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المؤلفون: Ira Fleming, Carolyn Winston, Benjamin Kruft, Alex K. Shalek, Wolfram Goessling, Satdarshan P.S. Monga, Florian Mueller, Sungjin Ko, Udayan Apte, Chad Walesky, Kellie E. Kolb, Jake Henderson
المساهمون: Brigham and Women’s Hospital [Boston, MA], Harvard Medical School [Boston] (HMS), Institute of Medical Engineering & Science [Cambridge, MA] (IMES), Massachusetts Institute of Technology (MIT), Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], Ragon Institute of MGH, MIT and Harvard, Koch Institute for Integrative Cancer Research at MIT [Cambridge, MA], University of Pittsburgh Medical Center [Pittsburgh, PA, États-Unis] (UPMC), Imagerie et Modélisation - Imaging and Modeling, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Department of Pharmacology, Toxicology, and Therapeutics [Kansas City, KS, USA], University of Kansas Medical Center [Kansas City, KS, USA], Harvard-MIT Division of Health Sciences and Technology [Cambridge], Dana-Farber Cancer Institute [Boston], Harvard Stem Cell Institute [Cambridge, USA] (HSCI), Harvard University, Massachusetts General Hospital [Boston, MA, USA], C..W. is supported by F32DK111151, the Cholangiocarcinoma Foundation Research Fellowship, and the American Liver Foundation Charles Trey, MD Memorial Post-doctoral Research Fellowship. W.G. is supported by R01DK090311, R01DK105198, R24OD017870, and the Claudia Adams Barr Program for Excellence in Cancer Research. W.G. is a Pew Scholar in Biomedical Sciences. A.K.S. was supported, in part, by the Searle Scholars Program, the Beckman Young Investigator Program, a Sloan Fellowship in Chemistry, the NIH (1DP2GM1194192 & RM1HG0061931), and the MIT Stem Cell Initiative through Fondation MIT. U.A. is supported by R01DK098414. S.P.M is supported by NIH/NIDDK P30DK120531, Pittsburgh Liver Research Centre Grant, and NIH/NIDDK (DK62277, DK100287, and CA204586)
المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications, 2020, 11 (1), pp.5785. ⟨10.1038/s41467-020-19558-3⟩مصطلحات موضوعية: 0301 basic medicine, MESH: beta Catenin, General Physics and Astronomy, MESH: Cell Cycle, MESH: Mice, Knockout, Biochemistry, Transcriptome, MESH: Hepatocytes, Mice, 0302 clinical medicine, Protein biosynthesis, MESH: Animals, lcsh:Science, Wnt Signaling Pathway, beta Catenin, Mice, Knockout, Multidisciplinary, Fluorescence in situ hybridization, Cell Cycle, MESH: Wnt Signaling Pathway, Wnt signaling pathway, Cell cycle, MESH: Hepatectomy, Liver regeneration, Cell biology, MESH: Wnt Proteins, Liver, 030211 gastroenterology & hepatology, MESH: Liver Regeneration, Reprogramming, Biotechnology, Science, MESH: Acetaminophen, Biology, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, MESH: Gene Expression Profiling, MESH: Mice, Inbred C57BL, MESH: Cell Proliferation, Detoxification, Genetics, Animals, Hepatectomy, Transcriptomics, MESH: Mice, Molecular Biology, Acetaminophen, Cell Proliferation, Mechanism (biology), Gene Expression Profiling, Macrophages, MESH: Macrophages, General Chemistry, Regenerative process, Liver Regeneration, Gene expression profiling, Mice, Inbred C57BL, Wnt Proteins, Disease Models, Animal, 030104 developmental biology, Hepatocytes, lcsh:Q, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Liver function, MESH: Disease Models, Animal, MESH: Liver
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المصدر: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)مصطلحات موضوعية: 0301 basic medicine, Scaffold protein, Cell biology, Science, General Physics and Astronomy, macromolecular substances, Article, General Biochemistry, Genetics and Molecular Biology, Gene Knockout Techniques, 03 medical and health sciences, 0302 clinical medicine, Axin Protein, Transcription (biology), Cell Line, Tumor, AXIN2, Humans, lcsh:Science, Wnt Signaling Pathway, Transcription factor, beta Catenin, Cancer, Cell Proliferation, Multidisciplinary, Drug discovery, Chemistry, HEK 293 cells, technology, industry, and agriculture, Wnt signaling pathway, General Chemistry, Wnt Proteins, HEK293 Cells, 030104 developmental biology, lcsh:Q, CRISPR-Cas Systems, Signal transduction, Colorectal Neoplasms, 030217 neurology & neurosurgery
