Medicine, CCA - Cancer biology and immunology, Radiotherapy

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature communications, 12(1):3464. Nature Publishing Group
Nature Communications
S-CORT Consortium 2021, ' Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis ', Nature Communications, vol. 12, 3464 . https://doi.org/10.1038/s41467-021-23717-5

مصطلحات موضوعية: 0301 basic medicine, Chemistry(all), MICROSATELLITE INSTABILITY, Carcinogenesis, Colorectal cancer, Cellular differentiation, Receptor, Transforming Growth Factor-beta Type I, General Physics and Astronomy, SESSILE SERRATED ADENOMAS, DISTAL COLON, Kaplan-Meier Estimate, medicine.disease_cause, COLORECTAL-CANCER, 0302 clinical medicine, Transforming Growth Factor beta, Wnt Signaling Pathway, IN-VIVO, Mutation, Multidisciplinary, Cancer stem cells, Wnt signaling pathway, LGR5, Cell Differentiation, Prognosis, Multidisciplinary Sciences, 030220 oncology & carcinogenesis, Colonic Neoplasms, Science & Technology - Other Topics, Stem cell, STEM-CELLS, Signal Transduction, EXPRESSION, Proto-Oncogene Proteins B-raf, Cell Survival, Colon, MAP Kinase Signaling System, Science, INHIBITION, Physics and Astronomy(all), Biology, Article, General Biochemistry, Genetics and Molecular Biology, WNT ACTIVATION, 03 medical and health sciences, Fetus, SDG 3 - Good Health and Well-being, Spheroids, Cellular, medicine, Animals, Progenitor cell, Cancer models, Adaptor Proteins, Signal Transducing, Inflammation, Science & Technology, Biochemistry, Genetics and Molecular Biology(all), INTESTINAL REGENERATION, Epithelial Cells, YAP-Signaling Proteins, General Chemistry, medicine.disease, digestive system diseases, Mice, Inbred C57BL, Wnt Proteins, 030104 developmental biology, Cancer research, Receptors, Transforming Growth Factor beta, Transcription Factors

وصف الملف: application/pdf; Electronic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad0a5ec9305d4966a39971a5afa4cf77
https://doi.org/10.1038/s41467-021-23717-5

المؤلفون: Andrey Glinka, Hyeyoon Lee, Rui Sun, Carina Seidl, Christof Niehrs

المصدر: Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

مصطلحات موضوعية: 0301 basic medicine, animal structures, Science, Ubiquitin-Protein Ligases, Xenopus, Embryonic Development, General Physics and Astronomy, Bone Morphogenetic Protein 4, Xenopus Proteins, Ligands, Article, General Biochemistry, Genetics and Molecular Biology, Xenopus laevis, 03 medical and health sciences, 0302 clinical medicine, Protein Domains, Cell Line, Tumor, Membrane proteins, Developmental biology, Animals, Humans, lcsh:Science, Receptor, RSPO2, Bone Morphogenetic Protein Receptors, Type I, In Situ Hybridization, Tissue homeostasis, Multidisciplinary, biology, Chemistry, Synexpression, Wnt signaling pathway, Gene Expression Regulation, Developmental, General Chemistry, biology.organism_classification, BMPR1A, Cell biology, Wnt Proteins, 030104 developmental biology, embryonic structures, Intercellular Signaling Peptides and Proteins, lcsh:Q, Stem cell, Thrombospondins, 030217 neurology & neurosurgery, Signal Transduction, Cell signalling

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970268727c5fdf4537b4e06bdc1f6e98
https://doi.org/10.1038/s41467-020-19373-w

المؤلفون: Ying Huang, Meng Jiang, Peter S. Dennis, Runsheng Chen, Keith Alder, Yu Xin, Ruben D. Carrasco, Ruiyang Liu, Helen Tanton, Amitabh Srivastava, Mengyun Zhang, Massimo Loda, Tomasz Sewastianik, Yue Kang, Jiao Wang, Ming Liu, Zhongqiu Wang

