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1
المؤلفون: Ira Fleming, Carolyn Winston, Benjamin Kruft, Alex K. Shalek, Wolfram Goessling, Satdarshan P.S. Monga, Florian Mueller, Sungjin Ko, Udayan Apte, Chad Walesky, Kellie E. Kolb, Jake Henderson
المساهمون: Brigham and Women’s Hospital [Boston, MA], Harvard Medical School [Boston] (HMS), Institute of Medical Engineering & Science [Cambridge, MA] (IMES), Massachusetts Institute of Technology (MIT), Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], Ragon Institute of MGH, MIT and Harvard, Koch Institute for Integrative Cancer Research at MIT [Cambridge, MA], University of Pittsburgh Medical Center [Pittsburgh, PA, États-Unis] (UPMC), Imagerie et Modélisation - Imaging and Modeling, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Department of Pharmacology, Toxicology, and Therapeutics [Kansas City, KS, USA], University of Kansas Medical Center [Kansas City, KS, USA], Harvard-MIT Division of Health Sciences and Technology [Cambridge], Dana-Farber Cancer Institute [Boston], Harvard Stem Cell Institute [Cambridge, USA] (HSCI), Harvard University, Massachusetts General Hospital [Boston, MA, USA], C..W. is supported by F32DK111151, the Cholangiocarcinoma Foundation Research Fellowship, and the American Liver Foundation Charles Trey, MD Memorial Post-doctoral Research Fellowship. W.G. is supported by R01DK090311, R01DK105198, R24OD017870, and the Claudia Adams Barr Program for Excellence in Cancer Research. W.G. is a Pew Scholar in Biomedical Sciences. A.K.S. was supported, in part, by the Searle Scholars Program, the Beckman Young Investigator Program, a Sloan Fellowship in Chemistry, the NIH (1DP2GM1194192 & RM1HG0061931), and the MIT Stem Cell Initiative through Fondation MIT. U.A. is supported by R01DK098414. S.P.M is supported by NIH/NIDDK P30DK120531, Pittsburgh Liver Research Centre Grant, and NIH/NIDDK (DK62277, DK100287, and CA204586)
المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications, 2020, 11 (1), pp.5785. ⟨10.1038/s41467-020-19558-3⟩مصطلحات موضوعية: 0301 basic medicine, MESH: beta Catenin, General Physics and Astronomy, MESH: Cell Cycle, MESH: Mice, Knockout, Biochemistry, Transcriptome, MESH: Hepatocytes, Mice, 0302 clinical medicine, Protein biosynthesis, MESH: Animals, lcsh:Science, Wnt Signaling Pathway, beta Catenin, Mice, Knockout, Multidisciplinary, Fluorescence in situ hybridization, Cell Cycle, MESH: Wnt Signaling Pathway, Wnt signaling pathway, Cell cycle, MESH: Hepatectomy, Liver regeneration, Cell biology, MESH: Wnt Proteins, Liver, 030211 gastroenterology & hepatology, MESH: Liver Regeneration, Reprogramming, Biotechnology, Science, MESH: Acetaminophen, Biology, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, MESH: Gene Expression Profiling, MESH: Mice, Inbred C57BL, MESH: Cell Proliferation, Detoxification, Genetics, Animals, Hepatectomy, Transcriptomics, MESH: Mice, Molecular Biology, Acetaminophen, Cell Proliferation, Mechanism (biology), Gene Expression Profiling, Macrophages, MESH: Macrophages, General Chemistry, Regenerative process, Liver Regeneration, Gene expression profiling, Mice, Inbred C57BL, Wnt Proteins, Disease Models, Animal, 030104 developmental biology, Hepatocytes, lcsh:Q, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Liver function, MESH: Disease Models, Animal, MESH: Liver
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المؤلفون: Troy L. Mitchell, Yang Li, Tom Z. Yuan, Meghah Vuppalapaty, Nikita Tripuraneni, Fowler Tristan William, Sung-Jin Lee, Jingjing Ye, Haili Zhang, Erica S. Rego, Hui Chen, Archana Dilip, Liqin Xie, Helene Baribault, Janda Claudia Yvonne, Wen-Chen Yeh, Shengjiang Tu, Maureen Newman, Brian Ouyang, Devin Mutha
المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
