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1دورية أكاديمية
المؤلفون: Burgos-Flórez F; Department of Medicine, Biotechnology Research Group, Universidad del Norte, Barranquilla, Colombia.; Department of Mechanical Engineering, Rational Use of Energy and Preservation of the Environment Group (UREMA), Universidad del Norte, Barranquilla, Colombia., Rodríguez A; Department of Medicine, Biotechnology Research Group, Universidad del Norte, Barranquilla, Colombia., Cervera E; Department of Medicine, Biotechnology Research Group, Universidad del Norte, Barranquilla, Colombia., Zucolotto V; GNano-Nanomedicine and Nanotoxicology Group, São Carlos Institute of Physics, University of São Paulo, São Carlos, São Paulo, Brazil., Sanjuán M; Department of Mechanical Engineering, Rational Use of Energy and Preservation of the Environment Group (UREMA), Universidad del Norte, Barranquilla, Colombia., Villalba PJ; Department of Medicine, Biotechnology Research Group, Universidad del Norte, Barranquilla, Colombia.
المصدر: PloS one [PLoS One] 2022 Feb 07; Vol. 17 (2), pp. e0263738. Date of Electronic Publication: 2022 Feb 07 (Print Publication: 2022).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Validation Study
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
مواضيع طبية MeSH: Biosensing Techniques*/instrumentation , Biosensing Techniques*/methods , Dielectric Spectroscopy*/instrumentation , Dielectric Spectroscopy*/methods , Point-of-Care Systems*, Brain Injuries, Traumatic/*diagnosis , S100 Calcium Binding Protein beta Subunit/*blood, Blood Chemical Analysis/instrumentation ; Blood Chemical Analysis/methods ; Brain Injuries, Traumatic/blood ; Brain Injuries, Traumatic/pathology ; Colombia ; Electric Impedance ; Electrochemical Techniques/instrumentation ; Electrodes ; Gold/chemistry ; Humans ; Potentiometry/instrumentation ; Potentiometry/methods ; S100 Calcium Binding Protein beta Subunit/analysis ; Software ; Trauma Severity Indices ; Wireless Technology/instrumentation
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2دورية أكاديمية
المؤلفون: Wang X; Department of Anesthesiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China., Chen X; Department of Anesthesiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China., Wu F; Department of Anesthesiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China., Liu Y; Department of Anesthesiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China., Yang Y; Department of Anesthesiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China., Chen W; Department of Anesthesiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China., Pan Z; Department of Neurosurgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China., Hu W; Department of Neurosurgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China., Zheng F; Department of Neurosurgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China., He H; Department of Anesthesiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China.
المصدر: PloS one [PLoS One] 2023 Apr 25; Vol. 18 (4), pp. e0284728. Date of Electronic Publication: 2023 Apr 25 (Print Publication: 2023).
نوع المنشور: Meta-Analysis; Journal Article; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
مواضيع طبية MeSH: Postoperative Cognitive Complications* , Cognitive Dysfunction*/diagnosis , Cognitive Dysfunction*/etiology, Humans ; Postoperative Complications/diagnosis ; Postoperative Complications/etiology ; Postoperative Complications/metabolism ; Biomarkers/metabolism ; S100 Calcium Binding Protein beta Subunit
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3دورية أكاديمية
المؤلفون: Yoshida S; Division of Life Science, Graduate School of Agriculture, Meiji University, Kanagawa, Japan.; Organization for the Strategic Coordination of Research and Intellectual Property, Meiji University, Kanagawa, Japan.; Institute of Reproduction and Endocrinology, Meiji University, Kanagawa, Japan., Nishimura N; Division of Life Science, Graduate School of Agriculture, Meiji University, Kanagawa, Japan., Yurino H; Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan., Kobayashi M; Department of Life Science, School of Agriculture, Meiji University, Kanagawa, Japan., Horiguchi K; Laboratory of Anatomy and Cell Biology, Department of Health Sciences, Kyorin University, Tokyo, Japan., Yano K; Department of Life Science, School of Agriculture, Meiji University, Kanagawa, Japan., Hashimoto SI; Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan., Kato T; Organization for the Strategic Coordination of Research and Intellectual Property, Meiji University, Kanagawa, Japan.; Institute of Reproduction and Endocrinology, Meiji University, Kanagawa, Japan., Kato Y; Division of Life Science, Graduate School of Agriculture, Meiji University, Kanagawa, Japan.; Institute of Reproduction and Endocrinology, Meiji University, Kanagawa, Japan.; Department of Life Science, School of Agriculture, Meiji University, Kanagawa, Japan.
