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1دورية أكاديمية
المؤلفون: Jelena Kornej, Katrin Friedrich, Matthias L Schroeter, A Veronica Witte, Maryna Polyakova, Arno Villringer, Markus Löffler, Samira Zeynalova
المصدر: PLoS ONE, Vol 17, Iss 6, p e0269815 (2022)
الوصف: BackgroundPR interval prolongation is a preliminary stage of atrial cardiomyopathy which is considered as an intermediate phenotype for atrial fibrillation (AF). AF is a known risk factor for cerebrovascular adverse outcomes including stroke. Cerebral ischemia is one cause of white matter hyperintensities (WMHs), and cognitive dysfunction.AimTo analyze the relationship between PR interval and WMHs.Materials and methodsWe performed a cross-sectional analysis with individuals from the LIFE-Adult-Study (a population-based cohort study of randomly selected individuals from Leipzig, Germany) with available brain MRI and ECG. The Fazekas stages were used to quantify WMHs (0 = none; 1 = punctate foci; 2 = beginning confluence; 3 = large confluent areas). Stages 2-3 were defined as advanced WMHs. The PR interval was measured from resting 12-lead ECG. PR duration >200ms was defined as PR interval prolongation. We used a binary logistic regression for statistical analysis. We examined the relationship between MRI and ECG measures and adjusted them for clinical risk factors.ResultsWe included 2464 individuals (age 59±15 years, 47% women) into analyses. The median PR interval was 160ms (interquartile range 143-179), and 319 (13%) individuals with advanced WMHs, were significantly older, had more cardiovascular comorbidities and risk factors compared to individuals without WMHs (all pConclusionPR interval duration is associated with advanced WMHs beside advanced age, hypertension, and history of stroke. Further research is needed to determine whether changes in PR interval indices are clinically relevant for changes in WMHs.
وصف الملف: electronic resource
Relation: https://doaj.org/toc/1932-6203
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2دورية أكاديمية
المؤلفون: Evelyn Medawar, Ronja Thieleking, Iryna Manuilova, Maria Paerisch, Arno Villringer, A Veronica Witte, Frauke Beyer
المصدر: PLoS ONE, Vol 16, Iss 10, p e0239021 (2021)
الوصف: Longitudinal imaging studies are crucial for advancing the understanding of brain development over the lifespan. Thus, more and more studies acquire imaging data at multiple time points or with long follow-up intervals. In these studies changes to magnetic resonance imaging (MRI) scanners often become inevitable which may decrease the reliability of the MRI assessments and introduce biases. We therefore investigated the difference between MRI scanners with subsequent versions (3 Tesla Siemens Verio vs. Skyra) on the cortical and subcortical measures of grey matter in 116 healthy, young adults using the well-established longitudinal FreeSurfer stream for T1-weighted brain images. We found excellent between-scanner reliability for cortical and subcortical measures of grey matter structure (intra-class correlation coefficient > 0.8). Yet, paired t-tests revealed statistically significant differences in at least 67% of the regions, with percent differences around 2 to 4%, depending on the outcome measure. Offline correction for gradient distortions only slightly reduced these biases. Further, T1-imaging based quality measures reflecting gray-white matter contrast systematically differed between scanners. We conclude that scanner upgrades during a longitudinal study introduce bias in measures of cortical and subcortical grey matter structure. Therefore, before upgrading a MRI scanner during an ongoing study, researchers should prepare to implement an appropriate correction method for these effects.
وصف الملف: electronic resource
Relation: https://doaj.org/toc/1932-6203
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3دورية أكاديمية
المؤلفون: Marcus Meinzer, Tobias Flaisch, Lauren Seeds, Stacy Harnish, Daria Antonenko, Veronica Witte, Robert Lindenberg, Bruce Crosson
المصدر: PLoS ONE, Vol 7, Iss 3, p e33631 (2012)
الوصف: The neural basis of word-retrieval deficits in normal aging has rarely been assessed and the few previous functional imaging studies found enhanced activity in right prefrontal areas in healthy older compared to younger adults. However, more pronounced right prefrontal recruitment has primarily been observed during challenging task conditions. Moreover, increased task difficulty may result in enhanced activity in the ventral inferior frontal gyrus (vIFG) bilaterally in younger participants as well. Thus, the question arises whether increased activity in older participants represents an age-related phenomenon or reflects task difficulty effects. In the present study, we manipulated task difficulty during overt semantic and phonemic word-generation and used functional magnetic resonance imaging to assess activity patterns in the vIFG in healthy younger and older adults (N = 16/group; mean age: 24 vs. 69 years). Both groups produced fewer correct responses during the more difficult task conditions. Overall, older participants produced fewer correct responses and showed more pronounced task-related activity in the right vIFG. However, increased activity during the more difficult conditions was found in both groups. Absolute degree of activity was correlated with performance across groups, tasks and difficulty levels. Activity modulation (difficult vs. easy conditions) was correlated with the respective drop in performance across groups and tasks. In conclusion, vIFG activity levels and modulation of activity were mediated by performance accuracy in a similar way in both groups. Group differences in the right vIFG activity were explained by performance accuracy which needs to be considered in future functional imaging studies of healthy and pathological aging.
