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المؤلفون: Ira Fleming, Carolyn Winston, Benjamin Kruft, Alex K. Shalek, Wolfram Goessling, Satdarshan P.S. Monga, Florian Mueller, Sungjin Ko, Udayan Apte, Chad Walesky, Kellie E. Kolb, Jake Henderson
المساهمون: Brigham and Women’s Hospital [Boston, MA], Harvard Medical School [Boston] (HMS), Institute of Medical Engineering & Science [Cambridge, MA] (IMES), Massachusetts Institute of Technology (MIT), Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], Ragon Institute of MGH, MIT and Harvard, Koch Institute for Integrative Cancer Research at MIT [Cambridge, MA], University of Pittsburgh Medical Center [Pittsburgh, PA, États-Unis] (UPMC), Imagerie et Modélisation - Imaging and Modeling, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Department of Pharmacology, Toxicology, and Therapeutics [Kansas City, KS, USA], University of Kansas Medical Center [Kansas City, KS, USA], Harvard-MIT Division of Health Sciences and Technology [Cambridge], Dana-Farber Cancer Institute [Boston], Harvard Stem Cell Institute [Cambridge, USA] (HSCI), Harvard University, Massachusetts General Hospital [Boston, MA, USA], C..W. is supported by F32DK111151, the Cholangiocarcinoma Foundation Research Fellowship, and the American Liver Foundation Charles Trey, MD Memorial Post-doctoral Research Fellowship. W.G. is supported by R01DK090311, R01DK105198, R24OD017870, and the Claudia Adams Barr Program for Excellence in Cancer Research. W.G. is a Pew Scholar in Biomedical Sciences. A.K.S. was supported, in part, by the Searle Scholars Program, the Beckman Young Investigator Program, a Sloan Fellowship in Chemistry, the NIH (1DP2GM1194192 & RM1HG0061931), and the MIT Stem Cell Initiative through Fondation MIT. U.A. is supported by R01DK098414. S.P.M is supported by NIH/NIDDK P30DK120531, Pittsburgh Liver Research Centre Grant, and NIH/NIDDK (DK62277, DK100287, and CA204586)
المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications, 2020, 11 (1), pp.5785. ⟨10.1038/s41467-020-19558-3⟩مصطلحات موضوعية: 0301 basic medicine, MESH: beta Catenin, General Physics and Astronomy, MESH: Cell Cycle, MESH: Mice, Knockout, Biochemistry, Transcriptome, MESH: Hepatocytes, Mice, 0302 clinical medicine, Protein biosynthesis, MESH: Animals, lcsh:Science, Wnt Signaling Pathway, beta Catenin, Mice, Knockout, Multidisciplinary, Fluorescence in situ hybridization, Cell Cycle, MESH: Wnt Signaling Pathway, Wnt signaling pathway, Cell cycle, MESH: Hepatectomy, Liver regeneration, Cell biology, MESH: Wnt Proteins, Liver, 030211 gastroenterology & hepatology, MESH: Liver Regeneration, Reprogramming, Biotechnology, Science, MESH: Acetaminophen, Biology, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, MESH: Gene Expression Profiling, MESH: Mice, Inbred C57BL, MESH: Cell Proliferation, Detoxification, Genetics, Animals, Hepatectomy, Transcriptomics, MESH: Mice, Molecular Biology, Acetaminophen, Cell Proliferation, Mechanism (biology), Gene Expression Profiling, Macrophages, MESH: Macrophages, General Chemistry, Regenerative process, Liver Regeneration, Gene expression profiling, Mice, Inbred C57BL, Wnt Proteins, Disease Models, Animal, 030104 developmental biology, Hepatocytes, lcsh:Q, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Liver function, MESH: Disease Models, Animal, MESH: Liver
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المؤلفون: Troy L. Mitchell, Yang Li, Tom Z. Yuan, Meghah Vuppalapaty, Nikita Tripuraneni, Fowler Tristan William, Sung-Jin Lee, Jingjing Ye, Haili Zhang, Erica S. Rego, Hui Chen, Archana Dilip, Liqin Xie, Helene Baribault, Janda Claudia Yvonne, Wen-Chen Yeh, Shengjiang Tu, Maureen Newman, Brian Ouyang, Devin Mutha
المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
مصطلحات موضوعية: 0301 basic medicine, Frizzled, Aging, Science, Osteoporosis, Drug Evaluation, Preclinical, General Physics and Astronomy, 030209 endocrinology & metabolism, Regenerative medicine, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Mice, Young Adult, 0302 clinical medicine, In vivo, Bone Density, Medicine, Animals, Humans, Femur, Bone Resorption, Wnt Signaling Pathway, Osteoporosis, Postmenopausal, Aged, Bone mineral, Phenocopy, Multidisciplinary, Bone Density Conservation Agents, Diphosphonates, business.industry, Wnt signaling pathway, Increased Bone Density, Drug Synergism, General Chemistry, medicine.disease, Wnt Proteins, Disease Models, Animal, 030104 developmental biology, Cancer research, Drug Therapy, Combination, Female, business, Femoral Fractures
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المؤلفون: Minomi Subapanditha, Chitra Venugopal, Neil Winegarden, Ashley A. Adile, Robin M. Hallett, Blake Yarascavitch, John Provias, David Bakhshinyan, Blessing Bassey-Archibong, Neil Savage, Bradley W. Doble, Laura M. Richards, Dillon McKenna, Trevor J. Pugh, Olufemi Ajani, Owen Whitley, Nazanin Tatari, Michelle Kameda-Smith, Adam Fleming, Anna Dvorkin-Gheva, Branavan Manoranjan, Sheila K. Singh, Gary D. Bader
المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communicationsمصطلحات موضوعية: 0301 basic medicine, Cancer therapy, Carcinogenesis, Cell, General Physics and Astronomy, 02 engineering and technology, medicine.disease_cause, Mice, lcsh:Science, Wnt Signaling Pathway, beta Catenin, Regulation of gene expression, Multidisciplinary, Cancer stem cells, Stem Cells, Wnt signaling pathway, 021001 nanoscience & nanotechnology, Gene Expression Regulation, Neoplastic, medicine.anatomical_structure, Heterografts, Stem cell, 0210 nano-technology, Science, Biology, Article, General Biochemistry, Genetics and Molecular Biology, Paediatric cancer, 03 medical and health sciences, Cancer stem cell, Cell Line, Tumor, medicine, Animals, Humans, Cerebellar Neoplasms, neoplasms, Cell Proliferation, Medulloblastoma, Cell growth, Gene Expression Profiling, General Chemistry, medicine.disease, nervous system diseases, Wnt Proteins, CNS cancer, Disease Models, Animal, stomatognathic diseases, 030104 developmental biology, Cancer research, lcsh:Q
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المؤلفون: Jina Yun, Daniel Jun-Kit Hu, Justin Elstrott, Heinrich Jasper
المصدر: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)مصطلحات موضوعية: Cell division, Science, Enteroendocrine Cells, General Physics and Astronomy, Enteroendocrine cell, Biology, General Biochemistry, Genetics and Molecular Biology, Article, Cell Movement, medicine, Regeneration, Animals, Drosophila Proteins, Cell migration, Intestinal Mucosa, Wnt Signaling Pathway, Adult stem cells, Multidisciplinary, Regeneration (biology), Time-lapse imaging, Stem Cells, Wnt signaling pathway, Receptor Protein-Tyrosine Kinases, General Chemistry, Intestinal epithelium, Epithelium, Cell biology, Intestines, Wnt Proteins, medicine.anatomical_structure, Wounds and Injuries, Drosophila, PTK7, Stem cell, Cell signalling
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المؤلفون: Yurun Zhang, Tiancheng Fang, Vivian Y. Chang, Martina Roos, Lia Signaevskaia, Heather A. Himburg, Paulina K. Lin, Amara Pang, Mindy M. Kim, Joshua P. Sasine, Christina M. Termini, Orel Tabibi, Avradip Chatterjee, Michelle Li, Ramachandran Murali, John P. Chute, Nicollette J Setiawan