المصدر: PloS one [PLoS One] 2018 Apr 23; Vol. 13 (4), pp. e0196029. Date of Electronic Publication: 2018 Apr 23 (Print Publication: 2018).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
مواضيع طبية MeSH: Adult Stem Cells/*cytology , Cell Culture Techniques/*methods , Pituitary Gland, Anterior/*cytology , S100 Calcium Binding Protein beta Subunit/*metabolism, Adult Stem Cells/metabolism ; Animals ; Biomarkers/metabolism ; Cell Differentiation ; Cell Plasticity ; Cell Proliferation ; Cells, Cultured ; Endocrine Cells/cytology ; Endocrine Cells/metabolism ; Pituitary Gland, Anterior/metabolism ; Rats ; S100 Calcium Binding Protein beta Subunit/genetics ; SOXB1 Transcription Factors/metabolism ; Stem Cell Niche
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4دورية أكاديمية
المؤلفون: Iwamoto T; Department of Stroke Medicine, Kawasaki Medical School, Okayama, Japan., Kitano T; Department of Stroke Medicine, Kawasaki Medical School, Okayama, Japan.; Department of Neurology, Osaka University Graduate School of Medicine, Osaka Japan.; Department of Neurology, Toyonaka Municipal Hospital, Osaka, Japan., Oyama N; Department of Stroke Medicine, Kawasaki Medical School, Okayama, Japan., Yagita Y; Department of Stroke Medicine, Kawasaki Medical School, Okayama, Japan.
المصدر: PloS one [PLoS One] 2021 Aug 16; Vol. 16 (8), pp. e0256170. Date of Electronic Publication: 2021 Aug 16 (Print Publication: 2021).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
مواضيع طبية MeSH: Brain Edema/*diagnosis , Cerebral Infarction/*diagnosis , Cerebrovascular Disorders/*diagnosis , Stroke/*diagnosis , Thrombectomy/*methods, Aged ; Aged, 80 and over ; Amyloid beta-Protein Precursor/blood ; Amyloid beta-Protein Precursor/genetics ; Biomarkers/blood ; Brain Edema/genetics ; Brain Edema/pathology ; Brain Edema/surgery ; Cerebral Infarction/genetics ; Cerebral Infarction/pathology ; Cerebral Infarction/surgery ; Cerebrovascular Disorders/genetics ; Cerebrovascular Disorders/pathology ; Cerebrovascular Disorders/surgery ; Claudin-5/blood ; Claudin-5/genetics ; Endothelin-1/blood ; Endothelin-1/genetics ; Female ; Gene Expression ; Humans ; Male ; Matrix Metalloproteinase 9/blood ; Matrix Metalloproteinase 9/genetics ; Predictive Value of Tests ; Prospective Studies ; S100 Calcium Binding Protein beta Subunit/blood ; S100 Calcium Binding Protein beta Subunit/genetics ; Stroke/genetics ; Stroke/pathology ; Stroke/surgery
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5دورية أكاديمية
المؤلفون: Mietani K; Department of Anaesthesiology and Pain relief Center, The University of Tokyo Hospital, Tokyo, Japan., Hasegawa-Moriyama M; Department of Pain and Palliative Medical Sciences, Faculty of Medicine, The University of Tokyo, Tokyo, Japan., Inoue R; Department of Anaesthesiology and Pain relief Center, The University of Tokyo Hospital, Tokyo, Japan., Ogata T; Department of Rehabilitation Medicine, The University of Tokyo Hospital, Tokyo, Japan., Shimojo N; Department of Emergency and Critical Care Medicine, Tsukuba University Hospital, Ibaraki, Japan., Kurano M; Department of Clinical Laboratory Medicine, The University of Tokyo Hospital, Tokyo, Japan., Sumitani M; Department of Pain and Palliative Medicines, Faculty of Medicine, The University of Tokyo, Tokyo, Japan., Uchida K; Department of Anaesthesiology and Pain relief Center, The University of Tokyo Hospital, Tokyo, Japan.
