المؤلفون: Deczkowska A; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel. aleksandra.deczkowska@pasteur.fr.; Departments of Immunology and Neuroscience, Institut Pasteur, Paris, France. aleksandra.deczkowska@pasteur.fr., David E; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel., Ramadori P; Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany., Pfister D; Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany., Safran M; Liver Disease Center, Sheba Medical Center, Tel Hashomer, Israel., Li B; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel., Giladi A; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel., Jaitin DA; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel., Barboy O; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel., Cohen M; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.; Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Yofe I; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel., Gur C; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.; Department of Medicine, Hadassah-Hebrew University Hospital, Jerusalem, Israel., Shlomi-Loubaton S; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel., Henri S; Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, Marseille, France., Suhail Y; Chirurgische Klinik, Allgemein, Viszeral und Transplantationschirurgie, Universitätsklinikum Heidelberg, Heidelberg, Germany., Qiu M; Chirurgische Klinik, Allgemein, Viszeral und Transplantationschirurgie, Universitätsklinikum Heidelberg, Heidelberg, Germany., Kam S; Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany., Hermon H; Department of Surgery C, Sheba Medical Center, Tel Hashomer, Israel., Lahat E; Department of Surgery B, Sheba Medical Center, Tel Hashomer, Israel., Ben Yakov G; Liver Disease Center, Sheba Medical Center, Tel Hashomer, Israel., Cohen-Ezra O; Liver Disease Center, Sheba Medical Center, Tel Hashomer, Israel., Davidov Y; Liver Disease Center, Sheba Medical Center, Tel Hashomer, Israel., Likhter M; Liver Disease Center, Sheba Medical Center, Tel Hashomer, Israel., Goitein D; Department of Surgery C, Sheba Medical Center, Tel Hashomer, Israel.; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel., Roth S; Chirurgische Klinik, Allgemein, Viszeral und Transplantationschirurgie, Universitätsklinikum Heidelberg, Heidelberg, Germany., Weber A; Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland., Malissen B; Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, Marseille, France.; Centre d'Immunophénomique, Aix Marseille Université, INSERM, CNRS, Marseille, France., Weiner A; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel., Ben-Ari Z; Liver Disease Center, Sheba Medical Center, Tel Hashomer, Israel.; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel., Heikenwälder M; Division of Chronic Inflammation and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany. m.heikenwaelder@dkfz-heidelberg.de., Elinav E; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel. eran.elinav@weizmann.ac.il.; Division of Microbiome and Cancer, German Cancer Research Center Heidelberg (DKFZ), Heidelberg, Germany. eran.elinav@weizmann.ac.il., Amit I; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel. ido.amit@weizmann.ac.il.

المصدر: Nature medicine [Nat Med] 2021 Jun; Vol. 27 (6), pp. 1043-1054. Date of Electronic Publication: 2021 May 20.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE

مواضيع طبية MeSH: Dendritic Cells/*immunology , Fatty Liver/*immunology , Non-alcoholic Fatty Liver Disease/*immunology , Receptors, Chemokine/*genetics, Animals ; Bone Marrow Cells/immunology ; Bone Marrow Cells/pathology ; Cellular Reprogramming/genetics ; Cellular Reprogramming/immunology ; Dendritic Cells/pathology ; Diet, High-Fat/adverse effects ; Disease Models, Animal ; Fatty Liver/genetics ; Fatty Liver/pathology ; Female ; Humans ; Liver/immunology ; Liver/pathology ; Lymph Nodes/immunology ; Lymph Nodes/pathology ; Male ; Mice ; Non-alcoholic Fatty Liver Disease/genetics ; Non-alcoholic Fatty Liver Disease/pathology ; Receptors, Chemokine/immunology ; T-Lymphocytes/immunology ; T-Lymphocytes/pathology