وصف الملف: electronic resource
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4
المؤلفون: Frauke Beyer, Ronja Thieleking, Iryna Manuilova, Maria Paerisch, Evelyn Medawar, Arno Villringer, A. Veronica Witte
المصدر: PLoS One
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0239021 (2021)مصطلحات موضوعية: Male, Central Nervous System, Longitudinal study, Computer science, Nervous System, Diagnostic Radiology, Thalamus, Medicine and Health Sciences, Contrast (vision), Longitudinal Studies, Gray Matter, Right Hemisphere, Tomography, Reliability (statistics), media_common, Multidisciplinary, medicine.diagnostic_test, Radiology and Imaging, Software Engineering, Brain, Middle Aged, Magnetic Resonance Imaging, White Matter, medicine.anatomical_structure, Research Design, Medicine, Engineering and Technology, Female, Anatomy, Cartography, Research Article, Adult, Computer and Information Sciences, Scanner, Correlation coefficient, Imaging Techniques, Science, media_common.quotation_subject, Neuroimaging, Grey matter, Research and Analysis Methods, Lateralization of brain function, Computer Software, Young Adult, Diagnostic Medicine, medicine, Humans, Left Hemisphere, Reproducibility of Results, Biology and Life Sciences, Magnetic resonance imaging, Computed Axial Tomography, Cerebral Hemispheres, Neuroscience
الوصف: Longitudinal imaging studies are crucial for advancing the understanding of brain development over the lifespan. Thus, more and more studies acquire imaging data at multiple time points or with long follow-up intervals. In these studies changes to magnetic resonance imaging (MRI) scanners often become inevitable which may decrease the reliability of the MRI assessments and introduce biases. We therefore investigated the difference between MRI scanners with subsequent versions (3 Tesla Siemens Verio vs. Skyra) on the cortical and subcortical measures of grey matter in 116 healthy, young adults using the well-established longitudinal FreeSurfer stream for T1-weighted brain images. We found excellent between-scanner reliability for cortical and subcortical measures of grey matter structure (intra-class correlation coefficient > 0.8). Yet, paired t-tests revealed statistically significant differences in at least 67% of the regions, with percent differences around 2 to 4%, depending on the outcome measure. Offline correction for gradient distortions only slightly reduced these biases. Further, T1-imaging based quality measures reflecting gray-white matter contrast systematically differed between scanners. We conclude that scanner upgrades during a longitudinal study introduce bias in measures of cortical and subcortical grey matter structure. Therefore, before upgrading a MRI scanner during an ongoing study, researchers should prepare to implement an appropriate correction method for these effects.
وصف الملف: application/pdf
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5دورية أكاديمية
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المؤلفون: Daria Antonenko, Marcus Meinzer, Stacy M. Harnish, Robert Lindenberg, Bruce Crosson, A. Veronica Witte, Tobias Flaisch, Lauren Seeds
المصدر: PLoS ONE, Vol 7, Iss 3, p e33631 (2012)
PLoS One
PLoS ONEمصطلحات موضوعية: Male, Aging, Anatomy and Physiology, lcsh:Medicine, Audiology, Neuropsychological Tests, Social and Behavioral Sciences, Task (project management), 0302 clinical medicine, ddc:150, Verbal fluency test, Psychology, 10. No inequality, lcsh:Science, Aged, 80 and over, Multidisciplinary, Language Tests, medicine.diagnostic_test, 05 social sciences, Middle Aged, Magnetic Resonance Imaging, Frontal Lobe, Semantics, Mental Health, Frontal lobe, Medicine, Female, Research Article, Adult, medicine.medical_specialty, Inferior frontal gyrus, Neuroimaging, 050105 experimental psychology, 03 medical and health sciences, Young Adult, Functional neuroimaging, medicine, Humans, 0501 psychology and cognitive sciences, Biology, Aged, Behavior, business.industry, Functional Neuroimaging, lcsh:R, Linguistics, Age difference, word-retrieval difficulties, Functional imaging, lcsh:Q, Functional magnetic resonance imaging, business, Physiological Processes, 030217 neurology & neurosurgery, Neuroscience
الوصف: The neural basis of word-retrieval deficits in normal aging has rarely been assessed and the few previous functional imaging studies found enhanced activity in right prefrontal areas in healthy older compared to younger adults. However, more pronounced right prefrontal recruitment has primarily been observed during challenging task conditions. Moreover, increased task difficulty may result in enhanced activity in the ventral inferior frontal gyrus (vIFG) bilaterally in younger participants as well. Thus, the question arises whether increased activity in older participants represents an age-related phenomenon or reflects task difficulty effects. In the present study, we manipulated task difficulty during overt semantic and phonemic word-generation and used functional magnetic resonance imaging to assess activity patterns in the vIFG in healthy younger and older adults (N = 16/group; mean age: 24 vs. 69 years). Both groups produced fewer correct responses during the more difficult task conditions. Overall, older participants produced fewer correct responses and showed more pronounced task-related activity in the right vIFG. However, increased activity during the more difficult conditions was found in both groups. Absolute degree of activity was correlated with performance across groups, tasks and difficulty levels. Activity modulation (difficult vs. easy conditions) was correlated with the respective drop in performance across groups and tasks. In conclusion, vIFG activity levels and modulation of activity were mediated by performance accuracy in a similar way in both groups. Group differences in the right vIFG activity were explained by performance accuracy which needs to be considered in future functional imaging studies of healthy and pathological aging.
وصف الملف: application/pdf
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