مصطلحات موضوعية: 0301 basic medicine, Frizzled, Aging, Science, Osteoporosis, Drug Evaluation, Preclinical, General Physics and Astronomy, 030209 endocrinology & metabolism, Regenerative medicine, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Mice, Young Adult, 0302 clinical medicine, In vivo, Bone Density, Medicine, Animals, Humans, Femur, Bone Resorption, Wnt Signaling Pathway, Osteoporosis, Postmenopausal, Aged, Bone mineral, Phenocopy, Multidisciplinary, Bone Density Conservation Agents, Diphosphonates, business.industry, Wnt signaling pathway, Increased Bone Density, Drug Synergism, General Chemistry, medicine.disease, Wnt Proteins, Disease Models, Animal, 030104 developmental biology, Cancer research, Drug Therapy, Combination, Female, business, Femoral Fractures
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المؤلفون: Hoon Ki Sung, Tae-Hee Kim, Sammy Shun Wai Shi, Lijiang Fei, Noah A. Hahn, Ji-Eun Kim, Wen-Chi Yin, Abilasha Rao-Bhatia, Ju Hee Lee, Xiaoyun Zhang, Chi-chung Hui, Sabrina Coquenlorge, Wasi Rizvi, Kyoung-Han Kim, Guoji Guo
المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communicationsمصطلحات موضوعية: 0301 basic medicine, Male, Stromal cell, Science, Cell, General Physics and Astronomy, Biology, Zinc Finger Protein Gli2, Ligands, General Biochemistry, Genetics and Molecular Biology, Article, Transcriptome, 03 medical and health sciences, Mice, 0302 clinical medicine, Single-cell analysis, Telocyte, medicine, Animals, Homeostasis, Regeneration, Genetic Testing, Telocytes, Cell Self Renewal, Stem Cell Niche, lcsh:Science, Wnt Signaling Pathway, Mice, Knockout, Multidisciplinary, Wnt signaling pathway, Epithelial Cells, General Chemistry, Cell biology, Gastrointestinal Tract, Wnt Proteins, 030104 developmental biology, medicine.anatomical_structure, lcsh:Q, Pericyte, Stem cell, Stromal Cells, 030217 neurology & neurosurgery, Stem-cell niche
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المؤلفون: Esther Sook Miin Wong, Liang Thing Tan, Swathi Yada, Si Hui Tan, Yoshihiro Ishida, Nick Barker, Carly Leung, Kazuhiro Murakami, Amin Hajamohideen, Hideki Itoh, Yusuke Yoshikawa, Katzrin Bte Ahmed Murad, Ryo Seishima, Satoshi Nakamizo
المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communicationsمصطلحات موضوعية: 0301 basic medicine, animal structures, Science, Uterus, General Physics and Astronomy, Reproductive biology, Mice, Transgenic, Biology, General Biochemistry, Genetics and Molecular Biology, Article, Receptors, G-Protein-Coupled, 03 medical and health sciences, Endometrium, 0302 clinical medicine, stomatognathic system, Pregnancy, medicine, Animals, Cell Lineage, Progenitor cell, lcsh:Science, Mullerian Ducts, Multidisciplinary, Stem Cells, Embryogenesis, Wnt signaling pathway, LGR5, Gene Expression Regulation, Developmental, General Chemistry, Cell biology, Uterine Disorder, Organoids, Wnt Proteins, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, embryonic structures, Female, lcsh:Q, Stem cell, Uterine gland, Stem-cell niche
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المؤلفون: Joshua D. G. Leach, Nikola Vlahov, Petros Tsantoulis, Rachel A. Ridgway, Dustin J. Flanagan, Kathryn Gilroy, Nathalie Sphyris, Ester G. Vázquez, David F. Vincent, William J. Faller, Michael C. Hodder, Alexander Raven, Sigrid Fey, Arafath K. Najumudeen, Douglas Strathdee, Colin Nixon, Mark Hughes, William Clark, Robin Shaw, S:CORT consortium, Sander R. van Hooff, David J. Huels, Jan Paul Medema, Simon T. Barry, Margaret C. Frame, Asier Unciti-Broceta, Simon J. Leedham, Gareth J. Inman, Rene Jackstadt, Barry J. Thompson, Andrew D. Campbell, Sabine Tejpar, Owen J. Sansom
المساهمون: Center of Experimental and Molecular Medicine, CCA - Cancer biology and immunology, Radiotherapy
المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature communications, 12(1):3464. Nature Publishing Group
Nature Communications
S-CORT Consortium 2021, ' Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis ', Nature Communications, vol. 12, 3464 . https://doi.org/10.1038/s41467-021-23717-5مصطلحات موضوعية: 0301 basic medicine, Chemistry(all), MICROSATELLITE INSTABILITY, Carcinogenesis, Colorectal cancer, Cellular differentiation, Receptor, Transforming Growth Factor-beta Type I, General Physics and Astronomy, SESSILE SERRATED ADENOMAS, DISTAL COLON, Kaplan-Meier Estimate, medicine.disease_cause, COLORECTAL-CANCER, 0302 clinical medicine, Transforming Growth Factor beta, Wnt Signaling Pathway, IN-VIVO, Mutation, Multidisciplinary, Cancer stem cells, Wnt signaling pathway, LGR5, Cell Differentiation, Prognosis, Multidisciplinary Sciences, 030220 oncology & carcinogenesis, Colonic Neoplasms, Science & Technology - Other Topics, Stem cell, STEM-CELLS, Signal Transduction, EXPRESSION, Proto-Oncogene Proteins B-raf, Cell Survival, Colon, MAP Kinase Signaling System, Science, INHIBITION, Physics and Astronomy(all), Biology, Article, General Biochemistry, Genetics and Molecular Biology, WNT ACTIVATION, 03 medical and health sciences, Fetus, SDG 3 - Good Health and Well-being, Spheroids, Cellular, medicine, Animals, Progenitor cell, Cancer models, Adaptor Proteins, Signal Transducing, Inflammation, Science & Technology, Biochemistry, Genetics and Molecular Biology(all), INTESTINAL REGENERATION, Epithelial Cells, YAP-Signaling Proteins, General Chemistry, medicine.disease, digestive system diseases, Mice, Inbred C57BL, Wnt Proteins, 030104 developmental biology, Cancer research, Receptors, Transforming Growth Factor beta, Transcription Factors
وصف الملف: application/pdf; Electronic
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المؤلفون: Sophie Balmer, Marek Mlodzik, Davide Esposito, Carlo Iomini, Stuart A. Aaronson, Linh T. Vuong
المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communicationsمصطلحات موضوعية: 0301 basic medicine, Science, Mutant, Active Transport, Cell Nucleus, Kinesins, General Physics and Astronomy, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Mediator, Microtubule, Animals, Drosophila Proteins, Wings, Animal, RNA, Small Interfering, lcsh:Science, Wnt Signaling Pathway, beta Catenin, Armadillo Domain Proteins, Cell Nucleus, Multidisciplinary, Chemistry, Wnt signaling pathway, General Chemistry, Cell biology, Wnt Proteins, Protein Transport, 030104 developmental biology, Cytoplasm, Catenin, Kinesin, Drosophila, RNA Interference, lcsh:Q, sense organs, Carrier Proteins, 030217 neurology & neurosurgery, Nuclear localization sequence, Signal Transduction
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المؤلفون: Jamie A. Hackett, Ufuk Günesdogan, Yun Huang, M. Azim Surani, Kristjan A. Gretarsson, Toshihiro Kobayashi
المساهمون: Surani, Azim [0000-0002-8640-4318], Hackett, Jamie [0000-0002-6237-3684], Apollo - University of Cambridge Repository
المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communicationsمصطلحات موضوعية: 0301 basic medicine, Pluripotent Stem Cells, endocrine system, Somatic cell, Chromosomal Proteins, Non-Histone, Science, Population, Green Fluorescent Proteins, Gene regulatory network, General Physics and Astronomy, Embryonic Development, Receptors, Cytoplasmic and Nuclear, Mice, Transgenic, Cell fate determination, Biology, General Biochemistry, Genetics and Molecular Biology, Germline, 03 medical and health sciences, Mice, 0302 clinical medicine, Genes, Reporter, medicine, Basic Helix-Loop-Helix Transcription Factors, CRISPR, Animals, Clustered Regularly Interspaced Short Palindromic Repeats, education, lcsh:Science, 030304 developmental biology, 0303 health sciences, education.field_of_study, Multidisciplinary, Wnt signaling pathway, Gene Expression Regulation, Developmental, General Chemistry, Publisher Correction, 3. Good health, Cell biology, DNA-Binding Proteins, Repressor Proteins, Wnt Proteins, 030104 developmental biology, medicine.anatomical_structure, Epiblast, lcsh:Q, Positive Regulatory Domain I-Binding Factor 1, 030217 neurology & neurosurgery, Germ cell