المؤلفون: Sahoo SS; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Pastor VB; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Goodings C; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA., Voss RK; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Kozyra EJ; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Szvetnik A; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Noellke P; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Dworzak M; Department of Pediatrics, St. Anna Children's Hospital and Children's Cancer Research Institute, Medical University of Vienna, Vienna, Austria., Starý J; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic., Locatelli F; Department of Pediatric Hematology and Oncology, IRCCS Ospedale Pediatrico Bambino Gesù, Sapienza University of Rome, Rome, Italy., Masetti R; Paediatric Oncology and Haematology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy., Schmugge M; Department of Hematology and Oncology, University Children's Hospital, Zurich, Switzerland., De Moerloose B; Department of Paediatric Haematology-Oncology, Ghent University Hospital Ghent, Ghent, Belgium., Catala A; Department of Hematology and Oncology, Hospital Sant Joan de Deu, Barcelona, Spain., Kállay K; Department of Pediatric Hematology and Stem Cell Transplantation, Central Hospital of Southern Pest - National Institute of Hematology and Infectious Diseases, Budapest, Hungary., Turkiewicz D; Department of Pediatric Oncology/Hematology, Skåne University Hospital, Lund, Sweden., Hasle H; Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark., Buechner J; Department of Pediatric Hematology and Oncology, Oslo University Hospital, Oslo, Norway., Jahnukainen K; Division of Hematology-Oncology and SCT Children's Hospital, University of Helsinki and Helsinki University Hospital, Hus, Finland., Ussowicz M; Department of Paediatric Bone Marrow Transplantation, Oncology and Hematology, Wroclaw Medical University, Wroclaw, Poland., Polychronopoulou S; Department of Pediatric Hematology/Oncology, Aghia Sophia Children's Hospital, Athens, Greece., Smith OP; Department of Pediatric Haematology/Oncology, Children's Health Ireland at Crumlin, Dublin, Ireland., Fabri O; Department. of Haematology and Transfusiology, National Institute of Children's Diseases Faculty of Medicine, Comenius University, Bratislava, Slovakia., Barzilai S; Pediatric Hematology Oncology, Schneider Children's Medical Center of Israel, Petah Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., de Haas V; Dutch Childhood Oncology Group, Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands., Baumann I; Institute of Pathology, Klinikum Kaufbeuren-Ravensburg, Kaufbeuren, Germany., Schwarz-Furlan S; Institute of Pathology, Klinikum Kaufbeuren-Ravensburg, Kaufbeuren, Germany.; Institute of Pathology, University Hospital Erlangen, Erlangen, Germany., Niewisch MR; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Sauer MG; Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany., Burkhardt B; Pediatric Hematology and Oncology, University Hospital Muenster, Muenster, Germany., Lang P; Department of Hematology/Oncology and General Pediatrics, Children's University Hospital, University of Tübingen, Tübingen, Germany., Bader P; Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital Frankfurt, Frankfurt am Main, Germany., Beier R; University Hospital Essen, Pediatric Haematology and Oncology, Essen, Germany., Müller I; Division of Pediatric Hematology and Oncology, Clinic of Pedatric Hematology and Oncology, University Medical Center of Hamburg-Eppendorf, Hamburg, Germany., Albert MH; Department of Pediatrics, Dr. von Hauner Children´s Hospital, University Hospital, LMU Munich, Munich, Germany., Meisel R; Department of Pediatric Oncology, Hematology and Clinical Immunology, Division of Pediatric Stem Cell Therapy, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany., Schulz A; Department of Pediatrics, University Medical Center Ulm, Ulm, Germany., Cario G; Department of Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Panda PK; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Wehrle J; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Institute of Digitalization in Medicine, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Hirabayashi S; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Derecka M; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA., Durruthy-Durruthy R; Mission Bio Inc., South San Francisco, CA, USA., Göhring G; Department of Human Genetics, Hannover Medical School, Hannover, Germany., Yoshimi-Noellke A; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Ku M; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Lebrecht D; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Erlacher M; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), Heidelberg and Freiburg, Germany., Flotho C; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), Heidelberg and Freiburg, Germany., Strahm B; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Niemeyer CM; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), Heidelberg and Freiburg, Germany., Wlodarski MW; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA. marcin.wlodarski@stjude.org.; Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany. marcin.wlodarski@stjude.org.