المصدر: PloS one [PLoS One] 2021 Nov 19; Vol. 16 (11), pp. e0259217. Date of Electronic Publication: 2021 Nov 19 (Print Publication: 2021).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
مواضيع طبية MeSH: Delirium/*diagnosis , Neurofilament Proteins/*blood , Phosphopyruvate Hydratase/*blood, Aged ; Aged, 80 and over ; Area Under Curve ; Biomarkers/blood ; Delirium/surgery ; Female ; Humans ; Male ; Middle Aged ; Phosphorylation ; Postoperative Period ; Prospective Studies ; Protein Subunits/blood ; ROC Curve ; S100 Calcium Binding Protein beta Subunit/blood
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6دورية أكاديمية
المؤلفون: Horiguchi K; Laboratory of Anatomy and Cell Biology, Department of Health Sciences, Kyorin University, Mitaka, Tokyo, Japan.; Institute of Endocrinology, Meiji University, Kawasaki, Kanagawa, Japan., Yako H; Division of Life Science, Graduate School of Agriculture, Meiji University, Kawasaki, Kanagawa, Japan., Yoshida S; Institute of Endocrinology, Meiji University, Kawasaki, Kanagawa, Japan.; Division of Life Science, Graduate School of Agriculture, Meiji University, Kawasaki, Kanagawa, Japan., Fujiwara K; Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan., Tsukada T; Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan., Kanno N; Division of Life Science, Graduate School of Agriculture, Meiji University, Kawasaki, Kanagawa, Japan., Ueharu H; Division of Life Science, Graduate School of Agriculture, Meiji University, Kawasaki, Kanagawa, Japan., Nishihara H; Division of Life Science, Graduate School of Agriculture, Meiji University, Kawasaki, Kanagawa, Japan., Kato T; Institute of Endocrinology, Meiji University, Kawasaki, Kanagawa, Japan., Yashiro T; Division of Histology and Cell Biology, Department of Anatomy, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan., Kato Y; Institute of Endocrinology, Meiji University, Kawasaki, Kanagawa, Japan.; Division of Life Science, Graduate School of Agriculture, Meiji University, Kawasaki, Kanagawa, Japan.
المصدر: PloS one [PLoS One] 2016 Oct 03; Vol. 11 (10), pp. e0163981. Date of Electronic Publication: 2016 Oct 03 (Print Publication: 2016).
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
مواضيع طبية MeSH: Mesenchymal Stem Cells/*metabolism , Pituitary Gland, Anterior/*cytology , Pituitary Gland, Anterior/*metabolism , S100 Calcium Binding Protein beta Subunit/*metabolism, Animals ; Biomarkers ; Fetus ; Fluorescent Antibody Technique ; Gene Expression ; Genes, Reporter ; Male ; Organogenesis/genetics ; Pituitary Hormones/metabolism ; Promoter Regions, Genetic ; Rats ; S100 Calcium Binding Protein beta Subunit/genetics
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7دورية أكاديمية
المؤلفون: Alasady MJ; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, United States of America.; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL USA., Terry AR; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL USA., Pierce AD; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, United States of America.; Center for Biomolecular Therapeutics, University of Maryland School of Medicine, Baltimore, MD, United States of America., Cavalier MC; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, United States of America.; Center for Biomolecular Therapeutics, University of Maryland School of Medicine, Baltimore, MD, United States of America., Blaha CS; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL USA., Adipietro KA; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, United States of America.; Center for Biomolecular Therapeutics, University of Maryland School of Medicine, Baltimore, MD, United States of America., Wilder PT; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, United States of America.; Center for Biomolecular Therapeutics, University of Maryland School of Medicine, Baltimore, MD, United States of America.; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, United States of America., Weber DJ; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, United States of America.; Center for Biomolecular Therapeutics, University of Maryland School of Medicine, Baltimore, MD, United States of America.; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, United States of America., Hay N; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL USA.
