المؤلفون: Dong J; Jonsson Comprehensive Cancer Center and Broad Stem Cell Research Center, UCLA, Los Angeles, CA, USA.; Laboratory of Molecular Signaling, Division of Oral Biology and Medicine, School of Dentistry, UCLA, Los Angeles, CA, USA., Li J; Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA, USA. jli29@vcu.edu.; Department of Oral and Craniofacial Molecular Biology, School of Dentistry, Richmond, VA, USA. jli29@vcu.edu., Li Y; Jonsson Comprehensive Cancer Center and Broad Stem Cell Research Center, UCLA, Los Angeles, CA, USA.; Laboratory of Molecular Signaling, Division of Oral Biology and Medicine, School of Dentistry, UCLA, Los Angeles, CA, USA., Ma Z; Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA, USA.; Department of Oral and Craniofacial Molecular Biology, School of Dentistry, Richmond, VA, USA., Yu Y; Jonsson Comprehensive Cancer Center and Broad Stem Cell Research Center, UCLA, Los Angeles, CA, USA.; Laboratory of Molecular Signaling, Division of Oral Biology and Medicine, School of Dentistry, UCLA, Los Angeles, CA, USA., Wang CY; Jonsson Comprehensive Cancer Center and Broad Stem Cell Research Center, UCLA, Los Angeles, CA, USA. cunywang@ucla.edu.; Laboratory of Molecular Signaling, Division of Oral Biology and Medicine, School of Dentistry, UCLA, Los Angeles, CA, USA. cunywang@ucla.edu.; Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, UCLA, Los Angeles, CA, USA. cunywang@ucla.edu.

المصدر: Nature communications [Nat Commun] 2021 Jun 25; Vol. 12 (1), pp. 3974. Date of Electronic Publication: 2021 Jun 25.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Enhancer Elements, Genetic*, Head and Neck Neoplasms/*pathology , Neoplastic Stem Cells/*drug effects , Squamous Cell Carcinoma of Head and Neck/*pathology, Animals ; Antineoplastic Agents/pharmacology ; Azepines/pharmacology ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/genetics ; Humans ; Lymphatic Metastasis/drug therapy ; Lymphatic Metastasis/prevention & control ; Mediator Complex Subunit 1/genetics ; Mediator Complex Subunit 1/metabolism ; Mice, Inbred C57BL ; Mice, SCID ; NF-kappa B/genetics ; Neoplastic Stem Cells/pathology ; Polycomb Repressive Complex 1/antagonists & inhibitors ; Polycomb Repressive Complex 1/genetics ; Polycomb Repressive Complex 1/metabolism ; Squamous Cell Carcinoma of Head and Neck/drug therapy ; Squamous Cell Carcinoma of Head and Neck/genetics ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Triazoles/pharmacology ; Xenograft Model Antitumor Assays ; Mice