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Cell biology, Molecular biology, Colorectal cancer, Science, General Physics and Astronomy, Cell Communication, Biology, Article, General Biochemistry, Genetics and Molecular Biology, Mice, 03 medical and health sciences, 0302 clinical medicine, BCL9, Cell Line, Tumor, medicine, Animals, Humans, lcsh:Science, Wnt Signaling Pathway, beta Catenin, Cancer, Tumor microenvironment, Multidisciplinary, Oncogene, Wnt signaling pathway, Paraspeckle, General Chemistry, medicine.disease, 3. Good health, Gene Expression Regulation, Neoplastic, Wnt Proteins, 030104 developmental biology, Tumor progression, 030220 oncology & carcinogenesis, Cancer research, lcsh:Q, Calcium, Colorectal Neoplasms, Protein Binding, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc12fda6f5787a87aac976d30cc8cc0
https://doi.org/10.1038/s41467-019-13842-7

المؤلفون: Igor Y. Iskusnykh, Victor V. Chizhikov, Nikolai Fattakhov, Shubha Tole, Achira Roy, Kathleen J. Millen, Ashwin S. Shetty, Ekaterina Y. Steshina, Anne G. Lindgren

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications

مصطلحات موضوعية: Male, 0301 basic medicine, Science, Mesenchyme, LIM-Homeodomain Proteins, Neuroepithelial Cells, General Physics and Astronomy, Lissencephaly, Developmental neurogenesis, Neocortex, Biology, Article, General Biochemistry, Genetics and Molecular Biology, Mesoderm, Mice, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, lcsh:Science, Gyrification, Mice, Knockout, Regulation of gene expression, Multidisciplinary, Wnt signaling pathway, Neural tube, Cell type diversity, Gene Expression Regulation, Developmental, General Chemistry, medicine.disease, Mice, Inbred C57BL, Wnt Proteins, Neuroepithelial cell, 030104 developmental biology, medicine.anatomical_structure, Female, lcsh:Q, Neuroscience, 030217 neurology & neurosurgery, Signal Transduction, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::525c0e26c1a722217656ebbd6878efaa
https://doi.org/10.1038/s41467-019-12913-z

المؤلفون: M. Cristina Nostro, Chi-chung Hui, Minggao Liang, Michael D. Wilson, Sabrina Coquenlorge, Emily C. McGaugh, Tae-Hee Kim, Frankie Poon, Theodora Yung

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Stromal cell, Organogenesis, Science, Cellular differentiation, education, Cell Culture Techniques, Cell- and Tissue-Based Therapy, Down-Regulation, General Physics and Astronomy, Stem cells, SPOP, Biology, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Insulin-Secreting Cells, Diabetes Mellitus, Humans, Hedgehog Proteins, lcsh:Science, Hedgehog, Embryonic Stem Cells, Multidisciplinary, Wnt signaling pathway, Nuclear Proteins, Cell Differentiation, General Chemistry, Embryonic stem cell, Hedgehog signaling pathway, Cell biology, Organoids, Repressor Proteins, Wnt Proteins, 030104 developmental biology, Differentiation, lcsh:Q, Stem cell, Stem-cell niche, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::308854f933cd9752d864758cc8ecec0e
https://doi.org/10.1038/s41467-019-12624-5

المؤلفون: Ryan A. Hlady, Katarina Lopusna, Jana Opavska, Peike Sheng, Pawel Nowialis, Olga A. Guryanova, Amarnath Natarajan, Mingyi Xie, Melanie A. Simpson, Alberto Riva, Rene Opavsky, Staci L. Haney, Ajay Abraham

المصدر: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)

مصطلحات موضوعية: 0301 basic medicine, Methyltransferase, Science, DNMT3B, Embryonic Development, General Physics and Astronomy, Mice, Transgenic, Biology, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Animals, Humans, Hedgehog Proteins, DNA (Cytosine-5-)-Methyltransferases, lcsh:Science, Mice, Knockout, Regulation of gene expression, DNA methylation, Multidisciplinary, HEK 293 cells, Wnt signaling pathway, Gene Expression Regulation, Developmental, General Chemistry, Methylation, Hedgehog signaling pathway, Cell biology, Mice, Inbred C57BL, Wnt Proteins, HEK293 Cells, 030104 developmental biology, Embryogenesis, embryonic structures, Biocatalysis, lcsh:Q, Epigenetics, Female, Gene expression, Transcription, 030217 neurology & neurosurgery, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba9b8b2e14926e9e1c8d9259b616aab3
https://doi.org/10.1038/s41467-019-12355-7

المؤلفون: Dominic B. Bernkopf, Martina Brückner, Jürgen Behrens, Michel V. Hadjihannas