مؤلفون مشاركون: European Working Group of MDS in Children (EWOG-MDS)

المصدر: Nature medicine [Nat Med] 2021 Oct; Vol. 27 (10), pp. 1806-1817. Date of Electronic Publication: 2021 Oct 07.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE

مواضيع طبية MeSH: Clonal Evolution/*genetics , Clonal Hematopoiesis/*genetics , Intracellular Signaling Peptides and Proteins/*genetics , Myelodysplastic Syndromes/*genetics , Tumor Suppressor Proteins/*genetics, Adolescent ; Bone Marrow Cells/metabolism ; Child ; Child, Preschool ; Female ; GATA2 Transcription Factor/genetics ; Germ-Line Mutation/genetics ; HEK293 Cells ; High-Throughput Nucleotide Sequencing ; Humans ; Infant ; Kaplan-Meier Estimate ; Male ; Myelodysplastic Syndromes/pathology ; Single-Cell Analysis

المؤلفون: Bai T; Department of Chemical Engineering, University of Washington, Seattle, WA, USA., Li J; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Sinclair A; Department of Chemical Engineering, University of Washington, Seattle, WA, USA., Imren S; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Merriam F; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Sun F; Department of Chemical Engineering, University of Washington, Seattle, WA, USA., O'Kelly MB; Department of Chemical Engineering, University of Washington, Seattle, WA, USA., Nourigat C; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Jain P; Department of Chemical Engineering, University of Washington, Seattle, WA, USA., Delrow JJ; Genomics and Bioinformatics Shared Resources, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Basom RS; Genomics and Bioinformatics Shared Resources, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Hung HC; Department of Chemical Engineering, University of Washington, Seattle, WA, USA., Zhang P; Department of Chemical Engineering, University of Washington, Seattle, WA, USA., Li B; Department of Bioengineering, University of Washington, Seattle, WA, USA., Heimfeld S; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Jiang S; Department of Chemical Engineering, University of Washington, Seattle, WA, USA. sjiang@uw.edu.; Department of Bioengineering, University of Washington, Seattle, WA, USA. sjiang@uw.edu., Delaney C; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. cdelaney@fredhutch.org.; Department of Pediatrics, University of Washington, Seattle, WA, USA. cdelaney@fredhutch.org.

المصدر: Nature medicine [Nat Med] 2019 Oct; Vol. 25 (10), pp. 1566-1575. Date of Electronic Publication: 2019 Oct 07.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE

مواضيع طبية MeSH: Cell- and Tissue-Based Therapy*, Cell Differentiation/*drug effects , Hematopoietic Stem Cells/*cytology , Hydrogels/*pharmacology, Animals ; Antigens, CD34/metabolism ; Bone Marrow Cells/cytology ; Bone Marrow Cells/metabolism ; Cell Culture Techniques ; Cell Proliferation/drug effects ; Coculture Techniques ; Fetal Blood/cytology ; Fetal Blood/metabolism ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/metabolism ; Humans ; Mice ; Reactive Oxygen Species/metabolism

المؤلفون: Reyes M; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Filbin MR; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Emergency Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Bhattacharyya RP; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Billman K; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Eisenhaure T; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hung DT; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Levy BD; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Baron RM; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Blainey PC; Broad Institute of MIT and Harvard, Cambridge, MA, USA. pblainey@broadinstitute.org.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. pblainey@broadinstitute.org., Goldberg MB; Broad Institute of MIT and Harvard, Cambridge, MA, USA. marcia.goldberg@mgh.harvard.edu.; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. marcia.goldberg@mgh.harvard.edu., Hacohen N; Broad Institute of MIT and Harvard, Cambridge, MA, USA. nhacohen@broadinstitute.org.; Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. nhacohen@broadinstitute.org.