المصدر: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)مصطلحات موضوعية: Male, Science, General Physics and Astronomy, Apoptosis, Bone Marrow Cells, General Biochemistry, Genetics and Molecular Biology, Article, Stress signalling, Mice, Bone Marrow, Neuropilin 1, medicine, Animals, Regeneration, Multidisciplinary, Chemistry, Regeneration (biology), Haematopoietic stem cells, Wnt signaling pathway, Hematopoietic stem cell, Cyclin-Dependent Kinase 5, Semaphorin-3A, General Chemistry, Hematopoietic Stem Cells, Cardiovascular biology, Neuropilin-1, Cell biology, Stem-cell research, Endothelial stem cell, Mice, Inbred C57BL, Wnt Proteins, Haematopoiesis, medicine.anatomical_structure, Female, Bone marrow, Stem cell, Transcriptome, Signal Transduction
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المؤلفون: Hoon Ki Sung, Tae-Hee Kim, Sammy Shun Wai Shi, Lijiang Fei, Noah A. Hahn, Ji-Eun Kim, Wen-Chi Yin, Abilasha Rao-Bhatia, Ju Hee Lee, Xiaoyun Zhang, Chi-chung Hui, Sabrina Coquenlorge, Wasi Rizvi, Kyoung-Han Kim, Guoji Guo
المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communicationsمصطلحات موضوعية: 0301 basic medicine, Male, Stromal cell, Science, Cell, General Physics and Astronomy, Biology, Zinc Finger Protein Gli2, Ligands, General Biochemistry, Genetics and Molecular Biology, Article, Transcriptome, 03 medical and health sciences, Mice, 0302 clinical medicine, Single-cell analysis, Telocyte, medicine, Animals, Homeostasis, Regeneration, Genetic Testing, Telocytes, Cell Self Renewal, Stem Cell Niche, lcsh:Science, Wnt Signaling Pathway, Mice, Knockout, Multidisciplinary, Wnt signaling pathway, Epithelial Cells, General Chemistry, Cell biology, Gastrointestinal Tract, Wnt Proteins, 030104 developmental biology, medicine.anatomical_structure, lcsh:Q, Pericyte, Stem cell, Stromal Cells, 030217 neurology & neurosurgery, Stem-cell niche
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المؤلفون: Esther Sook Miin Wong, Liang Thing Tan, Swathi Yada, Si Hui Tan, Yoshihiro Ishida, Nick Barker, Carly Leung, Kazuhiro Murakami, Amin Hajamohideen, Hideki Itoh, Yusuke Yoshikawa, Katzrin Bte Ahmed Murad, Ryo Seishima, Satoshi Nakamizo
المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communicationsمصطلحات موضوعية: 0301 basic medicine, animal structures, Science, Uterus, General Physics and Astronomy, Reproductive biology, Mice, Transgenic, Biology, General Biochemistry, Genetics and Molecular Biology, Article, Receptors, G-Protein-Coupled, 03 medical and health sciences, Endometrium, 0302 clinical medicine, stomatognathic system, Pregnancy, medicine, Animals, Cell Lineage, Progenitor cell, lcsh:Science, Mullerian Ducts, Multidisciplinary, Stem Cells, Embryogenesis, Wnt signaling pathway, LGR5, Gene Expression Regulation, Developmental, General Chemistry, Cell biology, Uterine Disorder, Organoids, Wnt Proteins, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, embryonic structures, Female, lcsh:Q, Stem cell, Uterine gland, Stem-cell niche
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المؤلفون: Won Kyung Kim, Adam W. Olson, Jiaqi Mi, Jinhui Wang, Dong-Hoon Lee, Vien Le, Alex Hiroto, Joseph Aldahl, Christian H. Nenninger, Alyssa J. Buckley, Robert Cardiff, Sungyong You, Zijie Sun
المصدر: Nature communications. 13(1)
مصطلحات موضوعية: Male, Multidisciplinary, Carcinogenesis, Stem Cells, Prostate, General Physics and Astronomy, Prostatic Neoplasms, General Chemistry, General Biochemistry, Genetics and Molecular Biology, Wnt Proteins, Cell Transformation, Neoplastic, Receptors, Androgen, Androgens, Humans, Insulin-Like Growth Factor I, Wnt Signaling Pathway, beta Catenin