المصدر: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

مصطلحات موضوعية: 0301 basic medicine, Scaffold protein, Cell biology, Science, General Physics and Astronomy, macromolecular substances, Article, General Biochemistry, Genetics and Molecular Biology, Gene Knockout Techniques, 03 medical and health sciences, 0302 clinical medicine, Axin Protein, Transcription (biology), Cell Line, Tumor, AXIN2, Humans, lcsh:Science, Wnt Signaling Pathway, Transcription factor, beta Catenin, Cancer, Cell Proliferation, Multidisciplinary, Drug discovery, Chemistry, HEK 293 cells, technology, industry, and agriculture, Wnt signaling pathway, General Chemistry, Wnt Proteins, HEK293 Cells, 030104 developmental biology, lcsh:Q, CRISPR-Cas Systems, Signal transduction, Colorectal Neoplasms, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09981b25d687f3e442034d92a1dfaa76
https://doi.org/10.1038/s41467-019-12203-8

المؤلفون: Oscar E. Ruiz, Elizabeth A. Sumner, Courtney K. Brock, Stephen T. Wallin, Amrita Mandal, George T. Eisenhoffer, Krystin M. Samms

المصدر: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

مصطلحات موضوعية: Programmed cell death, Cell signaling, Embryo, Nonmammalian, Cell division, Science, Cell, General Physics and Astronomy, Apoptosis, Biology, Epithelium, Article, General Biochemistry, Genetics and Molecular Biology, Extracellular Vesicles, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, ortho-Aminobenzoates, lcsh:Science, Zebrafish, Tissue homeostasis, Cell Proliferation, 030304 developmental biology, 0303 health sciences, Multidisciplinary, Phenylurea Compounds, Stem Cells, Wnt signaling pathway, Epithelial Cells, General Chemistry, Zebrafish Proteins, Cell biology, Wnt Proteins, Cytoskeletal Proteins, medicine.anatomical_structure, Caspases, 030220 oncology & carcinogenesis, lcsh:Q, Stem cell, Cell Division, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c2356028c041cd5d95ac34152ef29f
https://doi.org/10.1038/s41467-019-09010-6

المؤلفون: Yoonsung Lee, Albert D. Kim, Claire Pouget, David Traver, Jennifer E. Manegold, Wilson K. Clements, David L. Stachura

المصدر: Nature communications

مصطلحات موضوعية: Cellular differentiation, Notch signaling pathway, General Physics and Astronomy, Nerve Tissue Proteins, Biology, Fibroblast growth factor, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, DeltaC, medicine, FGF, Animals, Receptor, Fibroblast Growth Factor, Type 4, somites, Receptor, Notch1, Zebrafish, 030304 developmental biology, Homeodomain Proteins, 0303 health sciences, Multidisciplinary, fgfr4, Intracellular Signaling Peptides and Proteins, Wnt signaling pathway, Membrane Proteins, Cell Differentiation, General Chemistry, Zebrafish Proteins, Hematopoietic Stem Cells, Cell biology, Wnt Proteins, Somite, Haematopoiesis, Wnt16, medicine.anatomical_structure, Notch proteins, Stem cell, 030217 neurology & neurosurgery, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb3c4bf51a34df7a5ed1f73d9ed49915
https://doi.org/10.1038/ncomms6583

المؤلفون: Michael A. Rudnicki, Radoslav Zinoviev, C. Florian Bentzinger, Julia von Maltzahn, Natasha C. Chang

المصدر: Nature Communications

مصطلحات موضوعية: Amino Acid Motifs, General Physics and Astronomy, Biology, Article, General Biochemistry, Genetics and Molecular Biology, Receptors, G-Protein-Coupled, Mice, 03 medical and health sciences, 0302 clinical medicine, Palmitoylation, Animals, Muscle, Skeletal, Protein kinase B, PI3K/AKT/mTOR pathway, Sequence Deletion, 030304 developmental biology, 0303 health sciences, Multidisciplinary, Wnt signaling pathway, LRP6, LRP5, General Chemistry, Frizzled Receptors, 3. Good health, Mice, Inbred C57BL, Wnt Proteins, WNT7A, Biochemistry, Female, Signal transduction, 030217 neurology & neurosurgery, Protein Binding, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aab1e6b168e88101815d21b1a0c41ed
https://doi.org/10.1038/ncomms3869