المصدر: Nature medicine [Nat Med] 2020 Mar; Vol. 26 (3), pp. 333-340. Date of Electronic Publication: 2020 Feb 17.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE

مواضيع طبية MeSH: Bacteria/*immunology , Sepsis/*immunology , Sepsis/*microbiology, Biomarkers/blood ; Bone Marrow Cells/metabolism ; Cohort Studies ; Epigenesis, Genetic ; Gene Expression Profiling ; Humans ; Monocytes/metabolism ; ROC Curve ; Reproducibility of Results ; Sepsis/blood ; Sepsis/genetics ; Sequence Analysis, RNA ; Transcription, Genetic

المؤلفون: Río P; Hematopoietic Innovative Therapies Division, Centro de investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain.; Instituto de Investigaciones Sanitarias de la Fundación Jiménez Díaz, Madrid, Spain., Navarro S; Hematopoietic Innovative Therapies Division, Centro de investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain.; Instituto de Investigaciones Sanitarias de la Fundación Jiménez Díaz, Madrid, Spain., Wang W; Division of Translational Oncology, German Cancer Research Center and National Center for Tumor Diseases, Heidelberg, Germany.; GeneWerk, Heidelberg, Germany., Sánchez-Domínguez R; Hematopoietic Innovative Therapies Division, Centro de investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain.; Instituto de Investigaciones Sanitarias de la Fundación Jiménez Díaz, Madrid, Spain., Pujol RM; Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain.; Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Barcelona, Spain.; Servicio de Genética, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.; Instituto de Investigaciones Biomédicas, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Segovia JC; Hematopoietic Innovative Therapies Division, Centro de investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain.; Instituto de Investigaciones Sanitarias de la Fundación Jiménez Díaz, Madrid, Spain., Bogliolo M; Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain.; Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Barcelona, Spain.; Servicio de Genética, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.; Instituto de Investigaciones Biomédicas, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Merino E; Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain.; Servicio de Hematología y Oncología Pediátrica, Fundación de Investigación Biomédica, Hospital Infantil Universitario Niño Jesús, Madrid, Spain., Wu N; Division of Translational Oncology, German Cancer Research Center and National Center for Tumor Diseases, Heidelberg, Germany., Salgado R; Servicio de Hematología, Hospital Universitario Fundación Jiménez Diaz, Instituto de Investigaciones Sanitarias de la Fundación Jiménez Díaz, Madrid, Spain., Lamana ML; Hematopoietic Innovative Therapies Division, Centro de investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain.; Instituto de Investigaciones Sanitarias de la Fundación Jiménez Díaz, Madrid, Spain., Yañez RM; Hematopoietic Innovative Therapies Division, Centro de investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain.; Instituto de Investigaciones Sanitarias de la Fundación Jiménez Díaz, Madrid, Spain., Casado JA; Hematopoietic Innovative Therapies Division, Centro de investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain.; Instituto de Investigaciones Sanitarias de la Fundación Jiménez Díaz, Madrid, Spain., Giménez Y; Hematopoietic Innovative Therapies Division, Centro de investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain.; Instituto de Investigaciones Sanitarias de la Fundación Jiménez Díaz, Madrid, Spain., Román-Rodríguez FJ; Hematopoietic Innovative Therapies Division, Centro de investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain.; Instituto de Investigaciones Sanitarias