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المؤلفون: Joshua D. G. Leach, Nikola Vlahov, Petros Tsantoulis, Rachel A. Ridgway, Dustin J. Flanagan, Kathryn Gilroy, Nathalie Sphyris, Ester G. Vázquez, David F. Vincent, William J. Faller, Michael C. Hodder, Alexander Raven, Sigrid Fey, Arafath K. Najumudeen, Douglas Strathdee, Colin Nixon, Mark Hughes, William Clark, Robin Shaw, S:CORT consortium, Sander R. van Hooff, David J. Huels, Jan Paul Medema, Simon T. Barry, Margaret C. Frame, Asier Unciti-Broceta, Simon J. Leedham, Gareth J. Inman, Rene Jackstadt, Barry J. Thompson, Andrew D. Campbell, Sabine Tejpar, Owen J. Sansom
المساهمون: Center of Experimental and Molecular Medicine, CCA - Cancer biology and immunology, Radiotherapy
المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature communications, 12(1):3464. Nature Publishing Group
Nature Communications
S-CORT Consortium 2021, ' Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis ', Nature Communications, vol. 12, 3464 . https://doi.org/10.1038/s41467-021-23717-5مصطلحات موضوعية: 0301 basic medicine, Chemistry(all), MICROSATELLITE INSTABILITY, Carcinogenesis, Colorectal cancer, Cellular differentiation, Receptor, Transforming Growth Factor-beta Type I, General Physics and Astronomy, SESSILE SERRATED ADENOMAS, DISTAL COLON, Kaplan-Meier Estimate, medicine.disease_cause, COLORECTAL-CANCER, 0302 clinical medicine, Transforming Growth Factor beta, Wnt Signaling Pathway, IN-VIVO, Mutation, Multidisciplinary, Cancer stem cells, Wnt signaling pathway, LGR5, Cell Differentiation, Prognosis, Multidisciplinary Sciences, 030220 oncology & carcinogenesis, Colonic Neoplasms, Science & Technology - Other Topics, Stem cell, STEM-CELLS, Signal Transduction, EXPRESSION, Proto-Oncogene Proteins B-raf, Cell Survival, Colon, MAP Kinase Signaling System, Science, INHIBITION, Physics and Astronomy(all), Biology, Article, General Biochemistry, Genetics and Molecular Biology, WNT ACTIVATION, 03 medical and health sciences, Fetus, SDG 3 - Good Health and Well-being, Spheroids, Cellular, medicine, Animals, Progenitor cell, Cancer models, Adaptor Proteins, Signal Transducing, Inflammation, Science & Technology, Biochemistry, Genetics and Molecular Biology(all), INTESTINAL REGENERATION, Epithelial Cells, YAP-Signaling Proteins, General Chemistry, medicine.disease, digestive system diseases, Mice, Inbred C57BL, Wnt Proteins, 030104 developmental biology, Cancer research, Receptors, Transforming Growth Factor beta, Transcription Factors
وصف الملف: application/pdf; Electronic
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المؤلفون: Maria D. Barea, Minerva Bosch-Fortea, Mariam Hachimi, Claudia Carabaña, Raquel Martín, Jose A. Garcia-Sanz, Julia Tarnick, Tamara González, Fernando Martín-Belmonte, Ilenia Bernascone, Silvia Santamaría
المساهمون: Ministerio de Economía y Competitividad (España), Fundación Ramón Areces, La Caixa
المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communicationsمصطلحات موضوعية: 0301 basic medicine, Stromal cell, Science, Mammary gland, Morphogenesis, General Physics and Astronomy, Mammary Neoplasms, Animal, Cell Communication, 02 engineering and technology, Biology, Article, General Biochemistry, Genetics and Molecular Biology, Mice, 03 medical and health sciences, Mammary Glands, Animal, Stroma, Pregnancy, medicine, Animals, Drosophila Proteins, Sexual Maturation, lcsh:Science, Wnt Signaling Pathway, Transcription factor, Mice, Knockout, Multidisciplinary, Intracellular Signaling Peptides and Proteins, Wnt signaling pathway, Epithelial Cells, General Chemistry, 021001 nanoscience & nanotechnology, Cell biology, Wnt Proteins, Crosstalk (biology), Imaginal disc, 030104 developmental biology, medicine.anatomical_structure, Imaginal Discs, Differentiation, Drosophila, Female, lcsh:Q, Stromal Cells, 0210 nano-technology, Transcription Factors