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المؤلفون: Virginie Lecaudey, Hiroyuki Nakajima, Wiebke Herzog, Peng Xia, Naoki Mochizuki, Dorothee Bornhorst, Carl-Philipp Heisenberg, Salim Abdelilah-Seyfried, Deborah Yelon, Chaitanya Dingare
المصدر: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)مصطلحات موضوعية: 0301 basic medicine, General Physics and Astronomy, Extracellular matrix, 0302 clinical medicine, Transcriptional regulation, Morphogenesis, lcsh:Science, Zebrafish, YAP1, Multidisciplinary, Cadherins, Cell biology, Biomechanical Phenomena, Intercellular Junctions, cardiovascular system, Homeobox Protein Nkx-2.5, Signal transduction, Signal Transduction, animal structures, Science, Biology, Models, Biological, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Antigens, CD, ddc:570, Animals, cardiovascular diseases, Heart Atria, Endocardium, Institut für Biochemie und Biologie, Cell Proliferation, Cell Size, Cell Nucleus, Hippo signaling pathway, Cell growth, Myocardium, fungi, YAP-Signaling Proteins, General Chemistry, Zebrafish Proteins, biology.organism_classification, Wnt Proteins, Cytoskeletal Proteins, 030104 developmental biology, Mutation, Trans-Activators, lcsh:Q, 030217 neurology & neurosurgery
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المؤلفون: Oscar E. Ruiz, Elizabeth A. Sumner, Courtney K. Brock, Stephen T. Wallin, Amrita Mandal, George T. Eisenhoffer, Krystin M. Samms
المصدر: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)مصطلحات موضوعية: Programmed cell death, Cell signaling, Embryo, Nonmammalian, Cell division, Science, Cell, General Physics and Astronomy, Apoptosis, Biology, Epithelium, Article, General Biochemistry, Genetics and Molecular Biology, Extracellular Vesicles, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, ortho-Aminobenzoates, lcsh:Science, Zebrafish, Tissue homeostasis, Cell Proliferation, 030304 developmental biology, 0303 health sciences, Multidisciplinary, Phenylurea Compounds, Stem Cells, Wnt signaling pathway, Epithelial Cells, General Chemistry, Zebrafish Proteins, Cell biology, Wnt Proteins, Cytoskeletal Proteins, medicine.anatomical_structure, Caspases, 030220 oncology & carcinogenesis, lcsh:Q, Stem cell, Cell Division, Signal Transduction
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المؤلفون: Daniel Nyqvist, Fabrizio Orsenigo, Monica Corada, Elisabetta Dejana, Ralf H. Adams, Ferruccio Breviario, M. Luisa Iruela-Arispe, Marco Francesco Morini, Valentina Conti, Anaïs Briot, Mara E. Pitulescu, Ganesh Parameshwar Bhat
المصدر: Nature Communications
Nature communications, vol 4, iss 1
Corada, M; Orsenigo, F; Morini, MF; Pitulescu, ME; Bhat, G; Nyqvist, D; et al.(2013). Sox17 is indispensable for acquisition and maintenance of arterial identity. Nature Communications, 4(1), 2609. doi: 10.1038/ncomms3609. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/5kx070h4
Nature Communications; Vol 4مصطلحات موضوعية: SOXF Transcription Factors, Cellular differentiation, General Physics and Astronomy, Mice, 0302 clinical medicine, Receptors, Morphogenesis, Developmental, 0303 health sciences, Multidisciplinary, Neovascularization, Pathologic, Receptors, Notch, Endoderm, Wnt signaling pathway, Gene Expression Regulation, Developmental, Embryo, Cell Differentiation, Arteries, Cell biology, medicine.anatomical_structure, embryonic structures, Signal Transduction, Notch, animal structures, Biology, General Biochemistry, Genetics and Molecular Biology, Retina, Article, Vascular remodelling in the embryo, Veins, 03 medical and health sciences, HMGB Proteins, MD Multidisciplinary, medicine, Animals, Transcription factor, Neovascularization, 030304 developmental biology, Cell Proliferation, Pathologic, Mammalian, Endothelial Cells, General Chemistry, Embryo, Mammalian, Wnt Proteins, Gene Expression Regulation, 030217 neurology & neurosurgery
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