de la Fundación Jiménez Díaz, Madrid, Spain., Álvarez L; Hematopoietic Innovative Therapies Division, Centro de investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain.; Instituto de Investigaciones Sanitarias de la Fundación Jiménez Díaz, Madrid, Spain., Alberquilla O; Hematopoietic Innovative Therapies Division, Centro de investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain.; Instituto de Investigaciones Sanitarias de la Fundación Jiménez Díaz, Madrid, Spain., Raimbault A; Université de Paris (IRSL, INSERM, CNRS), Paris, France.; Hôpital Saint-Louis, Paris, France., Guenechea G; Hematopoietic Innovative Therapies Division, Centro de investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain.; Instituto de Investigaciones Sanitarias de la Fundación Jiménez Díaz, Madrid, Spain., Lozano ML; Hematopoietic Innovative Therapies Division, Centro de investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain.; Instituto de Investigaciones Sanitarias de la Fundación Jiménez Díaz, Madrid, Spain., Cerrato L; Hematopoietic Innovative Therapies Division, Centro de investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain.; Instituto de Investigaciones Sanitarias de la Fundación Jiménez Díaz, Madrid, Spain., Hernando M; Hematopoietic Innovative Therapies Division, Centro de investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain.; Instituto de Investigaciones Sanitarias de la Fundación Jiménez Díaz, Madrid, Spain., Gálvez E; Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain.; Servicio de Hematología y Oncología Pediátrica, Fundación de Investigación Biomédica, Hospital Infantil Universitario Niño Jesús, Madrid, Spain., Hladun R; Servicio de Oncología y Hematología Pediátricas, Hospital Universitari Vall d'Hebron, Barcelona, Spain.; Vall d'Hebron Institut de Recerca, Barcelona, Spain., Giralt I; Vall d'Hebron Institut de Recerca, Barcelona, Spain., Barquinero J; Vall d'Hebron Institut de Recerca, Barcelona, Spain., Galy A; Généthon, Evry, France., García de Andoín N; Hospital Universitario Donostia, San Sebastián, Spain., López R; Osakidetza Basque Health Service, Pediatric Oncology and Hematology Unit, Cruces University Hospital, Barakaldo, Spain., Catalá A; Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain.; Servicio de Hematología y Oncología, Hospital Sant Joan de Déu, Barcelona, Spain., Schwartz JD; Rocket Pharma, New York, NY, USA., Surrallés J; Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain.; Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Barcelona, Spain.; Servicio de Genética, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.; Instituto de Investigaciones Biomédicas, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Soulier J; Université de Paris (IRSL, INSERM, CNRS), Paris, France.; Hôpital Saint-Louis, Paris, France., Schmidt M; Division of Translational Oncology, German Cancer Research Center and National Center for Tumor Diseases, Heidelberg, Germany.; GeneWerk, Heidelberg, Germany., Díaz de Heredia C; Servicio de Oncología y Hematología Pediátricas, Hospital Universitari Vall d'Hebron, Barcelona, Spain.; Vall d'Hebron Institut de Recerca, Barcelona, Spain., Sevilla J; Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain.; Servicio de Hematología y Oncología Pediátrica, Fundación de Investigación Biomédica, Hospital Infantil Universitario Niño Jesús, Madrid, Spain., Bueren JA; Hematopoietic Innovative Therapies Division, Centro de investigaciones Energéticas, Medioambientales y Tecnológicas, Madrid, Spain. juan.bueren@ciemat.es.; Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain. juan.bueren@ciemat.es.; Instituto de Investigaciones Sanitarias de la Fundación Jiménez Díaz, Madrid, Spain. juan.bueren@ciemat.es.