وصف الملف: application/pdf
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المؤلفون: Andrey Glinka, Hyeyoon Lee, Rui Sun, Carina Seidl, Christof Niehrs
المصدر: Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)مصطلحات موضوعية: 0301 basic medicine, animal structures, Science, Ubiquitin-Protein Ligases, Xenopus, Embryonic Development, General Physics and Astronomy, Bone Morphogenetic Protein 4, Xenopus Proteins, Ligands, Article, General Biochemistry, Genetics and Molecular Biology, Xenopus laevis, 03 medical and health sciences, 0302 clinical medicine, Protein Domains, Cell Line, Tumor, Membrane proteins, Developmental biology, Animals, Humans, lcsh:Science, Receptor, RSPO2, Bone Morphogenetic Protein Receptors, Type I, In Situ Hybridization, Tissue homeostasis, Multidisciplinary, biology, Chemistry, Synexpression, Wnt signaling pathway, Gene Expression Regulation, Developmental, General Chemistry, biology.organism_classification, BMPR1A, Cell biology, Wnt Proteins, 030104 developmental biology, embryonic structures, Intercellular Signaling Peptides and Proteins, lcsh:Q, Stem cell, Thrombospondins, 030217 neurology & neurosurgery, Signal Transduction, Cell signalling
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المؤلفون: Ying Huang, Meng Jiang, Peter S. Dennis, Runsheng Chen, Keith Alder, Yu Xin, Ruben D. Carrasco, Ruiyang Liu, Helen Tanton, Amitabh Srivastava, Mengyun Zhang, Massimo Loda, Tomasz Sewastianik, Yue Kang, Jiao Wang, Ming Liu, Zhongqiu Wang
المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communicationsمصطلحات موضوعية: 0301 basic medicine, Cell biology, Molecular biology, Colorectal cancer, Science, General Physics and Astronomy, Cell Communication, Biology, Article, General Biochemistry, Genetics and Molecular Biology, Mice, 03 medical and health sciences, 0302 clinical medicine, BCL9, Cell Line, Tumor, medicine, Animals, Humans, lcsh:Science, Wnt Signaling Pathway, beta Catenin, Cancer, Tumor microenvironment, Multidisciplinary, Oncogene, Wnt signaling pathway, Paraspeckle, General Chemistry, medicine.disease, 3. Good health, Gene Expression Regulation, Neoplastic, Wnt Proteins, 030104 developmental biology, Tumor progression, 030220 oncology & carcinogenesis, Cancer research, lcsh:Q, Calcium, Colorectal Neoplasms, Protein Binding, Transcription Factors
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المؤلفون: Igor Y. Iskusnykh, Victor V. Chizhikov, Nikolai Fattakhov, Shubha Tole, Achira Roy, Kathleen J. Millen, Ashwin S. Shetty, Ekaterina Y. Steshina, Anne G. Lindgren
المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communicationsمصطلحات موضوعية: Male, 0301 basic medicine, Science, Mesenchyme, LIM-Homeodomain Proteins, Neuroepithelial Cells, General Physics and Astronomy, Lissencephaly, Developmental neurogenesis, Neocortex, Biology, Article, General Biochemistry, Genetics and Molecular Biology, Mesoderm, Mice, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, lcsh:Science, Gyrification, Mice, Knockout, Regulation of gene expression, Multidisciplinary, Wnt signaling pathway, Neural tube, Cell type diversity, Gene Expression Regulation, Developmental, General Chemistry, medicine.disease, Mice, Inbred C57BL, Wnt Proteins, Neuroepithelial cell, 030104 developmental biology, medicine.anatomical_structure, Female, lcsh:Q, Neuroscience, 030217 neurology & neurosurgery, Signal Transduction, Transcription Factors
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