المصدر: PloS one [PLoS One] 2021 Aug 19; Vol. 16 (8), pp. e0256238. Date of Electronic Publication: 2021 Aug 19 (Print Publication: 2021).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
مواضيع طبية MeSH: Interleukin-6/*genetics , Melanoma/*genetics , Ribosomal Protein S6 Kinases, 90-kDa/*genetics , S100 Calcium Binding Protein beta Subunit/*genetics , STAT3 Transcription Factor/*genetics, Calcium-Binding Proteins/genetics ; Cell Line, Tumor ; Cyclic AMP Response Element-Binding Protein/genetics ; Cytoplasm/genetics ; Doxycycline/pharmacology ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Melanoma/drug therapy ; Melanoma/pathology ; Signal Transduction/drug effects
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8دورية أكاديمية
المؤلفون: Bajor M; Department of Biophysics, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.; Department of Immunology, Centre for Biostructure Research, Medical University of Warsaw, Warsaw, Poland., Zaręba-Kozioł M; Department of Biophysics, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.; Department of Molecular and Cellular Neurobiology, Nencki Institute, Polish Academy of Sciences, Warsaw, Poland., Zhukova L; Department of Biophysics, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland., Goryca K; Department of Biophysics, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland., Poznański J; Department of Biophysics, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland., Wysłouch-Cieszyńska A; Department of Biophysics, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
المصدر: PloS one [PLoS One] 2016 May 09; Vol. 11 (5), pp. e0154822. Date of Electronic Publication: 2016 May 09 (Print Publication: 2016).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
مواضيع طبية MeSH: Astrocytes/*metabolism , Metals/*metabolism , Nitroso Compounds/*metabolism , S100 Calcium Binding Protein beta Subunit/*metabolism, Amino Acid Sequence ; Animals ; Calorimetry ; Cell Line, Tumor ; Male ; Mass Spectrometry ; Osmolar Concentration ; Protein Binding ; Rats ; Rats, Wistar ; S100 Calcium Binding Protein beta Subunit/chemistry ; Sequence Homology, Amino Acid
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9دورية أكاديمية
المؤلفون: Andersson M; Department of Anesthesiology and Intensive Care, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Oras J; Department of Anesthesiology and Intensive Care, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Thörn SE; Department of Anesthesiology and Intensive Care, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Karlsson O; Department of Anesthesiology and Intensive Care, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Kälebo P; Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Zetterberg H; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, United Kingdom.; UK Dementia Research Institute, London, United Kingdom., Blennow K; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden., Bergman L; Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.; Department of Obstetrics and Gynecology, Stellenbosch University, Cape Town, South Africa.
المصدر: PloS one [PLoS One] 2021 Feb 08; Vol. 16 (2), pp. e0246786. Date of Electronic Publication: 2021 Feb 08 (Print Publication: 2021).
نوع المنشور: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
مواضيع طبية MeSH: Axons/*metabolism , Brain Diseases/*cerebrospinal fluid , Pre-Eclampsia/*cerebrospinal fluid , S100 Calcium Binding Protein beta Subunit/*cerebrospinal fluid, Biomarkers/cerebrospinal fluid ; Brain Diseases/etiology ; Case-Control Studies ; Female ; Humans ; Pre-Eclampsia/pathology ; Pregnancy
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10دورية أكاديمية
المؤلفون: Akin M; Cardiac Arrest Centre, Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany., Garcheva V; Cardiac Arrest Centre, Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany., Sieweke JT; Cardiac Arrest Centre, Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany., Adel J; Cardiac Arrest Centre, Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany., Flierl U; Cardiac Arrest Centre, Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany., Bauersachs J; Cardiac Arrest Centre, Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany., Schäfer A; Cardiac Arrest Centre, Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
المصدر: PloS one [PLoS One] 2021 Jan 07; Vol. 16 (1), pp. e0245210. Date of Electronic Publication: 2021 Jan 07 (Print Publication: 2021).
نوع المنشور: Clinical Trial; Journal Article; Observational Study; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
مواضيع طبية MeSH: Hypothermia, Induced* , Nervous System Diseases*/blood , Nervous System Diseases*/mortality , Out-of-Hospital Cardiac Arrest*/blood , Out-of-Hospital Cardiac Arrest*/mortality , Out-of-Hospital Cardiac Arrest*/therapy , Registries*, Phosphopyruvate Hydratase/*blood , S100 Calcium Binding Protein beta Subunit/*blood, Aged ; Biomarkers/blood ; Disease-Free Survival ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Prospective Studies ; Survival Rate