المصدر: Nature medicine [Nat Med] 2019 Sep; Vol. 25 (9), pp. 1396-1401. Date of Electronic Publication: 2019 Sep 09.

نوع المنشور: Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Therapy* , Hematopoietic Stem Cell Transplantation*, Fanconi Anemia/*therapy , Fanconi Anemia Complementation Group A Protein/*genetics, Adolescent ; Adult ; Bone Marrow Cells/cytology ; Child ; Child, Preschool ; Fanconi Anemia/genetics ; Fanconi Anemia/physiopathology ; Female ; Genetic Vectors/genetics ; Hematopoietic Stem Cells/metabolism ; Humans ; Infant ; Lentivirus/genetics ; Male ; Mutation/genetics ; Spain/epidemiology ; Targeted Gene Repair ; Transduction, Genetic ; Young Adult

المؤلفون: Winkler IG; Stem Cells and Cancer Group, Mater Medical Research Institute, South Brisbane, Queensland, Australia. iwinkler@mmri.mater.org.au, Barbier V, Nowlan B, Jacobsen RN, Forristal CE, Patton JT, Magnani JL, Lévesque JP

المصدر: Nature medicine [Nat Med] 2012 Nov; Vol. 18 (11), pp. 1651-7. Date of Electronic Publication: 2012 Oct 21.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE

مواضيع طبية MeSH: Bone Marrow Cells*/cytology , Bone Marrow Cells*/metabolism , Cell Proliferation*/drug effects , Cell Proliferation*/radiation effects , E-Selectin*/genetics , E-Selectin*/metabolism , Hematopoietic Stem Cells*/metabolism , Neutrophils*/cytology , Neutrophils*/drug effects , Neutrophils*/metabolism , Neutrophils*/radiation effects, Animals ; Cell Differentiation ; Cell Lineage/drug effects ; Cell Lineage/radiation effects ; Cell Survival/drug effects ; Cell Survival/radiation effects ; Endothelial Cells/cytology ; Endothelial Cells/metabolism ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/radiation effects ; Hematopoietic Stem Cell Transplantation ; Hydroxyurea/pharmacology ; Ligands ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Radiation

المؤلفون: Moore MA; Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. m-moore@ski.mskcc.org

المصدر: Nature medicine [Nat Med] 2012 Nov; Vol. 18 (11), pp. 1613-4.

نوع المنشور: Journal Article; Comment

بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE

مواضيع طبية MeSH: Bone Marrow Cells* , Cell Proliferation* , E-Selectin* , Hematopoietic Stem Cells* , Neutrophils*, Animals

المؤلفون: Hilton MJ; Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, Missouri 63110, USA., Tu X, Wu X, Bai S, Zhao H, Kobayashi T, Kronenberg HM, Teitelbaum SL, Ross FP, Kopan R, Long F

المصدر: Nature medicine [Nat Med] 2008 Mar; Vol. 14 (3), pp. 306-14. Date of Electronic Publication: 2008 Feb 24.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE

مواضيع طبية MeSH: Cell Differentiation* , Signal Transduction*, Bone Marrow Cells/*cytology , Mesenchymal Stem Cells/*cytology , Osteoblasts/*cytology , Receptors, Notch/*metabolism, Aging ; Amyloid Precursor Protein Secretases/genetics ; Amyloid Precursor Protein Secretases/metabolism ; Animals ; Bone Development/genetics ; Bone Development/physiology ; Bone Marrow Cells/metabolism ; Cells, Cultured ; Embryo, Mammalian/cytology ; Embryo, Mammalian/embryology ; Embryo, Mammalian/metabolism ; Gene Deletion ; Mesenchymal Stem Cells/metabolism ; Mice ; Mutation ; Phenotype ; Receptors, Notch/deficiency ; Receptors, Notch/genetics

المؤلفون: Feuerer M; Tumor Immunology Program, German Cancer Research Center (DKFZ), Heidelberg, Germany., Beckhove P, Garbi N, Mahnke Y, Limmer A, Hommel M, Hämmerling GJ, Kyewski B, Hamann A, Umansky V, Schirrmacher V

المصدر: Nature medicine [Nat Med] 2003 Sep; Vol. 9 (9), pp. 1151-7. Date of Electronic Publication: 2003 Aug 10.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1078-8956 (Print) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE

مواضيع طبية MeSH: Antigens/*blood , Bone Marrow/*immunology , Bone Marrow Cells/*cytology , T-Lymphocytes/*immunology, Animals ; Antigens, CD/immunology ; Antigens, Differentiation, T-Lymphocyte/immunology ; Bone Marrow Cells/immunology ; CD11c Antigen/immunology ; CD4-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/immunology ; Dendritic Cells/immunology ; Female ; Immunologic Memory/immunology ; Lectins, C-Type ; Major Histocompatibility Complex/immunology ; Mice ; Mice, Inbred Strains ; Mice, Mutant Strains ; Mice, Transgenic ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/immunology ; Splenectomy

المؤلفون: Xu R; Department of Pathology and Laboratory Medicine, Cornell University, New York, NY, USA., Yallowitz A; Department of Pathology and Laboratory Medicine, Cornell University, New York, NY, USA., Qin A; Department of Orthopaedics, Shanghai Key Laboratory of Orthopaedic Implant, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China., Wu Z; Laboratory of Brain Development and Repair, The Rockefeller University, New York, NY, USA., Shin DY; Department of Pathology and Laboratory Medicine, Cornell University, New York, NY, USA., Kim JM; Division of Rheumatology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA., Debnath S; Department of Pathology and Laboratory Medicine, Cornell University, New York, NY, USA., Ji G; Research Division, Hospital for Special Surgery, New York, NY, USA.; Department of Joint Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China., Bostrom MP; Research Division, Hospital for Special Surgery, New York, NY, USA.; Division of Adult Reconstruction and Joint Replacement, Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, NY, USA., Yang X; Research Division, Hospital for Special Surgery, New York, NY, USA., Zhang C; Institute for Computational Biomedicine, Cornell University, New York, NY, USA., Dong H; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute and Harvard University Medical School, Boston, MA, USA.; Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA., Kermani P; Division of Regenerative Medicine, Department of Medicine, Ansary Stem Cell Institute, Cornell University, New York, NY, USA., Lalani S; Department of Pathology and Laboratory Medicine, Cornell University, New York, NY, USA., Li N; Department of Pathology and Laboratory Medicine, Cornell University, New York, NY, USA., Liu Y; Department of Pathology and Laboratory Medicine, Cornell University, New York, NY, USA., Poulos MG; Division of Regenerative Medicine, Department of Medicine, Ansary Stem Cell Institute, Cornell University, New York, NY, USA., Wach A; Department of Biomechanics, Hospital for Special Surgery, New York, NY, USA., Zhang Y; Department of Pathology and Laboratory Medicine, Cornell University, New York, NY, USA., Inoue K; Arthritis and Tissue Degeneration Program and David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, USA.; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY, USA., Di Lorenzo A; Department of Pathology and Laboratory Medicine, Cornell University, New York, NY, USA., Zhao B; Arthritis and Tissue Degeneration Program and David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, USA.; Department of Medicine, Weill Cornell Medical College, Cornell University, New York, NY, USA., Butler JM; Division of Regenerative Medicine, Department of Medicine, Ansary Stem Cell Institute, Cornell University, New York, NY, USA., Shim JH; Division of Rheumatology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA., Glimcher LH; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute and Harvard University Medical School, Boston, MA, USA. laurie_glimcher@dfci.harvard.edu.; Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA. laurie_glimcher@dfci.harvard.edu., Greenblatt MB; Department of Pathology and Laboratory Medicine, Cornell University, New York, NY, USA. mag3003@med.cornell.edu.

المصدر: Nature medicine [Nat Med] 2018 Jun; Vol. 24 (6), pp. 823-833. Date of Electronic Publication: 2018 May 21.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE

مواضيع طبية MeSH: Bone Resorption/*pathology , Bone and Bones/*pathology , Endothelium/*pathology, Animals ; Bone Marrow Cells/drug effects ; Bone Marrow Cells/metabolism ; Bone Resorption/diagnostic imaging ; Bone and Bones/diagnostic imaging ; Bone and Bones/drug effects ; DNA-Binding Proteins/deficiency ; DNA-Binding Proteins/metabolism ; Disease Models, Animal ; Endothelium/drug effects ; Fracture Healing/drug effects ; Humans ; Membrane Proteins/metabolism ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Neovascularization, Physiologic/drug effects ; Nerve Tissue Proteins/metabolism ; Osteoblasts/drug effects ; Osteoblasts/metabolism ; Osteoblasts/pathology ; Osteogenesis/drug effects ; Osteoporosis, Postmenopausal/drug therapy ; Osteoporosis, Postmenopausal/pathology ; Ovariectomy ; Platelet Endothelial Cell Adhesion Molecule-1/metabolism ; Receptors, Immunologic/metabolism ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/pharmacology ; Recombinant Proteins/therapeutic use ; Sialoglycoproteins/metabolism ; Roundabout Proteins